High-fat diet alters intestinal microbiota and induces endoplasmic reticulum stress via the activation of apoptosis and inflammation in blunt snout bream

Abasubong K, Li XF, Zhang DD, Jia ET, Xiang-Yang Y, Xu C, Liu WB (2018) Dietary supplementation of xylooligosaccharides benefits the growth performance and lipid metabolism of common carp (Cyprinus carpio) fed high-fat diets. Aquac Nutr 24:1416–1424. https://doi.org/10.1111/anu.12678 Abasubong KP, Li XF, Adjoumani JJY, Jiang GZ, Desouky HE, Liu, W.b. (2022) Effects of dietary xylooligosaccharide prebiotic supplementation on growth, antioxidant and intestinal immune-related genes expression in common carp Cyprinus carpio fed a high-fat diet. J Anim Physiol Anim Nutr 106:403–418. https://doi.org/10.1111/jpn.13669 Altieri C, Bevilacqua A, Cardillo D, Sinigaglia M (2009) Effectiveness of fatty acids and their monoglycerides against gram-negative pathogens. International. J Food Sci Technol 44:359–366. https://doi.org/10.1111/vde.12712 Arii K, Suehiro T, Yamamoto M, Ito H, Hashimoto K (1997) Suppression of plasma cholesteryl ester transfer protein activity in acute hyperinsulinemia and effect of plasma nonesterified fatty acid. Metabolism 46:1166–1170. https://doi.org/10.1016/s0026-0495(97)90211-0 Balasubramaniyan N, Ananthanarayanan M, Suchy FJ (2016) Nuclear factor-κB regulates the expression of multiple genes encoding liver transport proteins. American Journal of Physiology-Gastrointestinal and Liver. Physiology 310:G618–G628. https://doi.org/10.1152/ajpgi.00363.2015 Barnabei L, Laplantine E, Mbongo W, Rieux-Laucat F, Weil R (2021) NF-κB: at the borders of autoimmunity and inflammation. Front Immunol 12:716469. https://doi.org/10.3389/fimmu.2021.716469 Beard RS, Reynolds JJ, Bearden SE (2011) Hyperhomocysteinemia increases permeability of the blood-brain barrier by NMDA receptor-dependent regulation of adherens and tight junctions. Blood 118(7):2007–2014. https://doi.org/10.1182/blood-2011-02-338269 Bergmann KR, Liu SXL, Tian R, Kushnir A, Turner JR, Li H-L, Chou PM, Weber CR, De Plaen IG (2013) Bifidobacteria stabilize claudins at tight junctions and prevent intestinal barrier dysfunction in mouse necrotizing enterocolitis. Am J Pathol 182(5):1595–1606. https://doi.org/10.1016/j.ajpath.2013.01.013 Bhatt D, Ghosh S (2014) Regulation of the NF-κB-mediated transcription of inflammatory genes. Front Immunol 5:71. https://doi.org/10.3389/fimmu.2014.00071 Brugman S, Nieuwenhuis EE (2010) Mucosal control of the intestinal microbial community. J Mol Med 88:881–888. https://doi.org/10.1007/s00109-010-0639-9 Brunvold L, Sandaa R-A, Mikkelsen H, Welde E, Bleie H, Bergh Ø (2007) Characterisation of bacterial communities associated with early stages of intensively reared cod (Gadus morhua) using Denaturing Gradient Gel Electrophoresis (DGGE). Aquaculture 272(1-4):319–327. https://doi.org/10.1016/j.aquaculture.2007.08.053 Cani PD, Bibiloni R, Knauf C, Waget A, Neyrinck AM, Delzenne NM, Burcelin R (2008) Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet–induced obesity and diabetes in mice. Diabetes 57(6):1470–1481. https://doi.org/10.2337/db07-1403 Cantas L, Sørby JRT, Aleström P, Sørum, H (2012) Culturable gut microbiota diversity in zebrafish. Zebrafish 9(1):26–37. https://doi.org/10.1089/zeb.2011.0712 Capaldo CT, Nusrat A (2009) Cytokine regulation of tight junctions. Biochimica et Biophysica Acta (BBA). Biomembranes 1788:864–871. https://doi.org/10.1016/j.bbamem.2008.08.027 Carracedo A, Lorente M, Egia A (2006) The stress-regulated protein p8 mediates cannabinoid-induced apoptosis of tumor cells. Cancer Cell 9:301–312 Cerf-Bensussan N, Gaboriau-Routhiau V (2010) The immune system and the gut microbiota: friends or foes? Nat Rev Immunol 10:735–744. https://doi.org/10.1038/nri2850 Cebra JJ (1999) Influences of microbiota on intestinal immune system development. Am J Clin Nutr 69(5):1046s–1051s. https://doi.org/10.1093/ajcn/69.5.1046s Chasiotis H, Kolosov D, Bui P, Kelly SP (2012) Tight junctions, tight junction proteins and paracellular permeability across the gill epithelium of fishes: a review. Respir Physiol Neurobiol 184:269–281. https://doi.org/10.1016/j.resp.2012.05.020 Chelakkot C, Ghim J, Ryu SH (2018) Mechanisms regulating intestinal barrier integrity and its pathological implications. Exp Mol Med 50:1–9. https://doi.org/10.1038/s12276-018-0126-x Chen Q-Q, Liu W-B, Zhou M, Dai Y-J, Xu C, Tian H-Y, Xu W-N (2016) Effects of berberine on the growth and immune performance in response to ammonia stress and high-fat dietary in blunt snout bream Megalobrama amblycephala. Fish Shellfish Immunol 55:165–172. https://doi.org/10.1016/j.fsi.2016.05.023 Chen X, Yang S, Pan Y, Li X, Ma S (2018) Mitochondrial pathway-mediated apoptosis is associated with erlotinib-induced cytotoxicity in hepatic cells. Oncol Lett 15:783–788. https://doi.org/10.3892/ol.2017.7359 Choi Y, Abdelmegeed MA, Akbar M, Song B-J (2016) Dietary walnut reduces hepatic triglyceride content in high-fat-fed mice via modulation of hepatic fatty acid metabolism and adipose tissue inflammation. J Nutr Biochem 30:116–125. https://doi.org/10.1016/j.jnutbio.2015.12.005 Dai Y-J, Cao X-F, Zhang D-D, Li X-F, Liu W-B, Jiang G-Z (2019) Chronic inflammation is a key to inducing liver injury in blunt snout bream (Megalobrama amblycephala) fed with high-fat diet. Dev Comp Immunol 97:28–37. https://doi.org/10.1016/j.dci.2019.03.009 Dai Y-J, Jiang G-Z, Yuan X-Y, Liu W-B (2018) High-fat-diet-induced inflammation depresses the appetite of blunt snout bream (Megalobrama amblycephala) through the transcriptional regulation of leptin/mammalian target of rapamycin. Br J Nutr 120:1422–1431. https://doi.org/10.1017/S000711451800288X Dawood MA, Koshio S, El-Sabagh M, Billah MM, Zaineldin AI, Zayed MM, Omar AAE-D (2017) Changes in the growth, humoral and mucosal immune responses following β-glucan and vitamin C administration in red sea bream, Pagrus major. Aquaculture 470:214–222. https://doi.org/10.1016/j.aquaculture.2016.12.036 De RB, Youmans BP, Danzeisen JL, Tran H, Johnson TJ (2018) Microbiome profiling of commercial pigs from farrow to finish. J Anim Sci 96:1778–1794. https://doi.org/10.1093/jas/sky109 Deng Y-P, Jiang W-D, Liu Y, Jiang J, Kuang S-Y, Tang L, Wu P, Zhang Y-A, Feng L, Zhou X-Q (2014) Differential growth performance, intestinal antioxidant status and relative expression of Nrf2 and its target genes in young grass carp (Ctenopharyngodon idella) fed with graded levels of leucine. Aquaculture 434:66–73. https://doi.org/10.1016/j.aquaculture.2014.07.026 Desouky HE, Jiang GZ, Zhang DD, Abasubong KP, Yuan X, Li XF, Liu WB (2020) Influences of glycyrrhetinic acid (GA) dietary supplementation on growth, feed utilization, and expression of lipid metabolism genes in channel catfish (Ictalurus punctatus) fed a high-fat diet. Fish Physiol Biochem 46:653–663. https://doi.org/10.1007/s10695-019-00740-4 Du Z-Y, Clouet P, Zheng W-H, Degrace P, Tian L-X, Liu Y-J (2006) Biochemical hepatic alterations and body lipid composition in the herbivorous grass carp (Ctenopharyngodon idella) fed high-fat diets. Br J Nutr 95:905–915. https://doi.org/10.1079/bjn20061733 Du Z, Clouet P, Huang L, Degrace P, Zheng W, He J, Tian L, Liu Y (2008) Utilization of different dietary lipid sources at a high level in herbivorous grass carp (Ctenopharyngodon idella): mechanism related to hepatic fatty acid oxidation. Aquac Nutr 14:77–92. https://doi.org/10.1111/j.1365-2095.2007.00507.x Eddy SD, Jones SH (2002) Microbiology of summer flounder Paralichthys dentatus fingerling production at a marine fish hatchery. Aquaculture 211(1-4):9–28. https://doi.org/10.1016/S0044-8486(01)00882-1 Frayn KN (1998) Non-esterified fatty acid metabolism and postprandial lipaemia. Atherosclerosis 141:S41–S46. https://doi.org/10.1016/s0021-9150(98)00216-0 Habte-Tsion H-M, Ren M, Liu B, Ge, X, Xie J, Chen R (2016) Threonine modulates immune response, antioxidant status, and gene expressions of antioxidant enzymes and antioxidantimmune-cytokine-related signaling molecules in juvenile blunt snout bream (Megalobrama amblycephala). Fish Shellfish Immuno 51:189–199. https://doi.org/10.1016/j.fsi.2015.11.033 Haywood J, Yammani RR (2016) Free fatty acid palmitate activates unfolded protein response pathway and promotes apoptosis in meniscus cells. Osteoarthr Cartil 24:942–945 Galindo-Villegas J, García-Moreno D, De Oliveira S, Meseguer J, Mulero V (2012) Regulation of immunity and disease resistance by commensal microbes and chromatin modifications during zebrafish development. Proc Natl Acad Sci 109:E2605–E2614. https://doi.org/10.1073/pnas.1209920109 Guo G, Shi F, Zhu J, Shao Y, Gong W, Zhou G, Wu H, She J, Shi W (2020) Piperine, a functional food alkaloid, exhibits inhibitory potential against TNBS-induced colitis via the inhibition of IκB-α/NF-κB and induces tight junction protein (claudin-1, occludin, and ZO-1) signaling pathway in experimental mice. Hum Exp Toxicol 39:477–491. https://doi.org/10.1177/0960327119892042 Hagi T, Tanaka D, Iwamura Y, Hoshino T (2004) Diversity and seasonal changes in lactic acid bacteria in the intestinal tract of cultured freshwater fish. Aquaculture 234:335–346. https://doi.org/10.1016/j.aquaculture.2004.01.018 Han J, Kaufman RJ (2016) The role of ER stress in lipid metabolism and lipotoxicity. J Lipid Res 57:1329–1338. https://doi.org/10.1194/jlr.R067595 Hansen JØ, Berge GM, Hillestad M, Krogdahl Å, Galloway TF, Holm H, Holm J, Ruyter B (2008) Apparent digestion and apparent retention of lipid and fatty acids in Atlantic cod (Gadus morhua) fed increasing dietary lipid levels. Aquaculture 284:159–166. https://doi.org/10.1016/j.aquaculture.2008.07.043 He C, Cheng D, Peng C, Li Y, Zhu Y, Lu N (2018) High-fat diet induces dysbiosis of gastric microbiota prior to gut microbiota in association with metabolic disorders in mice. Front Microbiol 9:639. https://doi.org/10.3389/fmicb.2018.00639 Hu C, Xu Y, Xia M, Xiong L, Xu Z (2007) Effects of Cu2+-exchanged montmorillonite on growth performance, microbial ecology and intestinal morphology of Nile tilapia (Oreochromis niloticus). Aquaculture 270:200–206. https://doi.org/10.1016/j.aquaculture.2007.01.027 Ismail M, Al-Naqeep G, Chan KW (2010) Nigella sativa thymoquinone-rich fraction greatly improves plasma antioxidant capacity and expression of antioxidant genes in hypercholesterolemic rats. Free Radic Biol Med 48:664–672. https://doi.org/10.1016/j.freeradbiomed.2009.12.002 Kammoun HL, Chabanon H, Hainault I, Luquet S, Magnan C, Koike T, Ferré P, Foufelle F (2009) GRP78 expression inhibits insulin and ER stress–induced SREBP-1c activation and reduces hepatic steatosis in mice. J Clin Invest 119:1201–1215. https://doi.org/10.1172/JCI37007 Kikuchi K, Furuta T, Iwata N, Onuki K, Noguchi T (2009) Effect of dietary lipid levels on the growth, feed utilization, body composition and blood characteristics of tiger puffer Takifugu rubripes. Aquaculture 298:111–117. https://doi.org/10.1016/j.aquaculture.2009.10.026 Kim S, Joe Y, Kim HJ, Kim Y-S, Jeong SO, Pae H-O, Ryter SW, Surh Y-J, Chung HT (2015) Endoplasmic reticulum stress–induced IRE1α activation mediates cross-talk of GSK-3β and XBP-1 To regulate inflammatory cytokine production. J Immunol 194:4498–4506. https://doi.org/10.4049/jimmunol.1401399 Kühlwein H, Emery M, Rawling M, Harper G, Merrifield D, Davies S (2013) Effects of a dietary β-(1, 3)(1, 6)-D-glucan supplementation on intestinal microbial communities and intestinal ultrastructure of mirror carp (Cyprinus carpio L.). J Appl Microbiol 115:1091–1106. https://doi.org/10.1111/jam.12313 Kuwana T, Olson NH, Kiosses WB, Peters B, Newmeyer DD (2016) Pro-apoptotic Bax molecules densely populate the edges of membrane pores. Sci Rep 6:27299. https://doi.org/10.1038/srep27299 Lagrost L, Florentin E, Guyard-Dangremont V, Athias A, Gandjini H, Lallemant C, Gambert P (1995) Evidence for nonesterified fatty acids as modulators of neutral lipid transfers in normolipidemic human plasma. Arterioscler Thromb Vasc Biol 15:1388–1396. https://doi.org/10.1161/01.atv.15.9.1388 Lam YY, Ha CW, Hoffmann JM, Oscarsson J, Dinudom A, Mather TJ, Cook DI, Hunt NH, Caterson ID, Holmes AJ (2015) Effects of dietary fat profile on gut permeability and microbiota and their relationships with metabolic changes in mice. Obesity 23:1429–1439. https://doi.org/10.1002/oby.21122 Lappi J, Salojärvi J, Kolehmainen M, Mykkänen H, Poutanen K, de Vos WM (2013) Intake of whole-grain and fiber-rich rye bread versus refined wheat bread does not differentiate intestinal microbiota composition in Finnish adults with metabolic syndrome. J Nutr 143:648–655. https://doi.org/10.3945/jn.112.172668 Lee AH, Iwakoshi NN, Glimcher LH (2003) XBP-1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response. Mol Cell Biol 23:7448–7459 Lee J-S, Mendez R, Heng HH, Yang ZQ, Zhang K (2012) Pharmacological ER stress promotes hepatic lipogenesis and lipid droplet formation. Am J Transl Res 4:102–113 Li A, Yuan X, Liang X-F, Liu L, Li J, Li B, Fang J, Li J, He S, Xue M (2016a) Adaptations of lipid metabolism and food intake in response to low and high fat diets in juvenile grass carp (Ctenopharyngodon idellus). Aquaculture 457:43–49. https://doi.org/10.1016/j.aquaculture.2016.01.014 Li H, Jiang W, Liu Y, Jiang J, Zhang Y, Wu P, Zhao J, Duan X, Zhou X, Feng L (2016b) The metabolites of glutamine prevent hydroxyl radical-induced apoptosis through inhibiting mitochondria and calcium ion involved pathways in fish erythrocytes. Free Radic Biol Med 92:126–140. https://doi.org/10.1016/j.freeradbiomed.2016.01.007 Liang XP, Li Y, Hou YM, Qiu H, Zhou QC (2017) Effect of dietary vitamin C on the growth performance, antioxidant ability and innate immunity of juvenile yellow catfish (P elteobagrus fulvidraco Richardson). Aquac Res 48(1):149–160. https://doi.org/10.1016/j.fsi.2012.01.024 Ling S-C, Wu K, Zhang D-G, Luo Z (2019) Endoplasmic reticulum stress-mediated autophagy and apoptosis alleviate dietary fat-induced triglyceride accumulation in the intestine and in isolated intestinal epithelial cells of yellow catfish. J Nutr 149(10):1732–1741. https://doi.org/10.1093/jn/nxz135 Liu T, Zhang L, Joo D, Sun S-C (2017) NF-κB signaling in inflammation. Signal Transduct Target Ther 2:1–9. https://doi.org/10.1038/sigtrans.2017.23 Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2− ΔΔCT method. Methods 25:402–408. https://doi.org/10.1006/meth.2001.1262 Llewellyn MS, McGinnity P, Dionne M, Letourneau J, Thonier F, Carvalho GR, Creer S, Derome N (2016) The biogeography of the Atlantic salmon (Salmo salar) gut microbiome. The ISME J 10:1280–1284. https://doi.org/10.1038/ismej.2015.189 Lu K-L, Xu W-N, Liu W-B, Wang L-N, Zhang C-N, Li X-F (2013) Association of mitochondrial dysfunction with oxidative stress and immune suppression in blunt snout bream Megalobrama amblycephala fed a high-fat diet. J Aquat Anim Health 26(2):100–112. https://doi.org/10.1080/08997659.2014.893460 Martin-Antonio B, Manchado M, Infante C, Zerolo R, Labella A, Alonso C, Borrego JJ (2007) Intestinal microbiota variation in Senegalese sole (Solea senegalensis) under different feeding regimes. Aquac Res 38:1213–1222. https://doi.org/10.1111/j.1365-2109.2007.01790.x Martínez-Llorens S, Baeza-Ariño R, Nogales-Mérida S, Jover-Cerdá M, Tomás-Vidal A (2012) Carob seed germ meal as a partial substitute in gilthead sea bream (Sparus aurata) diets: amino acid retention, digestibility, gut and liver histology. Aquaculture 338:124–133. https://doi.org/10.1016/j.aquaculture.2012.01.029 Merrifield D, Dimitroglou A, Bradley G, Baker R, Davies S (2009) Soybean meal alters autochthonous microbial populations, microvilli morphology and compromises the intestinal enterocyte integrity of rainbow trout, Oncorhynchus mykiss (Walbaum). J Fish Dis 32(9):755–766. https://doi.org/10.1111/j.1365-2761.2009.01052.x Morales P, Brignardello J, Gotteland M (2010) The association of intestinal microbiota with obesity. Rev Med Chil 138:1020–1027 Mu H, Shen H, Liu J, Xie F, Zhang W, Mai K (2018) High level of dietary soybean oil depresses the growth and anti-oxidative capacity and induces inflammatory response in large yellow croaker Larimichthys crocea. Fish Shellfish Immunol 77:465–473. https://doi.org/10.1016/j.fsi.2018.04.017 Nazli SA, Loeser RF, Chubinskaya S, Willey JS, Yammani RR (2017) High fat-diet and saturated fatty acid palmitate inhibits IGF-1 function in chondrocytes. Osteoarthr Cartil 25:1516–1521 Ozcan L, Ergin AS, Lu A, Chung J, Sarkar S, Nie D, Myers MG, Ozcan U (2009) Endoplasmic reticulum stress plays a central role in development of leptin resistance. Cell Metab 9:35–51. https://doi.org/10.1111/obr.12673 Regost C, Arzel J, Cardinal M, Robin J, Laroche M, Kaushik S (2001) Dietary lipid level, hepatic lipogenesis and flesh quality in turbot (Psetta maxima). Aquaculture 193(3-4):291–309. https://doi.org/10.1016/S0044-8486(00)00493-2 Ringø E, Zhou Z, Vecino JG, Wadsworth S, Romero J, Krogdahl Å, Olsen RE, Dimitroglou A, Foey A, Davies S (2015) Effect of dietary components on the gut microbiota ofaquatic animals. A never‐ending story? Aquac Nutr 22(2):219–282. https://doi.org/10.1111/anu.12346 Reinecker H-C, Loh EY, Ringler DJ, Mehta A, Rombeau JL, MacDermott RP (1995) Monocyte-chemoattractant protein 1 gene expression in intestinal epithelial cells and inflammatory bowel disease mucosa. Gastroenterology 108:40–50. https://doi.org/10.1002/jlb.59.6.804 Rizzatti G, Lopetuso L, Gibiino G, Binda C, Gasbarrini A (2017) Proteobacteria: a common factor in human diseases. Biomed Res Int 2017:9351507. https://doi.org/10.1155/2017/9351507 Rochfort KD, Cummins PM (2015) Cytokine-mediated dysregulation of zonula occludens-1 properties in human brain microvascular endothelium. Microvasc Res 100:48–53. https://doi.org/10.1016/j.mvr.2015.04.010 Rohr MW, Narasimhulu CA, Rudeski-Rohr TA, Parthasarathy S (2020) Negative effects of a high-fat diet on intestinal permeability: a review. Adv Nutr 11(1):77–91. https://doi.org/10.1093/advances/nmz061 Rueda-Jasso R et al (2004) Effect of dietary non-protein energy levels on condition and oxidative status of Senegalese sole (Solea senegalensis) juveniles. Aquaculture 231:417–433 Rutkowski DT, Wu J, Back S-H, Callaghan MU, Ferris SP, Iqbal J, Clark R, Miao H, Hassler JR, Fornek J (2008) UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators. Dev Cell 15:829–840. https://doi.org/10.1016/j.devcel.2008.10.015 Safari Z, Monnoye M, Abuja PM, Mariadassou M, Kashofer K, Gerard P, Zatloukal K (2019) Steatosis and gut microbiota dysbiosis induced by high-fat diet are reversed by 1-week chow diet administration. Nutr Res 71:72–88. https://doi.org/10.1016/j.nutres.2019.09.004 Simoes CD, Maukonen J, Kaprio J, Rissanen A, Pietiläinen KH, Saarela M (2013) Habitual dietary intake is associated with stool microbiota composition in monozygotic twins. J Nutr 143:417–423. https://doi.org/10.3945/jn.112.166322 Song B, Li H, Wu Y, Zhen W, Wang Z, Xia Z, Guo Y (2017) Effect of microencapsulated sodium butyrate dietary supplementation on growth performance and intestinal barrier function of broiler chickens infected with necrotic enteritis. Anim Feed Sci Technol 232:6–15. https://doi.org/10.1016/j.anifeedsci.2017.07.009 Stamatovic SM, Keep RF, Kunkel SL, Andjelkovic AV (2003) Potential role of MCP-1 in endothelial cell tight junction opening': signaling via Rho and Rho kinase. J Cell Sci 116:4615–4628. https://doi.org/10.1242/jcs.00755 Tam AB, Mercado EL, Hoffmann A, Niwa M (2012) ER stress activates NF-κB by integrating functions of basal IKK activity, IRE1 and PERK. PLoS One 7(10):e45078. https://doi.org/10.1371/journal.pone.0045078 Tang W, Pan L, Cheng J, Wang X, Zheng L, Wang S, Zhou Y, Wang H (2022) High-fat-diet-induced gut microbiome changes in mice. Stress and Brain 2:17–30. https://doi.org/10.26599/SAB.2022.9060012 Tarnecki AM, Burgos FA, Ray CL, Arias CR (2017) Fish intestinal microbiome: diversity and symbiosis unraveled by metagenomics. J Appl Microbiol 123:2–17. https://doi.org/10.1111/jam.13415 Trust T, Sparrow R (1974) The bacterial flora in the alimentary tract of freshwater salmonid fishes. Can J Microbiol 20:1219–1228. https://doi.org/10.1139/m74-188 Todd DJ, Lee AH, Glimcher LH (2008) The endoplasmic reticulum stress response in immunity and autoimmunity. Nat Rev Immunol 8:663–674 Walter P, Ron D (2011) The unfolded protein response: from stress pathway to homeostatic regulation. Science. 334:1081–1086 Wang A, Zhang Z, Ding Q, Yang Y, Bindelle J, Ran C, Zhou Z (2021) Intestinal Cetobacterium and acetate modify glucose homeostasis via parasympathetic activation in zebrafish. Gut Microbes 13:1–15. https://doi.org/10.1080/19490976.2021.1900996 Wang J-T, Liu Y-J, Tian L-X, Mai K-S, Du Z-Y, Wang Y, Yang H-J (2005) Effect of dietary lipid level on growth performance, lipid deposition, hepatic lipogenesis in juvenile cobia (Rachycentron canadum). Aquaculture 249:439–447. https://doi.org/10.1016/j.aquaculture.2005.04.038 Xie M, Zhou W, Xie Y, Li Y, Zhang Z, Yang Y, Olsen RE, Ran C, Zhou Z (2021) Effects of Cetobacterium somerae fermentation product on gut and liver health of common carp (Cyprinus carpio) fed diet supplemented with ultra-micro ground mixed plant proteins. Aquaculture 543:736943. https://doi.org/10.1016/j.aquaculture.2021.736943 Xu X, Huang E, Tai Y (2017) Nupr1 modulates methamphetamine-induced dopaminergic neuronal apoptosis and autophagy through CHOP-Trib3-mediated endoplasmic reticulum stress signaling pathway. Front Mol Neurosci 10:203 Yan J, Liao K, Wang T, Mai K, Xu W, Ai Q (2015) Dietary lipid levels influence lipid deposition in the liver of large yellow croaker (Larimichthys crocea) by regulating lipoprotein receptors, fatty acid uptake and triacylglycerol synthesis and catabolism at the transcriptional level. PLoS One 10:e0129937. https://doi.org/10.1371/journal.pone.0129937 Yu H, Huang X, Ma Y, Gao M, Wang O, Gao T, Shen Y, Liu X (2013) Interleukin-8 regulates endothelial permeability by down-regulation of tight junctions but not dependent on integrins induced focal adhesions. Int J Biol Sci 9:966–979. https://doi.org/10.7150/ijbs.6996 Zhang K, Shen X, Wu J, Sakaki K, Saunders T, Rutkowski DT, Back SH, Kaufman RJ (2006) Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response. Cell 124:587–599. https://doi.org/10.1016/j.cell.2005.11.040 Zhu S, Stavrovskaya IG, Drozda M, Kim BYS, Ona V, Li M, Sarang S, Liu AS, Hartley DM, Wu DC, Gullans S, Ferrante RJ, Przedborski S, Kristal BS, Friedlander RM (2002) Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice. Nature 417:74–78. https://doi.org/10.1038/417074a