Hyperactivated Motility in Sperm

Reproduction in Domestic Animals - Tập 38 Số 2 - Trang 119-124 - 2003
SS Suarez1, Shih‐Kai Hung1
1Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA

Tóm tắt

ContentsHyperactivation is a movement pattern seen in sperm at the site and time of fertilization in mammals. It may be critical to the success of fertilization, because it enhances the ability of sperm to detach from the wall of the oviduct, to move around in the labyrinthine lumen of the oviduct, to penetrate mucous substances and, finally, to penetrate the zona pellucida of the oocyte. The movement of hyperactivated sperm appears different under different physical conditions and in different species, but basically it involves an increase in flagellar bend amplitude and, usually, beat asymmetry. Presumably, a signal or signals exist in the oviduct to initiate hyperactivation at the appropriate time; however, none has yet been identified with certainty. While the signal transduction cascade regulating hyperactivation remains to be completely described, it is clear that calcium ions interact with the axoneme of the flagellum to switch on hyperactivation. Although hyperactivation often occurs during the process of capacitation, the two events are regulated by somewhat different pathways.

Từ khóa


Tài liệu tham khảo

10.1002/(SICI)1098-2795(199905)53:1<77::AID-MRD9>3.0.CO;2-C

Bannai H, 2000, Calcium regulation of microtubule sliding in reactivated sea urchin sperm flagella, J Cell Sci, 113, 831, 10.1242/jcs.113.5.831

10.1016/S0006-291X(05)81422-6

10.1095/biolreprod44.5.806

10.1002/cm.970180207

10.1016/S0015-0282(97)00440-8

10.1126/science.289.5479.625

Cook SP, 1993, Activation of Ca2+ permeability by cAMP is coordinated through the pH increase induced by speract, J Biol Chem, 268, 22408, 10.1016/S0021-9258(18)41544-X

10.1006/dbio.1994.1229

10.1002/mrd.1120020105

10.1095/biolreprod46.5.779

10.1095/biolreprod52.6.1395

10.1095/biolreprod51.2.184

10.1002/mrd.1080300211

10.1095/biolreprod65.5.1606

10.1530/rep.0.1220519

10.1006/dbio.2002.0797

10.1016/0028-2243(83)90264-2

10.1095/biolreprod21.5.1135

10.1095/biolreprod64.6.1806

10.1126/science.580814

10.1095/biolreprod22.4.759

10.1093/oxfordjournals.humrep.a138445

Lindemann CB, 1991, Comparative Spermatology: 20 Years After, 491

10.1095/biolreprod60.5.1239

10.1071/RD99019

10.1002/mrd.1080380309

10.1002/mrd.1120180204

10.1530/jrf.0.0960699

10.1016/S0021-9258(17)39295-5

10.1016/S0012-1606(89)80018-1

10.1038/316255a0

10.1073/pnas.221454998

10.1095/biolreprod50.4.774

10.1038/35098027

10.1095/biolreprod61.1.247

10.1095/biolreprod61.1.240

10.1095/biolreprod53.6.1280

10.1046/j.1439-0531.2002.00346.x

10.1095/biolreprod46.4.686

10.1095/biolreprod36.5.1191

10.1095/biolreprod44.2.375

10.1002/j.1939-4640.1992.tb01631.x

10.1073/pnas.90.10.4660

10.1095/biolreprod56.2.447

10.1016/S0015-0282(16)56051-8

10.1002/cm.970140303

10.1083/jcb.123.6.1441

10.1083/jcb.130.4.857

10.1007/BF03401561

10.1074/jbc.M002068200

10.1002/mrd.1120220205

10.1083/jcb.142.2.473

10.1530/jrf.0.0180275

Yanagimachi R, 1994, The Physiology of Reproduction, 189

10.1016/S0015-0282(99)00637-8

Thông tin
Thông tin xuất bản

Reproduction in Domestic Animals

Tập 38 Số 2

119-124

Thông tin tác giả