High resolution electrospray ionization ion mobility spectrometry
Tóm tắt
Current commercially available ion mobility spectrometers are intended for the analysis of chemicals in the gas phase. Sample introduction methods, such as direct air sampling, a GC injector or a thermal desorber, are commonly an integral part of these instruments. This paper describes an electrospray ionization ion mobility spectrometer system that allows direct introduction samples in solution phase. This allows direct analysis of non-volatile organic and biological samples, and avoids decomposition of thermally liable samples, providing reliable chemical identification. In addition, the new ion mobility spectrometer allows mobility analysis with high resolving power. Commonly used commercial IMS systems provide resolving powers between 10 and 30; this new ion mobility spectrometer has resolving power greater than 60 for routine analysis. A high resolution instrument is necessary for many applications where a complex mixture needs to be separated and quantified. This paper demonstrates the advantages of using a high resolution ion mobility spectrometer and an electrospray ionization source for the analysis of non-volatile pharmaceuticals as well as dissolved explosive in solution phase.
Tài liệu tham khảo
Shumate CB, Hill HH (1989) Coronaspray nebulization and ionization of liquid samples for ion mobility spectrometry. Anal Chem 61:601–606
Wu C, Gamerdinger AP, Hill HH (1998) Electrospray ionization ion mobility spectrometry as a field monitoring method for the detection of atrazine in natural water. Field Anal Chem Technol 2(3):155–161
Clowers BH, Steiner WE, Dion HM, Matz LM, Tam M, Tarver EE, Hill HH (2002) Evaluation of sulfonylurea herbicides using high resoluiton electrospray ionization ion mobility quadrupole mass spectrometry. Field Anal Chem Technol 5(6):302–312
Dwivedi P, Matz LM, Atkinson DA, Hill HH (2004) Electrospray ionization-ion mobility spectrometry: a rapid analytical method for aqueous nitrate and nitrite analysis. Analyst 129:139–144
Wu C, Siems WF, HH Hill (2000) Secondary electrospray ionization ion mobility spectrometry—mass spectrometry of illicit drugs. Anal Chem 72(2):396–403
Steiner WE, Clowers BH, Fuhrur KH, Gonin M, Matz LM, Siems WF, Schultz AJ, Hill HH (2001) Electrospray ionization with ambient pressure ion mobility separation and mass analysis by orthogonal time of flight mass spectrometry. Rapid Commun in Mass Spectrometry 15:2221–2226
Matz LM, Hill HH (2002) Evaluating the separation of amphetamines by electrospray ionization/ion mobility spectrometry/MS and charge competition within the ESI process. Anal Chem 74:420–427
Matz LM, Hill HH (2002) Separation of Benzodiazepines by electrospray ionization ion mobility spectrometry-mass spectrometry. Analytica Chimica Acta 457:235–245
Matz LM, Hill HH (2001) Evaluation of opiate separation by high-resolution electrospray ionization-ion mobility spectrometry/mass spectrometry. Anal Chem 73:1664–1669
Dwivedi P, Wu C, Matz LM, Clowers BH, Siems WF, Hill HH (2006) Gas phase chiral separations by ion mobility spectrometry. Anal Chem 78:8200–8206
Steiner WE, Clowers BH, Matz LM, Siems WF, Hill HH (2002) Rapid screening of aqueous chemical warfare agent degradation products: ambient pressure ion mobility mass spectrometry. Anal Chem 74:4343–4352
Asbury GR, Siems WF, Hill HH (2000) Separation and identification of some chemical warfare degradation products using electrospray high resolution ion mobility spectrometry with mass selected detection. Anal Chimica Acta 404(2):273–283
Steiner WE, Clowers BH, Haigh PE, Hill HH (2003) Secondary ionization of chemical warfare agent simulants: atmospheric pressure ion mobility time-of-flight mass spectrometry. Anal Chem 75:6068–6076
Asbury GR, Klasmeier J, Hill HH (2000) Analysis of explosives using electrospray ionization/ion mobility spectrometry (ESI/IMS). Talanta 50(6):1291–1298
Tam M, Hill HH (2004) Secondary electrospray ionization-ion mobility spectrometry (SESI-IMS) for explosive vapor detection. Anal Chem 76(10):2741–2747