Human Milk Oligosaccharides Protect Against Enteropathogenic Escherichia coli Attachment In Vitro and EPEC Colonization in Suckling Mice

Journal of Pediatric Gastroenterology and Nutrition - Tập 58 Số 2 - Trang 165-168 - 2014
Carolin F. Manthey1, Chloe Autran2, Lars Eckmann1, Lars Bode2
1Department of Medicine, Hepatology and Nutrition University of California San Diego La Jolla CA
2Department of Pediatrics, Division of Neonatology and Division of Gastroenterology, Hepatology and Nutrition, University of California, San Diego, La Jolla, CA.

Tóm tắt

ABSTRACTBreast‐feeding reduces the risk of enteric bacterial infections in newborns in part because of human milk oligosaccharides (HMOs), complex glycans that are present in human milk, but not in infant formula. Enteropathogenic Escherichia coli (EPEC) are attaching/effacing pathogens that cause serious diarrheal illness with potentially high mortality in infants. We isolated HMOs from pooled human milk and found that they significantly reduce EPEC attachment to cultured epithelial cells. In suckling mice, administration of HMOs significantly reduced colonization with EPEC compared with untreated controls. These data suggest an essential role for HMOs in the prevention of EPEC infections in human infants.

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Thông tin xuất bản

Journal of Pediatric Gastroenterology and Nutrition

Tập 58 Số 2

165-168

Thông tin tác giả