Histochemistry and fine structure of endocrine cells in foetal lungs of the rabbit, mouse and guinea-pig
Tóm tắt
Endocrine cells in the bronchial epithelium in the glandular and beginning of the canalicular period of lung development, of rabbits, mice and guinea-pigs were searched for by use of the formaldehyde-fluorescence technique, by silver stains, staining of endocrine cell granules and by electron microscopy. One type was observed but differences between various animal species were noted. In rabbit foetuses numerous argyrophil cells in the bronchial epithelium were shown to contain amine and to have the capacity to take up and store further amounts of amine upon administration in vivo and in vitro of amine precursors. This capacity to produce and store amine under experimental conditions was shown by a smaller number of cells in the bronchial epithelium of mouse foetuses and by few scattered cells in the bronchial epithelium of guinea pig foetuses. By electron microscopic examination cells characterized by cytoplasmic secretory granules were observed, similar in number and distribution to those demonstrated by fluorescence microscopy. Differences were noted with respect to the texture, electron-density and size of the granules as well as in the contact of the cells to the lumen of the bronchi.
Tài liệu tham khảo
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