Human vaccination against RH5 induces neutralizing antimalarial antibodies that inhibit RH5 invasion complex interactions

JCI insight - Tập 2 Số 21 - 2017
Ruth Payne1, Sarah E. Silk1, Sean C. Elias1, Kazutoyo Miura2, Ababacar Diouf2, Francis Galaway3, Hans de Graaf4, Nathan J. Brendish4, Ian Poulton1, Oliver J. Griffiths1, Nick J. Edwards1, Jing Jin1, Geneviève M. Labbé1, Daniel G. W. Alanine1, Loredana Siani5, Stefania Di Marco5, Rachel Roberts1, Nicky Green6, Eleanor Berrie6, Andrew S. Ishizuka1, Carolyn M. Nielsen1, Martino Bardelli1, Frederica Dedo Partey7,8,1, Michael F. Ofori8, Lea Barfod1, Juliana Wambua9, Linda Murungi9,1, Faith Osier9, Sumi Biswas1, James McCarthy10, Angela M. Minassian1, Rebecca Ashfield1, Beate Kampmann11, Fay L. Nugent1, Alexander D. Douglas1, Johan Vekemans12, Gavin J. Wright3, Saul N. Faust4, Adrian V. S. Hill1, Carole A. Long2, Alison M. Lawrie1, Simon J. Draper1
1The Jenner Institute, University of Oxford, Oxford, United Kingdom
2Laboratory of Malaria and Vector Research, NIAID/NIH, Rockville, Maryland, USA
3Cell Surface Signalling Laboratory, Wellcome Trust Sanger Institute, Cambridge, United Kingdom
4NIHR Wellcome Trust Clinical Research Facility, University Hospital Southampton NHS Foundation Trust and Faculty of Medicine, University of Southampton, Southampton, United Kingdom.
5ReiThera SRL (formerly Okairos SRL), Viale Città d'Europa, Rome, Italy.
6Clinical Biomanufacturing Facility, University of Oxford, Oxford, United Kingdom.
7Centre for Medical Parasitology, Department of Immunology and Microbiology (ISIM), Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
8Department of Immunology, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana
9KEMRI Centre for Geographic Medicine Research, Kilifi, Kenya
10QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia
11European Vaccine Initiative, UniversitätsKlinikum Heidelberg, Heidelberg, Germany
12GSK Vaccines, Wavre, Belgium

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