High-content approaches to anthelmintic drug screening

Trends in Parasitology - Tập 37 - Trang 780-789 - 2021
Mostafa Zamanian1, John D. Chan1,2
1Department of Pathobiological Sciences, University of Wisconsin, Madison, WI, USA
2Department of Chemistry, University of Wisconsin –, Oshkosh, WI, USA

Tài liệu tham khảo

de Moraes, 2020, FDA-approved antiparasitic drugs in the 21st century: a success for helminthiasis?, Trends Parasitol., 36, 573, 10.1016/j.pt.2020.04.005 Wolstenholme, 2004, Drug resistance in veterinary helminths, Trends Parasitol., 20, 469, 10.1016/j.pt.2004.07.010 Geary, 2015, Anthelmintic drug discovery: into the future, J. Parasitol., 101, 125, 10.1645/14-703.1 Nixon, 2020, Where are all the anthelmintics? Challenges and opportunities on the path to new anthelmintics, Int. J. Parasitol. Drugs Drug Resist., 14, 8, 10.1016/j.ijpddr.2020.07.001 Reimers, 2015, Drug-induced exposure of Schistosoma mansoni antigens SmCD59a and SmKK7, PLoS Negl. Trop. Dis., 9, 10.1371/journal.pntd.0003593 Panic, 2017, Immunohistochemical investigations of treatment with Ro 13-3978, praziquantel, oxamniquine, and mefloquine in Schistosoma mansoni-infected mice, Antimicrob. Agents Chemother., 61, 10.1128/AAC.01142-17 McCusker, 2021, Schistosoma mansoni alter transcription of immunomodulatory gene products following in vivo praziquantel exposure, PLoS Negl. Trop. Dis., 15, 10.1371/journal.pntd.0009200 Chan, 2017, The anthelmintic praziquantel is a human serotoninergic G-protein-coupled receptor ligand, Nat. Commun., 8, 1910, 10.1038/s41467-017-02084-0 Eyoh, 2019, The anthelmintic drug praziquantel promotes human Tr1 differentiation, Immunol. Cell Biol., 97, 512, 10.1111/imcb.12229 Moreno, 2010, Ivermectin disrupts the function of the excretory-secretory apparatus in microfilariae of Brugia malayi, Proc. Natl. Acad. Sci. U. S. A., 107, 20120, 10.1073/pnas.1011983107 Berrafato, 2019, Macrocyclic lactone anthelmintic-induced leukocyte binding to Dirofilaria immitis microfilariae: Influence of the drug resistance status of the parasite, Int. J. Parasitol. Drugs Drug Resist., 10, 45, 10.1016/j.ijpddr.2019.04.004 Martin, 2021, Ivermectin: an anthelmintic, an insecticide, and much more, Trends Parasitol., 37, 48, 10.1016/j.pt.2020.10.005 Hawking, 1948, Mode of action of hetrazan in filariasis, Lancet, 2, 730, 10.1016/S0140-6736(48)91165-9 Verma, 2020, Diethylcarbamazine activates TRP channels including TRP-2 in filaria, Brugia malayi, Commun. Biol., 3 Denham, 1978, Studies with Brugia pahangi 17. The anthelmintic effects of diethylcarbamazine, J. Parasitol., 64, 463, 10.2307/3279784 Cesbron, 1987, Platelets mediate the action of diethylcarbamazine on microfilariae, Nature, 325, 533, 10.1038/325533a0 McGarry, 2005, Diethylcarbamazine activity against Brugia malayi microfilariae is dependent on inducible nitric-oxide synthase and the cyclooxygenase pathway, Filaria J., 4, 4, 10.1186/1475-2883-4-4 Xiao, 2001, Artemether administered together with haemin damages schistosomes in vitro, Trans. R. Soc. Trop. Med. Hyg., 95, 67, 10.1016/S0035-9203(01)90336-0 Probst, 2020, Efficacy, metabolism and pharmacokinetics of Ro 15-5458, a forgotten schistosomicidal 9-acridanone hydrazone, J. Antimicrob. Chemother., 75, 2925, 10.1093/jac/dkaa247 Keiser, 2015, Aryl hydantoin Ro 13-3978, a broad-spectrum antischistosomal, J. Antimicrob. Chemother., 70, 1788, 10.1093/jac/dkv016 Pica-Mattoccia, 1989, Binding of oxamniquine to the DNA of schistosomes, Trans. R. Soc. Trop. Med. Hyg., 83, 373, 10.1016/0035-9203(89)90508-7 Nwaka, 2006, Innovative lead discovery strategies for tropical diseases, Nat. Rev. Drug Discov., 5, 941, 10.1038/nrd2144 Burns, 2015, Caenorhabditis elegans is a useful model for anthelmintic discovery, Nat. Commun., 6, 7485, 10.1038/ncomms8485 Burns, 2017, The novel nematicide wact-86 interacts with aldicarb to kill nematodes, PLoS Negl. Trop. Dis., 11, 10.1371/journal.pntd.0005502 Kamal, 2019, The marginal cells of the Caenorhabditis elegans pharynx scavenge cholesterol and other hydrophobic small molecules, Nat. Commun., 10, 3938, 10.1038/s41467-019-11908-0 Geary, 1999, Mechanism-based screening: discovery of the next generation of anthelmintics depends upon more basic research, Int. J. Parasitol., 29, 105, 10.1016/S0020-7519(98)00170-2 Elfawal, 2019, Drug screening for discovery of broad-spectrum agents for soil-transmitted nematodes, Sci. Rep., 9, 12347, 10.1038/s41598-019-48720-1 Mansour, 2016, High throughput screening identifies novel lead compounds with activity against larval, juvenile and adult Schistosoma mansoni, PLoS Negl. Trop. Dis., 10, 10.1371/journal.pntd.0004659 Guidi, 2017, Discovery by organism based high-throughput screening of new multi-stage compounds affecting Schistosoma mansoni viability, egg formation and production, PLoS Negl. Trop. Dis., 11, 10.1371/journal.pntd.0005994 Moffat, 2017, Opportunities and challenges in phenotypic drug discovery: an industry perspective, Nat. Rev. Drug Discov., 16, 531, 10.1038/nrd.2017.111 Voronin, 2019, Development of a preliminary in vitro drug screening assay based on a newly established culturing system for pre-adult fifth-stage Onchocerca volvulus worms, PLoS Negl. Trop. Dis., 13, 10.1371/journal.pntd.0007108 Malkmus, 2020, Preliminary evaluations of 3-dimensional human skin models for their ability to facilitate in vitro the long-term development of the debilitating obligatory human parasite Onchocerca volvulus, PLoS Negl. Trop. Dis., 14, 10.1371/journal.pntd.0008503 Feather, 2017, Ancylostoma ceylanicum infective third-stage larvae are activated by co-culture with HT-29-MTX intestinal epithelial cells, Parasit. Vectors, 10, 606, 10.1186/s13071-017-2513-x Duque-Correa, 2020, Organoids – new models for host–helminth interactions, Trends Parasitol., 36, 170, 10.1016/j.pt.2019.10.013 Vatta, 2014, Ivermectin-dependent attachment of neutrophils and peripheral blood mononuclear cells to Dirofilaria immitis microfilariae in vitro, Vet. Parasitol., 1–2, 38, 10.1016/j.vetpar.2014.02.004 Bulman, 2015, Repurposing auranofin as a lead candidate for treatment of lymphatic filariasis and onchocerciasis, PLoS Negl. Trop. Dis., 9, 10.1371/journal.pntd.0003534 Keiser, 2016, Evaluation of an FDA approved library against laboratory models of human intestinal nematode infections, Parasit. Vectors, 9, 376, 10.1186/s13071-016-1616-0 Abdulla, 2009, Drug discovery for schistosomiasis: hit and lead compounds identified in a library of known drugs by medium-throughput phenotypic screening, PLoS Negl. Trop. Dis., 3, 10.1371/journal.pntd.0000478 Panic, 2015, Activity profile of an FDA-approved compound library against Schistosoma mansoni, PLoS Negl. Trop. Dis., 9, 10.1371/journal.pntd.0003962 Duguet, 2020, Identification of annotated bioactive molecules that impair motility of the blood fluke Schistosoma mansoni, Int. J. Parasitol. Drugs Drug Resist., 13, 73, 10.1016/j.ijpddr.2020.05.002 Spensley, 2018, Acute effects of drugs on Caenorhabditis elegans movement reveal complex responses and plasticity, G3, 8, 2941, 10.1534/g3.118.200374 Del Borrello, 2019, Rhodoquinone biosynthesis in C. elegans requires precursors generated by the kynurenine pathway, eLife, 8, 10.7554/eLife.48165 Mostafa, 2015, Transient effects of levamisole on Brugia malayi microfilariae, Invertebr. Neurosci., 15, 5, 10.1007/s10158-015-0181-0 Loghry, 2020, Ivermectin inhibits extracellular vesicle secretion from parasitic nematodes, J. Extracell. Vesicles, 10, 10.1002/jev2.12036 Moreno, 2021, When secretomes meet anthelmintics: Lessons for therapeutic interventions, Trends Parasitol., 37, 468, 10.1016/j.pt.2021.01.007 Jawahar, 2021, Drugs that target early stages of Onchocerca volvulus: A revisited means to facilitate the elimination goals for onchocerciasis, PLoS Negl. Trop. Dis., 15, 10.1371/journal.pntd.0009064 Chen, 2020, A multi-dimensional, time-lapse, high content screening platform applied to schistosomiasis drug discovery, Commun. Biol., 3, 747, 10.1038/s42003-020-01402-5 McDermott-Rouse, 2021, Behavioral fingerprints predict insecticide and anthelmintic mode of action, bioRxiv Gunderson, 2020, The endosymbiont Wolbachia rebounds following antibiotic treatment, PLoS Pathog., 16, 10.1371/journal.ppat.1008623 Jumani, 2019, A suite of phenotypic assays to ensure pipeline diversity when prioritizing drug-like Cryptosporidium growth inhibitors, Nat. Commun., 10, 1862, 10.1038/s41467-019-09880-w Abraham, 2020, Probing the Open Global Health Chemical Diversity Library for multistage-active starting points for next-generation antimalarials, ACS Infect. Dis., 6, 613, 10.1021/acsinfecdis.9b00482 Chandrasekaran, 2021, Image-based profiling for drug discovery: due for a machine-learning upgrade?, Nat. Rev. Drug Discov., 20, 145, 10.1038/s41573-020-00117-w Harischandra, 2018, Profiling extracellular vesicle release by the filarial nematode Brugia malayi reveals sex-specific differences in cargo and a sensitivity to ivermectin, PLoS Negl. Trop. Dis., 12, 10.1371/journal.pntd.0006438 James, 2007, A rapid colorimetric assay for the quantitation of the viability of free-living larvae of nematodes in vitro, Parasitol. Res., 101, 975, 10.1007/s00436-007-0572-1 Howe, 2015, Lactate as a novel quantitative measure of viability in Schistosoma mansoni drug sensitivity assays, Antimicrob. Agents Chemother., 59, 1193, 10.1128/AAC.03809-14 Lalli, 2015, Development and validation of a luminescence-based, medium-throughput assay for drug screening in Schistosoma mansoni, PLoS Negl. Trop. Dis., 9, 10.1371/journal.pntd.0003484 Aguiar, 2017, A high-throughput colorimetric assay for detection of Schistosoma mansoni viability based on the tetrazolium salt XTT, Parasit. Vectors, 10, 300, 10.1186/s13071-017-2240-3 Hovlid, 2016, Phenotypic screens in antimalarial drug discovery, Trends Parasitol., 32, 697, 10.1016/j.pt.2016.04.014 Babes, 2017, The anthelminthic drug praziquantel is a selective agonist of the sensory transient receptor potential melastatin type 8 channel, Toxicol. Appl. Pharmacol., 336, 55, 10.1016/j.taap.2017.10.012 Park, 2019, The anthelmintic drug praziquantel activates a schistosome transient receptor potential channel, J. Biol. Chem., 294, 18873, 10.1074/jbc.AC119.011093 Swinney, 2011, How were new medicines discovered?, Nat. Rev. Drug Discov., 10, 507, 10.1038/nrd3480 International Helminth Genomes Consortium, 2019, Comparative genomics of the major parasitic worms, Nat. Genet., 51, 163, 10.1038/s41588-018-0262-1 Curran, 2020, Modeling the metabolic interplay between a parasitic worm and its bacterial endosymbiont allows the identification of novel drug targets, eLife, 9, 10.7554/eLife.51850 Bryant, 2018, A critical role for thermosensation in host seeking by skin-penetrating nematodes, Curr. Biol., 28, 2338, 10.1016/j.cub.2018.05.063 Lok, 2019, CRISPR/Cas9 mutagenesis and expression of dominant mutant transgenes as functional genomic approaches in parasitic nematodes, Front. Genet., 10, 656, 10.3389/fgene.2019.00656 Liu, 2020, In vivo imaging of transgenic Brugia malayi, PLoS Negl. Trop. Dis., 14, 10.1371/journal.pntd.0008182 Ittiprasert, 2019, Programmed genome editing of the omega-1 ribonuclease of the blood fluke, Schistosoma mansoni, eLife, 8, 10.7554/eLife.41337 Anderson, 2018, Genetic crosses and linkage mapping in schistosome parasites, Trends Parasitol., 34, 982, 10.1016/j.pt.2018.08.001 Doyle, 2019, Genome-wide approaches to investigate anthelmintic resistance, Trends Parasitol., 35, 289, 10.1016/j.pt.2019.01.004 Wit, 2021, Complementary approaches with free-living and parasitic nematodes to understanding anthelmintic resistance, Trends Parasitol., 37, 240, 10.1016/j.pt.2020.11.008 Hansen, 2017, Pathway of oxfendazole from the host into the worm: Trichuris suis in pigs, Int. J. Parasitol. Drugs Drug Resist., 7, 416, 10.1016/j.ijpddr.2017.11.002 Rottmann, 2010, Spiroindolones, a potent compound class for the treatment of malaria, Science, 329, 1175, 10.1126/science.1193225 Zhang, 2020, A marine microbiome antifungal targets urgent-threat drug-resistant fungi, Science, 370, 974, 10.1126/science.abd6919 Gao, 2019, A rotifer-derived paralytic compound prevents transmission of schistosomiasis to a mammalian host, PLoS Biol., 17, 10.1371/journal.pbio.3000485 Walker, 2017, Macrofilaricidal efficacy of repeated doses of ivermectin for the treatment of river blindness, Clin. Infect. Dis., 65, 2026, 10.1093/cid/cix616 Archer, 1985, The chemotherapy of schistosomiasis, Annu. Rev. Pharmacol. Toxicol., 25, 485, 10.1146/annurev.pa.25.040185.002413 Valentim, 2013, Genetic and molecular basis of drug resistance and species-specific drug action in schistosome parasites, Science, 342, 1385, 10.1126/science.1243106 Nare, 1992, Mechanisms of inactivation of Schistosoma mansoni and mammalian glutathione S-transferase activity by the antischistosomal drug oltipraz, Biochem. Pharmacol., 43, 1345, 10.1016/0006-2952(92)90512-H Tracy, 1983, Reductive metabolism of niridazole by adult Schistosoma mansoni. Correlation with covalent drug binding to parasite macromolecules, Mol. Pharmacol., 24, 291 Wang, 2015, Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum, Nat. Commun., 6, 10111, 10.1038/ncomms10111