Hydroxy- and alkoxymethylation of polyfluoroalkyl pyrazoles

Springer Science and Business Media LLC - Tập 67 - Trang 521-524 - 2018
А. Е. Ivanova1, E. V. Shchegol´kov1, Ya. V. Burgart1, V. I. Saloutin1
1Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, Ekaterinburg, Russian Federation

Tóm tắt

A synthetic route to 1-hydroxy- and 1-alkoxymethyl-3-polyfluoroalkylpyrazoles via regioselective N-hydroxy- and alkoxymethylation of N-unsubstituted pyrazoles with paraformaldehyde has been proposed. The alkoxyalkylation of polyfluoroalkylpyrazoles proceeds in aqueous-alcohol medium, whereas hydroxymethylation requires anhydrous conditions.

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Springer Science and Business Media LLC

Tập 67

521-524

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