Human Protothecosis

Clinical Microbiology Reviews - Tập 20 Số 2 - Trang 230-242 - 2007
Cornelia Lass‐Flörl1, Astrid Mayr1
1Department of Hygiene, Microbiology and Social Medicine, Innsbruck Medical University, Innsbruck, Austria

Tóm tắt

SUMMARYHuman protothecosis is a rare infection caused by members of the genusPrototheca. Protothecaspecies are generally considered to be achlorophyllic algae and are ubiquitous in nature. The occurrence of protothecosis can be local or disseminated and acute or chronic, with the latter being more common. Diseases have been classified as (i) cutaneous lesions, (ii) olecranon bursitis, or (iii) disseminated or systemic manifestations. Infections can occur in both immunocompetent and immunosuppressed patients, although more severe and disseminated infections tend to occur in immunocompromised individuals.Prototheca wickerhamiiandPrototheca zopfiihave been associated with human disease. Usually, treatment involves medical and surgical approaches; treatment failure is not uncommon. Antifungals such as ketoconazole, itraconazole, fluconazole, and amphotericin B are the most commonly used drugs to date. Among them, amphotericin B displays the best activity againstProtothecaspp. Diagnosis is largely made upon detection of characteristic structures observed on histopathologic examination of tissue.

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