Hub genes in adenocarcinoma of the esophagogastric junction based on weighted gene co-expression network analysis and immunohistochemistry

Bray, 2018, Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries, CA Cancer J. Clin., 68, 394, 10.3322/caac.21492 Chen, 2016, Cancer statistics in China, 2015, CA Cancer J. Clin., 66, 115, 10.3322/caac.21338 Devesa, 1998, Changing patterns in the incidence of esophageal and gastric carcinoma in the United States, Cancer, 83, 2049, 10.1002/(SICI)1097-0142(19981115)83:10<2049::AID-CNCR1>3.0.CO;2-2 Bai, 2006, Adenocarcinoma of the Esophagogastric Junction in China according to Siewert's classification, Jpn. J. Clin. Oncol., 36, 364, 10.1093/jjco/hyl042 Blot, 1991, Rising incidence of adenocarcinoma of the esophagus and gastric cardia, JAMA, 265, 1287, 10.1001/jama.1991.03460100089030 Zhou, 2008, A rising trend of gastric cardia cancer in Gansu Province of China, Cancer Lett., 269, 18, 10.1016/j.canlet.2008.04.013 Chung, 2009, Unchanging trend of esophagogastric junction adenocarcinoma in Korea: experience at a single institution based on Siewert's classification, Dis. Esophagus, 22, 676, 10.1111/j.1442-2050.2009.00946.x Kusano, 2008, Changing trends in the proportion of adenocarcinoma of the esophagogastric junction in a large tertiary referral center in Japan, J. Gastroenterol. Hepatol., 23, 1662, 10.1111/j.1440-1746.2008.05572.x Marsman, 2004, Loss of heterozygosity and immunohistochemistry of adenocarcinomas of the esophagus and gastric cardia, Clin. Cancer Res., 10, 8479, 10.1158/1078-0432.CCR-04-0839 Ott, 2003, Fluorodeoxyglucose-positron emission tomography in adenocarcinomas of the distal esophagus and cardia, World J. Surg., 27, 1035, 10.1007/s00268-003-7058-9 2014, Comprehensive molecular characterization of gastric adenocarcinoma, Nature, 513, 202, 10.1038/nature13480 2017, Integrated genomic characterization of oesophageal carcinoma, Nature, 541, 169, 10.1038/nature20805 2012, Comprehensive molecular characterization of human colon and rectal cancer, Nature, 487, 330, 10.1038/nature11252 2012, Comprehensive genomic characterization of squamous cell lung cancers, Nature, 489, 519, 10.1038/nature11404 2012, Comprehensive molecular portraits of human breast tumours, Nature, 490, 61, 10.1038/nature11412 Geng, 2020, Identification of the distinct genomic features in gastroesophageal junction adenocarcinoma and itsS iewert subtypes, J. Pathol., 252, 263, 10.1002/path.5516 Nagahashi, 2016, Genomic landscape of colorectal cancer in Japan: clinical implications of comprehensive genomic sequencing for precision medicine, Genome Med., 8, 136, 10.1186/s13073-016-0387-8 Langfelder, 2008, WGCNA: an R package for weighted correlation network analysis, BMC Bioinf., 9, 559, 10.1186/1471-2105-9-559 Yepes, 2016, Co-expressed miRNAs in gastric adenocarcinoma, Genomics, 108, 93, 10.1016/j.ygeno.2016.07.002 Giulietti, 2016, Weighted gene co-expression network analysis reveals key genes involved in pancreatic ductal adenocarcinoma development, Cell Oncol., 39, 379, 10.1007/s13402-016-0283-7 Chen, 2018, Candidate genes in gastric cancer identified by constructing a weighted gene co-expression network, PeerJ, 6, e4692, 10.7717/peerj.4692 Liu, 2017, Identification of Key Gene Modules in Human Osteosarcoma by Co-Expression Analysis Weighted Gene Co-Expression Network Analysis (WGCNA), J. Cell. Biochem., 118, 3953, 10.1002/jcb.26050 Shi, 2015, Identify the signature genes for diagnose of uveal melanoma by weight gene co-expression network analysis, Int. J. Ophthalmol., 8, 269 Yu, 2012, clusterProfiler: an R package for comparing biological themes among gene clusters, OMICS-J. Integr. Biol., 16, 284, 10.1089/omi.2011.0118 Prieto, 2008, Human gene coexpression landscape: confident network derived from tissue transcriptomic profiles, PLoS One, 3, e3911, 10.1371/journal.pone.0003911 Vazquez, 2004, The topological relationship between the large-scale attributes and local interaction patterns of complex networks, Proc. Natl. Acad. Sci. USA., 101, 17940, 10.1073/pnas.0406024101 Wan, 2018, Co-expression modules construction by WGCNA and identify potential prognostic markers of uveal melanoma, Exp. Eye Res., 166, 13, 10.1016/j.exer.2017.10.007 Szász AM, Lánczky A, Nagy Á, Förster S, Hark K, Green JE, Boussioutas A, Busuttil R, Szabó A, Győrffy B: Cross-validation of survival associated biomarkers in gastric cancer using transcriptomic data of 1,065 patients, Oncotarget, doi:10.18632/oncotarget.10337. Chou, 2014, Visual gene-network analysis reveals the cancer gene co-expression in human endometrial cancer, Bmc Genomics [Electronic Resource], 15, 300 Greenlee-Wacker, 2012, CD93: recent advances and implications in disease, Curr. Drug Targets, 13, 411, 10.2174/138945012799424651 Nepomuceno, 1997, cDNA cloning and primary structure analysis of C1qR(P), the human C1q/MBL/SPA receptor that mediates enhanced phagocytosis in vitro, Immunity, 6, 119, 10.1016/S1074-7613(00)80419-7 Ronca, 2017, Tumor angiogenesis revisited: Regulators and clinical implications, Med. Res. Rev., 37, 1231, 10.1002/med.21452 Langenkamp, 2015, Elevated expression of the C-type lectin CD93 in the glioblastoma vasculature regulates cytoskeletal rearrangements that enhance vessel function and reduce host survival, Cancer Res., 75, 4504, 10.1158/0008-5472.CAN-14-3636 Bao, 2016, Elevated expression of CD93 promotes angiogenesis and tumor growth in nasopharyngeal carcinoma, Biochem. Biophys. Res. Commun., 476, 467, 10.1016/j.bbrc.2016.05.146 Masiero, 2013, A core human primary tumor angiogenesis signature identifies the endothelial orphan receptor ELTD1 as a key regulator of angiogenesis, Cancer Cell, 24, 229, 10.1016/j.ccr.2013.06.004 Sun, 2021, Blockade of the CD93 pathway normalizes tumor vasculature to facilitate drug delivery and immunotherapy, Sci. Transl. Med., 13 Galvagni, 2017, Dissecting the CD93-Multimerin 2 interaction involved in cell adhesion and migration of the activated endothelium, Matrix Biol., 64, 112, 10.1016/j.matbio.2017.08.003 Balac, 2012, The CD34-microvascular density in colorectal cancer patients [published correction appears, BUON, 17, 97