Human cytomegalovirus harbors its own unique IL-10 homolog (cmvIL-10)

Proceedings of the National Academy of Sciences of the United States of America - Tập 97 Số 4 - Trang 1695-1700 - 2000
Sergei V. Kotenko1, Simona Saccani1,2, Lara S. Izotova1,2, Olga Mirochnitchenko1,2, Sidney Pestka1,2
1Department of Molecular Genetics and Microbiology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, NJ 08854-5635
2National Institutes of Health, Bethesda, MD, and

Tóm tắt

We identified a viral IL-10 homolog encoded by an ORF (UL111a) within the human cytomegalovirus (CMV) genome, which we designated cmvIL-10. cmvIL-10 can bind to the human IL-10 receptor and can compete with human IL-10 for binding sites, despite the fact that these two proteins are only 27% identical. cmvIL-10 requires both subunits of the IL-10 receptor complex to induce signal transduction events and biological activities. The structure of the cmvIL-10 gene is unique by itself. The gene retained two of four introns of the IL-10 gene, but the length of the introns was reduced. We demonstrated that cmvIL-10 is expressed in CMV-infected cells. Thus, expression of cmvIL-10 extends the range of counter measures developed by CMV to circumvent detection and destruction by the host immune system.

Từ khóa


Tài liệu tham khảo

10.1146/annurev.iy.11.040193.001121

10.3109/02841869509094034

10.1016/S0002-9440(10)65667-2

10.3109/10428199809068561

B K Halak, H C Maguire, E C Lattime Cancer Res 59, 911–917 (1999).

10.1084/jem.174.6.1549

10.1084/jem.174.4.915

10.1084/jem.178.3.1041

10.1126/science.2161559

10.1126/science.2173142

10.1128/jvi.67.12.7406-7413.1993

S Swaninathan, E Kieff Viroceptors, Virokines and Related Immune Modulators Encoded by DNA Viruses, ed G McFadden (Landes, Austin, TX), pp. 111–125 (1994).

10.1128/jvi.71.6.4857-4861.1997

W J Britt, C A Alford Fields of Virology, eds B N Fields, D N Knipe, P M Howley (Lippincott-Raven, Philadelphia), pp. 2493–2523 (1996).

10.1001/jama.1989.03420240075030

10.1002/bies.950171012

10.1056/NEJM199608293350903

10.1097/00007890-198411000-00004

10.1097/00007890-199602270-00015

10.2144/96216bm10

10.1093/emboj/16.19.5894

10.1016/0092-8674(94)90354-9

10.1073/pnas.88.4.1172

10.1128/jvi.70.12.8691-8700.1996

10.1073/pnas.96.9.5007

10.1074/jbc.270.36.20915

10.1074/jbc.271.29.17174

Y Liu, S H Wei, A S Ho, M de Waal, K W Moore J Immunol 152, 1821–1829 (1994).

10.1126/science.1902591

10.1016/S0969-2126(01)00193-9

10.1021/bi00038a004

10.1002/pro.5560051001

10.1073/pnas.87.18.6934

10.1016/0014-5793(91)80437-8

10.1038/376230a0

10.1006/jmbi.1997.0990

10.1084/jem.172.6.1625

L Qin, K D Chavin, Y Ding, H Tahara, J P Favaro, J E Woodward, T Suzuki, P D Robbins, M T Lotze, J S Bromberg J Immunol 156, 2316–2323 (1996).

10.1084/jem.182.2.477

Ding Y. Qin L. Kotenko S. V. Pestka S & Bromberg J. S. (2000) J. Exp. Med. in press.

M S Chee, A T Bankier, S Beck, R Bohni, C M Brown, R Cerny, T Horsnell, C A Hutchison, T Kouzarides, J A Martignetti, et al. Curr Top Microbiol Immunol 154, 125–169 (1990).

10.1126/science.280.5361.248

S Redpath, A Angulo, N R Gascoigne, P Ghazal J Immunol 162, 6701–6707 (1999).

10.1084/jem.178.2.439

10.1084/jem.177.2.295

10.1007/978-3-642-84850-6_20

10.1126/science.1659743

10.1128/CMR.12.3.367

Thông tin
Thông tin xuất bản

Proceedings of the National Academy of Sciences of the United States of America

Tập 97 Số 4

1695-1700

Thông tin tác giả