Histopathology of castration-resistant prostate cancer confirms changes in bone metastasis during radium-223 treatment: A case report

Abou, 2015, Whole-body and microenvironmental localization of radium-223 in naïve and mouse models of prostate cancer metastasis, J Natl Cancer Inst, 108 C1, 2013, Effects of androgen deprivation therapy and bisphosphonate treatment on bone in patients with metastatic castration-resistant prostate cancer: results from the University of Washington Rapid Autopsy Series, J Bone Miner Res, 28, 333, 10.1002/jbmr.1749 Bruland, 2006, High-linear energy transfer irradiation targeted to skeletal metastases by the alpha-emitter 223Ra: adjuvant or alternative to conventional modalities?, Clin Canc Res, 12, 6250s, 10.1158/1078-0432.CCR-06-0841 McKay, 2016, Radium-223 use in clinical practice and variables associated with completion of therapy, Clin Genitourin Canc, 15, e289, 10.1016/j.clgc.2016.08.015 de Groot, 2018, The anti-tumor effect of RANKL inhibition in malignant solid tumors – a systematic review, Canc Treat Rev, 62, 18, 10.1016/j.ctrv.2017.10.010