François Teasdale1, Eugene W. Adcock1, Charles S. August1, Sheila Cox1, F. C. Battaglia1, Michael A. Naughton
1Division of Perinatal Medicine, Departments of Pediatrics and Obstetrics-Gynecology, University of Colorado Medical Center, Denver, Colo.
Tóm tắt
Human chorionic gonadotropin can inhibit the blast cell transformation of human lymphocytes, both Phytohemagglutinin-induced and in mixed-lymphocyte reactions. This immunosuppression is noncytotoxic, and specific as shown by the contrasting response of lymphocytes to human serum albumin in similar culture systems. These findings and the high rate of production of this hormone at the surface of the implanting trophoblast support the hypothesis that human chorionic gonadotropin may play an important immunosuppressive role <i>in vivo</i> to prevent the rejection of the fetal allograft by the maternal host.
