Hyalinized Uterine Mesenchymal Neoplasms with HMB-45-Positive Epithelioid Cells: Epithelioid Leiomyomas or Angiomyolipomas? Report of Four Cases

International Journal of Surgical Pathology - Tập 8 Số 4 - Trang 323-328 - 2000
Michal Michal1,2, Michal Zamecnikt3
1Department of Pathology, Medical Faculty, Charles University, Pilsen, Czech Republic
2Department of Pathology, Medical Faculty, Charles University Pilsen, Czech Republic; Department of Pathology, Laboratore Spec. Diagnostiky Medical Faculty Hospital, Alej Svobody 80, 323 18 PILSEN, Czech Republic
3Department of Pathology, Slovak Postgraduate Academy of Medicine, Bratislava, Slovak Republic

Tóm tắt

We present 4 cases of uterine mesenchymal tumors that were located mostly in the myometrium in middle-aged women. Grossly the tumors vaguely resembled conventional leiomyomas. All tumors were extremely hyalinized. The tumor cells were remarkable because of their large size and epithelioid shape. They occurred singly or more often in variously sized clusters with pericellular clear spaces looking like a halo. The extracellular matrix often formed lacunae around the neoplastic cells. The lacunar type of growth was somewhat reminiscent of immature cartilage. In some places the cells lined up in vague cord-like structures. The epithelioid cells often grew within vessel walls and subendothelially, simulating angioinvasion. In 2 cases there were periodic acid-Schiff (PAS)-positive, needle-shaped crystalloids in the cytoplasm of the tumor cells. No atypias and no mitoses were found in any of the 4 tumors. Mucicarmine stain was negative in all cases. Immunohistochemically the tumor cells were negative for cytokeratins, synaptophysin, chromogranin, epithelial membrane antigen (EMA), S-I 00 protein, and inhibin. They were instead strongly positive for smooth muscle actin, desmin and HMB-45. All patients are disease free after a 1-4-year follow-up.

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International Journal of Surgical Pathology

Tập 8 Số 4

323-328

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