High Prevalence of Hormonal Changes and Hepatic Osteodystrophy in Frail Patients with Cirrhosis—An Observational Study

Journal of Clinical and Experimental Hepatology - Tập 12 - Trang 800-807 - 2022
Surender Singh1, Sunil Taneja1, Puneeta Tandon2, Arka De1, Nipun Verma1, Madhumita Premkumar1, Ajay Duseja1, Radha Krishan Dhiman1, Virendra Singh1
1Department of Hepatology, Postgraduate Institute of Medical Education & Research, Chandigarh, India
2Division of Gastroenterology, University of Alberta, Edmonton, Canada

Tài liệu tham khảo

Tsochatzis, 2014, Liver cirrhosis, Lancet, 383, 1749, 10.1016/S0140-6736(14)60121-5 Eshraghian, 2014, Systematic review: endocrine abnormalities in patients with liver cirrhosis, Arch Iran Med, 17, 713 Trifan, 2013, Update on adrenal insufficiency in patients with liver cirrhosis, World J Gastroenterol WJG, 19, 445, 10.3748/wjg.v19.i4.445 Rakici, 2017, Adrenal insufficiency in cirrhosis patients: evaluation of 108 case series, Euroasian J Hepato-Gastroenterol, 7, 150, 10.5005/jp-journals-10018-1237 Kley, 1976, Estrone and estradiol in patients with cirrhosis of the liver: effects of ACTH and dexamethasone, J Clin Endocrinol Metab, 43, 557, 10.1210/jcem-43-3-557 Sinclair, 2015, Testosterone in men with advanced liver disease: abnormalities and implications, J Gastroenterol Hepatol, 30, 244, 10.1111/jgh.12695 Moctezuma-Velázquez, 2018, Association between low testosterone levels and sarcopenia in cirrhosis: a cross-sectional study, Ann Hepatol, 17, 615, 10.5604/01.3001.0012.0930 Miroliaee, 2010, Disturbances of parathyroid hormone–vitamin D axis in non-cholestatic chronic liver disease: a cross-sectional study, Hepatol Int, 4, 634, 10.1007/s12072-010-9194-2 Sorvillo, 2003, Increased serum reverse triiodothyronine levels at diagnosis of hepatocellular carcinoma in patients with compensated HCV-related liver cirrhosis, Clin Endocrinol (Oxf)., 58, 207, 10.1046/j.1365-2265.2003.01697.x Acevedo, 2013, Relative adrenal insufficiency in decompensated cirrhosis: relationship to short-term risk of severe sepsis, hepatorenal syndrome, and death, Hepatol Baltim Md, 58, 1757, 10.1002/hep.26535 Zietz, 2003, Dysfunction of the hypothalamic-pituitary-glandular axes and relation to Child-Pugh classification in male patients with alcoholic and virus-related cirrhosis, Eur J Gastroenterol Hepatol, 15, 495 Triantos C, Aggeletopoulou I, Thomopoulos K, Mouzaki A. Vitamin D - liver disease association: biological basis and mechanisms of action. Hepatology [Internet]. [cited 2021 Jan 31];n/a(n/a). Available from: https://aasldpubs.onlinelibrary.wiley.com/doi/abs/10.1002/hep.31699. Choudhary, 2011, Hepatic osteodystrophy is common in patients with noncholestatic liver disease, Dig Dis Sci, 56, 3323, 10.1007/s10620-011-1722-y Guañabens, 2018, Osteoporosis in chronic liver disease, Liver Int, 38, 776, 10.1111/liv.13730 Laube, 2018, Frailty in advanced liver disease, Liver Int, 38, 2117, 10.1111/liv.13917 Guaraldi, 2017, A frailty index predicts post-liver transplant morbidity and mortality in HIV-positive patients, AIDS Res Ther, 14, 37, 10.1186/s12981-017-0163-x Tandon, 2016, A rapid bedside screen to predict unplanned hospitalization and death in outpatients with cirrhosis: a prospective evaluation of the clinical frailty scale, Am J Gastroenterol, 111, 1759, 10.1038/ajg.2016.303 Essam Behiry, 2019, Ability of the short physical performance battery frailty index to predict mortality and hospital readmission in patients with liver cirrhosis, Int J Hepatol, 2019, 1, 10.1155/2019/8092865 Lai, 2017, Development of a novel frailty index to predict mortality in patients with end-stage liver disease, Hepatol Baltim Md, 66, 564, 10.1002/hep.29219 Bhanji, 2019, Differing impact of sarcopenia and frailty in nonalcoholic steatohepatitis and alcoholic liver disease, Liver Transplant Off Publ Am Assoc Study Liver Dis Int Liver Transplant Soc, 25, 14 Lai, 2019, Frailty associated with waitlist mortality independent of ascites and hepatic encephalopathy in a multicenter study, Gastroenterology, 156, 1675, 10.1053/j.gastro.2019.01.028 Sinclair, 2017, Frailty is independently associated with increased hospitalisation days in patients on the liver transplant waitlist, World J Gastroenterol, 23, 899, 10.3748/wjg.v23.i5.899 Lai, 2014, Frailty predicts wait-list mortality in liver transplant candidates, Am J Transplant Off J Am Soc Transplant Am Soc Transpl Surg, 14, 1870, 10.1111/ajt.12762 Tapper, 2019, Frailty, psychoactive medications, and cognitive dysfunction are associated with poor patient-reported outcomes in cirrhosis, Hepatol Baltim Md, 69, 1676, 10.1002/hep.30336 Fede, 2012, Adrenocortical dysfunction in liver disease: a systematic review, Hepatology, 55, 1282, 10.1002/hep.25573 Klein, 1989, Absence of hyperparathyroidism in severe liver disease, Calcif Tissue Int, 44, 330, 10.1007/BF02556312 Kirch, 1990, Parathyroid hormone and cirrhosis of the liver, J Clin Endocrinol Metab, 71, 1561, 10.1210/jcem-71-6-1561 Cervoni, 2016, Prognostic value of C-reactive protein in cirrhosis: external validation from the CANONIC cohort, Eur J Gastroenterol Hepatol, 28, 1028, 10.1097/MEG.0000000000000676 Kubesch, 2018, Vitamin D deficiency is associated with hepatic decompensation and inflammation in patients with liver cirrhosis: a prospective cohort study, PLoS One, 13, 10.1371/journal.pone.0207162 Lai, 2018, The liver frailty index improves mortality prediction of the subjective clinician assessment in patients with cirrhosis, Am J Gastroenterol, 113, 235, 10.1038/ajg.2017.443 Leslie, 2003, AGA technical review on osteoporosis in hepatic disorders, Gastroenterology, 125, 941, 10.1016/S0016-5085(03)01062-X Huynh, 2015, Nutritional care in hospitalized patients with chronic liver disease, World J Gastroenterol, 21, 12835, 10.3748/wjg.v21.i45.12835 Frisancho, 1974, Triceps skin fold and upper arm muscle size norms for assessment of nutrition status, Am J Clin Nutr, 27, 1052, 10.1093/ajcn/27.10.1052 Detsky, 1987, What is subjective global assessment of nutritional status?, J Parenter Enter Nutr, 11, 8, 10.1177/014860718701100108 Nagasue, 1985, Serum levels of estrogens and testosterone in cirrhotic men with and without hepatocellular carcinoma, Gastroenterology, 88, 768, 10.1016/0016-5085(85)90149-0 Gordon, 1975, Conversion of androgens to estrogens in cirrhosis of the liver, J Clin Endocrinol Metab, 40, 1018, 10.1210/jcem-40-6-1018 Bone Mineral Density Loss in Patients with Cirrhosis Muhsen IN, AlFreihi O, Abaalkhail F, AlKhenizan A, Khan M, Eldali A, Alsohaibani F - Saudi J Gastroenterol [Internet]. [cited 2020 Jan 12]. Available from: http://www.saudijgastro.com/article.asp?issn=1319-3767;year=2018;volume=24;issue=6;spage=342;epage=347;aulast=Muhsen. Fernández Fernández, 2016, Vitamin D deficiency in chronic liver disease, clinical-epidemiological analysis and report after vitamin d supplementation, Gastroenterol Hepatol Engl Ed, 39, 305, 10.1016/j.gastrohep.2015.10.003 Konstantakis, 2016, Vitamin D deficiency in patients with liver cirrhosis, Ann Gastroenterol, 29, 297 Zheng, 2018, Risk factors for osteoporosis in liver cirrhosis patients measured by transient elastography, Medicine (Baltim), 97 Cijevschi, 2005, Osteoporosis in liver cirrhosis, Rom J Gastroenterol, 14, 337 Sinclair, 2016, Testosterone therapy increases muscle mass in men with cirrhosis and low testosterone: a randomised controlled trial, J Hepatol, 65, 906, 10.1016/j.jhep.2016.06.007 Velissaris, 2017, C-reactive protein and frailty in the elderly: a literature review, J Clin Med Res, 9, 461, 10.14740/jocmr2959w Pieri, 2014, C-reactive protein and bacterial infection in cirrhosis, Ann Gastroenterol Q Publ Hell Soc Gastroenterol, 27, 113 Deutsch, 2018, Bacterial infections in patients with liver cirrhosis: clinical characteristics and the role of C-reactive protein, Ann Gastroenterol, 31, 77 Das, 2011, Comparison of haematological parameters in patients with non-alcoholic fatty liver disease and alcoholic liver disease, Singapore Med J, 52, 175 Oikonomou, 2017, High serum ferritin is associated with worse outcome of patients with decompensated cirrhosis, Ann Gastroenterol Q Publ Hell Soc Gastroenterol, 30, 217 Ripoll, 2015, Serum ferritin in patients with cirrhosis is associated with markers of liver insufficiency and circulatory dysfunction, but not of portal hypertension, J Clin Gastroenterol, 49, 784, 10.1097/MCG.0000000000000283 Bedogni, 2008, Natural course of chronic HCV and HBV infection and role of alcohol in the general population: the Dionysos Study, Am J Gastroenterol, 103, 2248, 10.1111/j.1572-0241.2008.01948.x Singh, 2021, A comparison of different frailty scores and impact of frailty on outcome in patients with cirrhosis, J Clin Exp Hepatol Tsuchihashi, 2021, Effects of in-hospital exercise on frailty in patients with hepatocellular carcinoma, Cancers, 13, E194, 10.3390/cancers13020194 Santa Mina, 2014, Effect of total-body prehabilitation on postoperative outcomes: a systematic review and meta-analysis, Physiotherapy, 100, 196, 10.1016/j.physio.2013.08.008 Yamada, 2021, Significance of frailty in prognosis after hepatectomy for elderly patients with hepatocellular carcinoma, Ann Surg Oncol, 28, 439, 10.1245/s10434-020-08742-w