Human Milk Composition
Tóm tắt
Từ khóa
Tài liệu tham khảo
Section on Breastfeeding, 2012, Breastfeeding and the use of human milk, Pediatrics, 129, e827, 10.1542/peds.2011-3552
WHO, 2003
Oftedal, 2012, The evolution of milk secretion and its ancient origins, Animal, 6, 355, 10.1017/S1751731111001935
Castellote, 2011, Premature delivery influences the immunological composition of colostrum and transitional and mature human milk, J Nutr, 141, 1181
Pang, 2007, Initiation of human lactation: secretory differentiation and secretory activation, J Mammary Gland Biol Neoplasia, 12, 211, 10.1007/s10911-007-9054-4
Kulski, 1981, Changes in human milk composition during the initiation of lactation, Aust J Exp Biol Med Sci, 59, 101, 10.1038/icb.1981.6
Henderson, 2008, Effect of preterm birth and antenatal corticosteroid treatment on lactogenesis II in women, Pediatrics, 121, e92, 10.1542/peds.2007-1107
Nommsen-Rivers, 2012, Timing of stage II lactogenesis is predicted by antenatal metabolic health in a cohort of primiparas, Breastfeed Med, 7, 43, 10.1089/bfm.2011.0007
Cregan, 2002, Initiation of lactation in women after preterm delivery, Acta Obstet Gynecol Scand, 81, 870, 10.1034/j.1600-0412.2002.810913.x
Nommsen, 1991, Determinants of energy, protein, lipid, and lactose concentrations in human milk during the first 12 mo of lactation: the DARLING Study, Am J Clin Nutr, 53, 457, 10.1093/ajcn/53.2.457
Bauer, 2011, Longitudinal analysis of macronutrients and minerals in human milk produced by mothers of preterm infants, Clin Nutr, 30, 215, 10.1016/j.clnu.2010.08.003
Geraghty, 2005, The development of a research human milk bank, J Hum Lact, 21, 59, 10.1177/0890334404273162
Prentice, 1995, Regional variations in the composition of human milk, 919
Liao, 2011, Proteomic characterization of human milk whey proteins during a twelve-month lactation period, J Proteome Res, 10, 1746, 10.1021/pr101028k
Gao, 2012, Temporal changes in milk proteomes reveal developing milk functions, J Proteome Res, 11, 3897, 10.1021/pr3004002
Lonnerdal, 2004, Human milk proteins: key components for the biological activity of human milk, Adv Exp Med Biol, 554, 11, 10.1007/978-1-4757-4242-8_4
Jensen, 1995
Valentine, 2010, Docosahexaenoic acid and amino acid contents in pasteurized donor milk are low for preterm infants, J Pediatr, 157, 906, 10.1016/j.jpeds.2010.06.017
Saarela, 2005, Macronutrient and energy contents of human milk fractions during the first six months of lactation, Acta Paediatr, 94, 1176, 10.1080/08035250510036499
Kent, 2006, Volume and frequency of breastfeedings and fat content of breast milk throughout the day, Pediatrics, 117, e387, 10.1542/peds.2005-1417
Valentine, 2012, Randomized controlled trial of docosahexaenoic acid supplementation in midwestern U.S. Human milk donors, Breastfeed Med, 10.1089/bfm.2011.0126
Martin, 2012, Fatty acid composition in the mature milk of Bolivian forager-horticulturalists: controlled comparisons with a US sample, Matern Child Nutr, 8, 404, 10.1111/j.1740-8709.2012.00412.x
Newburg, 2005, Human milk glycans protect infants against enteric pathogens, Annu Rev Nutr, 25, 37, 10.1146/annurev.nutr.25.050304.092553
Morrow, 2005, Human-milk glycans that inhibit pathogen binding protect breast-feeding infants against infectious diarrhea, J Nutr, 135, 1304
Gabrielli, 2011, Preterm milk oligosaccharides during the first month of lactation, Pediatrics, 128, e1520, 10.1542/peds.2011-1206
Michaelsen, 1990, Variation in macronutrients in human bank milk: influencing factors and implications for human milk banking, J Pediatr Gastroenterol Nutr, 11, 229, 10.1097/00005176-199008000-00013
Arslanoglu, 2010, Optimization of human milk fortification for preterm infants: new concepts and recommendations, J Perinat Med, 38, 233, 10.1515/jpm.2010.073
Greer, 2001, Do breastfed infants need supplemental vitamins?, Pediatr Clin North Am, 48, 415, 10.1016/S0031-3955(08)70034-8
Allen, 2012, B vitamins in breast milk: relative importance of maternal status and intake, and effects on infant status and function, Adv Nutr, 3, 362, 10.3945/an.111.001172
Dawodu, 2012, Heightened attention to supplementation is needed to improve the vitamin D status of breastfeeding mothers and infants when sunshine exposure is restricted, Matern Child Nutr, 10.1111/j.1740-8709.2012.00422.x
American Academy of Pediatrics, 2009
Cavaletto, 2004, The proteomic approach to analysis of human milk fat globule membrane, Clin Chim Acta, 347, 41, 10.1016/j.cccn.2004.04.026
Van de Perre, 2003, Transfer of antibody via mother's milk, Vaccine, 21, 3374, 10.1016/S0264-410X(03)00336-0
Kobata, 2008, High levels of growth factors in human breast milk, Early Hum Dev, 84, 67, 10.1016/j.earlhumdev.2007.07.005
Patki, 2012, Comparison of the levels of the growth factors in umbilical cord serum and human milk and its clinical significance, Cytokine, 59, 305, 10.1016/j.cyto.2012.04.010
Hirai, 2002, Trophic effect of multiple growth factors in amniotic fluid or human milk on cultured human fetal small intestinal cells, J Pediatr Gastroenterol Nutr, 34, 524, 10.1097/00005176-200205000-00010
Wagner, 2008, Host factors in amniotic fluid and breast milk that contribute to gut maturation, Clin Rev Allergy Immunol, 34, 191, 10.1007/s12016-007-8032-3
Read, 1984, Changes in the growth-promoting activity of human milk during lactation, Pediatr Res, 18, 133, 10.1203/00006450-198402000-00004
Chang, 2002, Effect of human milk and epidermal growth factor on growth of human intestinal caco-2 cells, J Pediatr Gastroenterol Nutr, 34, 394, 10.1097/00005176-200204000-00015
Khailova, 2009, Changes in hepatic cell junctions structure during experimental necrotizing enterocolitis: effect of EGF treatment, Pediatr Res, 66, 140, 10.1203/PDR.0b013e3181aa3198
Radulescu, 2011, Heparin-binding EGF-like growth factor promotes intestinal anastomotic healing, J Surg Res, 171, 540, 10.1016/j.jss.2010.06.036
Dvorak, 2003, Increased epidermal growth factor levels in human milk of mothers with extremely premature infants, Pediatr Res, 54, 15, 10.1203/01.PDR.0000065729.74325.71
Dvorak, 2004, Concentrations of epidermal growth factor and transforming growth factor-alpha in preterm milk, Advances in experimental medicine and biology, 554, 407, 10.1007/978-1-4757-4242-8_52
Rodrigues, 2011, Glial cell line-derived neurotrophic factor is a key neurotrophin in the postnatal enteric nervous system, Neurogastroenterol Motil, 23, e44, 10.1111/j.1365-2982.2010.01626.x
Boesmans, 2008, Brain-derived neurotrophic factor amplifies neurotransmitter responses and promotes synaptic communication in the enteric nervous system, Gut, 57, 314, 10.1136/gut.2007.131839
Sánchez, 1996, Renal agenesis and the absence of enteric neurons in mice lacking GDNF, Nature, 382, 70, 10.1038/382070a0
Li, 2011, S100B protein, brain-derived neurotrophic factor, and glial cell line-derived neurotrophic factor in human milk, PLoS One, 6, e21663, 10.1371/journal.pone.0021663
Fichter, 2011, Breast milk contains relevant neurotrophic factors and cytokines for enteric nervous system development, Mol Nutr Food Res, 55, 1592, 10.1002/mnfr.201100124
Blum, 2002, Colostral and milk insulin-like growth factors and related substances: mammary gland and neonatal (intestinal and systemic) targets, Domest Anim Endocrinol, 23, 101, 10.1016/S0739-7240(02)00149-2
Burrin, 1997, Is milk-borne insulin-like growth factor-I essential for neonatal development?, J Nutr, 127, 975S
Philipps, 2002, Intestinal transport of insulin-like growth factor-I (IGF-I) in the suckling rat, J Pediatr Gastroenterol Nutr, 35, 539, 10.1097/00005176-200210000-00015
Milsom, 2008, Temporal changes in insulin-like growth factors I and II and in insulin-like growth factor binding proteins 1, 2, and 3 in human milk, Horm Res, 69, 307, 10.1159/000114863
Prosser, 1996, Insulin-like growth factors in milk and mammary gland, J Mammary Gland Biol Neoplasia, 1, 297, 10.1007/BF02018082
Elmlinger, 2007, Insulin-like growth factors and binding proteins in early milk from mothers of preterm and term infants, Horm Res, 68, 124, 10.1159/000100488
Peterson, 2000, Enterotrophic effect of insulin-like growth factor-I but not growth hormone and localized expression of insulin-like growth factor-I, insulin-like growth factor binding protein-3 and -5 mRNAs in jejunum of parenterally fed rats, JPEN J Parenter Eternal Nutr, 24, 288, 10.1177/0148607100024005288
Murali, 2005, Insulin-like growth factor-I (IGF-I) attenuates jejunal atrophy in association with increased expression of IGF-I binding protein-5 in parenterally fed mice, J Nutr, 135, 2553
Corpeleijn, 2008, Effect of enteral IGF-1 supplementation on feeding tolerance, growth, and gut permeability in enterally fed premature neonates, J Pediatr Gastroenterol Nutr, 46, 184, 10.1097/MPG.0b013e31815affec
Büyükkayhan, 2003, Umbilical serum insulin-like growth factor 1 (IGF-1) in newborns: effects of gestational age, postnatal age, and nutrition, Int J Vitam Nutr Res, 73, 343, 10.1024/0300-9831.73.5.343
Philipps, 2000, Absorption of milk-borne insulin-like growth factor-I into portal blood of suckling rats, J Pediatr Gastroenterol Nutr, 31, 128, 10.1097/00005176-200008000-00008
Kling, 2006, Insulin-like growth factor-I stimulates erythropoiesis when administered enterally, Growth Factors, 24, 218, 10.1080/08977190600783162
Loui, 2012, Vascular endothelial growth factor (VEGF) and soluble VEGF Receptor 1 (Sflt-1) levels in early and mature human milk from mothers of preterm versus term infants, J Hum Lact, 28, 522, 10.1177/0890334412447686
Reynolds, 2001, The management of retinopathy of prematurity, Paediatr Drugs, 3, 263, 10.2165/00128072-200103040-00003
DiBiasie, 2006, Evidence-based review of retinopathy of prematurity prevention in VLBW and ELBW infants, Neonatal Netw, 25, 393, 10.1891/0730-0832.25.6.393
Soubasi, 1995, Follow-up of very low birth weight infants after erythropoietin treatment to prevent anemia of prematurity, J Pediatr, 127, 291, 10.1016/S0022-3476(95)70313-6
Carbonell-Estrany, 2005, Erythropoietin and prematurity—where do we stand?, J Perinat Med, 33, 277, 10.1515/JPM.2005.054
Kling, 2008, Enteral erythropoietin and iron stimulate erythropoiesis in suckling rats, J Pediatr Gastroenterol Nutr, 46, 202, 10.1097/MPG.0b013e3181559e8b
Pasha, 2008, Enteral erythropoietin increases plasma erythropoietin level in preterm infants: a randomized controlled trial, Indian Pediatr, 45, 25
Shiou, 2011, Erythropoietin protects intestinal epithelial barrier function and lowers the incidence of experimental neonatal necrotizing enterocolitis, J Biol Chem, 286, 12123, 10.1074/jbc.M110.154625
Arsenault, 2010, Association between breast milk erythropoietin and reduced risk of mother-to-child transmission of HIV, J Infect Dis, 202, 370, 10.1086/653706
Claud, 2003, Modulation of human intestinal epithelial cell IL-8 secretion by human milk factors, Pediatr Res, 53, 419, 10.1203/01.PDR.0000050141.73528.AD
Struck, 2002, High concentrations of procalcitonin but not mature calcitonin in normal human milk, Horm Metab Res, 34, 460, 10.1055/s-2002-33596
Wookey, 2012, Transient expression of the calcitonin receptor by enteric neurons of the embryonic and early post-natal mouse, Cell Tissue Res, 347, 311, 10.1007/s00441-011-1303-6
Rao, 1999, Effect of milk on somatostatin degradation in suckling rat jejunum in vivo, J Pediatr Gastroenterol Nutr, 28, 84, 10.1097/00005176-199901000-00019
Gama, 1996, LHRH and somatostatin effects on the cell proliferation of the gastric epithelium of suckling and weaning rats, Regul Pept, 63, 73, 10.1016/0167-0115(96)00013-4
Newburg, 2010, Characteristics and potential functions of human milk adiponectin, J Pediatr, 156, S41, 10.1016/j.jpeds.2009.11.020
Martin, 2006, Adiponectin is present in human milk and is associated with maternal factors, Am J Clin Nutr, 83, 1106, 10.1093/ajcn/83.5.1106
Woo, 2012, Human milk adiponectin affects infant weight trajectory during the second year of life, J Pediatr Gastroenterol Nutr, 54, 532, 10.1097/MPG.0b013e31823fde04
Savino, 2012, Resistin and leptin in breast milk and infants in early life, Early Hum Dev, 88, 779, 10.1016/j.earlhumdev.2012.05.004
Savino, 2008, Update on breast milk hormones: leptin, ghrelin and adiponectin, Clin Nutr, 27, 42, 10.1016/j.clnu.2007.06.006
Palou, 2009, Nutrient–gene interactions in early life programming: leptin in breast milk prevents obesity later on in life, Advances in experimental medicine and biology, 646, 95, 10.1007/978-1-4020-9173-5_10
Dündar, 2010, Ghrelin and adiponectin levels in colostrum, cord blood and maternal serum, Pediatr Int, 52, 622, 10.1111/j.1442-200X.2010.03100.x
Goldman, 2000, Modulation of the gastrointestinal tract of infants by human milk. Interfaces and interactions. An evolutionary perspective1, J Nutr, 130, 426S
Jarvinen, 2002, Leucocytes in human milk and lymphocyte subsets in cow's milk-allergic infants, Pediatr Allergy Immunol, 13, 243, 10.1034/j.1399-3038.2002.00087.x
Patki, 2010, Human breast milk is a rich source of multipotent mesenchymal stem cells, Hum Cell, 23, 35, 10.1111/j.1749-0774.2010.00083.x
Ichikawa, 2003, Breast milk macrophages spontaneously produce granulocyte-macrophage colony-stimulating factor and differentiate into dendritic cells in the presence of exogenous interleukin-4 alone, Immunology, 108, 189, 10.1046/j.1365-2567.2003.01572.x
Indumathi, 2012, Exploring the stem cell and non-stem cell constituents of human breast milk, Cytotechnology, 10.1007/s10616-012-9492-8
Riskin, 2012, Changes in immunomodulatory constituents of human milk in response to active infection in the nursing infant, Pediatr Res, 71, 220, 10.1038/pr.2011.34
Sabbaj, 2012, Cellular immunity in breast milk: implications for postnatal transmission of HIV-1 to the infant, Adv Exp Med Biol, 743, 161, 10.1007/978-1-4614-2251-8_11
Yagi, 2010, Inhibition of DC-SIGN-mediated transmission of human immunodeficiency virus type 1 by Toll-like receptor 3 signalling in breast milk macrophages, Immunology, 130, 597, 10.1111/j.1365-2567.2010.03264.x
Agarwal, 2011, Immune markers in breast milk and fetal and maternal body fluids: a systematic review of perinatal concentrations, J Hum Lact, 27, 171, 10.1177/0890334410395761
Groer, 2011, Multidimensional scaling of multiplex data: human milk cytokines, Biol Res Nurs, 13, 289, 10.1177/1099800411402055
Kverka, 2007, Cytokine profiling in human colostrum and milk by protein array, Clin Chem, 53, 955, 10.1373/clinchem.2006.077107
Penttila, 2010, Milk-derived transforming growth factor-b and the infant immune response, J Pediatr, 156, S21, 10.1016/j.jpeds.2009.11.016
Kalliomäki, 1999, Transforming growth factor-β in breast milk: a potential regulator of atopic disease at an early age, J Allergy Clin Immunol, 104, 1251, 10.1016/S0091-6749(99)70021-7
Saito, 1993, Transforming growth factor-beta (TGF-β) in human milk, Clin Exp Immunol, 94, 220, 10.1111/j.1365-2249.1993.tb06004.x
Nakamura, 2009, The latent form of transforming growth factor-β administered orally is activated by gastric acid in mice, J Nutr, 139, 1463
Letterio, 1994, Maternal rescue of transforming growth factor-β1 null mice, Science, 264, 1936, 10.1126/science.8009224
Ando, 2007, Orally administered TGF-β is biologically active in the intestinal mucosa and enhances oral tolerance, J Allergy Clin Immunol, 120, 916, 10.1016/j.jaci.2007.05.023
Ozawa, 2009, Transforming growth factor-β activity in commercially available pasteurized cow milk provides protection against inflammation in mice, J Nutr, 139, 69
Donnet-Hughes, 2000, Bioactive molecules in milk and their role in health and disease: the role of transforming growth factor-β, Immunol Cell Biol, 78, 74, 10.1046/j.1440-1711.2000.00882.x
Gilmore, 1994, Human milk contains granulocyte colony stimulating factor, Eur J Clin Nutr, 48, 222
Gersting, 2003, Bioavailability of granulocyte colony-stimulating factor administered enterally to suckling mice, Pharmacol Res, 48, 643, 10.1016/S1043-6618(03)00249-4
Calhoun, 2003, Recombinant granulocyte colony-stimulating factor administered enterally to neonates is not absorbed, Pediatrics, 112, 421, 10.1542/peds.112.2.421
Gersting, 2004, Effects of enterally administering granulocyte colony-stimulating factor to suckling mice, Pediatr Res, 55, 802, 10.1203/01.PDR.0000117846.51197.7C
Ngom, 2004, Improved thymic function in exclusively breastfed infants is associated with higher interleukin 7 concentrations in their mothers' breast milk, Am J Clin Nutr, 80, 722, 10.1093/ajcn/80.3.722
Aspinall, 2011, Interleukin 7 from maternal milk crosses the intestinal barrier and modulates T-cell development in offspring, PLoS One, 6, e20812, 10.1371/journal.pone.0020812
Ustundag, 2005, Levels of cytokines (IL-1beta, IL-2, IL-6, IL-8, TNF-alpha) and trace elements (Zn, Cu) in breast milk from mothers of preterm and term infants, Mediators Inflamm, 2005, 331, 10.1155/MI.2005.331
Buescher, 1998, Soluble tumor necrosis factor-α (TNF-α) receptors in human colostrum and milk bind to TNF-α and neutralize TNF-α bioactivity, Pediatr Res, 44, 37, 10.1203/00006450-199807000-00006
Buescher, 1996, Soluble receptors and cytokine antagonists in human milk, Pediatr Res, 40, 839, 10.1203/00006450-199612000-00011
Erbağci, 2005, Persistency of high proinflammatory cytokine levels from colostrum to mature milk in preeclampsia, Clin Biochem, 38, 712, 10.1016/j.clinbiochem.2005.05.004
Meki, 2003, Interleukins -6, -8 and -10 and tumor necrosis factor alpha and its soluble receptor I in human milk at different periods of lactation, Nutr Res, 23, 845, 10.1016/S0271-5317(03)00035-6
Maheshwari, 2002, Effects of Interleukin-8 on the developing human intestine, Cytokine, 20, 256, 10.1006/cyto.2002.1996
Maheshwari, 2004, Interleukin-8/CXCL8 forms an autocrine loop in fetal intestinal mucosa, Pediatr Res, 56, 240, 10.1203/01.PDR.0000133196.25949.98
Mizuno, 2012, Mastitis is associated with IL-6 Levels and milk fat globule size in breast milk, J Hum Lact, 28, 529, 10.1177/0890334412455946
Hunt, 2012, Mastitis is associated with increased free fatty acids, somatic cell count, and interleukin-8 concentrations in human milk, Breastfeed Med, 10.1089/bfm.2011.0141
Hrdý, 2012, Cytokine expression in the colostral cells of healthy and allergic mothers, Folia Microbiol (Praha), 57, 215, 10.1007/s12223-012-0112-y
Strand, 2012, Risk factors for extended duration of acute diarrhea in young children, PLoS One, 7, e36436, 10.1371/journal.pone.0036436
Lamberti, 2011, Breastfeeding and the risk for diarrhea morbidity and mortality, BMC Public Health, 11, S15, 10.1186/1471-2458-11-S3-S15
Brandtzaeg, 2010, The mucosal immune system and its integration with the mammary glands, J Pediatr, 156, S8, 10.1016/j.jpeds.2009.11.014
Kadaoui, 2007, Secretory IgA mediates bacterial translocation to dendritic cells in mouse Peyer’s patches with restriction to mucosal compartment, J Immunol, 179, 7751, 10.4049/jimmunol.179.11.7751
Corthesy, 2009, Secretory immunoglobulin a: well beyond immune exclusion at mucosal surfaces, Immunopharmacol Immunotoxicol, 31, 174, 10.1080/08923970802438441
Hurley, 2011, Perspectives on immunoglobulins in colostrum and milk, Nutrients, 3, 442, 10.3390/nu3040442
Velona, 1999, Protein profiles in breast milk from mothers delivering term and preterm babies, Pediatr Res, 45, 658, 10.1203/00006450-199905010-00008
Adamkin, 2012, Mother's milk, feeding strategies, and lactoferrin to prevent necrotizing enterocolitis, JPEN J Parenter Enteral Nutr, 36, 25S, 10.1177/0148607111420158
Beljaars, 2004, Inhibition of cytomegalovirus infection by lactoferrin in vitro and in vivo, Antiviral Res, 63, 197, 10.1016/j.antiviral.2004.05.002
Kuipers, 1999, Synergistic fungistatic effects of lactoferrin in combination with antifungal drugs against clinical Candida isolates, Antimicrob Agents Chemother, 43, 2635, 10.1128/AAC.43.11.2635
Leitch, 1999, Lactoferrin increases the susceptibility of S. epidermidis biofilms to lysozyme and vancomycin, Curr Eye Res, 19, 12, 10.1076/ceyr.19.1.12.5342
Manzoni, 2009, Bovine lactoferrin supplementation for prevention of late-onset sepsis in very low-birth-weight neonates: a randomized trial, JAMA, 302, 1421, 10.1001/jama.2009.1403
Sherman, 2004, Neonatal small bowel epithelia: enhancing anti-bacterial defense with lactoferrin and Lactobacillus GG, Biometals, 17, 285, 10.1023/B:BIOM.0000027706.51112.62
Stubbs, 1990, cDNA cloning of a mouse mammary epithelial cell surface protein reveals the existence of epidermal growth factor-like domains linked to factor VIII-like sequences, Proc Natl Acad Sci U S A, 87, 8417, 10.1073/pnas.87.21.8417
Peterson, 1998, Milk fat globule glycoproteins in human milk and in gastric aspirates of mother's milk-fed preterm infants, Pediatr Res, 44, 499, 10.1203/00006450-199810000-00006
Newburg, 1998, Role of human-milk lactadherin in protection against symptomatic rotavirus infection, Lancet, 351, 1160, 10.1016/S0140-6736(97)10322-1
Aziz, 2011, Review: milk fat globule-EGF factor 8 expression, function and plausible signal transduction in resolving inflammation, Apoptosis, 16, 1077, 10.1007/s10495-011-0630-0
Shi, 2004, Lactadherin binds selectively to membranes containing phosphatidyl-l-serine and increased curvature, Biochim Biophys Acta, 1667, 82, 10.1016/j.bbamem.2004.09.006
Kusunoki, 2012, Roles of milk fat globule-epidermal growth factor 8 in intestinal inflammation, Digestion, 85, 103, 10.1159/000334679
Chogle, 2011, Milk fat globule-EGF factor 8 is a critical protein for healing of dextran sodium sulfate-induced acute colitis in mice, Mol Med, 17, 502, 10.2119/molmed.2010.00074
Baghdadi, 2012, MFG-E8 regulates the immunogenic potential of dendritic cells primed with necrotic cell-mediated inflammatory signals, PLoS One, 7, e39607, 10.1371/journal.pone.0039607
Landberg, 2000, Changes in glycosylation of human bile-salt-stimulated lipase during lactation, Arch Biochem Biophys, 377, 246, 10.1006/abbi.2000.1778
Stax, 2011, Binding of human milk to pathogen receptor DC-SIGN varies with bile salt-stimulated lipase (BSSL) gene polymorphism, PLoS One, 6, e17316, 10.1371/journal.pone.0017316
Naarding, 2006, Bile salt-stimulated lipase from human milk binds DC-SIGN and inhibits human immunodeficiency virus type 1 transfer to CD4+ T cells, Antimicrob Agents Chemother, 50, 3367, 10.1128/AAC.00593-06
Ruvoen-Clouet, 2006, Bile-salt-stimulated lipase and mucins from milk of ‘secretor’ mothers inhibit the binding of Norwalk virus capsids to their carbohydrate ligands, Biochem J, 393, 627, 10.1042/BJ20050898
Hettinga, 2011, The host defense proteome of human and bovine milk, PLoS One, 6, e19433, 10.1371/journal.pone.0019433
Saeland, 2009, MUC1 in human milk blocks transmission of human immunodeficiency virus from dendritic cells to T cells, Mol Immunol, 46, 2309, 10.1016/j.molimm.2009.03.025
Yolken, 1992, Human milk mucin inhibits rotavirus replication and prevents experimental gastroenteritis, J Clin Invest, 90, 1984, 10.1172/JCI116078
Parker, 2010, Bovine Muc1 inhibits binding of enteric bacteria to Caco-2 cells, Glycoconj J, 27, 89, 10.1007/s10719-009-9269-2
Liu, 2012, Human milk mucin 1 and mucin 4 inhibit Salmonella enterica serovar typhimurium invasion of human intestinal epithelial cells in vitro, J Nutr, 142, 1504
Bode, 2012, Human milk oligosaccharide concentration and risk of postnatal transmission of HIV through breastfeeding, Am J Clin Nutr, 96, 831, 10.3945/ajcn.112.039503
De Leoz, 2012, Lacto-N-tetraose, fucosylation, and secretor status are highly variable in human milk oligosaccharides from women delivering preterm, J Proteome Res, 11, 4662, 10.1021/pr3004979
Hunt, 2011, Characterization of the diversity and temporal stability of bacterial communities in human milk, PLoS One, 6, e21313, 10.1371/journal.pone.0021313
Cabrera-Rubio, 2012, The human milk microbiome changes over lactation and is shaped by maternal weight and mode of delivery, Am J Clin Nutr, 96, 544, 10.3945/ajcn.112.037382
Rasmussen, 2011, The quiet revolution: breastfeeding transformed with the use of breast pumps, Am J Public Health, 101, 1356, 10.2105/AJPH.2011.300136
Baro, 2011, Effect of two pasteurization methods on the protein content of human milk, Front Biosci (Elite Ed), 3, 818
Chantry, 2011, Effect of flash-heat treatment on antimicrobial activity of breastmilk, Breastfeed Med, 6, 111, 10.1089/bfm.2010.0078
Israel-Ballard, 2007, Flash-heat inactivation of HIV-1 in human milk: a potential method to reduce postnatal transmission in developing countries, J Acquir Immune Defic Syndr, 45, 318, 10.1097/QAI.0b013e318074eeca
Peroni, 2009, Transforming growth factor-β1 is elevated in unpasteurized cow's milk, Pediatr Allergy Immunol, 20, 42, 10.1111/j.1399-3038.2008.00737.x
Agennix. Phase 1/2 study of talactoferrin oral solution for nosocomial infection in preterm infants: Available at: http://clinicaltrials.gov/ct2/show/NCT00854633. Accessed August 23, 2012.
Ewaschuk, 2011, Effect of pasteurization on selected immune components of donated human breast milk, J Perinatol, 31, 593, 10.1038/jp.2010.209
Akinbi, 2010, Alterations in the host defense properties of human milk following prolonged storage or pasteurization, J Pediatr Gastroenterol Nutr, 51, 347, 10.1097/MPG.0b013e3181e07f0a
Valentine, 2011, Optimizing human milk fortification for the preterm infant, PNPG Building Block for Life, 34, 9
Steinhoff, 2012, A review of fetal and infant protection associated with antenatal influenza immunization, Am J Obstet Gynecol, 207, S21, 10.1016/j.ajog.2012.06.071
Neville, 2012, Lactation and neonatal nutrition: defining and refining the critical questions, J Mammary Gland Biol Neoplasia, 17, 167, 10.1007/s10911-012-9261-5
Wojcik, 2009, Macronutrient analysis of a nationwide sample of donor breast milk, Journal of the American Dietetic Association, 109, 137, 10.1016/j.jada.2008.10.008
Cianga, 1999, Identification and function of neonatal Fc receptor in mammary gland of lactating mice, Eur J Immunol, 29, 2515, 10.1002/(SICI)1521-4141(199908)29:08<2515::AID-IMMU2515>3.0.CO;2-D
VandePerre, 1993, Infective and anti-infective properties of breastmilk from HIV-1-infected women, The Lancet, 341, 914, 10.1016/0140-6736(93)91210-D
Mehta, 2011, Very preterm gestation and breastmilk cytokine content during the first month of lactation, Breastfeeding Med, 6, 21, 10.1089/bfm.2010.0024
Verhasselt, 2008, Breast milk–mediated transfer of an antigen induces tolerance and protection from allergic asthma, Nat Med, 14, 170, 10.1038/nm1718
Verhasselt, 2010, Neonatal tolerance under breastfeeding influence: The presence of allergen and transforming growth factor-b in breast milk protects the progeny from allergic asthma, J Pediatr, 156, S16, 10.1016/j.jpeds.2009.11.015
Penttila, 2003, Maternal milk regulation of cell infiltration and interleukin 18 in the intestine of suckling rat pups, Gut, 52, 1579, 10.1136/gut.52.11.1579
Mosconi, 2010, Breast milk immune complexes are potent inducers of oral tolerance in neonates and prevent asthma development, Nat Mucos Immun, 3, 461, 10.1038/mi.2010.23
Okamoto, 2005, Suppression of serum IgE response and systemic anaphylaxis in a food allergy model by orally administered high-dose TGF-b, Int Immunol, 17, 705, 10.1093/intimm/dxh250
Penttila, 2006, Effects of transforming growth factor-beta and formula feeding on systemic immune responses to dietary b-lactoglobulin in allergy-prone rats, Pediatr Res, 59, 650, 10.1203/01.pdr.0000203149.75465.74
McPherson, 2001, The effect of pasteurization on transforming growth factor alpha and transforming growth factor beta 2 concentrations in human milk, Adv Exp Med Biol, 501, 559, 10.1007/978-1-4615-1371-1_70
Rudloff, 1992, Tumor Necrosis Factor-a in human milk, Pediatr Res, 31, 29, 10.1203/00006450-199201000-00005
Magi, 2002, Presence of macrophage migration inhibitory factor in human milk: evidence in the aqueous phase and milk fat globules, Pediatr Res, 51, 619, 10.1203/00006450-200205000-00013
Vigh, 2011, Longitudinal changes in macrophage migration inhibitory factor in breast milk during the first three months of lactation, J Reprod Immunol, 89, 92, 10.1016/j.jri.2010.11.007
Coursodon, 2012, Epidermal growth factor and necrotizing enterocolitis, Curr Opinion Pediatr, 24, 160, 10.1097/MOP.0b013e3283504ddb
Clark, 2004, Epidermal growth factor reduces intestinal apoptosis in an experimental model of necrotizing enterocolitis, Am J Physiol Gastrointest Liver Physiol, 288, G755, 10.1152/ajpgi.00172.2004
Untalan, 2009, Heat susceptibility of interleukin-10 and other cytokines in donor human milk, Breastfeeding Med, 4, 137, 10.1089/bfm.2008.0145
Ozgurtas, 2011, Soluble Vascular Endothelial Growth Factor Receptor 1 in Human Breast Milk, Horm Res Paediatr, 76, 17, 10.1159/000324057
Chellakooty, 2006, A prospective study of serum insulin-like growth factor I (IGF-I) and IGF-binding protein-3 in 942 healthy infants: associations with birth weight, gender, growth velocity, and breastfeeding, J Clin Endocrin & Metab, 91, 820, 10.1210/jc.2005-0950
Baregamian, 2006, IGF-1 protects intestinal epithelial cells from oxidative stress-induced apoptosis, J Surg Res, 136, 31, 10.1016/j.jss.2006.04.028
Baregamian, 2012, Effects of oxidative stress on intestinal type I insulinlLike growth factor receptor expression, Eur J Ped Surg, 22, 97, 10.1055/s-0032-1306261
Juul, 2003, Absorption of enteral recombinant human erythropoietin by neonates, Ann Pharmocother, 37, 782, 10.1345/aph.1C428
Miller-Gilbert, 2001, Enteral absorption of erythropoietin in the suckling rat, Pediatr Res, 50, 261, 10.1203/00006450-200108000-00016
Miller, 2002, Breastmilk erythropoietin and mother-to-child HIV transmission through breastmilk, The Lancet, 360, 1246, 10.1016/S0140-6736(02)11277-3
Hirotani, 2008, Protective effects of lactoferrin against intestinal mucosal damage induced by lipopolysaccharide in human intestinal Caco-2 cells, Yakugaku Zasshi, 128, 1363, 10.1248/yakushi.128.1363
Buccigrossi, 2007, Lactoferrin induces concentration-dependent functional modulation of intestinal proliferation and differentiation, Pediatr Res, 61, 410, 10.1203/pdr.0b013e3180332c8d
Shah, 2012, Recombinant human milk fat globule-EGF factor 8 produces dose-dependent benefits in sepsis, Intensive Care Med, 38, 128, 10.1007/s00134-011-2353-7
Miksa, 2006, Dendritic cell derived exosomes containing Milk Fat Globule-Epidermal Growth Factor VIII attenuate proinflammatory responses in sepsis, Shock, 25, 586, 10.1097/01.shk.0000209533.22941.d0
Komura, 2009, Milk Fat Globule Epidermal Growth Factor-Factor VIII is down-regulated in sepsis via the lipopolysaccharide-CD14 pathway, J Immunol, 182, 581, 10.4049/jimmunol.182.1.581
Miksa, 2009, Immature dendritic cell-derived exosomes rescue septic animals via Milk Fat Globule Epidermal Growth Factor VIII, J Immunol, 183, 5983, 10.4049/jimmunol.0802994
Wu, 2012, Enhancing apoptotic cell clearance mitigates bacterial translocation and promotes tissue repair after gut ischemia-reperfusion injury, Int J Mol Med, 30, 593, 10.3892/ijmm.2012.1044
Matsuda, 2011, Milk Fat Globule-EGF Factor VIII in sepsis and ischemia-reperfusion injury, Mol Med, 17, 126, 10.2119/molmed.2010.00135
Silvestre, 2005, Lactadherin promotes VEGF-dependent neovascularization, Nature Med, 11, 499, 10.1038/nm1233
Woo, 2012, Human milk adiponectin affects infant weight trajectory during the second year of life, JPGN, 54, 532
Ley, 2011, Effects of pasteurization on adiponectin and insulin concentrations in donor human milk, Pediatr Res, 70, 278, 10.1203/PDR.0b013e318224287a
Dündar, 2010, Ghrelin and adiponectin levels in colostrum, cord blood and maternal serum, Pediatr Int, 52, 622, 10.1111/j.1442-200X.2010.03100.x
Ozarda, 2012, The concentration of adiponectin in breast milk is related to maternal hormonal and inflammatory status during 6 months of lactation, Clin Chem Lab Med, 50, 911, 10.1515/cclm-2011-0724
Weyermann, 2007, Adipokines in human milk and risk of overweight in early childhood: a prospective cohort study, Epidemiol, 18, 722, 10.1097/EDE.0b013e3181567ed4
Marcobal, 2012, Human milk oligosaccharide consumption by intestinal microbiota, Clin Microbiol Infect, 18, 12, 10.1111/j.1469-0691.2012.03863.x
Rudloff, 2012, Milk oligosaccharides and metabolism in infants, Adv Nutr, 3, 398S, 10.3945/an.111.001594
Ruhaak, 2012, Analysis and role of oligosaccharides in milk, BMB Rep, 45, 442, 10.5483/BMBRep.2012.45.8.161
Wang, 2012, Molecular mechanism underlying sialic acid as an essential nutrient for brain development and cognition, Adv Nutr, 3, 465S, 10.3945/an.112.001875
Coppa, 2012, Glycosaminoglycan content in term and preterm milk during the first month of lactation, Neonatology, 101, 74, 10.1159/000330848
Coppa, 2011, Composition and structure elucidation of human milk glycosaminoglycans, Glycobiology, 21, 295, 10.1093/glycob/cwq164
Sando, 2009, Bovine Muc1 is a highly polymorphic gene encoding an extensively glycosylated mucin that binds bacteria, J Dairy Sci, 92, 5276, 10.3168/jds.2009-2216