High ambient temperature and risk of intestinal obstruction in cystic fibrosis

Journal of Paediatrics and Child Health - Tập 52 Số 4 - Trang 430-435 - 2016
Chee Y. Ooi1,2, Christina Jeyaruban2, J. Y. W. Lau2, Tamarah Katz3, A. Matson4,5, Scott C. Bell4,6, Susan Adams7,2, Usha Krishnan1,2
1Department of Gastroenterology, Sydney Children's Hospital Randwick, Randwick, New South Wales, Australia
2Discipline of Paediatrics, School of Women's and Children's Health, Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia
3Department of Nutrition and Dietetics, Sydney Children's Hospital Randwick, Randwick, New South Wales, Australia
4Adult Cystic Fibrosis Centre, The Prince Charles Hospital, Brisbane, Queensland, Australia
5Department of Nutrition and Dietetics, The Prince Charles Hospital, Brisbane, Queensland, Australia
6Queensland Children’s Medical Research Institute, Brisbane, Queensland, Australia
7Department of Paediatric Surgery, Sydney Children's Hospital Randwick, Randwick, New South Wales, Australia

Tóm tắt

AimsDistal intestinal obstruction syndrome (DIOS) and constipation in cystic fibrosis (CF) are conditions associated with impaction and/or obstruction by abnormally viscid mucofaecal material within the intestinal lumen. Dehydration has been proposed as a risk factor for DIOS and constipation in CF. The study primarily aimed to determine whether warmer ambient temperature and lower rainfall are risk factors for DIOS and constipation in CF.MethodsHospitalisations for DIOS (incomplete or complete) and/or constipation were retrospectively identified (2000–2012). Genotype, phenotype, temperatures and rainfall data (for the week preceding and season of hospitalisation) were collected.ResultsTwenty‐seven DIOS (59.3% incomplete; 40.7% complete) and 44 constipation admissions were identified. All admitted patients were pancreatic insufficient. Meconium ileus was significantly more likely in DIOS than constipation (64.7% vs. 33.3%; P = 0.038) and in complete than incomplete DIOS (100% vs. 57.1%; P = 0.04). The maximum temperature of the week before DIOS admission (mean (standard deviation) = 28.0 (5.8) °C) was significantly higher than the maximum temperature of the season of admission (25.2 (3.4) °C; P = 0.002). Similarly, the maximum temperature of the week before hospitalisation for constipation (mean (standard deviation) = 27.9 (6.3) °C) was significantly warmer compared with the season of admission (24.0 (4.1) °C; P < 0.0001). There were no significant differences between levels of rainfall during the week before hospitalisation and the season of admission for both DIOS and constipation.ConclusionsRelatively high ambient temperature may play a role in the pathogenesis of DIOS and constipation in CF.

Từ khóa


Tài liệu tham khảo

10.1016/S0022-3476(89)80134-9

10.1016/S0140-6736(09)60327-5

10.1097/MPG.0000000000000683

10.1155/2012/948367

10.1097/MPG.0b013e3182769768

10.1053/j.gastro.2010.09.046

10.1016/j.jcf.2012.05.001

10.1111/jgh.12842

10.1097/MPG.0b013e3181a6e01d

10.1016/S1542-3565(04)00169-7

10.1007/s11605-009-0924-5

10.1016/j.jcf.2009.11.003

10.1371/journal.pone.0027784

10.1128/JCM.01360-13

10.1016/j.dld.2003.10.008

10.1067/mpd.2002.129845

10.1164/ajrccm.159.1.9712108

10.1053/j.gastro.2006.07.016

10.1136/gut.52.8.1159

10.1007/s11894-011-0185-9

10.1093/ije/dyp176

10.1136/gut.27.1.41

Thông tin
Thông tin xuất bản

Journal of Paediatrics and Child Health

Tập 52 Số 4

430-435

Thông tin tác giả