High altitude training of dogs results in elevated erythropoietin and endothelin-1 serum levels

Banks, 1998, Release of the angiogenic cytokine vascular endothelial growth factor (VEGF) from platelets. Significance for VEGF measurements and cancer biology, Br. J. Cancer, 77, 956, 10.1038/bjc.1998.158 Biondo, 2003, Comparative sequences of canine and feline endothelin1, Vet. Clin. Pathol., 32, 188, 10.1111/j.1939-165X.2003.tb00334.x Chen, 2000, Endothelin and pulmonary hypertension, J. Cardiovasc. Pharmacol., 35, S49, 10.1097/00005344-200000002-00012 Christou, 1998, Increased vascular endothelial growth factor production in the lungs of rats with hypoxia-induced pulmonary hypertension, Am. J. Respir. Cell Mol. Biol., 18, 768, 10.1165/ajrcmb.18.6.2980 Clifford, 2001, Plasma vascular endothelial growth factor concentrations in healthy dogs and dogs with hemangiosarcoma, J. Vet. Intern. Med., 14, 131, 10.1111/j.1939-1676.2001.tb01244.x Cook, 1994, Serum erythropoietin concentrations measured by radioimmunoassay in normal, polycythemic, and anemic dogs and cats, J. Vet. Intern. Med., 8, 18, 10.1111/j.1939-1676.1994.tb03191.x Douglas, 1993, Endothelin-1 does not mediate hypoxic vasoconstriction in canine isolated blood vessels: effect of BQ-123, Br. J. Pharmacol., 108, 418, 10.1111/j.1476-5381.1993.tb12819.x Glaus, 2003, Non-invasive measurement of cardiovascular effects of chronic hypoxaemia on dogs living at moderately high altitude, Vet. Rec., 152, 800, 10.1136/vr.152.26.800 Glaus, 2003, Pulmonary hypertension induced by hypoxia at different high-altitude levels in dogs, Vet. Res. Commun., 27, 661, 10.1023/A:1027380614534 Glaus, 2004, Echocardiographic changes induced by moderate to marked hypobaric hypoxia in dogs, Vet. Radiol. Ultrasound, 45, 233, 10.1111/j.1740-8261.2004.04041.x Goerre, 1995, Endothelin-1 in pulmonary hypertension associated with high-altitude exposure, Circulation, 91, 359, 10.1161/01.CIR.91.2.359 Grosenbaugh, 1998, Evaluation of a portable clinical analyser in a veterinary hospital setting, J. Am. Vet. Med. Assoc., 213, 691 Grover, 1988, Pulmonary hypertension and pulmonary vascular reactivity in beagles at high altitude, J. Appl. Physiol., 65, 2632, 10.1152/jappl.1988.65.6.2632 Grover, 1998, The influence of environmental factors on the cardiovascular system, 2327 Heinicke, 2003, Long-term exposure to intermittent hypoxia results in increased hemoglobin mass, reduced plasma volume, and elevated erythropoietin plasma levels in man, Eur. J. Appl. Physiol. Occup. Physiol., 88, 535, 10.1007/s00421-002-0732-z Hopfl, 2004, HIFs and tumors—causes and consequences, Am. J. Physiol., 286, R608 Horgan, 1991, Mechanism of endothelin-1-induced pulmonary vasoconstriction, Circ. Res., 69, 157, 10.1161/01.RES.69.1.157 Keith, 2000, The role of endogenous lung neuropeptides in regulation of the pulmonary circulation, Physiol. Res., 49, 519 Koistinen, 2000, EPO, red cells, and serum transferring receptor in continuous and intermittent hypoxia, Med. Sci. Sports Exerc., 32, 800, 10.1097/00005768-200004000-00012 Louzier, 2003, Role of VEGF-B in the lung during development of chronic hypoxic pulmonary hypertension, Am. J. Physiol., Lung Cell. Mol. Physiol., 284, L926, 10.1152/ajplung.00247.2002 Mazzeo, 1994, Sympathetic response during 21 days at high altitude (4300 m) as determined by urinary and arterial catecholamines, Metabolism, 43, 1226, 10.1016/0026-0495(94)90215-1 Partovian, 2000, Adenovirus-mediated lung vascular endothelial growth factor overexpression protects against hypoxic pulmonary hypertension in rats, Am. J. Respir. Cell Mol. Biol., 23, 762, 10.1165/ajrcmb.23.6.4106 Pechereau, 1997, Plasma erythropoietin concentrations in dogs and cats: reference values and changes with anaemia and/or chronic renal failure, Res. Vet. Sci., 62, 185, 10.1016/S0034-5288(97)90144-2 Sanchez, 1970, Simultaneous measurement of plasma volume and cell mass in polycythemia of high altitude, J. Appl. Physiol., 28, 775, 10.1152/jappl.1970.28.6.775 Scheidegger, 1999, Vascular endothelial growth factor (VEGF) and its receptors in tumour-bearing dogs, Biol. Chem., 380, 1449, 10.1515/BC.1999.187 Syvertsen, 1973, Erythropoietin production in dogs exposed to high altitude and carbon monoxide, Am. J. Physiol., 225, 293, 10.1152/ajplegacy.1973.225.2.293 Voelkl, 2002, Janus face of vascular endothelial growth factor: the obligatory survival factor for lung vascular endothelium controls precapillary artery remodelling in severe pulmonary hypertension, Crit. Care Med., 30, 251, 10.1097/00003246-200205001-00013 Vollmar, 1995, Endothelin concentration in plasma of healthy dogs and dogs with congestive heart failure, renal failure, diabetes mellitus, and hyperadrenocorticism, J. Vet. Intern. Med., 9, 105, 10.1111/j.1939-1676.1995.tb03280.x Webb, 1998, Vascular endothelial growth factor (VEGF) is released from platelets during blood clotting: implications for measurement of circulating VEGF levels in clinical disease, Clin. Sci., 94, 395, 10.1042/cs0940395 Wenger, 2000, Mammalian oxygen sensing, signalling and gene regulation, J. Exp. Biol., 203, 1253, 10.1242/jeb.203.8.1253 Wergin, 2004, Plasma vascular endothelial growth factor (VEGF) measured in seventy dogs with spontaneously occurring tumours, In Vivo, 18, 15 Wolfel, 1994, Systemic hypertension at 4300 m is related to sympathoadrenal activity, J. Appl. Physiol., 76, 1643, 10.1152/jappl.1994.76.4.1643