High incidence of TERT mutation in brain tumor cell lines

Tanner M. Johanns1, Yujie Fu2, Dale K. Kobayashi2, Mei Yu3, Ian F. Dunn3, Diane D. Mao4, Albert H. Kim4, Gavin P. Dunn4
1Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA
2Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO, USA
3Department of Neurosurgery, Brigham and Women’s Hospital, Boston, MA, USA
4Department of Neurological Surgery, Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, 660 South Euclid, Box 8057, St. Louis, MO, 63110, USA

Tóm tắt

Từ khóa


Tài liệu tham khảo

Stupp R et al (2005) Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med 352(10):987–996

Network TCGA (2008) Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature 455(7216):1061–1068

Brennan CW et al (2013) The somatic genomic landscape of glioblastoma. Cell 155(2):462–477

Parsons DW et al (2008) An integrated genomic analysis of human glioblastoma multiforme. Science 321(5897):1807–1812

Hahn WC et al (1999) Creation of human tumour cells with defined genetic elements. Nature 400(6743):464–468

Martinez P, Blasco MA (2011) Telomeric and extra-telomeric roles for telomerase and the telomere-binding proteins. Nat Rev Cancer 11(3):161–176

Kim NW et al (1994) Specific association of human telomerase activity with immortal cells and cancer. Science 266(5193):2011–2015

Huang FW et al (2013) Highly recurrent TERT promoter mutations in human melanoma. Science 339(6122):957–959

Bell RJ et al (2015) Cancer. The transcription factor GABP selectively binds and activates the mutant TERT promoter in cancer. Science 348(6238):1036–1039

Killela PJ et al (2013) TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal. Proc Natl Acad Sci USA 110(15):6021–6026

Heidenreich B et al (2014) TERT promoter mutations in cancer development. Curr Opin Genet Dev 24:30–37

Heidenreich B et al (2015) TERT promoter mutations and telomere length in adult malignant gliomas and recurrences. Oncotarget 6(12):10617–10633

Labussiere M et al (2014) Combined analysis of TERT, EGFR, and IDH status defines distinct prognostic glioblastoma classes. Neurology 83(13):1200–1206

Barretina J et al (2012) The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity. Nature 483(7391):603–607

Mao DD et al (2015) A CDC20-APC/SOX2 signaling axis regulates human glioblastoma stem-like cells. Cell Rep 11(11):1809–1821

Eckel-Passow JE et al (2015) Glioma groups based on 1p/19q, IDH, and TERT promoter mutations in tumors. N Engl J Med 372(26):2499–2508

Simon M et al (2015) TERT promoter mutations: a novel independent prognostic factor in primary glioblastomas. Neuro Oncol 17(1):45–52

Sahm F et al (2016) TERT promoter mutations and risk of recurrence in meningioma. J Natl Cancer Inst 108(5). doi: 10.1093/jnci/djv377

Goutagny S et al (2014) High incidence of activating TERT promoter mutations in meningiomas undergoing malignant progression. Brain Pathol 24(2):184–189

Cancer Genome Atlas Research network et al (2015) Comprehensive, integrative genomic analysis of diffuse lower-grade gliomas. N Engl J Med 372(26):2481–2498

Stewart SA et al (2002) Telomerase contributes to tumorigenesis by a telomere length-independent mechanism. Proc Natl Acad Sci USA 99(20):12606–12611

Huang FW et al (2015) TERT promoter mutations and monoallelic activation of TERT in cancer. Oncogenesis 4:e176

Shankar GM et al (2015) Rapid intraoperative molecular characterization of glioma. JAMA Oncol 1(5):662–667

Arita H et al (2013) Upregulating mutations in the TERT promoter commonly occur in adult malignant gliomas and are strongly associated with total 1p19q loss. Acta Neuropathol 126(2):267–276

Greider CW (2012) Molecular biology. Wnt regulates TERT—putting the horse before the cart. Science 336(6088):1519–1520