Early Breast Cancer Trialists’ Collaborative Group (EBCTCG), Darby S, McGale P, Correa C et al (2011) Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: meta-analysis of individual patient data for 10,801 women in 17 randomised trials. Lancet 378:1707–1716
Clarke M, Collins R, Darby S et al (2005) Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: an overview of the randomised trials. Lancet 366:2087–2106
Vinh-Hung V, Verschraegen C (2004) Breast-conserving surgery with or without radiotherapy: pooled-analysis for risks of ipsilateral breast tumor recurrence and mortality. J Natl Cancer Inst 96:115–121
Bartelink H, Horiot JC, Poortmans PM et al (2007) Impact of a higher radiation dose on local control and survival in breast-conserving therapy of early breast cancer: 10-year results of the randomized boost versus no boost EORTC 22881–10882 trial. J Clin Oncol 25:3259–3265
Jones HA, Antonini N, Hart AM et al (2009) Impact of pathological characteristics on local relapse after breast-conserving therapy: a subgroup analysis of the EORTC boost versus no boost trial. J Clin Oncol 27:4939–4947
Dellas K, Vonthein R, Zimmer J et al (2014) Hypofractionation with simultaneous integrated boost for early breast cancer: results of the German multicenter phase II trial (ARO-2010-01). Strahlenther Onkol 190:646–653
Haviland JS, Owen RJ, Dewar JA et al (2013) The UK Standardisation of Breast Radiotherapy (START) trials of radiotherapy hypofractionation for treatment of early breast cancer: 10-year follow-up results of two randomised controlled trials. Lancet Oncol 4:1086–1094
Whelan TJ, Pignol JP, Levine MN et al (2010) Long-term results of hypofractionated radiation therapy for breast cancer. N Engl J Med 362:513–520
James ML, Lehman M, Hider PN et al (2010) Fraction size in radiation treatment for breast conservation in early breast cancer. Cochrane Database Syst Rev 7:CD003860. https://doi.org/10.1002/14651858.CD003860.pub3
Alford SL, Prassas GN, Vogelesang CR et al (2013) Adjuvant breast radiotherapy using a simultaneous integrated boost: clinical and dosimetric perspectives. J Med Imaging Radiat Oncol 57:222–229
Van Parijs H, Reynders T, Heuninckx K et al (2014) Breast conserving treatment for breast cancer: dosimetric comparison of different non-invasive techniques for additional boost delivery. Radiat Oncol 9:36
Bantema-Joppe EJ, Vredeveld EJ, de Bock GH et al (2013) Five year outcomes of hypofractionated simultaneous integrated boost irradiation in breast conserving therapy; patterns of recurrence. Radiother Oncol 108:269–272
Balaji K, Yadav P, BalajiSubramanian S et al (2018) Hybrid volumetric modulated arc therapy for chest wall irradiation: for a good plan, get the right mixture. Phys Med 52:86–92. https://doi.org/10.1016/j.ejmp.2018.06.641
Balaji K, Subramanian B, Yadav P et al (2016) Radiation therapy for breast cancer: literature review. Med Dosim 41(3):253–257. https://doi.org/10.1016/j.meddos.2016.06.005
Filippi AR, Ragona R, Piva C et al (2015) Optimized volumetric modulated arc therapy versus 3D-CRT for early stage mediastinal Hodgkin lymphoma without axillary involvement: a comparison of second cancers and heart disease risk. Int J Radiat Oncol Biol Phys 92(1):161–168. https://doi.org/10.1016/j.ijrobp.2015.02.030
Mayo CS, Urie MM, Fitzgerald TJ (2005) Hybrid IMRT plans–concurrently treating conventional and IMRT beams for improved breast irradiation and reduced planning time. Int J Radiat Oncol Biol Phys 61:922–932. https://doi.org/10.1016/j.ijrobp.2004.10.033
Jeulink M, Dahele M, Meijnen P et al (2015) Is there a preferred IMRT technique for left-breast irradiation? J Appl Clin Med Phys 16:197–205. https://doi.org/10.1120/jacmp.v16i3.5266
Chen YG, Li AC, Li WY et al (2017) The feasibility study of a hybrid coplanar arc technique versus hybrid intensity-modulated radiotherapy in treatment of early-stage left-sided breast cancer with simultaneous-integrated boost. J Med Phys 42(1):1–8. https://doi.org/10.4103/jmp.JMP_56_17
Lin J, Yeh D, Yeh H et al (2015) Dosimetric comparison of hybrid volumetric-modulated arc therapy, volumetric-modulated arc therapy and intensity-modulated radiation therapy for left-sided early breast cancer. Med Dosim 40(3):262–267. https://doi.org/10.1016/j.meddos.2015.05.003
BalajiSubramanian S, Balaji K, Thirunavukarasu M et al (2016) Bilateral breast irradiation using hybrid Volumetric Modulated Arc Therapy (h-VMAT) technique: a planning case report. Cureus 8(12):e914. https://doi.org/10.7759/cureus.91424
Aly MM, Glatting G, Jahnke L et al (2015) Comparison of breast simultaneous integrated boost (SIB) radiotherapy techniques. Radiat Oncol 10:139. https://doi.org/10.1186/s13014-015-0452-2
Jost V, Kretschmer M, Sabatino M et al (2015) Heart dose reduction in breast cancer treatment with simultaneous integrated boost: comparison of treatment planning and dosimetry for a novel hybrid technique and 3D-CRT. Strahlenther Onkol 191:734–741
Kragl G, Wetterstedt S, Knausl B et al (2009) Dosimetric characteristics of 6 and 10 MV unflattened photonbeams. Radiother Oncol 93(1):141–146
Sharma SD (2011) Unflattened photon beams from the standard flattening filter free accelerators for radiotherapy: advantages, limitations and challenges. J Med Phys 36(3):123–125
Georg D, Knoos T, McClean B (2011) Current status and future perspective of flattening filter free photon beams. Med Phys 38(3):1280–1293
Spruijt KH, Dahele M, Cuijpers JP et al (2013) Flattening filter free vs flattened beams for breast irradiation. Int J Radiat Oncol Biol Phys 85(2):506–513. https://doi.org/10.1016/j.ijrobp.2012.03.040
Subramaniam S, Thirumalaiswamy S, Srinivas C et al (2012) Chest wall radiotherapy with volumetric modulated arcs and the potential role of flattening filter free photon beams. Strahlenther Onkol 188:484–491. https://doi.org/10.1007/s00066-012-0075-6
Dobler B, Maier J, Knott B et al (2016) Second Cancer Risk after simultaneous integrated boost radiation therapy of right sided breast cancer with and without flattening filter. Strahlenther Onkol 192:687–695. https://doi.org/10.1007/s00066-016-1025-5
Bahrainy M, Kretschmer M, Jost V et al (2016) Treatment of breast cancer with simultaneous integrated boost in hybrid plan technique. Strahlenther Onkol 192:333–341. https://doi.org/10.1007/s00066-016-0960-5
White J, Tai A, Arthur D et al (2019) RTOG breast cancer atlas for radiation therapy planning: consensus definitions. https://www.rtog.org/CoreLab/ContouringAtlases/BreastCancerAtlas.aspx. Accessed 15 Apr 2019
Nicolini G, Fogliata A, Clivio A et al (2011) Planning strategies in volumetric modulated arc therapy for breast. Med Phys 38:4025–4031
Nakamura JL, Verhey LJ, Smith V et al (2001) Dose conformity of gamma knife radiosurgery and risk factors for complications. Int J Radiat Oncol Biol Phys 51(5):1313–1319
International Commission on Radiation Units and Measurements (2010) ICRU Report 83: prescribing recording and reporting photon beam intensity modulated radiation therapy (IMRT). ICRU Rep 10(1):1–92
Ohtakara K, Hayashi S, Hoshi H (2011) Dose gradient analyses in linac-based Intracranial stereotactic radiosurgery using Paddick’s gradient index: consideration of the optimal method for plan evaluation. J Radiat Res 52:592–599. https://doi.org/10.1269/jrr.11005
Kundrat P, Remmele J, Rennau H (2019) Minimum breast distance largely explains individual variability in doses to contralateral breast from breast-cancer radiotherapy. Radiother Oncol 131:186–191. https://doi.org/10.1016/j.radonc.2018.08.022
Koulis TA, Phan T, Olivotto IA (2015) Hypofractionated whole breast radiotherapy: current perspectives. Breast Cancer 7:363–370. https://doi.org/10.2147/BCTT.S81710
Kim KS, Shin KH, Choi N, Lee S (2016) Hypofractionated whole breast irradiation: new standard in early breast cancer after breast-conserving surgery. Radiat Oncol J 34(2):81–87. https://doi.org/10.3857/roj.2016.01697
Bentzen SM, Agrawal RK, Aird EG et al (2008) The UK standardisation of breast radiotherapy (START) Trial A of radiotherapy hypofractionation for treatment of early breast cancer: a randomised trial. Lancet 9:331–341. https://doi.org/10.1016/S1470-2045(08)70077-9
Bentzen SM, Agrawal RK, Aird EG et al (2008) The UK standardisation of breast radiotherapy (START) Trial B of radiotherapy hypofractionation for treatment of early breast cancer: a randomised trial. Lancet 371:1098–1107. https://doi.org/10.1016/S0140-6736(08)60348-7
Agrawal RK, Alhasso A, BarrettLee PJ et al (2011) First results of the randomised UK FAST Trial of radiotherapy hypofractionation for treatment of early breast cancer (CRUKE/04/015). Radiother Oncol 100:93–100. https://doi.org/10.1016/j.radonc.2011.06.026
Brunt AM, Wheatley D, Yarnold J et al (2016) Acute skin toxicity associated with a 1-week schedule of whole breast radiotherapy compared with a standard 3‑week regimen delivered in the UK FAST-Forward Trial. Radiother Oncol 120:114–118. https://doi.org/10.1016/j.radonc.2016.02.027
Scorsetti M, Alongi F, Fogliata A et al (2012) Phase i–ii study of hypofractionated simultaneous integrated boost using volumetric modulated arc therapy for adjuvant radiation therapy in breast cancer patients: a report of feasibility and early toxicity results in the first 50 treatments. Radiat Oncol 7:145
Zhou S, Zhu X, Zhang M et al (2016) Estimation of internal organ motion-induced variance in radiation dose in non-gated radiotherapy. Phys Med Biol 61:8157–8179. https://doi.org/10.1088/0031-9155/61/23/8157
Ramasubramanian V, Balaji K, Balaji Subramanian S et al (2019) Hybrid volumetric modulated arc therapy for whole breast irradiation: a dosimetric comparison of different arc designs. Radiol med 124(6):546–554. https://doi.org/10.1007/s11547-019-00994-1
Jin G, Chen L, Deng X et al (2013) A comparative dosimetric study for treating left-sided breast cancer for small breast size using five different radiotherapy techniques: conventional tangential field, filed-in-filed, Tangential-IMRT, Multi-beam IMRT and VMAT. Radiat Oncol 8:89
Viren T, Heikkilä J, Myllyoja K et al (2015) Tangential volumetric modulated arc therapy technique for left-sided breast cancer radiotherapy. Radiat Oncol 10:79
Haciislamoglu E, Colak F, Canyilmaz E et al (2015) Dosimetric comparison of left-sided whole-breast irradiation with 3DCRT, forward-planned IMRT, inverse-planned IMRT, helical tomotherapy, and volumetric arc therapy. Phys Med 31(4):360–367. https://doi.org/10.1016/j.ejmp.2015.02.005
Wang Y, Vassil A, Tendulkar R et al (2014) Feasibility of using nonflat photon beams for whole-breast irradiation with breath hold. J Appl Clin Med Phys 15(1):4397. https://doi.org/10.1120/jacmp.v15i1.4397
Hall EJ (2006) Intensity-modulated radiation therapy, protons, and the risk of second cancers. Int J Radiat Oncol Biol Phys 65(1):1–7. https://doi.org/10.1016/j.ijrobp.2006.01.027
Darby SC, Ewertz M, McGale P et al (2013) Risk of ischemic heart disease in women after radiotherapy for breast cancer. N Engl J Med 368(11):987–998. https://doi.org/10.1056/NEJMoa1209825
Gagliardi G, Constine LS, Moiseenko V et al (2010) Radiation dose-volume effects in the heart. Int J Radiat Oncol Biol Phys 76(3):S77–S85. https://doi.org/10.1016/j.ijrobp.2009.04.093
Marks LB, Bentzen SM, Deasy JO et al (2010) Radiation dose-volume effects in the lung. Int J Radiat Oncol Biol Phys 76(3):70–76. https://doi.org/10.1016/j.ijrobp.2009.06.091
Blom GU, Wennberg B, Svane G et al (2010) Reduction of radiation pneumonitis by V20-constraints in breast cancer. Radiat Oncol 5:99. https://doi.org/10.1186/1748-717X-5-99
Mah D, Miller E, Kuo H et al (2011) Flattening filter free beams for 3D breast planning. Med Phys 38:3632