High-volume cellular screening for anticancer agents with combinatorial chemical libraries: A new methodology

DeVita, V.T., Oliverio, V.T., Muggia, F.M., Wiernik, P.W., Ziegler, J.L., Goldin, A., Rubin, D., Henney, J. and Schepartz, S.,The drug development and clinical trials program of the Division of Cancer Treatment, National Cancer Institute, Cancer Clin. Trials, 2 (1979) 195–216.

Salmon, S.E.,Applications of the human tumor stem cell assay to new drug evaluation and screening, In Salmon, S.E. (Ed.) Cloning of Human Tumor Stem Cells, Alan R. Liss, New York, NY, U.S.A., 1990, pp. 291–312.

Boyd, M.R. and Paull, K.D.,Some practical considerations and applications of the National Cancer Institute in vitro anticancer drug discovery screen, Drug Dev. Res., 34 (1995) 91–109.

Lam, K.S., Salmon, S.E., Hersh, E.M., Hruby, V., Kazmierski, W.M. and Knapp, R.J.,A new type of synthetic peptide library for identifying ligand-binding activity, Nature, 354 (1991) 82–84.

Lam, K.S. and Lebl, M.,Selectide technology — Bead binding screening, Methods: A companion to Methods Enzymol., 6 (1994) 372–380.

Lebl, M., Krchñák, V., Salmon, S.E. and Lam, K.S.,Screening of completely random one-bead-one-peptide libraries for activities in solution, Methods: A companion to Methods Enzymol., 6 (1994) 381–387.

Lebl, M., Krchñák, V., Sepetov, N.F., Seligmann, B., Strop, P., Felder, S. and Lam, K.S.,One-bead-one-structure combinatorial libraries, Biopolymers (Pept. Sci.), 37 (1995) 177–198.

Lam, K.S. and Lebl, M.,Combinatorial library based on the one-bead-one-chemical concept, In Jung, G. (Ed.) Peptide and Nonpeptide Libraries — A Handbook, VCH, New York, NY, U.S.A., 1996, pp. 173–201.

Lam, K.S. and Salmon, S.E.,Method of screening a peptide library, United States Patent No. 5 510240, April 23, 1996.

Salmon, S.E., Lam, K.S., Lebl, M., Kandola, A., Khattri, P., Healy, S., Wade, S., Patek, M., Kocis, P., Krchñák, V., Thorpe, D. and Felder, S.,An orthogonal partial cleavage approach far solution-phase identification of biologically synthesized peptide libraries, In Hodges, R.S. and Smith, J.A. (Eds.) Peptides: Chemistry, Structure and Biology (Proceedings of the 13th American Peptide Symposium), ESCOM, Leiden, The Netherlands, 1994, pp. 1005–1006.

Salmon, S.E., Lam, K.S., Lebl, M., Kandola, A., Khattri, P., Wade, S., Patek, M., Kocis, P. and Krchñák, V.,An orthogonal partial cleavage approach for solution-phase identification of biologically active peptides from large chemical-synthesized peptide libraries, Proc. Natl. Acad. Sci. USA, 90 (1993) 11708–11712.

Salmon, S.E., Lam, K.S., Felder, S., Yeoman, H., Schlessinger, J., Ullrich, A., Krchñák, V. and Lebl, M.,One-bead-one-chemical-compound: Use of the Selectide process for anticancer drug discovery, Acta Oncol., 33 (1994) 127–131.

Jayawickreme, C.K., Graminski, G.F., Quillan, J.M. and Lerner, M.R.,Creation and functional screening of a multi-use peptide library, Proc. Natl. Acad. Sci. USA, 91 (1994) 1614–1618.

Furka, A., Sebestyen, F., Asgedom, M. and Dibo, G.,General method for rapid synthesis of multicomponent peptide mixtures, Int. J. Pept. Protein Res., 37 (1991) 487–493.

Houghten, R.A., Pinilla, C., Blondelle, S.E., Appel, J.R., Dooley, C.T. and Cuervo, J.H.,Generation and use of synthetic peptide combinatorial libraries for basic research and drug discovery, Nature, 354 (1991) 84–86.

Lebl, M., Patek, M., Kocis, P., Krchñák, V., Hruby, V.J., Salmon, S.E. and Lam, K.S.,Multiple release of equimolar amounts of linker free peptides from the polymeric carrier, Int. J. Pept. Protein Res., 41 (1993) 201–203.

Kocis, P., Krchñák, V. and Lebl, M.,Symmetrical structure allowing the Selectide multiple release of a defined quantity of peptide from a single bead of polymeric support, Tetrahedron Lett., 34 (1993) 7251–7252.