Human Umbilical Cord Blood Cells Protect Against Hypothalamic Apoptosis and Systemic Inflammation Response During Heatstroke in Rats

Bouchama, 2002, Heat stroke, N Engl J Med, 346, 1978, 10.1056/NEJMra011089 Shen, 2008, Premarin can act via estrogen receptors to rescue mice from heat-stroke-induced lethality, Shock, 30, 668, 10.1097/SHK.0b013e31817538cb Morecroft, 1997, The role of inflammatory mediators in necrotizing enterocolitis, Semin Neonatol, 2, 273, 10.1016/S1084-2756(97)80034-6 Menger, 1996, Adhesion molecules as determinants of disease: from molecular biology to surgical research, Br J Surg, 83, 588, 10.1002/bjs.1800830506 Boldt, 1995, Do plasma levels of circulating soluble adhesion molecules differ between surviving and nonsurviving critically ill patients?, Chest, 107, 787, 10.1378/chest.107.3.787 Lasky, 1995, Selectin-carbohydrate interactions and the initiation of the inflammatory response, Annu Rev Biochem, 64, 113, 10.1146/annurev.bi.64.070195.000553 Kansas, 1999, Selectins and their ligands: current concepts and controversies, Blood, 88, 3259, 10.1182/blood.V88.9.3259.bloodjournal8893259 Varki, 1994, Selectin ligands, Proc Natl Acad Sci USA, 91, 7390, 10.1073/pnas.91.16.7390 Etzioni, 1996, Adhesion molecules: their role in health and disease, Pediatr Res, 39, 191, 10.1203/00006450-199602000-00001 Endo, 1995, Levels of soluble adhesion molecules and cytokines in patients with septic multiple organ failure, J Inflamm, 46, 212 Goda, 1999, Characterization of an apparently conserved epitope in E-and P-selectin identified by dual-specific monoclonal antibodies, Eur J Immunol, 29, 1551, 10.1002/(SICI)1521-4141(199905)29:05<1551::AID-IMMU1551>3.0.CO;2-0 Lewis, 2002, Clinical and experimental uses of umbilical cord blood, Intern Med J, 32, 601, 10.1046/j.1445-5994.2002.00276.x Chen, 2001, Intravenous administration of human umbilical cord blood reduces behavioral deficits after stroke in rats, Stroke, 32, 2682, 10.1161/hs1101.098367 Lu, 2002, Intravenous administration of human umbilical cord blood reduces neurological deficit in the rat after traumatic brain injury, Cell Transplant, 11, 275, 10.3727/096020198389924 Saporta, 2003, Human umbilical cord blood stem cells infusion in spinal cord injury: engraftment and beneficial influence on behavior, J Hematother Stem Cell Res, 12, 271, 10.1089/152581603322023007 Willing, 2003, Intravenous versus intrastriatal cord blood administration in a rodent model of stroke, J Neurosci Res, 73, 296, 10.1002/jnr.10659 Chen, 2005, Resuscitation from experimental heatstroke by transplantation of human umbilical cord blood cells, Crit Care Med, 33, 1377, 10.1097/01.CCM.0000165966.28936.89 Chen, 2006, Infusion of human umbilical cord blood cells protect against cerebral ischemia and damage during heatstroke in the rat, Exp Neurol, 199, 67, 10.1016/j.expneurol.2005.11.015 Pulsinelli, 1982, Regional cerebral blood flow and glucose metabolism following transient forebrain ischemia, Ann Neurol, 11, 499, 10.1002/ana.410110510 Epstein, 1999, Exertional heat stroke: a case series, Med Sci Sports Exerc, 31, 224, 10.1097/00005768-199902000-00004 Epstein, 1995, Exertional heatstroke: a preventable condition, Isr J Med Sci, 31, 454 Shibolet, 1967, Heatstroke: its clinical picture and mechanism in 36 cases, Q J Med, 36, 525 Shapiro, 1973, Experimental heatstroke: model in dogs, Arch Intern Med, 131, 688, 10.1001/archinte.1973.00320110072010 Dematte, 1998, Near-fatal heat stroke during the 1995 heat wave in Chicago, Ann Intern Med, 129, 173, 10.7326/0003-4819-129-3-199808010-00001 Knochel, 1994, Disorder of heat regulation, 1549 Bouchama, 1991, Ineffectiveness of dantrolene sodium in the treatment of heatstroke, Crit Care Med, 19, 176, 10.1097/00003246-199102000-00011 Bynum, 1978, Induced hyperthermia in sedated humans and the concept of critical thermal maximum, Am J Physiol, 235, R228 Pettigrew, 1974, Circulatory and biochemical effects of whole-body hyperthermia, Br J Surg, 61, 727, 10.1002/bjs.1800610914 Chang, 2006, Prevention and repair of circulatory shock and cerebral ischemia/injury by various agents in experimental heatstroke, Curr Med Chem, 13, 3145, 10.2174/092986706778742945 Leon, 2006, Time course of cytokine, cortico sterone, and tissue injury responses in mice during heat strain recovery, J Appl Physiol, 100, 1400, 10.1152/japplphysiol.01040.2005 Chatterjee, 2006, Arginine metabolic pathways determine its therapeutic benefit in experimental heatstroke: role of Th1/Th2 cytokine balance, Nitric Oxide, 15, 408, 10.1016/j.niox.2006.04.003 Chatterjee, 2005, Therapeutic treatment with L-arginine rescues mice from heat stroke-induced death: physiological and molecular mechanisms, Shock, 24, 341, 10.1097/01.shk.0000180983.55623.2b Vendrame, 2004, Infusion of human umbilical cord blood cells in a rat model of stroke dosedependently rescues behavioral deficits and reduces infarct volume, Stroke, 35, 2390, 10.1161/01.STR.0000141681.06735.9b Zigova, 2002, Human umbilical cord blood cells express neural antigens after transplantation into the developing rat brain, Cell Transplant, 11, 265, 10.3727/096020198389915 Bouchama, 1991, Endotoxemia and release of tumor necrosis factor and interleukin 1 alpha in acute heatstroke, J Appl Physiol, 70, 2640, 10.1152/jappl.1991.70.6.2640 Chang, 1993, The role of cytokines in heat stroke, Immunol Invest, 22, 553, 10.3109/08820139309084183 Bouchama, 1993, Elevated pyrogenic cytokines in heatstroke, Chest, 104, 1498, 10.1378/chest.104.5.1498 Hammami, 1998, Elevated serum level of soluble interleukin-2 receptor in heatstroke, Intensive Care Med, 24, 988, 10.1007/PL00012687 Lin, 1997, Involvement of interleukin-1 receptor mechanisms in development of arterial hypotension in rat heatstroke, Am J Physiol, 273, H2072 Lin, 1994, Interleukin-1 beta production during the onset of heat stroke in rabbits, Neurosci Lett, 174, 17, 10.1016/0304-3940(94)90108-2 Rennick, 1997, Studies with IL-10-/-mice: an overview, J Leukoc Biol, 61, 389, 10.1002/jlb.61.4.389 Berg, 1995, Interleukin-10 is a central regulator of the response to LPS in murine models of endotoxic shock and the Shwartzman reaction but not endotoxin tolerance, J Clin Invest, 96, 2339, 10.1172/JCI118290 Gerard, 1993, Interleukin 10 reduces the release of tumor necrosis factor and prevents lethality in experimental endotoxemia, J Exp Med, 177, 547, 10.1084/jem.177.2.547 Standiford, 1995, Neutralization of IL-10 increases lethality in endotoxemia: cooperative effects of macrophage inflammatory protein-2 and tumor necrosis factor, J Immunol, 155, 2222, 10.4049/jimmunol.155.4.2222 Liu, 2000, Glucocorticoids reduce interleukin-1 concentration and result in neuroprotective effects in rat heatstroke, J Physiol, 527, 333, 10.1111/j.1469-7793.2000.t01-1-00333.x Wyble, 1996, Physiologic concentrations of TNFalpha and IL-1beta released from reperfused human intestine upregulate E-selectin and ICAM-1, J Surg Res, 63, 333, 10.1006/jsre.1996.0271 Menger, 1996, Adhesion molecules as determinants of disease: from molecular biology to surgical research, Br J Surg, 83, 588, 10.1002/bjs.1800830506 Hogg, 1991, Structure and function of intercellular adhesion molecule-1, Chem Immunol, 50, 98, 10.1159/000420679 Chen, 2003, The two faces of IKK and NF-kappaB inhibition: prevention of systemic inflammation but increased local injury following intestinal ischemia-reperfusion, Nat Med, 9, 575, 10.1038/nm849 Kuzu, 2002, Role of integrins and intracellular adhesion molecule-1 in lung injury after intestinal ischemia-reperfusion, Am J Surg, 183, 70, 10.1016/S0002-9610(01)00846-7 Olanders, 2002, The effect of intestinal ischemia and reperfusion injury on ICAM-1 expression, endothelial barrier function, neutrophil tissue influx, and protease inhibitor levels in rats, Shock, 18, 86, 10.1097/00024382-200207000-00016 Bevilacqua, 1987, Identification of an inducible endothelial-leukocyte adhesion molecule, Proc Natl Acad Sci USA, 84, 9238, 10.1073/pnas.84.24.9238 Phillips, 1990, ELAM-1 mediates cell adhesion by recognition of a carbohydrate ligand, sialyl-Lex, Science, 250, 1130, 10.1126/science.1701274 Bevilacqua, 1994, Endothelial-leukocyte adhesion molecules in human disease, Annu Rev Med, 45, 361, 10.1146/annurev.med.45.1.361 Yoshida, 1996, Leukocyte adhesion to vascular endothelium induces E-selectin linkage to the actin cytoskeleton, J Cell Biol, 133, 445, 10.1083/jcb.133.2.445