Hybrid hepatitis B virus core antigen as a vaccine carrier moiety: I. Presentation of foreign epitopes

Journal of Biotechnology - Tập 44 - Trang 91-96 - 1996
F. Schödel1, D. Peterson2, J. Hughes3, R. Wirtz4, D. Milich3
1INSERM U 80, Pavillon P, Hôpital Edouard Herriot, 69437 Lyon Cedex 03, France
2Department of Biochemistry, Virginia Commonwealth University, Richmond, VA, 23298, USA
3Department of Molecular Biology, The Scripps Research Institute, La Jolla CA 92037, USA
4Department of Entomology, Walter Reed Army Institute of Research, Washington, DC 20307-5100, USA

Tài liệu tham khảo

Borisova, 1993, Hybrid hepatitis-B virus nucleocapsid bearing an immunodominant region from hepatitis-B virus surface-antigen, J. Virol., 67, 3696, 10.1128/JVI.67.6.3696-3701.1993 Clarke, 1987, Improved immunogenicity of a peptide epitope after fusion to hepatitis B core protein, Nature, 330, 381, 10.1038/330381a0 Charoenvit, 1991, Monoclonal, but not polyclonal, antibodies protect against Plasmodium yoelii sporozoites, Infect. Immun., 146, 1020 Crowther, 1994, Three-dimensional structure of hepatitis B virus core particles determined by electron microscopy, Cell, 77, 943, 10.1016/0092-8674(94)90142-2 Herzenberg, 1983, Epitope-specific regulation, I. carrier-specific induction of suppression for IgG anti-hapten antibody response, J. Exp. Med., 155, 1730, 10.1084/jem.155.6.1730 Milich, 1986, The nucleocapsid of the hepatitis B virus is both a T-cell in dependent and a T-cell dependent antigen, Science, 234, 1398, 10.1126/science.3491425 Milich, 1987, Immune responses to hepatitis B virus core antigen (HBcAg) : localization of T cell recognition sites within HBcAg/HBeAg, J. Immunol., 139, 1223, 10.4049/jimmunol.139.4.1223 Milich, 1987, Antibody production to the nucleocapsid and envelope of the hepatitis B virus primed by a single synthetic T cell site, Nature, 329, 547, 10.1038/329547a0 Milich, 1988, T and B cell recognition of hepatitis B viral antigens, Immunol. Today, 9, 380, 10.1016/0167-5699(88)91239-X Schödel, 1992, The position of heterologous epitopes inserted in hepatitis B virus core particles determines their immunogenicity, J. Virol., 66, 106, 10.1128/JVI.66.1.106-114.1992 Schödel, 1994, Hepatitis B virus core particles as a vaccine carrier moiety, Int. Rev. Immunol., 11, 153, 10.3109/08830189409061723 Schödel, 1994, Immunity to malaria elicited by hybrid hepatitis B virus core particles carrying circumsporozoite protein epitopes, J. Exp. Med., 180, 1037, 10.1084/jem.180.3.1037 Schödel, 1995, Immunity to Plasmodium yoelii infection elicited by hybrid hepatitis B virus core particles (HBcAg) carrying circumsporozoite antigen epitopes Schödel, 1995, Hybrid hepatitis B virus core antigens as a vaccine carrier moiety: II. Expression in avirulent Salmonella spp. for mucosal immunization