Hindlimb Stretching Alters Locomotor Function After Spinal Cord Injury in the Adult Rat

Neurorehabilitation and Neural Repair - Tập 29 Số 3 - Trang 268-277 - 2015
Krista L. Caudle1, Darryn A. Atkinson1, Edward H. Brown1, Katie Donaldson1, Erik Seibt1, Tim Chea1, Erin Smith1, Karianne Chung1, Alice Shum-Siu1, Courtney C. Cron1, David S.K. Magnuson1
1University of Louisville, Louisville, Ky., USA

Tóm tắt

Background. Stretching is a widely accepted standard-of-care therapy following spinal cord injury (SCI) that has not been systematically studied in animal models. Objective. To investigate the influence of a daily stretch-based physical therapy program on locomotor recovery in adult rats with moderate T9 contusive SCI. Methods. A randomized treatment and control study of stretching in an animal model of acute SCI. Moderate SCIs were delivered with the NYU Impactor. Daily stretching (30 min/day, 5 days/wk for 8 weeks) was provided by a team of animal handlers. Hindlimb function was assessed using the BBB Open Field Locomotor Scale and kinematically. Passive range-of-motion for each joint was determined weekly using a goniometer. Results. Declines in hindlimb function during overground stepping were observed for the first 4 weeks for stretched animals. BBB scores improved weeks 5 to 10 but remained below the control group. Stretched animals had significant deficits in knee passive range of motion starting at week 4 and for the duration of the study. Kinematic assessment showed decreased joint excursion during stepping that partially recovered beginning at week 5. Conclusion. Stretch-based therapy significantly impaired functional recovery in adult rats with a moderate contusive SCI at T10. The negative impact on function was greatest acutely but persisted even after the stretching ceased at 8 weeks postinjury.

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Thông tin xuất bản

Neurorehabilitation and Neural Repair

Tập 29 Số 3

268-277

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