High-dose folic acid supplementation effects on endothelial function and blood pressure in hypertensive patients: a meta-analysis of randomized controlled clinical trials

Journal of Chiropractic Medicine - Tập 8 - Trang 15-24 - 2009
Marc P. McRae1
1Assistant Professor, Department of Physiology and Biochemistry, National University of Health Sciences, Lombard, IL 60148

Tài liệu tham khảo

Burt, 1995, Prevalence of hypertension in the US adult population. Results from the Third National Health and Nutrition Examination Survey, 1988-1991, Hypertension, 25, 305, 10.1161/01.HYP.25.3.305 Robinson, 1998, Low circulating folate and vitamin B6 concentrations: risk factors for stroke, peripheral vascular disease, and coronary artery disease. European COMAC Group, Circulation, 97, 437, 10.1161/01.CIR.97.5.437 Bunout, 2000, Low serum folate but normal homocysteine levels in patients with atherosclerotic vascular disease and matched healthy controls, Nutrition, 16, 434, 10.1016/S0899-9007(00)00289-6 Voutilainen, 2001, Kuopio Ischemic Heart Disease Risk Factor Study. Low dietary folate intake is associated with an excess incidence of acute coronary events: the Kuopio Ischemic Heart Disease Risk Factor Study, Circulation, 103, 2674, 10.1161/01.CIR.103.22.2674 Forman, 2005, Folate intake and the risk of incident hypertension among US women, JAMA, 293, 320, 10.1001/jama.293.3.320 Title, 2000, Effect of folic acid and antioxidant vitamins on endothelial dysfunction in patients with coronary artery disease, J Am Coll Cardiol, 36, 758, 10.1016/S0735-1097(00)00809-3 Doshi, 2001, Folate improves endothelial function in coronary artery disease: an effect mediated by reduction of intracellular superoxide?, Arterioscler Thromb Vasc Biol, 21, 1196, 10.1161/hq0701.092000 Doshi, 2002, Folic acid improves endothelial function in coronary artery disease via mechanisms largely independent of homocysteine lowering, Circulation, 105, 22, 10.1161/hc0102.101388 Mangoni, 2005, Short-term oral folic acid supplementation enhances endothelial function in patients with type 2 diabetes, Am J Hypertens, 18, 220, 10.1016/j.amjhyper.2004.08.036 Williams, 2005, Folic acid supplementation for 3 wk reduces pulse pressure and large artery stiffness independent of MTHFR genotype, Am J Clin Nutr, 82, 26, 10.1093/ajcn/82.1.26 Title, 2006, Folic acid improves endothelial dysfunction in type 2 diabetes—an effect independent of homocysteine-lowering, Vasc Med, 11, 101, 10.1191/1358863x06vm664oa Moens, 2007, Effect of folic acid on endothelial function following acute myocardial infarction, Am J Cardiol, 99, 476, 10.1016/j.amjcard.2006.08.057 Bellamy, 1999, Oral folate enhances endothelial function in hyperhomocysteinaemic subjects, Eur J Clin Invest, 29, 659, 10.1046/j.1365-2362.1999.00527.x Verhaar, 1999, Effects of oral folic acid supplementation on endothelial function in familial hypercholesterolemia. A randomized placebo-controlled trial, Circulation, 100, 335, 10.1161/01.CIR.100.4.335 Wilmink, 2000, Influence of folic acid on postprandial endothelial dysfunction, Arterioscler Thromb Vasc Biol, 20, 185, 10.1161/01.ATV.20.1.185 Mangoni, 2002, Folic acid enhances endothelial function and reduces blood pressure in smokers: a randomized controlled trial, J Intern Med, 252, 497, 10.1046/j.1365-2796.2002.01059.x Suwaidi, 2000, Long-term follow-up of patients with mild coronary artery disease and endothelial dysfunction, Circulation, 101, 948, 10.1161/01.CIR.101.9.948 Schächinger, 2000, Prognostic impact of coronary vasodilator dysfunction on adverse long-term outcome of coronary heart disease, Circulation, 101, 1899, 10.1161/01.CIR.101.16.1899 Moens, 2005, Flow-mediated vasodilation: a diagnostic instrument, or an experimental tool?, Chest, 127, 2254, 10.1378/chest.127.6.2254 Yoshida, 2006, Prognostic value of flow-mediated dilation of the brachial artery in patients with cardiovascular disease, Intern Med, 45, 575, 10.2169/internalmedicine.45.1534 Woo, 1999, Folic acid improves arterial endothelial function in adults with hyperhomocystinemia, J Am Coll Cardiol, 34, 2002, 10.1016/S0735-1097(99)00469-6 Lekakis, 2004, Oral folic acid enhances endothelial function in patients with hypercholesterolaemia receiving statins, Eur J Cardiovasc Prev Rehabil, 11, 416, 10.1097/00149831-200410000-00010 Thambyrajah, 2000, Does folic acid decrease plasma homocysteine and improve endothelial function in patients with predialysis renal failure?, Circulation, 102, 871, 10.1161/01.CIR.102.8.871 Thambyrajah, 2001, A randomized double-blind placebo-controlled trial of the effect of homocysteine-lowering therapy with folic acid on endothelial function in patients with coronary artery disease, J Am Coll Cardiol, 37, 1858, 10.1016/S0735-1097(01)01235-9 Woodman, 2004, Folic acid does not improve endothelial function in healthy hyperhomocysteinaemic subjects, Clin Sci (Lond), 106, 353, 10.1042/CS20030296 Pullin, 2001, Optimization of dietary folate or low-dose folic acid supplements lower homocysteine but do not enhance endothelial function in healthy adults, irrespective of the methylenetetrahydrofolate reductase (C677T) genotype, J Am Coll Cardiol, 38, 1799, 10.1016/S0735-1097(01)01668-0 Hirsch, 2002, Hyperhomocysteinemia and endothelial function in young subjects: effects of vitamin supplementation, Clin Cardiol, 25, 495, 10.1002/clc.4960251105 Olthof, 2006, Effect of folic acid and betaine supplementation on flow-mediated dilation: a randomized, controlled study in healthy volunteers, PLoS Clin Trials, 1, e10, 10.1371/journal.pctr.0010010 de Bree, 2007, Folic acid improves vascular reactivity in humans: a meta-analysis of randomized controlled trials, Am J Clin Nutr, 86, 610, 10.1093/ajcn/86.3.610 Follmann, 1992, Variance imputation for overviews of clinical trials with continuous response, J Clin Epidemiol, 45, 769, 10.1016/0895-4356(92)90054-Q Franklin, 2001, Does the relation of blood pressure to coronary heart disease risk change with aging? The Framingham Heart Study, Circulation, 103, 1245, 10.1161/01.CIR.103.9.1245 Bowman, 2006, Blood pressure measures and risk of total, ischemic, and hemorrhagic stroke in men, Neurology, 67, 820, 10.1212/01.wnl.0000233981.26176.e1 Menotti, 2006, The relationship of age, blood pressure, serum cholesterol and smoking habits with the risk of typical and atypical coronary heart disease death in the European cohorts of the Seven Countries Study, Int J Cardiol, 106, 157, 10.1016/j.ijcard.2004.12.092 Witte, 2005, Is the association between flow-mediated dilation and cardiovascular risk limited to low-risk populations?, J Am Coll Cardiol, 45, 1987, 10.1016/j.jacc.2005.02.073 Brevetti, 2003, Endothelial dysfunction and cardiovascular risk prediction in peripheral arterial disease: additive value of flow-mediated dilation to ankle-brachial pressure index, Circulation, 108, 2093, 10.1161/01.CIR.0000095273.92468.D9 Stehouwer, 2003, Does homocysteine cause hypertension?, Clin Chem Lab Med, 41, 1408, 10.1515/CCLM.2003.216 Tawakol, 2005, High-dose folic acid acutely improves coronary vasodilator function in patients with coronary artery disease, J Am Coll Cardiol, 45, 1580, 10.1016/j.jacc.2005.02.038 Usui, 1999, Endothelial dysfunction by acute hyperhomocyst(e)inaemia: restoration by folic acid, Clin Sci (Lond), 96, 235, 10.1042/CS19980382 McDowell, 2000, Homocysteine and endothelial dysfunction: a link with cardiovascular disease, J Nutr, 130, 369S, 10.1093/jn/130.2.369S Pruefer, 1999, Homocysteine provokes leukocyte-endothelium interaction by downregulation of nitric oxide, Gen Pharmacol, 33, 487, 10.1016/S0306-3623(99)00045-2 Kahleová, 2002, Essential hypertension in adolescents: association with insulin resistance and with metabolism of homocysteine and vitamins, Am J Hypertens, 15, 857, 10.1016/S0895-7061(02)02984-9 Lim, 2002, Homocysteine and blood pressure in the Third National Health and Nutrition Examination Survey, 1988-1994, Am J Epidemiol, 156, 1105, 10.1093/aje/kwf157 van Dijk, 2001, Arterioscler Thromb Vasc Biol, 21, 2072, 10.1161/hq1201.100223 Kedziora-Kornatowska, 2004, The markers of oxidative stress and activity of the antioxidant system in the blood of elderly patients with essential arterial hypertension, Cell Mol Biol Lett, 9, 635 Bellamy, 1998, Hyperhomocysteinemia after an oral methionine load acutely impairs endothelial function in healthy adults, Circulation, 98, 1848, 10.1161/01.CIR.98.18.1848 2002, Homocysteine and risk of ischemic heart disease and stroke: a meta-analysis, JAMA, 288, 2015, 10.1001/jama.288.16.2015 Verhaar, 1998, 5-Methyltetrahydrofolate, the active form of folic acid, restores endothelial function in familial hypercholesterolemia, Circulation, 97, 237, 10.1161/01.CIR.97.3.237 Stroes, 2000, Folic acid reverts dysfunction of endothelial nitric oxide synthase, Circ Res, 86, 1129, 10.1161/01.RES.86.11.1129 Huang, 2000, Ascorbic acid enhances endothelial nitric-oxide synthase activity by increasing intracellular tetrahydrobiopterin, J Biol Chem, 275, 17399, 10.1074/jbc.M002248200 Baker, 2001, Effect of vitamin C on the availability of tetrahydrobiopterin in human endothelial cells, J Cardiovasc Pharmacol, 37, 333, 10.1097/00005344-200103000-00012 Heller, 2001, l-ascorbic acid potentiates endothelial nitric oxide synthesis via a chemical stabilization of tetrahydrobiopterin, J Biol Chem, 276, 40, 10.1074/jbc.M004392200 Xia, 1998, Superoxide generation from endothelial nitric-oxide synthase. A Ca2+/calmodulin-dependent and tetrahydrobiopterin regulatory process, J Biol Chem, 273, 25804, 10.1074/jbc.273.40.25804 Vásquez-Vivar, 1998, Superoxide generation by endothelial nitric oxide synthase: the influence of cofactors, Proc Natl Acad Sci U S A, 95, 9220, 10.1073/pnas.95.16.9220 Vásquez-Vivar, 2003, The role of tetrahydrobiopterin in superoxide generation from eNOS: enzymology and physiological implications, Free Radic Res, 37, 121, 10.1080/1071576021000040655 Alp, 2004, Regulation of endothelial nitric oxide synthase by tetrahydrobiopterin in vascular disease, Arterioscler Thromb Vasc Biol, 24, 413, 10.1161/01.ATV.0000110785.96039.f6 Stroes, 1998, Origin of superoxide production by endothelial nitric oxide synthase, FEBS Lett, 438, 161, 10.1016/S0014-5793(98)01292-7 Dixon, 2003, Functional consequences of endothelial nitric oxide synthase uncoupling in congestive cardiac failure, Circulation, 107, 1725, 10.1161/01.CIR.0000066283.13253.78 Verhaar, 2002, Folates and cardiovascular disease, Arterioscler Thromb Vasc Biol, 22, 6, 10.1161/hq0102.102190 Moat, 2006, Folic acid reverses endothelial dysfunction induced by inhibition of tetrahydrobiopterin biosynthesis, Eur J Pharmacol, 530, 250, 10.1016/j.ejphar.2005.11.047 Hyndman, 2002, Interaction of 5-methyltetrahydrofolate and tetrahydrobiopterin on endothelial function, Am J Physiol Heart Circ Physiol, 282, H2167, 10.1152/ajpheart.00935.2001 Doshi, 2004, Short-term high-dose folic acid does not alter markers of endothelial cell damage in patients with coronary heart disease, Int J Cardiol, 94, 203, 10.1016/j.ijcard.2003.04.004 Bazzano, 2006, Effect of folic acid supplementation on risk of cardiovascular diseases: a meta-analysis of randomized controlled trials, JAMA, 296, 2720, 10.1001/jama.296.22.2720 Bostom, 2006, Rationale and design of the Folic Acid for Vascular Outcome Reduction In Transplantation (FAVORIT) trial, Am Heart J, 152, 448.e1, 10.1016/j.ahj.2006.03.004 2006, Homocysteine-lowering trials for prevention of cardiovascular events: a review of the design and power of the large randomized trials, Am Heart J, 151, 282, 10.1016/j.ahj.2005.04.025 Cole, 2007, Folic acid for the prevention of colorectal adenomas: a randomized clinical trial, JAMA, 297, 2351, 10.1001/jama.297.21.2351 Hultdin, 2005, Plasma folate, vitamin B12, and homocysteine and prostate cancer risk: a prospective study, Int J Cancer, 113, 819, 10.1002/ijc.20646 Stevens, 2006, Folate nutrition and prostate cancer incidence in a large cohort of US men, Am J Epidemiol, 163, 989, 10.1093/aje/kwj126 Kim, 2003, Role of folate in colon cancer development and progression, J Nutr, 133, 3731S, 10.1093/jn/133.11.3731S Kim, 2004, Will mandatory folic acid fortification prevent or promote cancer?, Am J Clin Nutr, 80, 1123, 10.1093/ajcn/80.5.1123 Campbell, 1996, How safe are folic acid supplements?, Arch Intern Med, 156, 1638, 10.1001/archinte.1996.00440140058005