Histological study on sinus lift grafting by Fisiograft and Bio-Oss
Tóm tắt
The work aims to provide a histological investigation of Fisiograft®, a PLA/PGA copolymer, used as filler for bone defects in humans. The study was performed on biopsies of sinus lifts where Bio-Oss® and Fisiograft® gel were applied as graft material. Bone regeneration was satisfactory in all sinus lifts, even when Fisiograft® was applied alone. Due to remarkable osteoclast activity, Bio-Oss® granules were cleared from the majority of biopsy cores. At histology, Fisiograft® gel appeared as globes enveloped by fibroblasts, displaying an epithelial-like cell appearance. Due to its solubility in solvents, undegraded Fisiograft® (recorded for 7 months or more) did not stain whereas degraded Fisiograft® stained positive. The loose connective tissue, that surrounded Fisiograft® and bone contained isolated mastocytes. Bone grew inside the loose connective and often reached the surface of Fisiograft® by intervening cells. The results seem to indicate that Fisiograft® may be considered both a polymer useful for fastening bone substitutes inside a defect and in addition a material capable of prompting bone regeneration, with or without the use of a bone substitute. In addition to space-former and space-maintainer functions, Fisiograft® shows potential bone stimulation function, which may be labelled as osteopromotive capability.
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