Human Induced Pluripotent Stem Cell-Derived Astrocytes Are Differentially Activated by Multiple Sclerosis-Associated Cytokines

Elsevier BV - Tập 11 - Trang 1199-1210 - 2018
Sylvain Perriot1, Amandine Mathias1, Guillaume Perriard1, Mathieu Canales1, Nils Jonkmans1, Nicolas Merienne2, Cécile Meunier2, Lina El Kassar3, Anselme L. Perrier4, David-Axel Laplaud5, Myriam Schluep6, Nicole Déglon2, Renaud Du Pasquier1,6
1Laboratory of Neuroimmunology, Neuroscience Research Centre, Department of Clinical Neurosciences, CHUV, Lausanne, Switzerland
2Laboratory of Neurotherapies and NeuroModulation, Neuroscience Research Centre, Department of Clinical Neurosciences, CHUV, Lausanne, Switzerland
3Institute for Stem Cell Therapy and Exploration of Monogenic Diseases (I-Stem), Corbeil-Essonnes, France
4Institut National de la Santé et de la Recherche Médicale (INSERM) UMR861, I-Stem, AFM, Corbeil-Essonnes, France
5Centre de Recherche en Transplantation et Immunologie UMR1064, INSERM, Université de Nantes, Nantes, France
6Service of Neurology, Department of Clinical Neurosciences, CHUV, CHUV BH-10/131, 46, rue du Bugnon, Lausanne 1011, Switzerland

Tài liệu tham khảo

Babbe, 2000, Clonal expansions of CD8(+) T cells dominate the T cell infiltrate in active multiple sclerosis lesions as shown by micromanipulation and single cell polymerase chain reaction, J. Exp. Med., 192, 393, 10.1084/jem.192.3.393 Baker, 2015, Mouse models of multiple sclerosis: lost in translation?, Curr. Pharm. Des., 21, 2440, 10.2174/1381612821666150316122706 Bazargani, 2016, Astrocyte calcium signaling: the third wave, Nat. Neurosci., 19, 182, 10.1038/nn.4201 Becher, 2017, Cytokine networks in neuroinflammation, Nat. Rev. Immunol., 17, 49, 10.1038/nri.2016.123 Boissart, 2013, Differentiation from human pluripotent stem cells of cortical neurons of the superficial layers amenable to psychiatric disease modeling and high-throughput drug screening, Transl. Psychiatry, 3, e294, 10.1038/tp.2013.71 Bonni, 1997, Regulation of gliogenesis in the central nervous system by the JAK-STAT signaling pathway, Science, 278, 477, 10.1126/science.278.5337.477 Brosnan, 2013, The astrocyte in multiple sclerosis revisited, Glia, 61, 453, 10.1002/glia.22443 Capani, 2016, Astrocytes as the main players in primary degenerative disorders of the human central nervous system, Front. Aging Neurosci., 8, 45, 10.3389/fnagi.2016.00045 Chambers, 2009, Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling, Nat. Biotechnol., 27, 275, 10.1038/nbt.1529 Chandrasekaran, 2016, Astrocyte differentiation of human pluripotent stem cells: new tools for neurological disorder research, Front. Cell. Neurosci., 10, 215, 10.3389/fncel.2016.00215 Colombo, 2016, Astrocytes: key regulators of neuroinflammation, Trends Immunol., 37, 608, 10.1016/j.it.2016.06.006 Correale, 2015, The role of astrocytes in multiple sclerosis progression, Front. Neurol., 6, 180, 10.3389/fneur.2015.00180 Domingues, 2016, Oligodendrocyte, astrocyte, and microglia crosstalk in myelin development, damage, and repair, Front. Cell Dev. Biol., 4, 71 Farina, 2007, Astrocytes are active players in cerebral innate immunity, Trends Immunol., 28, 138, 10.1016/j.it.2007.01.005 Galloway, 2017, Effects of fumarates on inflammatory human astrocyte responses and oligodendrocyte differentiation, Ann. Clin. Transl. Neurol., 4, 381, 10.1002/acn3.414 Giralt, 2013, Induction of atypical EAE mediated by transgenic production of IL-6 in astrocytes in the absence of systemic IL-6, Glia, 61, 587, 10.1002/glia.22457 Hartmann, 2014, Multiple sclerosis-associated IL2RA polymorphism controls GM-CSF production in human TH cells, Nat. Commun., 5, 5056, 10.1038/ncomms6056 Hohlfeld, 2015, The search for the target antigens of multiple sclerosis, part 1: autoreactive CD4+ T lymphocytes as pathogenic effectors and therapeutic targets, Lancet Neurol., 15, 198, 10.1016/S1474-4422(15)00334-8 Huseby, 2015, Role of T cell-glial cell interactions in creating and amplifying central nervous system inflammation and multiple sclerosis disease symptoms, Front. Cell. Neurosci., 9, 295, 10.3389/fncel.2015.00295 Ireland, 2015, Seeking balance: potentiation and inhibition of multiple sclerosis autoimmune responses by IL-6 and IL-10, Cytokine, 73, 236, 10.1016/j.cyto.2015.01.009 Jilek, 2007, CSF enrichment of highly differentiated CD8+ T cells in early multiple sclerosis, Clin. Immunol., 123, 105, 10.1016/j.clim.2006.11.004 Jilek, 2008, Strong EBV-specific CD8+ T-cell response in patients with early multiple sclerosis, Brain, 131, 1712, 10.1093/brain/awn108 Khakh, 2015, Diversity of astrocyte functions and phenotypes in neural circuits, Nat. Neurosci., 18, 942, 10.1038/nn.4043 Krencik, 2011, Directed differentiation of functional astroglial subtypes from human pluripotent stem cells, Nat. Protoc., 6, 1710, 10.1038/nprot.2011.405 Kwilasz, 2015, The therapeutic potential of interleukin-10 in neuroimmune diseases, Neuropharmacology, 96, 55, 10.1016/j.neuropharm.2014.10.020 Liddelow, 2017, Reactive astrocytes: production, function, and therapeutic potential, Immunity, 46, 957, 10.1016/j.immuni.2017.06.006 Liddelow, 2017, Neurotoxic reactive astrocytes are induced by activated microglia, Nature, 541, 481, 10.1038/nature21029 Lundin, 2018, Human iPS-derived astroglia from a stable neural precursor state show improved functionality compared with conventional astrocytic models, Stem Cell Reports, 10, 1030, 10.1016/j.stemcr.2018.01.021 Mathias, 2016, Increased ex vivo antigen presentation profile of B cells in multiple sclerosis, Mult. Scler., 23, 802, 10.1177/1352458516664210 Mayo, 2012, The innate immune system in demyelinating disease, Immunol. Rev., 248, 170, 10.1111/j.1600-065X.2012.01135.x Mayo, 2014, Regulation of astrocyte activation by glycolipids drives chronic CNS inflammation, Nat. Med., 20, 1147, 10.1038/nm.3681 Moore, 2011, How factors secreted from astrocytes impact myelin repair, J. Neurosci. Res., 89, 13, 10.1002/jnr.22482 Nedergaard, 2003, New roles for astrocytes: redefining the functional architecture of the brain, Trends Neurosci., 26, 523, 10.1016/j.tins.2003.08.008 Okita, 2011, A more efficient method to generate integration-free human iPS cells, Nat. Methods, 8, 409, 10.1038/nmeth.1591 Perriard, 2015, Interleukin-22 is increased in multiple sclerosis patients and targets astrocytes, J. Neuroinflammation, 12, 119, 10.1186/s12974-015-0335-3 Prinz, 2012, Type I interferons as ambiguous modulators of chronic inflammation in the central nervous system, Front. Immunol., 3, 67, 10.3389/fimmu.2012.00067 Ritchie, 2015, limma powers differential expression analyses for RNA-sequencing and microarray studies, Nucleic Acids Res., 43, e47, 10.1093/nar/gkv007 Robinson, 2010, edgeR: a Bioconductor package for differential expression analysis of digital gene expression data, Bioinformatics, 26, 139, 10.1093/bioinformatics/btp616 Rothhammer, 2016, Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor, Nat. Med., 22, 586, 10.1038/nm.4106 Rothhammer, 2017, Sphingosine 1-phosphate receptor modulation suppresses pathogenic astrocyte activation and chronic progressive CNS inflammation, Proc. Natl. Acad. Sci. U S A, 114, 2012, 10.1073/pnas.1615413114 Roybon, 2013, Human stem cell-derived spinal cord astrocytes with defined mature or reactive phenotypes, Cell Rep., 4, 1035, 10.1016/j.celrep.2013.06.021 Santos, 2017, Differentiation of inflammation-responsive astrocytes from glial progenitors generated from human induced pluripotent stem cells, Stem Cell Reports, 8, 1757, 10.1016/j.stemcr.2017.05.011 Sawcer, 2011, Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis, Nature, 476, 214, 10.1038/nature10251 Schonrock, 2000, Interleukin-6 expression in human multiple sclerosis lesions, Neurosci. Lett., 294, 45, 10.1016/S0304-3940(00)01543-3 Sofroniew, 2010, Astrocytes: biology and pathology, Acta Neuropathol., 119, 7, 10.1007/s00401-009-0619-8 Sospedra, 2005, Immunology of multiple sclerosis, Annu. Rev. Immunol., 23, 683, 10.1146/annurev.immunol.23.021704.115707 Tarassishin, 2014, LPS and IL-1 differentially activate mouse and human astrocytes: role of CD14, Glia, 62, 999, 10.1002/glia.22657 Tcw, 2017, An efficient platform for astrocyte differentiation from human induced pluripotent stem cells, Stem Cell Reports, 9, 600, 10.1016/j.stemcr.2017.06.018 Tyzack, 2016, Human stem cell-derived astrocytes: specification and relevance for neurological disorders, Curr. Stem Cell Reports, 2, 236, 10.1007/s40778-016-0049-1 Yan, 2002, Hepatocyte growth factor stimulates the proliferation and migration of oligodendrocyte precursor cells, J. Neurosci. Res., 69, 597, 10.1002/jnr.10323 Zamanian, 2012, Genomic analysis of reactive astrogliosis, J. Neurosci., 32, 6391, 10.1523/JNEUROSCI.6221-11.2012 Zhang, 2016, Purification and characterization of progenitor and mature human astrocytes reveals transcriptional and functional differences with mouse, Neuron, 89, 37, 10.1016/j.neuron.2015.11.013