High-fat diet or low-protein diet changes peritoneal macrophages function in mice

Nutrire - Tập 41 Số 1 - 2016
Ed Wilson Santos1, Daniel Capucho de Oliveira1, Araceli Aparecida Hastreiter1, Jackeline Soares de Oliveira Beltran1, Marcelo Macedo Rogero2, Ricardo Ambrósio Fock1, Primavera Borelli1
1Experimental Hematology Laboratory, Department of Clinical e Toxicological Analyses, Faculty of Pharmaceutical Sciences, University of Sao Paulo, Avenida Lineu Prestes, 580 – Bloco 17, São Paulo, SP, 05508-900, Brazil
2Department of Nutrition, School of Public Health, University of Sao Paulo, Sao Paulo, Brazil

Tóm tắt

Abstract Background Obesity and protein malnutrition are major food problems nowadays, affecting billions of people around the world. The nutrition transition that has occurred in recent decades is changing the nutritional profile, reducing malnutrition and increasing the percentage of obese people. The innate immune response is greatly influenced by diet, with significant changes in both malnutrition and obesity. Therefore, we investigate the effects of protein malnutrition and obesity in nutritional and immunological parameters in mice. Results Peritoneal macrophages of malnourished animals showed reduced functions of adhesion, spreading, and fungicidal activity; production of hydrogen peroxide and nitric oxide were lower, reflecting changes in the innate immune response. However, the high-fat animals had macrophage functions slightly increased. Conclusions Animals subjected to low-protein diet have immunosuppression, and animals subjected to high-fat diet increased visceral adipose tissue and the presence of an inflammatory process with increased peritoneal macrophage activity and similar systemic changes to metabolic syndrome.

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