High‐powered percutaneous microwave ablation of stage I medically inoperable non‐small cell lung cancer: A preliminary study

Journal of Medical Imaging and Radiation Oncology - Tập 57 Số 4 - Trang 466-474 - 2013
Howard Liu1, Karin Steinke1
1 Department of Medical Imaging, Royal Brisbane & Women's Hospital, Brisbane, Queensland, Australia.

Tóm tắt

AbstractPurposeTo retrospectively evaluate the feasibility and outcome of using high‐powered percutaneous microwave ablation (MWA) in treating medically inoperable early stage non‐small cell lung cancer.Materials and MethodsFrom November 2010 to June 2012, 15 patients underwent CT‐guided MWA of 15 tumours in 16 sessions. One patient had a second ablation session for local tumour progression. Each tumour had a diameter of 40 mm or less (median 24 mm). Treatment outcome was evaluated using modified response evaluation criteria in solid tumours criteria based on follow‐up contrast‐enhanced CT studies and 18‐F fluorodeoxyglucose positron emission tomography scans.ResultsThirty‐three ablation cycles of 15 tumours were performed in 16 sessions (2.1 per session), with a median duration of 2.5 min per ablation. Treatment was completed in all cases with no 30‐day mortality. At a median follow‐up period of 1 year, local progression was identified following 5/16 (31%) ablation sessions. Eleven out of 16 (69%) of MWAs had shown local treatment response, with 9/11 displaying complete response and 2/11 displaying partial response. Local progression on follow up was predominantly seen in pleural‐based tumours that were greater than 30 mm in longest axial diameter (4/5 cases). The main adverse event was a pneumothorax, which occurred in 10/16 (63%) of procedures, but a chest tube was only required in 2/16 (13%) cases.ConclusionPercutaneous MWA in early stage non‐small cell lung cancer is well tolerated and has promising midterm outcomes.

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Thông tin xuất bản

Journal of Medical Imaging and Radiation Oncology

Tập 57 Số 4

466-474

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