Hydrocortisone has a biphasic effect on rat gastric mucosal prostaglandin generation in vivo: Inhibition at low doses, stimulation at high doses

Conn, 1976, Non-association of adrenocorticosteroid therapy and peptic ulcer, N Engl J Med, 294, 473, 10.1056/NEJM197602262940905 Messer, 1983, Association of adreno-cortiosteroid therapy and peptic ulcer disease, N Engl J Med, 309, 21, 10.1056/NEJM198307073090105 Conn, 1985, Adrenocorticoid administration and peptic ulcer: a critical analysis, J Chron Dis, 457, 10.1016/0021-9681(85)90028-1 Jama, 1975, Incidence of stress ulcer formation associated with steroid therapy in various shock states, Am J Surg, 130, 328, 10.1016/0002-9610(75)90395-5 Bayer, 1984, Influence of steroids on the prevention or aggravation of stress gastric ulcer in rats, Isr J Med Sci, 20, 254 Robert, 1981, Current history of cytoprotection, Prostaglandins, 21, 89, 10.1016/0090-6980(81)90123-4 Miller, 1983, Protective effects of prostaglandins against gastric mucosal damage: current knowledge and proposed mechanisms, Am J Physiol, 245, G601 Casey, 1985, Despite a massive increase in cortisol secretion in women during parturition, there is an equally massive increase in prostaglandin synthesis, J Clin Invest, 75, 1852, 10.1172/JCI111899 Eastwood, 1989, Hydrocortisone inhibits rat gastric mucosal prostaglandin generation in vitro, Gastroent, 96, A134 Burstein, 1982, Prostaglandins and cannabis: IX. Stimulation of prostaglandin E2 synthesis in human lung fibroblasts by 1-tetrahydrocannabinol, Biochem Pharmacol, 31, 2361, 10.1016/0006-2952(82)90530-5 Quimby, 1986, Active smoking depresses prostaglandin synthesis in human gastric mucosa, Ann Int Med, 104, 616, 10.7326/0003-4819-104-5-616 Whittle, 1981, Prostaglandin-cyclo-oxygenase inhibition and its relationship to gastric damage, 197, 2110 Flower, 1986, The mediators of steroid action, Nature, 320, 20, 10.1038/320020a0 Flower, 1979, Anti-inflammatory steroids induce biosynthesis of a phospholipase A2 inhibitor which prevents prostaglandin generation, Nature, 278, 456, 10.1038/278456a0 Blackwell, 1980, Macrocortin: a polypeptide causing the anti-phospholipase effect of glucocorticoids, Nature, 287, 147, 10.1038/287147a0 Hong, 1976, Inhibition of arachidonic acid release from cells as the biochemical action of anti-inflammatory corticosteroids, 73, 1730 Hirata, 1980, A phospholipase A2 inhibitory protein in rabbit neutrophils induced by glucocorticoids, 77, 2533 Mitchell, 1988, Paradoxical stimulation of both lipcortin and prostaglandin production in human amnion cells by dexamethasone, Biochem Biophys Res Com, 151, 137, 10.1016/0006-291X(88)90569-4 Duval, 1986, Dexamethasone induced stimulation of arachidonic acid release by U937 cells grown in defined medium, Biochem Biophys Acta, 887, 204, 10.1016/0167-4889(86)90056-X Tsai, 1983, The effect of prenatal dexamethasone on fetal lung prostaglandin synthesis, Prostaglandins, Leukotrienes Med, 11, 171, 10.1016/0262-1746(83)90017-3 Potestio, 1988, Glucocorticoids stimulate prostaglandin synthesis in human amnion cells by a receptor mediated mechanism, J Clin Endocrinol Metab, 67, 1205, 10.1210/jcem-67-6-1205 Jung-Testas, 1983, Inhibition of glucocorticosteroid action in cultured L-929 mouse fibroblasts by RU 486, a new antiglucocorticosteroid of high affinity for the glucocorticoid receptor, Exp Cell Res, 147, 177, 10.1016/0014-4827(83)90282-3 Eastwood, 1981, Effects of chronic steroid ingestion on gastroduodenal epithelial renewal in the rat, Cell Tissue Kinet, 14, 405 Eastwood, 1982, Inhibition of human gastric epithelial proliferation by prednisone, Gastroenterology, 82, 1048 Kuwayama, 1988, Effects of parenteral hydrocortisone sodium succinate on epithelial renewal in hamster gastric mucosa, Dig Dis Sci, 33, 1064, 10.1007/BF01535779 Sandberg, 1964, Relationship between administration of cortisone and wound healing in rats, Acta Clin Scand, 127, 446 Ehrlich, 1973, Effect of vitamin a and glucocorticoids upon inflammation and collagen synthesis, Ann Surg, 177, 222, 10.1097/00000658-197302000-00017 Folkman, 1985, Angiogenesis inhibition and tumor regression caused by heparin or a heparin fragment in the presence of cortisone, Science, 230, 1375, 10.1126/science.2416056