Histologic evaluation of a catheter coated with paclitaxel PLGA nanoparticles in the internal jugular veins of rats
Tóm tắt
The aim of this study is to investigate the potential impact of catheterization on intimal hyperplasia and explore the efficacy of Paclitaxel loaded PLGA nanoparticles (PTX-NPs) in preventing stenosis at the site of venous injury. Under general anesthesia, Central Venous Catheters were inserted into the rat’s right internal jugular veins (IJV) using the cut-down technique. Twenty bare catheters (C) and twenty PTX-NPs coated catheters (P) were assigned to one of four groups (C2, C4, P2, or P4) based on catheter type and expected survival time. 2 or 4 weeks after surgery, IJVs were completely harvested by formalin fixation and gelatin infusion and slides were stained with H&E (Haematoxylin and Eosin) and Masson's technique. The P2 (Paclitaxel coating, 2 weeks) group showed the most proliferation among the four groups and the P4 (Paclitaxel coating, 4 weeks) showed a tendency to decrease proliferation. Additionally, the lumen size in the P4 group was about 6% smaller than in the P2 group, and there was a lower prevalence of stenotic grade in the P4 group. Our study suggests that PTX-NPs coated catheters may be effective in preventing venous stenosis if the intended usage is prolonged, rather than for a short-term period. Schematic representation of catheter functionalization and coating of PTX-NPs on Catheter
Tài liệu tham khảo
Forauer AR, Theoharis CG, Dasika NL. Jugular vein catheter placement: histologic features and development of catheter-related (fibrin) sheaths in a swine model. Radiology. 2006;240(2):427–34.
Argoti-Velasco YL, et al. Proper electrocardiography-guided placement of a central venous catheter. Revista Médica del Hospital General de México. 2018;81(4):262–7.
Neoh KG, et al. Surface modification strategies for combating catheter-related complications: recent advances and challenges. J Mater Chem B. 2017;5(11):2045–67.
Matsuzaki A, Suminoe A, Koga Y, et al. Long-term use of peripherally inserted central venous catheters for cancer chemotherapy in children. Support Care Cancer. 2006;14:153–60.
Loughran SC, Borzatta M. peripherally inserted central catheters: a report of 2506 catheter days. J Parent Enteral Nutr. 1995;19:133–6.
Tedla FM, Clerger G, et al. Prevalence of central vein stenosis in patients referred for vein mapping. CJASN. 2018;13(7):1163–8.
Agarwal AK. Central vein stenosis: current concepts. Adv Chronic Kidney Dis. 2009;16(5):360–70.
Chopra V, Anand S, et al. Risk of venous thromboembolism associated with peripherally inserted central catheters: a systematic review and meta-analysis. Lancet. 2013;382:311–25.
Shi Y-X, Ye M, et al. Endovascular treatment of central venous stenosis and obstruction in hemodialysis patients. Chin Med J. 2013;126(3):426–30.
Wong FK, Kwok PC, et al. Prevention of restenosis of central venous stricture after percutaneous transluminal angioplasty and endovascular stenting by brachytherapy. Kidney Int. 1999;55:724–32.
Kim YL, Moon SB, et al. Histological changes of the unligated vein wall adjacent to the central venous catheter after open cutdown in rats. J pediatr Surg. 2015;50(11):1928–32.
Wang L, Jia L, et al. Correlation of caveolin-1 with vascular intimal thickness for different locations of catheter tips in a dog model. Iran J Kidney Dis. 2018;12(4):232–9.
Wang LH, Wei F, et al. Fibrin sheath formation and intimal thickening after catheter placement in dog model: role of hemodynamic wall shear stress. J Vasc Access. 2015;16(4):275–84.
Minami Y, Kaneda H, et al. Endothelial dysfunction following drug-eluting stent implantation: a systematic review of the literature. Int J Cardiol. 2013;165(2):222–8.
Singh GD, Armstrong EJ, et al. Femoropopliteal in-stent restenosis: current treatment strategies. J Cardiovasc Surg. 2014;55(3):325–33.
Dippel EJ, Makam P, et al. Randomized controlled study of excimer laser atherectomy for treatment of femoropopliteal in-stent restenosis: initial results from the EXCITE ISR trial (EXCImer Laser Randomized Controlled Study for Treatment of FemoropopliTEal In-Stent Restenosis). JACC Cardiovasc Interv. 2015;8(1Pt A):92–101.
Xiaolong T, et al. Paclitaxel-loaded nanoparticles of star-shaped cholic acid-core PLA-TPGS copolymer for breast cancer treatment. Nanoscale Res Lett. 2013;8(1):420.
Sahin A, et al. Development of paclitaxel and flurbiprofen coloaded PLGA nanoparticles: understanding critical formulation and process parameters using Plackett-Burman design. İstanbul J Pharm. 2019;49(3):161–6.
Lim HJ, et al. A novel technique for loading of paclitaxel-PLGA nanoparticles onto ePTFE vascular grafts. Biotechnol Prog. 2007;23(3):693–7.
Kesarwani P, Tekade RK, Jain NK. Spectrophotometric estimation of paclitaxel. Int J Adv Pharm Sci 2. 2011;29-32.
Lee BH, et al. Paclitaxel-coated expanded polytetrafluoroethylene haemodialysis grafts inhibit neointimal hyperplasia in porcine model of graft stenosis. Nephrol Dial Transplant. 2006;21(9):2432–8.
Carmeliet P, Moons L, et al. Vascular wound healing and neointima formation induced by perivascular electric injury in mice. Am J Pathol. 1997;150(2):761–76.
Regar E, Sianos G, Serruys PW. Stent development and local drug delivery. Br Med Bull. 2001;59(1):227–48.
Sousa JE, Costa MA, et al. Lack of neointimal proliferation after implantation of sirolimus-eluting stents in human coronary arteries: a quantitative coronary angiography and three-dimensional intravascular ultrasound study. Circulation. 2001;103:192–5.
Kitrou PM, et al. Paclitaxel-coated balloons for the treatment of symptomatic central venous stenosis in dialysis access: results from a randomized controlled trial. J Vasc Interv Radiol. 2017;28(6):811–7.
Fonseca C, Simoes S, Gaspar R. Paclitaxel-loaded PLGA nanoparticles: preparation, physicochemical characterization and in vitro anti-tumoral activity. J Control Release. 2002;83(2):273–86.
Gan Q, Wang T. Chitosan nanoparticle as protein delivery carrier—Systematic examination of fabrication conditions for efficient loading and release. Colloids Surf, B. 2007;59:24–34.
Niikura K, Iyo N, et al. Sub-100 nm gold nanoparticle vesicles as a drug delivery carrier enabling rapid drug release upon light irradiation. ACS Appl Mater Interfaces. 2013;5(9):3900–7.
Kim SY, Kwon OH, et al. Paclitaxel coating on ePTFE artificial graft and the release behavior. Polymer (Korea). 2011;36(3):326–31.
Tabatabaei Mirakabad FS, Joo SW, et al. PLGA-based nanoparticles as cancer drug delivery systems. Asian Pac J Cancer Prev. 2014;15(2):517–35.
Scheller B, Hehrlein C, et al. Treatment of Coronary In-Stent Restenosis with a Paclitaxel-Coated Balloon Catheter. N Engl J Med. 2006;355(20):2113–24.
Pablo HM, Irene CG, et al. Quantification and statistical analysis methods for vessel wall components from stained images with Masson’s trichrome. PLoS ONE. 2016;11(1):e0146954.