Host transcriptomic signature as alternative test-of-cure in visceral leishmaniasis patients co-infected with HIV

Burza, 2018, Leishmaniasis, Lancet, 392, 951, 10.1016/S0140-6736(18)31204-2 2018, Surveillance of leishmaniasis in the WHO European region, Wkly Epidomiological Rec, 93, 521 Diro, 2014, Visceral leishmaniasis and HIV coinfection in East Africa, PLoS Negl Trop Dis, 8, e2869, 10.1371/journal.pntd.0002869 Lindoso, 2016, Leishmaniasis-HIV coinfection: current challenges, HIV AIDS (Auckl), 8, 147 Alvar, 2008, The relationship between leishmaniasis and AIDS: the second 10 years, Clin Microbiol Rev, 21, 334, 10.1128/CMR.00061-07 Srivastava, 2011, Diagnosis of visceral leishmaniasis, Trans R Soc Trop Med Hyg, 105, 1, 10.1016/j.trstmh.2010.09.006 Pourabbas, 2013, Quantification of leishmania infantum kinetoplast DNA for monitoring the response to meglumine antimoniate therapy in visceral leishmaniasis, Am J Trop Med Hyg, 88, 868, 10.4269/ajtmh.12-0440 Croft, 2006, Drug resistance in leishmaniasis, Clin Microbiol Rev, 19, 111, 10.1128/CMR.19.1.111-126.2006 Liu, 2017, Transcriptomic signatures differentiate survival from fatal outcomes in humans infected with Ebola virus, Genome Biol, 18, 4, 10.1186/s13059-016-1137-3 Robinson M, Sweeney TE, Barouch-Bentov R, Sahoo MK, Kalesinskas L, Vallania F, et al. A 20-Gene set predictive of progression to severe dengue. Cell Rep 26(5), 1104–11. e4. https://doi.org/10.1016/j.celrep.2019.01.033. Thompson, 2017, Host blood RNA signatures predict the outcome of tuberculosis treatment, Tuberculosis, 107, 48, 10.1016/j.tube.2017.08.004 Fakiola, 2019, Transcriptional blood signatures for active and amphotericin B treated visceral leishmaniasis in India, PLoS Negl Trop Dis, 13, 10.1371/journal.pntd.0007673 Salih, 2017, Expression profiling of Sudanese visceral leishmaniasis patients pre- and post-treatment with sodium stibogluconate, Parasite Immunol, 39, e12431, 10.1111/pim.12431 Gardinassi, 2016, Blood transcriptional profiling reveals immunological signatures of distinct states of infection of humans with leishmania infantum, PLoS Negl Trop Dis, 10, 10.1371/journal.pntd.0005123 Diro, 2019, A randomized trial of ambisome monotherapy and ambisome and miltefosine combination to treat visceral leishmaniasis in HIV co-infected patients in Ethiopia, PLoS Negl Trop Dis, 13, 10.1371/journal.pntd.0006988 Diro, 2019, Long term outcomes and prognostics of visceral leishmaniasis in HIV infected patients with use of pentamidine as secondary prophylaxis based on CD4 level: a prospective cohort study in Ethiopia, PLoS Negl Trop Dis, 13, 10.1371/journal.pntd.0007132 Chaussabel, 2008, A modular analysis framework for blood genomics studies: application to systemic lupus erythematosus, Immunity, 29, 150, 10.1016/j.immuni.2008.05.012 Li, 2014, Molecular signatures of antibody responses derived from a systems biology study of five human vaccines, Nat Immunol, 15, 195, 10.1038/ni.2789 Shannon, 2003, Cytoscape: a software environment for integrated models of biomolecular interaction networks, Genome Res, 13, 2498, 10.1101/gr.1239303 Bindea, 2009, ClueGO: a cytoscape plug-in to decipher functionally grouped gene ontology and pathway annotation networks, Bioinformatics, 25, 1091, 10.1093/bioinformatics/btp101 Pedregosa, 2011, Scikit-learn: machine learning in python, J Mach Learn Res, 12, 2825 Nakayama, 2018, Assessment of suitable reference genes for RT-QPCR studies in chronic rhinosinusitis, Sci Rep, 8, 10.1038/s41598-018-19834-9 Watson, 2007, Determination of suitable housekeeping genes for normalisation of quantitative real time PCR analysis of cells infected with human immunodeficiency virus and herpes viruses, Virol J, 4, 10.1186/1743-422X-4-130 Rodrigues, 2016, Regulation of immunity during visceral leishmania infection, Parasit Vectors, 9, 118, 10.1186/s13071-016-1412-x Nylén, 2007, Interleukin-10 and the pathogenesis of human visceral leishmaniasis, Trends Immunol, 28, 378, 10.1016/j.it.2007.07.004 Rodríguez, 2014, Eosinophils and mast cells in leishmaniasis, Immunol Res, 59, 129, 10.1007/s12026-014-8536-x Thangam, 2018, The role of histamine and histamine receptors in mast cell-mediated allergy and inflammation: the hunt for new therapeutic targets, Front Immunol, 9, 1873, 10.3389/fimmu.2018.01873 Fletcher, 2015, SLFN14 mutations underlie thrombocytopenia with excessive bleeding and platelet secretion defects, J Clin Invest, 125, 3600, 10.1172/JCI80347 Atianand, 2017, Immunobiology of long noncoding RNAs, Annu Rev Immunol, 35, 177, 10.1146/annurev-immunol-041015-055459 Warsinske, 2019, Host-response-based gene signatures for tuberculosis diagnosis: a systematic comparison of 16 signatures, PLoS Med, 16, 10.1371/journal.pmed.1002786 Burel, 2019, Host transcriptomics as a tool to identify diagnostic and mechanistic immune signatures of tuberculosis, Front Immunol, 10, 221, 10.3389/fimmu.2019.00221