Human Cytomegalovirus Induces TGF-β1 Activation in Renal Tubular Epithelial Cells after Epithelial-to-Mesenchymal Transition

PLoS Pathogens - Tập 6 Số 11 - Trang e1001170
Masako Shimamura1, Joanne E. Murphy-Ullrich2, William J. Britt1
1Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama, United States of America.
2Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

Tóm tắt

Từ khóa


Tài liệu tham khảo

RH Rubin, 1985, Multicenter seroepidemiologic study of the impact of cytomegalovirus infection on renal transplantation., Transplantation, 40, 243, 10.1097/00007890-198509000-00004

MA Schnitzler, 1997, The effects of cytomegalovirus serology on graft and recipient survival in cadaveric renal transplantation: implications for organ allocation., American Journal of Kidney Diseases, 29, 428, 10.1016/S0272-6386(97)90205-5

MA Schnitzler, 1997, Impact of cytomegalovirus serology on graft survival in living related kidney transplantation: implications for donor selection., Surgery, 121, 563, 10.1016/S0039-6060(97)90112-4

C Gerstenkorn, 2000, The impact of cytomegalovirus serology for 7-year graft survival in cadaveric kidney transplantation—the Newcastle experience., Transplant International, 13, S372

S Sagedal, 2004, Impact of early cytomegalovirus infection and disease on long-term recipient and kidney graft survival., Kidney International, 66, 329, 10.1111/j.1523-1755.2004.00735.x

PK Koskinen, 1996, Rat cytomegalovirus infection and chronic kidney allograft rejection., Transplant International, 9, S3, 10.1111/j.1432-2277.1996.tb01635.x

I Lautenschlager, 1997, CMV increases inflammation and accelerates chronic rejection in rat kidney allografts., Transplantation Proceedings, 29, 802, 10.1016/S0041-1345(96)00109-1

JG van Dam, 2000, Effects of cytomegalovirus infection and prolonged cold ischemia on chronic rejection of rat renal allografts., Transplant International, 13, 54, 10.1007/s001470050009

AH Cohen, 1998, TGF-β in Renal Allograft Rejection., Mineral and Electrolyte Metabolism, 24, 197, 10.1159/000057370

M Suthanthiran, 1998, Mechanisms and management of acute renal allograft rejection., Surg Clin North Am, 78, 77, 10.1016/S0039-6109(05)70636-8

JM Campistol, 2001, Role of transforming growth factor-beta1 in the progression of chronic allograft nephropathy., Nephrology Dialysis Transplantation, 1, 114, 10.1093/ndt/16.suppl_1.114

H Robertson, 2001, Tubulitis after renal transplantation: Demonstration of an association between CD103+ T cells, transforming growth factor-β1 expression and rejection grade., Transplantation January 27, 71, 306, 10.1097/00007890-200101270-00024

BH Ozdemir, 2005, TGF-beta1 expression in renal allograft rejection and cyclosporine A toxicity., Transplantation, 80, 1681, 10.1097/01.tp.0000185303.92981.d6

OG Pankewycz, 1996, Increased renal tubular expression of transforming growth factor beta in human allografts correlates with cyclosporine toxicity., Kidney International, 50, 1634, 10.1038/ki.1996.479

I Helantera, 2005, Persistent cytomegalovirus infection is associated with increased expression of TGF-β1, PDGF-AA and ICAM-1 and arterial intimal thickening in kidney allografts., Nephrology Dialysis Transplantation, 20, 790, 10.1093/ndt/gfh714

I Lautenschlager, 1999, Time-related effects of cytomegalovirus infection on the development of chronic renal allograft rejection in a rat model., Intervirology, 42, 279, 10.1159/000053961

K Inkinen, 2003, Expression of TGF-beta and PDGF-AA antigens and corresponding mRNAs in cytomegalovirus-infected rat kidney allografts., Transplantation Proceedings, 35, 804, 10.1016/S0041-1345(03)00078-2

PJ Stahl, 2001, Transforming growth factor-beta, basement membrane, and epithelial-mesenchymal transdifferentiation: implications for fibrosis in kidney disease., American Journal of Pathology, 159, 1187, 10.1016/S0002-9440(10)62503-5

EP Bottinger, 2002, TGF-beta signaling in renal disease., Journal of the American Society of Nephrology, 13, 2600, 10.1097/01.ASN.0000033611.79556.AE

MP Rastaldi, 2002, Epithelial-mesenchymal transition of tubular epithelial cells in human renal biopsies., Kidney International, 62, 137, 10.1046/j.1523-1755.2002.00430.x

WA Border, 1994, Transforming growth factor beta in tissue fibrosis., N Engl J Med, 331, 1286, 10.1056/NEJM199411103311907

Y Liu, 2004, Epithelial to mesenchymal transition in renal fibrogenesis: pathologic significance, molecular mechanism, and therapeutic intervention., Journal of the American Society of Nephrology, 15, 1, 10.1097/01.ASN.0000106015.29070.E7

J Yang, 2002, Disruption of tissue-type plasminogen activator gene in mice reduces renal interstitial fibrosis in obstructive nephropathy., Journal of Clinical Investigation, 110, 1525, 10.1172/JCI0216219

M Zeisberg, 2003, BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury., Nature Medicine, 9, 964, 10.1038/nm888

S Michelson, 1994, Human cytomegalovirus infection induces transcription and secretion of transforming growth factor beta 1., Journal of Virology, 68, 5730, 10.1128/JVI.68.9.5730-5737.1994

T Kossmann, 2003, Cytomegalovirus production by infected astrocytes correlates with transforming growth factor-beta release., Journal of Infectious Diseases, 187, 534, 10.1086/373995

YJ Kwon, 2004, Human cytomegalovirus (HCMV) infection in osteosarcoma cell line suppresses GM-CSF production by induction of TGF-beta., Microbiology & Immunology, 48, 195, 10.1111/j.1348-0421.2004.tb03505.x

YD Yoo, 1996, The IE2 regulatory protein of human cytomegalovirus induces expression of the human transforming growth factor beta1 gene through an Egr-1 binding site., Journal of Virology, 70, 7062, 10.1128/JVI.70.10.7062-7070.1996

K Koli, 2001, Latency, activation, and binding proteins of TGF-beta., Microscopy Research & Technique, 52, 354, 10.1002/1097-0029(20010215)52:4<354::AID-JEMT1020>3.0.CO;2-G

JP Annes, 2003, Making sense of latent TGFbeta activation., Journal of Cell Science, 116, 217, 10.1242/jcs.00229

T Tabata, 2008, Induction of an Epithelial Integrin {alpha}v{beta}6 in Human Cytomegalovirus-Infected Endothelial Cells Leads to Activation of Transforming Growth Factor-{beta}1 and Increased Collagen Production., Am J Pathol, 172, 1127, 10.2353/ajpath.2008.070448

W Ulrich, 1986, The histopathologic identification of CMV infected cells in biopsies of human renal allografts. An evaluation of 100 transplant biopsies by in situ hybridization., Pathology, Research & Practice, 181, 739, 10.1016/S0344-0338(86)80050-4

RM Hendrix, 1997, Widespread presence of cytomegalovirus DNA in tissues of healthy trauma victims., Journal of Clinical Pathology, 50, 59, 10.1136/jcp.50.1.59

K Holma, 2000, Expression of the cytomegalovirus genome in kidney allografts during active and latent infection., Transplant International, 13, S363, 10.1111/j.1432-2277.2000.tb02061.x

J Markovic-Lipkovski, 1992, Human cytomegalovirus in rejected kidney grafts; detection by polymerase chain reaction., Nephrology Dialysis Transplantation, 7, 865

C Gerstenkorn, 2000, Detection of cytomegalovirus (CMV) antigens in kidney biopsies and transplant nephrectomies as a marker for renal graft dysfunction., Clinical Chemistry & Laboratory Medicine, 38, 1201, 10.1515/CCLM.2000.188

J Alcami, 1993, Antagonistic modulation of human cytomegalovirus replication by transforming growth factor beta and basic fibroblastic growth factor., J Gen Virol, 74, 269, 10.1099/0022-1317-74-2-269

J Massague, 2000, How cells read TGF-beta signals., Nature Reviews Molecular Cell Biology, 1, 169, 10.1038/35043051

E Van Obberghen-Schilling, 1988, Transforming growth factor beta 1 positively regulates its own expression in normal and transformed cells., Journal of Biological Chemistry, 263, 7741, 10.1016/S0021-9258(18)68561-8

D Wang, 2005, Human Cytomegalovirus UL131 Open Reading Frame Is Required for Epithelial Cell Tropism., J Virol, 79, 10330, 10.1128/JVI.79.16.10330-10338.2005

H Zhao, 2004, Differential inhibition of membrane type 3 (MT3)-matrix metalloproteinase (MMP) and MT1-MMP by tissue inhibitor of metalloproteinase (TIMP)-2 and TIMP-3 rgulates pro-MMP-2 activation., Journal of Biological Chemistry, 279, 8592, 10.1074/jbc.M308708200

I Helantera, 2006, Increased urinary excretion of transforming growth factor-[beta]1 in renal transplant recipients during cytomegalovirus infection., Transplant Immunology, 15, 217, 10.1016/j.trim.2005.11.001

M Zeisberg, 2002, Renal fibrosis. Extracellular matrix microenvironment regulates migratory behavior of activated tubular epithelial cells., American Journal of Pathology, 160, 2001

JM Catania, 2007, Role of matrix metalloproteinases in renal pathophysiologies., Am J Physiol Renal Physiol, 292, F905, 10.1152/ajprenal.00421.2006

E Rodrigo, 2000, Circulating levels of matrix metalloproteinases MMP-3 and MMP-2 in renal transplant recipients with chronic transplant nephropathy., Nephrology Dialysis Transplantation, 15, 2041, 10.1093/ndt/15.12.2041

ML Nicholson, 2002, Renal transplant fibrosis correlates with intragraft expression of tissue inhibitor of metalloproteinase messenger RNA., British Journal of Surgery, 89, 933, 10.1046/j.1365-2168.2002.02118.x

S Hernandez-Barrantes, 2000, Binding of active (57 kDa) membrane type 1-matrix metalloproteinase (MT1-MMP) to tissue inhibitor of metalloproteinase (TIMP)-2 regulates MT1-MMP processing and pro-MMP-2 activation., Journal of Biological Chemistry, 275, 12080, 10.1074/jbc.275.16.12080

MM Bernardo, 2003, TIMP-2 (tissue inhibitor of metalloproteinase-2) regulates MMP-2 (matrix metalloproteinase-2) activity in the extracellular environment after pro-MMP-2 activation by MT1 (membrane type 1)-MMP., Biochemical Journal, 374, 739, 10.1042/bj20030557

Y-C Tian, 2007, Epidermal growth factor and transforming growth factor-[beta]1 enhance HK-2 cell migration through a synergistic increase of matrix metalloproteinase and sustained activation of ERK signaling pathway., Experimental Cell Research, 313, 2367, 10.1016/j.yexcr.2007.03.022

DN Streblow, 2008, The role of angiogenic and wound repair factors during CMV-accelerated transplant vascular sclerosis in rat cardiac transplants., Am J Transplant, 8, 277, 10.1111/j.1600-6143.2007.02062.x

MD Sternlicht, 2001, How matrix metalloproteinases regulate cell behavior., Annual Review of Cell & Developmental Biology, 17, 463, 10.1146/annurev.cellbio.17.1.463

M Hummel, 2001, Allogeneic transplantation induces expression of cytomegalovirus immediate-early genes in vivo: a model for reactivation from latency., Journal of Virology, 75, 4814, 10.1128/JVI.75.10.4814-4822.2001

Z Zhang, 2009, TNF-alpha signaling is not required for in vivo transcriptional reactivation of latent murine cytomegalovirus., Transplantation, 88, 640, 10.1097/TP.0b013e3181b242a7

M Abe, 1994, An assay for transforming growth factor-beta using cells transfected with a plasminogen activator inhibitor-1 promoter-luciferase construct., Analytical Biochemistry, 216, 276, 10.1006/abio.1994.1042

WJ Britt, 1986, Synthesis and processing of the envelope gp55-116 complex of human cytomegalovirus., Journal of Virology, 58, 185, 10.1128/JVI.58.1.185-191.1986

KA Cassady, 2005, Human Cytomegalovirus TRS1 and IRS1 Gene Products Block the Double-Stranded-RNA-Activated Host Protein Shutoff Response Induced by Herpes Simplex Virus Type 1 Infection., J Virol, 79, 8707, 10.1128/JVI.79.14.8707-8715.2005

SB Boppana, 1992, Evaluation of a microtiter plate fluorescent-antibody assay for rapid detection of human cytomegalovirus infection., J Clin Microbiol, 30, 721, 10.1128/JCM.30.3.721-723.1992

KB Balcarek, 1993, Neonatal screening for congenital cytomegalovirus infection by detection of virus in saliva., J Infect Dis, 167, 1433, 10.1093/infdis/167.6.1433

M Shimamura, 2006, Human cytomegalovirus infection elicits a glycoprotein M (gM)/gN-specific virus-neutralizing antibody response., J Virol, 80, 4591, 10.1128/JVI.80.9.4591-4600.2006

NC Andrews, 1991, A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells., Nucleic Acids Res, 19, 2499, 10.1093/nar/19.9.2499

Y Sato, 1990, Characterization of the activation of latent TGF-beta by co-cultures of endothelial cells and pericytes or smooth muscle cells: a self-regulating system., Journal of Cell Biology, 111, 757, 10.1083/jcb.111.2.757

RE Galardy, 1994, Low molecular weight inhibitors in corneal ulceration., Ann N Y Acad Sci, 732, 315, 10.1111/j.1749-6632.1994.tb24746.x

X Huang, 1998, The integrin alphavbeta6 is critical for keratinocyte migration on both its known ligand, fibronectin, and on vitronectin., J Cell Sci, 111, 2189, 10.1242/jcs.111.15.2189

Y Zhou, 2004, Thy-1 expression regulates the ability of rat lung fibroblasts to activate transforming growth factor-beta in response to fibrogenic stimuli., American Journal of Pathology, 165, 659, 10.1016/S0002-9440(10)63330-5

DR Todor, 1998, Identification of a Serum Gelatinase Associated With the Occurrence of Cerebral Aneurysms as Pro-Matrix Metalloproteinase-2., Stroke, 29, 1580, 10.1161/01.STR.29.8.1580

IL Smith, 1997, High-level resistance of cytomegalovirus to ganciclovir is associated with alterations in both the UL97 and DNA polymerase genes., J Infect Dis, 176, 69, 10.1086/514041

IL Smith, 1998, Clinical Failure of CMV Retinitis With Intravitreal Cidofovir Is Associated With Antiviral Resistance., Arch Ophthalmol, 116, 178, 10.1001/archopht.116.2.178

SL Williams-Aziz, 2005, Comparative Activities of Lipid Esters of Cidofovir and Cyclic Cidofovir against Replication of Herpesviruses In Vitro., Antimicrob Agents Chemother, 49, 3724, 10.1128/AAC.49.9.3724-3733.2005

D Bradford Russell, 2005, Detection of Cytomegalovirus (CMV) DNA by Polymerase Chain Reaction Is Associated with Hearing Loss in Newborns with Symptomatic Congenital CMV Infection Involving the Central Nervous System., The Journal of Infectious Diseases, 191, 227, 10.1086/426456