How single-cell transcriptomics provides insight on hepatic responses to TCDD

Cano, 2021, Role of endocrine-disrupting chemicals in the pathogenesis of non-alcoholic fatty liver disease: a comprehensive review, Int J Mol Sci, 22, 10.3390/ijms22094807 Wahlang, 2013, Toxicant-associated steatohepatitis, Toxicol Pathol, 41, 343, 10.1177/0192623312468517 Wahlang, 2019, Mechanisms of environmental contributions to fatty liver disease, Curr Environ Health Rep, 6, 80, 10.1007/s40572-019-00232-w Boverhof, 2005, Temporal and dose-dependent hepatic gene expression patterns in mice provide new insights into TCDD-Mediated hepatotoxicity, Toxicol Sci, 85, 1048, 10.1093/toxsci/kfi162 Pierre, 2014, Aryl hydrocarbon receptor-dependent induction of liver fibrosis by dioxin, Toxicol Sci, 137, 114, 10.1093/toxsci/kft236 Vos, 1974, Toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in C57B1/6 mice, Toxicol Appl Pharmacol, 29, 229, 10.1016/0041-008X(74)90060-X AbdulHameed, 2019, Mining public toxicogenomic data reveals insights and challenges in delineating liver steatosis adverse outcome pathways, Front Genet, 10, 1007, 10.3389/fgene.2019.01007 Fader, 2017, Beyond the aryl hydrocarbon receptor: pathway interactions in the hepatotoxicity of 2,3,7,8-Tetrachlorodibenzo-p-dioxin and related compounds, Curr Opin Toxicol, 2, 36, 10.1016/j.cotox.2017.01.010 Baptista, 2022, 3D organ-on-a-chip: the convergence of microphysiological systems and organoids, Front Cell Dev Biol, 10, 1043117, 10.3389/fcell.2022.1043117 Xiong, 2019, Landscape of intercellular crosstalk in healthy and NASH liver revealed by single-cell secretome gene analysis, Mol Cell, 75, 644, 10.1016/j.molcel.2019.07.028 Krenkel, 2019, Single cell RNA sequencing identifies subsets of hepatic stellate cells and myofibroblasts in liver fibrosis, Cells, 8, 10.3390/cells8050503 Umbaugh, 2021, Spatial reconstruction of the early hepatic transcriptomic landscape after an acetaminophen overdose using single-cell RNA-sequencing, Toxicol Sci, 182, 327, 10.1093/toxsci/kfab052 Goldfarb, 2022, Interplay between GH-regulated, sex-biased liver transcriptome and hepatic zonation revealed by single-nucleus RNA sequencing, Endocrinology, 163, 10.1210/endocr/bqac059 Chu, 2021, The power of single-cell analysis for the study of liver pathobiology, Hepatology, 73, 437, 10.1002/hep.31485 Nault, 2021, Single-nuclei RNA sequencing assessment of the hepatic effects of 2,3,7,8-Tetrachlorodibenzo-p-dioxin, Cell Mol Gastroenterol Hepatol, 11, 147, 10.1016/j.jcmgh.2020.07.012 Haimbaugh, 2022, Insight into 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced disruption of zebrafish spermatogenesis via single cell RNA-seq, PNAS Nexus, 1, pgac060, 10.1093/pnasnexus/pgac060 Nault, 2023, Single-cell transcriptomics shows dose-dependent disruption of hepatic zonation by TCDD in mice, Toxicol Sci, 191, 135, 10.1093/toxsci/kfac109 Lau, 2021, The Voronoi theory of the normal liver lobular architecture and its applicability in hepatic zonation, Sci Rep, 11, 9343, 10.1038/s41598-021-88699-2 Halpern, 2017, Single-cell spatial reconstruction reveals global division of labour in the mammalian liver, Nature, 542, 352, 10.1038/nature21065 Andersen, 1997, Regional hepatic CYP1A1 and CYP1A2 induction with 2,3,7,8-tetrachlorodibenzo-p-dioxin evaluated with a multicompartment geometric model of hepatic zonation, Toxicol Appl Pharmacol, 144, 145, 10.1006/taap.1996.8067 Yang, 2022, A negative feedback loop and transcription factor cooperation regulate zonal gene induction by 2, 3, 7, 8-Tetrachlorodibenzo-p-Dioxin in the mouse liver, Hepatol Commun, 6, 750, 10.1002/hep4.1848 Karri, 2023, TCDD dysregulation of lncRNA expression, liver zonation and intercellular communication across the liver lobule, Toxicol Appl Pharmacol, 471, 116550, 10.1016/j.taap.2023.116550 Chang, 2005, A histochemical and pathological study on the interrelationship between TCDD-induced AhR expression, AhR activation, and hepatotoxicity in mice, J Toxicol Environ Health, 68, 1567, 10.1080/15287390590967513 Schleicher, 2017, Zonation of hepatic fat accumulation: insights from mathematical modelling of nutrient gradients and fatty acid uptake, J R Soc Interface, 14, 10.1098/rsif.2017.0443 Nault, 2023, Analysis of cell-cell communication by single-nuclei RNA sequencing identifies AHR-mediated induction of NRG-ERBB signaling, Receptors, 2, 148, 10.3390/receptors2020009 Walesky, 2020, Functional compensation precedes recovery of tissue mass following acute liver injury, Nat Commun, 11, 5785, 10.1038/s41467-020-19558-3 Lee, 2015, Male and female mice show significant differences in hepatic transcriptomic response to 2,3,7,8-tetrachlorodibenzo-p-dioxin, BMC Genom, 16, 625, 10.1186/s12864-015-1840-6 Boverhof, 2006, Comparative toxicogenomic analysis of the hepatotoxic effects of TCDD in Sprague Dawley rats and C57BL/6 mice, Toxicol Sci, 94, 398, 10.1093/toxsci/kfl100 Freitas-Lopes, 2017, Differential location and distribution of hepatic immune cells, Cells, 6, 10.3390/cells6040048 Guilliams, 2022, Spatial proteogenomics reveals distinct and evolutionarily conserved hepatic macrophage niches, Cell, 185, 379, 10.1016/j.cell.2021.12.018 Cannon, 2022, AhR activation leads to attenuation of murine autoimmune hepatitis: single-cell RNA-seq analysis reveals unique immune cell phenotypes and gene expression changes in the liver, Front Immunol, 13, 10.3389/fimmu.2022.899609 Fullerton, 2013, 2,3,7,8-TCDD enhances the sensitivity of mice to concanavalin A immune-mediated liver injury, Toxicol Appl Pharmacol, 266, 317, 10.1016/j.taap.2012.11.009 Vogel, 2007, Modulation of the chemokines KC and MCP-1 by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in mice, Arch Biochem Biophys, 461, 169, 10.1016/j.abb.2007.01.015 Katayama, 2015, Beneficial impact of Gpnmb and its significance as a biomarker in nonalcoholic steatohepatitis, Sci Rep, 5, 16920, 10.1038/srep16920 Vonderlin, 2023, The multifaceted roles of macrophages in NAFLD pathogenesis, Cell Mol Gastroenterol Hepatol, 15, 1311, 10.1016/j.jcmgh.2023.03.002 Yan, 2019, Aryl hydrocarbon receptor signaling prevents activation of hepatic stellate cells and liver fibrogenesis in mice, Gastroenterology, 157, 793, 10.1053/j.gastro.2019.05.066 Duval, 2018, Aryl hydrocarbon receptor and liver fibrosis, Current Opinion in Toxicology, 8, 8, 10.1016/j.cotox.2017.11.010 Harvey, 2016, Exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) increases human hepatic stellate cell activation, Toxicology, 344–346, 26, 10.1016/j.tox.2016.02.001 Andrews, 2022, Single-cell, single-nucleus, and spatial RNA sequencing of the human liver identifies cholangiocyte and mesenchymal heterogeneity, Hepatol Commun, 6, 821, 10.1002/hep4.1854 Kitto, 2021, Hepatic stellate cell regulation of liver regeneration and repair, Hepatol Commun, 5, 358, 10.1002/hep4.1628 Dobie, 2019, Single-cell transcriptomics uncovers zonation of function in the mesenchyme during liver fibrosis, Cell Rep, 29, 1832, 10.1016/j.celrep.2019.10.024 Zhang, 2020, Targeting the Wnt signaling pathway through R-spondin 3 identifies an anti-fibrosis treatment strategy for multiple organs, PLoS One, 15 Miyao, 2015, Pivotal role of liver sinusoidal endothelial cells in NAFLD/NASH progression, Lab Invest, 95, 1130, 10.1038/labinvest.2015.95 Ma, 2021, Liver sinusoidal endothelial cells are implicated in multiple fibrotic mechanisms, Mol Biol Rep, 48, 2803, 10.1007/s11033-021-06269-1 Korenaga, 2007, Long-term effects of subcutaneously injected 2,3,7,8-tetrachlorodibenzo-p-dioxin on the liver of rhesus monkeys, Chemosphere, 67, S399, 10.1016/j.chemosphere.2006.05.135 Straub, 2007, Arsenic stimulates sinusoidal endothelial cell capillarization and vessel remodeling in mouse liver, Hepatology, 45, 205, 10.1002/hep.21444 Duan, 2023, Age-related liver endothelial zonation triggers steatohepatitis by inactivating pericentral endothelium-derived C-kit, Nat Aging, 3, 258, 10.1038/s43587-022-00348-z Gomez-Salinero, 2022, Specification of fetal liver endothelial progenitors to functional zonated adult sinusoids requires c-Maf induction, Cell Stem Cell, 29, 593, 10.1016/j.stem.2022.03.002 Josyula, 2019, Gene co-regulation and co-expression in the aryl hydrocarbon receptor-mediated transcriptional regulatory network in the mouse liver, Arch Toxicol