High Thyroid-stimulating Hormone Levels Increase Proinflammatory and Cardiovascular Markers in Patients with Extreme Obesity

Archives of Medical Research - Tập 47 - Trang 476-482 - 2016
Jaime Héctor Gómez-Zamudio1, Victoria Mendoza-Zubieta2, Aldo Ferreira-Hermosillo2, Marío Antonio Molina-Ayala2, Adán Valladares-Sálgado1, Fernando Suárez-Sánchez1, Jose de Jesús Peralta-Romero1, Miguel Cruz1
1Unidad de Investigación Médica en Bioquímica, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, México City, México
2Clínica de Obesidad, Servicio de Endocrinología, Unidad Médica de Alta Especialidad, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, México City, México

Tài liệu tham khảo

Eshita, 2014, A novel link between leptin, TSH and obesity among hypothyroid patients, Int J Curr Sci, 13, E98 Gutiérrez, 2012 Haslam, 2005, Obesity, Lancet, 366, 1197, 10.1016/S0140-6736(05)67483-1 Michalaki, 2006, Thyroid function in humans with morbid obesity, Thyroid, 16, 73, 10.1089/thy.2006.16.73 Krotkiewski, 2002, Thyroid hormones in the pathogenesis and treatment of obesity, Eur J Pharmacol, 440, 85, 10.1016/S0014-2999(02)01420-6 Garber, 2012, Clinical practice guidelines for hypothyroidism in adults: cosponsored by the American Association of Clinical Endocrinologists and the American Thyroid Association, Endocr Pract, 18, 988, 10.4158/EP12280.GL Santini, 2014, Mechanisms in endocrinology: The crosstalk between thyroid gland and adipose tissue: signal integration in health and disease, Eur J Endocrinol, 171, R137, 10.1530/EJE-14-0067 Verma, 2008, Hypothyroidism and obesity. Cause or effect?, Saudi Med J, 29, 1135 Bakiner, 2014, Are plasma thyroid-stimulating hormone levels associated with degree of obesity and metabolic syndrome in euthyroid obese patients? A Turkish cohort study, ISRN Endocrinol, 2014, 803028, 10.1155/2014/803028 de Moura, 2011, Association between serum TSH concentration within the normal range and adiposity, Eur J Endocrinol, 165, 11, 10.1530/EJE-11-0261 Spoto, 2014, Pro- and anti-inflammatory cytokine gene expression in subcutaneous and visceral fat in severe obesity, Nutr Metab Cardiovasc Dis, 24, 1137, 10.1016/j.numecd.2014.04.017 Trayhurn, 2004, Adipokines: inflammation and the pleiotropic role of white adipose tissue, Br J Nutr, 92, 347, 10.1079/BJN20041213 Yaturu, 2004, Changes in adipocyte hormones leptin, resistin, and adiponectin in thyroid dysfunction, J Cell Biochem, 93, 491, 10.1002/jcb.20188 Zhang, 2014, Fat cell size and adipokine expression in relation to gender, depot, and metabolic risk factors in morbidly obese adolescents, Obesity (Silver Spring), 22, 691, 10.1002/oby.20528 Bonetti, 2003, Endothelial dysfunction: a marker of atherosclerotic risk, Arterioscler Thromb Vasc Biol, 23, 168, 10.1161/01.ATV.0000051384.43104.FC Kaperonis, 2006, Inflammation and atherosclerosis, Eur J Vasc Endovasc Surg, 31, 386, 10.1016/j.ejvs.2005.11.001 Kvetny, 2004, Subclinical hypothyroidism is associated with a low-grade inflammation, increased triglyceride levels and predicts cardiovascular disease in males below 50 years, Clin Endocrinol (Oxf), 61, 232, 10.1111/j.1365-2265.2004.02088.x Taddei, 2006, Low-grade systemic inflammation causes endothelial dysfunction in patients with Hashimoto's thyroiditis, J Clin Endocrinol Metab, 91, 5076, 10.1210/jc.2006-1075 Hak, 2000, Subclinical hypothyroidism is an independent risk factor for atherosclerosis and myocardial infarction in elderly women: the Rotterdam Study, Ann Intern Med, 132, 270, 10.7326/0003-4819-132-4-200002150-00004 Valentina, 2011, Subclinical hypothyroidism and risk to carotid atherosclerosis, Arq Bras Endocrinol Metabol, 55, 475, 10.1590/S0004-27302011000700007 Moulin de Moraes, 2005, Prevalence of subclinical hypothyroidism in a morbidly obese population and improvement after weight loss induced by Roux-en-Y gastric bypass, Obes Surg, 15, 1287, 10.1381/096089205774512537 Rotondi, 2010, Risk of coronary heart disease and mortality for adults with subclinical hypothyroidism, JAMA, 304, 2481, 10.1001/jama.2010.1786 Matthews, 1985, Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man, Diabetologia, 28, 412, 10.1007/BF00280883 Marchiori, 2015, Improvement of blood inflammatory marker levels in patients with hypothyroidism under levothyroxine treatment, BMC Endocr Disord, 15, 32, 10.1186/s12902-015-0032-3 Rotondi, 2009, Raised serum TSH levels in patients with morbid obesity: is it enough to diagnose subclinical hypothyroidism?, Eur J Endocrinol, 160, 403, 10.1530/EJE-08-0734 Montoya-Morales, 2015, Rev Med Inst Mex Seguro Soc, 53 Suppl 1, S18 Shao, 2014, Dietary high-fat lard intake induces thyroid dysfunction and abnormal morphology in rats, Acta Pharmacol Sin, 35, 1411, 10.1038/aps.2014.82 Laway, 2014, Alteration of lipid parameters in patients with subclinical hypothyroidism, Int J Endocrinol Metab, 12, e17496, 10.5812/ijem.17496 Rotondi, 2014, Raised serum TSH in morbid-obese and non-obese patients: effect on the circulating lipid profile, Endocrine, 45, 92, 10.1007/s12020-013-9928-8 Tagliaferri, 2001, Subclinical hypothyroidism in obese patients: relation to resting energy expenditure, serum leptin, body composition, and lipid profile, Obes Res, 9, 196, 10.1038/oby.2001.21 Gierach, 2015, The effect of hypothyroidism occurring in patients with metabolic syndrome, Endokrynol Pol, 66, 288, 10.5603/EP.2015.0036 Ozdemir, 2015, Serum adiponectin levels and changes in glucose metabolism before and after treatment for thyroid dysfunction, Intern Med, 54, 1849, 10.2169/internalmedicine.54.0668 Anantarapu, 2015, Effects of thyroid hormone replacement on glycated hemoglobin levels in nondiabetic subjects with overt hypothyroidism, Arch Endocrinol Metab, 59, 495, 10.1590/2359-3997000000065 Kitahara, 2012, Body fatness and markers of thyroid function among U.S. men and women, PLoS One, 7, e34979, 10.1371/journal.pone.0034979 Duntas, 2013, The interconnections between obesity, thyroid function, and autoimmunity: the multifold role of leptin, Thyroid, 23, 646, 10.1089/thy.2011.0499 Janeckova, 2001, The role of leptin in human physiology and pathophysiology, Physiol Res, 50, 443 Pinkney, 1998, Leptin and the pituitary-thyroid axis: a comparative study in lean, obese, hypothyroid and hyperthyroid subjects, Clin Endocrinol (Oxf), 49, 583, 10.1046/j.1365-2265.1998.00573.x Nillni, 2010, Regulation of the hypothalamic thyrotropin releasing hormone (TRH) neuron by neuronal and peripheral inputs, Front Neuroendocrinol, 31, 134, 10.1016/j.yfrne.2010.01.001 Menendez, 2003, TSH stimulates leptin secretion by a direct effect on adipocytes, J Endocrinol, 176, 7, 10.1677/joe.0.1760007 Eke, 2013, Serum resistin and insulin-like growth factor-1 levels in patients with hypothyroidism and hyperthyroidism, J Thyroid Res, 2013, 306750 Sieminska, 2015, Associations between metabolic syndrome, serum thyrotropin, and thyroid antibodies status in postmenopausal women, and the role of interleukin-6, Endokrynol Pol, 66, 394 Rodondi, 2013, Subclinical hypothyroidism and cardiovascular risk: how to end the controversy, J Clin Endocrinol Metab, 98, 2267, 10.1210/jc.2013-1875 Danesh, 2008, Long-term interleukin-6 levels and subsequent risk of coronary heart disease: two new prospective studies and a systematic review, PLoS Med, 5, e78, 10.1371/journal.pmed.0050078 Fisman, 2006, Interleukin-6 and the risk of future cardiovascular events in patients with angina pectoris and/or healed myocardial infarction, Am J Cardiol, 98, 14, 10.1016/j.amjcard.2006.01.045 Kaptoge, 2014, Inflammatory cytokines and risk of coronary heart disease: new prospective study and updated meta-analysis, Eur Heart J, 35, 578, 10.1093/eurheartj/eht367 Turemen, 2011, Endothelial dysfunction and low grade chronic inflammation in subclinical hypothyroidism due to autoimmune thyroiditis, Endocr J, 58, 349, 10.1507/endocrj.K10E-333 Bilgir, 2014, Subclinical hypothyroidism: Comparison of adhesion molecule levels before and after levothyroxine therapy, J Int Med Res, 42, 806, 10.1177/0300060514526566 Donnini, 2003, Thyrotropin stimulates production of procoagulant and vasodilative factors in human aortic endothelial cells, Thyroid, 13, 517, 10.1089/105072503322238764 Williams, 2011, Extrathyroidal expression of TSH receptor, Ann Endocrinol (Paris), 72, 68, 10.1016/j.ando.2011.03.006 Lu, 2012, Role of extrathyroidal TSHR expression in adipocyte differentiation and its association with obesity, Lipids Health Dis, 11, 17, 10.1186/1476-511X-11-17 Antunes, 2008, Thyroid-stimulating hormone induces interleukin-6 release from human adipocytes through activation of the nuclear factor-kappaB pathway, Endocrinology, 149, 3062, 10.1210/en.2007-1588 Gagnon, 2014, TSH signaling pathways that regulate MCP-1 in human differentiated adipocytes, Metabolism, 63, 812, 10.1016/j.metabol.2014.02.015 Tian, 2014, Effects of TSH on the function of human umbilical vein endothelial cells, J Mol Endocrinol, 52, 215, 10.1530/JME-13-0119 Pearce, 2011, In people with subclinical hypothyroidism, TSH level >10 mIU/l may predict increased risk of coronary heart disease and related mortality, Evid Based Med, 16, 31, 10.1136/ebm1166