Căng thẳng oxy hóa do tăng đường huyết trong các biến chứng tiểu đường

Springer Science and Business Media LLC - Tập 122 - Trang 333-338 - 2004
George L. King1,2, Mary R. Loeken3,2
1Section on Vascular Cell Biology and Complications, Joslin Diabetes Center, Boston, USA
2Department of Medicine, Harvard Medical School, Boston, USA
3Section on Development and Stem Cell Biology, Joslin Diabetes Center, Boston, USA

Tóm tắt

Loại oxy phản ứng được tăng cường bởi tình trạng tăng đường huyết. Tình trạng tăng đường huyết, xảy ra trong bệnh tiểu đường (cả loại 1 và loại 2) và, ở mức độ thấp hơn, trong các tình trạng kháng insulin, gây ra căng thẳng oxy hóa. Axit béo tự do, có thể tăng cao trong các trường hợp kiểm soát đường huyết không đầy đủ, cũng có thể góp phần vào tình trạng này. Trong bài tổng quan này, chúng tôi sẽ thảo luận về vai trò của căng thẳng oxy hóa trong các biến chứng tiểu đường. Căng thẳng oxy hóa có thể quan trọng trong bệnh tiểu đường, không chỉ vì vai trò của nó trong sự phát triển của các biến chứng, mà còn vì tình trạng tăng đường huyết kéo dài, thứ phát do kháng insulin, có thể gây ra căng thẳng oxy hóa và góp phần vào sự phá hủy tế bào beta trong bệnh tiểu đường loại 2. Sự tập trung của bài tổng quan này sẽ vào vai trò của căng thẳng oxy hóa trong nguyên nhân của các biến chứng tiểu đường.

Từ khóa

#Căng thẳng oxy hóa #biến chứng tiểu đường #tăng đường huyết #kháng insulin #tế bào beta.

Tài liệu tham khảo

Baynes JW, Thorpe SR (1999) Role of oxidative stress in diabetic complications: a new perspective on an old paradigm. Diabetes 48:1–9 Beckman JA, Goldfine AB, Gordon MB, Creager MA (2001) Ascorbate restores endothelium-dependent vasodilation impaired by acute hyperglycemia in humans. Circulation 103:1618–1623 Benigni A, Perico N, Remuzzi G (2000) Endothelin antagonists and renal protection. J Cardiovasc Pharmacol 35:S75–S78 Boaz M, Smetana S, Weinstein T, Matas Z, Gafter U, Iaina A, Knecht A, Weissgarten Y, Brunner D, Fainaru M, Green MS (2000) Secondary prevention with antioxidants of cardiovascular disease in endstage renal disease (SPACE): randomised placebo-controlled trial. Lancet 356:1213–1218 Bursell SE, Clermont AC, Aiello LP, Aiello LM, Schlossman DK, Feener EP, Laffel L, King GL (1999) High-dose vitamin E supplementation normalizes retinal blood flow and creatinine clearance in patients with type 1 diabetes. Diabetes Care 22:1245–1251 Cederberg J, Galli J, Luthman H, Eriksson UJ (2000) Increased mRNA levels of Mn-SOD and catalase in embryos of diabetic rats from a malformation-resistant strain. Diabetes 49:101–107 Chang TI, Horal M, Jain S, Wang F, Patel R, Loeken MR (2003) Oxidant regulation of gene expression and neural tube development: insights gained from diabetic pregnancy on molecular causes of neural tube defects. Diabetologia 46:538–545 Du X, Matsumura T, Edelstein D, Rossetti L, Zsengeller Z, Szabo C, Brownlee M (2003) Inhibition of GAPDH activity by poly(ADP-ribose) polymerase activates three major pathways of hyperglycemic damage in endothelial cells. J Clin Invest 112:1049–1057 Dunlop M (2000) Aldose reductase and the role of the polyol pathway in diabetic nephropathy. Kidney Int Suppl 77:S3–S12 Eriksson U, Siman CM (1996) Pregnant diabetic rats fed the antioxidant butylated hydroxytoluene show decreased occurrence of malformations in offspring. Diabetes 45:1497–1502 Feldman EL, Stevens MJ, Greene DA (1997) Pathogenesis of diabetic neuropathy. Clin Neurosci 4:365–370 Fine E, Horal M, Chang T, Fortin G, Loeken M (1999) Hyperglycemia is responsible for altered gene expression, apoptosis, and neural tube defects associated with diabetic pregnancy. Diabetes 48:2454–2462 Forsberg H, Borg LA, Cagliero E, Eriksson UJ (1996) Altered levels of scavenging enzymes in embryos subjected to a diabetic environment. Free Radic Res 24:451–459 Gaede P, Poulsen HE, Parving HH, Pedersen O (2001) Double-blind, randomised study of the effect of combined treatment with vitamin C and E on albuminuria in type 2 diabetic patients. Diabet Med 18:756–760 Garcia-Ruiz C, Colell A, Morales A, Kaplowitz N, Fernandez-Checa JC (1995) Role of oxidative stress generated from the mitochondrial electron transport chain and mitochondrial glutathione status in loss of mitochondrial function and activation of transcription factor nuclear factor-kappa B: studies with isolated mitochondria and rat hepatocytes. Mol Pharmacol 48:825–834 Giugliano D, Ceriello A (1996) Oxidative stress and diabetic vascular complications. Diabetes Care 19:257–267 Goldberg HJ, Whiteside CI, Fantus IG (2002) The hexosamine pathway regulates the plasminogen activator inhibitor-1 gene promoter and Sp1 transcriptional activation through protein kinase C-beta I and -delta. J Biol Chem 277:33833–33841 Greene EL, Nelson BA, Robinson KA, Buse MG (2001) Alpha-lipoic acid prevents the development of glucose-induced insulin resistance in 3T3-L1 adipocytes and accelerates the decline in immunoreactive insulin during cell incubation. Metabolism 50:1063–1069 Griendling KK, FitzGerald GA (2003) Oxidative stress and cardiovascular injury. I. basic mechanisms and in vivo monitoring of ROS. Circulation 108:1912–1916 Hagay ZJ, Weiss Y, Zusman I, Peled-Kamar M, Reece EA, Eriksson UJ, Groner Y (1995) Prevention of diabetes-associated embryopathy by overexpression of the free radical scavenger copper zinc superoxide dismutase in transgenic mouse embryos. Am J Obstet Gynecol 173:1036–1041 Hammes HP, Du X, Edelstein D, Taguchi T, Matsumura T, Ju Q, Lin J, Bierhaus A, Nawroth P, Hannak D, Neumaier M, Bergfeld R, Giardino I, Brownlee M (2003) Benfotiamine blocks three major pathways of hyperglycemic damage and prevents experimental diabetic retinopathy. Nat Med 9:294–299 Hancock JT, Desikan R, Neill SJ (2001) Role of reactive oxygen species in cell signalling pathways. Biochem Soc Trans 29:345–350 Hoffman BB, Sharma K, Ziyadeh FN (1998) Potential role of TGF-beta in diabetic nephropathy. Miner Electrolyte Metab 24:190–196 Hounsom L, Corder R, Patel J, Tomlinson DR (2001) Oxidative stress participates in the breakdown of neuronal phenotype in experimental diabetic neuropathy. Diabetologia 44:424–428 Inoguchi T, Li P, Umeda F, Yu HY, Kakimoto M, Imamura M, Aoki T, Etoh T, Hashimoto T, Naruse M, Sano H, Utsumi H, Nawata H (2000) High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C-dependent activation of NAD(P)H oxidase in cultured vascular cells. Diabetes 49:1939–1945 Ishii H, Jirousek MR, Koya D, Takagi C, Xia P, Clermont A, Bursell SE, Kern TS, Ballas LM, Heath WF, Stramm LE, Feener EP, King GL (1996) Amelioration of vascular dysfunctions in diabetic rats by an oral PKC beta inhibitor. Science 272:728–731 Itani SI, Ruderman NB, Schmieder F, Boden G (2002) Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha. Diabetes 51:2005–2011 Kanji MI, Toews ML, Carper WR (1976) A kinetic study of glucose-6-phosphate dehydrogenase. J Biol Chem 251:2258–2262 Kashiwagi A, Asahina T, Nishio Y, Motoyoshi I, Tanaka Y, Kikkawa R, Shigeta Y (1996) Glycation, oxidative stress, and scavenger activity. Glucose metabolism and radical scavenger dysfunction in endothelial cells. Diabetes 45:S84–S86 King GL, Kunisaki M, Nishio Y, Inoguchi T, Shiba T, Xia P (1996) Biochemical and molecular mechanisms in the development of diabetic vascular complications. Diabetes 45(suppl 3):S105–S108 Konrad D, Somwar R, Sweeney G, Yaworsky K, Hayashi M, Ramlal T, Klip A (2001) The antihyperglycemic drug alpha-lipoic acid stimulates glucose uptake via both GLUT4 translocation and GLUT4 activation: potential role of p38 mitogen-activated protein kinase in GLUT4 activation. Diabetes 50:1464–1471 Kowluru RA, Kennedy A (2001) Therapeutic potential of anti-oxidants and diabetic retinopathy. Expert Opin Investig Drugs 10:1665–1676 Kunisaki M, Bursell S-E, Clermont AC, Ishii H, Ballas LM, Jirousek MR, Umeda F, Naata H, King GL (1995) Vitamin E prevents diabetes-induced abnormal retinal blood flow via the diacylglycerol-protein kinase C pathway. Am J Physiol Endocrinol Metab 269:E239–E246 Kunisaki M, Fumio U, Nawata H, King GL (1996) Vitamin E normalizes diacylglycerol-protein kinase C activation induced by hyperglycemia in rat vascular tissues. Diabetes 45(suppl 3):117–119 Liu PK, Grossman RG, Hsu CY, Robertson CS (2001) Ischemic injury and faulty gene transcripts in the brain. Trends Neurosci 24:581–588 Lonn E, Yusuf S, Hoogwerf B, Pogue J, Yi Q, Zinman B, Bosch J, Dagenais G, Mann JF, Gerstein HC (2002) Effects of vitamin E on cardiovascular and microvascular outcomes in high-risk patients with diabetes: results of the HOPE study and MICRO-HOPE substudy. Diabetes Care 25:1919–1927 Marshall HE, Merchant K, Stamler JS (2000) Nitrosation and oxidation in the regulation of gene expression. FASEB J 14:1889–1900 McDonagh PF, Hokama JY (2000) Microvascular perfusion and transport in the diabetic heart. Microcirculation 7:163–181 Napoli C, de Nigris F, Palinski W (2001) Multiple role of reactive oxygen species in the arterial wall. J Cell Biochem 82:674–682 Natarajan R, Bai W, Lanting L, Gonzales N, Nadler J (1997) Effects of high glucose on vascular endothelial growth factor expression in vascular smooth muscle cells. Am J Physiol 273:H2224–H2231 Nemoto S, Takeda K, Yu ZX, Ferrans VJ, Finkel T (2000) Role for mitochondrial oxidants as regulators of cellular metabolism. Mol Cell Biol 20:7311–7318 Nicoletti VG, Stella AM (2003) Role of PARP under stress conditions: cell death or protection? Neurochem Res 28:187–194 Nishikawa T, Edelstein D, Du XL, Yamagishi S-I, Matsumura T, Kaneda Y, Yorek MA, Beebe D, Oates PJ, Hammes H-P, Giardino I, Brownlee M (2000) Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage. Nature 404:787–790 Oren M (2003) Decision making by p53: life, death and cancer. Cell Death Differ 10:431–442 Owuor ED, Kong AN (2002) Antioxidants and oxidants regulated signal transduction pathways. Biochem Pharmacol 64:765–770 Ozes ON, Mayo LD, Gustin JA, Pfeffer SR, Pfeffer LM, Donner DB (1999) NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase. Nature 401:82–85 Packer L, Kraemer K, Rimbach G (2001) Molecular aspects of lipoic acid in the prevention of diabetes complications. Nutrition 17:888–895 Phelan SA, Ito M, Loeken MR (1997) Neural tube defects in embryos of diabetic mice: role of the Pax-3 gene and apoptosis. Diabetes 46:1189–1197 Ruggiero D, Lecomte M, Michoud E, Lagarde M, Wiernsperger N (1997) Involvement of cell-cell interactions in the pathogenesis of diabetic retinopathy. Diabetes Metab 23:30–42 Rutter J, Reick M, Wu LC, McKnight SL (2001) Regulation of clock and NPAS2 DNA binding by the redox state of NAD cofactors. Science 293:510–514 Savitsky PA, Finkel T (2002) Redox regulation of Cdc25C. J Biol Chem 277:20535–20540 Sharpe PC, Liu W-H, Yue KKM, McMasgter D, Catherwood MA, McGinty AM, Trimble ER (1998) Glucose-induced oxidative stress in vascular contractile cells: comparison of aortic smooth muscle cells and retinal pericytes. Diabetes 47:801–809 Shin SJ, Lee YJ, Lin SR, Tan MS, Lai YH, Tsai JH (1995) Decrease of renal endothelin 1 content and gene expression in diabetic rats with moderate hyperglycemia. Nephron 70:486–493 Siman CM, Eriksson UJ (1997a) Vitamin E decreases the occurrence of malformations in the offspring of diabetic rats. Diabetes 46:1054–1061 Siman CM, Eriksson UJ (1997b) Vitamin C supplementation of the maternal diet reduces the rate of malformation in the offspring of diabetic rats. Diabetologia 40:1416–1424 Sivan E, Reece EA, Wu Y-K, Homko CJ, Polansky M, Borenstein M (1996) Dietary vitamin E prophylaxis and diabetic embryopathy: morphologic and biochemical analysis. Am J Obstet Gynecol 175:793–799 Stepanovic V, Awad O, Jiao C, Dunnwald M, Schatteman GC (2003) Leprdb diabetic mouse bone marrow cells inhibit skin wound vascularization but promote wound healing. Circ Res 92:1247–1253 Stephens NG, Parsons A, Schofield PM, Kelly F, Cheeseman K, Mitchinson MJ, Brown MJ (1996) Randomised controlled trial of vitamin E in patients with coronary disease: Cambridge heart antioxidant study (CHAOS). Lancet 347:781–786 Sugimoto H, Shikata K, Makino H, Ota K, Ota Z (1996) Increased gene expression of insulin-like growth factor-I receptor in experimental diabetic rat glomeruli. Nephron 72:648–653 Sundaresan M, Yu ZX, Ferrans VJ, Irani K, Finkel T (1995) Requirement for generation of H2O2 for platelet-derived growth factor signal transduction. Science 270:296–299 Trocino RA, Akazawa S, Ishibashi M, Matsumoto K, Matsuo H, Yamamoto H, Goto S, Urata Y, Kondo T, Nagataki S (1995) Significance of glutathione depletion and oxidative stress in early embryogenesis in glucose-induced rat embryo culture. Diabetes 44:992–998 Viana M, Herrera E, Bonet B (1996) Terotogenic effects of diabetes mellitus in the rat. Prevention by vitamin E. Diabetologia 39:1041–1046 Vinik AI, Park TS, Stansberry KB, Pittenger GL (2000) Diabetic neuropathies. Diabetologia 43:957–973 Wentzel P, Eriksson UJ (1998) Antioxidants diminish developmental damage induced by high glucose and cyclooxygenase inhibitors in rat embryos in vitro. Diabetes 47:677–684 Wentzel P, Thunberg L, Eriksson UJ (1997) The teratogenic effect of diabetic serum is prevented by supplementation of superoxide dismutase and N-acetylcysteine in rat embryo culture. Diabetologia 40:7–14 Wentzel P, Welsh N, Eriksson UJ (1999) Developmental damage, increased lipid peroxidation, diminished cyclooxygenase-2 gene expression, and lowered prostaglandin E2 levels in rat embryos exposed to a diabetic environment. Diabetes 48:813–820 Xia P, Inoguchi T, Kern TS, Engerman RL, Oates PJ, King GL (1994) Characterization of the mechanism for the chronic activation of diacylglycerol-protein kinase C pathway in diabetes and hypergalactosemia. Diabetes 43:1122–1129 Xia P, Aiello LP, Ishii H, Jiang ZY, Park DJ, Robinson GS, Takagi H, Newsome WP, Jirousek MR, King GL (1996) Characterization of vascular endothelial growth factor’s effect on the activation of protein kinase C, its isoforms, and endothelial cell growth. J Clin Invest 98:2018–2026 Yamamoto Y, Gaynor RB (2001) Role of the NF-kappaB pathway in the pathogenesis of human disease states. Curr Mol Med 1:287–296 Yang X, Borg LA, Eriksson UJ (1997) Altered metabolism and superoxide generation in neural tissue of rat embryos exposed to high glucose. Am J Physiol 272:E173–E180 Zheng L, Roeder RG, Luo Y (2003) S phase activation of the histone H2B promoter by OCA-S, a coactivator complex that contains GAPDH as a key component. Cell 114:255–266