High 18F-FDOPA PET Uptake in Primary Central Nervous System Lymphoma

Clinical Nuclear Medicine - Tập 46 Số 1 - Trang e59-e60 - 2021
Betty Salgues1,2,3,4, Elsa Kaphan5, Elicia Molines6, Gilles Brun7, Eric Guedj1,2,4
1Aix-Marseille Université, CERIMED
2Aix-Marseille Université, CNRS, Ecole Centrale Marseille, UMR 7249, Institut Fresnel
3Betty Salgues, MD, Service Central de Biophysique et Médecine Nucléaire, Hôpital de la Timone, 264 rue Saint Pierre, 13005 Marseille, France. E-mail: [email protected].
4Nuclear Medicine Department, APHM, Timone Hospital
5Neurology Department
6Pathology and Neuropathology Department
7Neuroradiology Department, APHM, Timone Hospital, Marseille, France.

Tóm tắt

Abstract We present a 42-year-old woman with primary central nervous system lymphoma (PCNSL) and strong 18F-FDOPA PET uptake. 18F-FDOPA PET has high diagnostic accuracy in gliomas and brain metastases. The l-type amino acid transporter 1, targeted by 18F-FDOPA and 11C-MET PET, is a cell-type transporter usually upregulated in malignant tumors, including PCNSL. In this line, strong uptake was already shown with 11C-MET in PCNSL. We report the same findings with 18F-FDOPA. Consequently, PCNSL is a possible differential neoplastic diagnosis of 18F-FDOPA uptake among neoplastic lesions.

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Tài liệu tham khảo

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Clinical Nuclear Medicine

Tập 46 Số 1

e59-e60

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