Hexanal-induced changes in miRNA-mRNA interactions in A549 human alveolar epithelial cells

Samet, J. M., Marbury, M. C. & Spengler, J. D. Health effects and sources of indoor air pollution. Part I. The Am. Rev. Respir. Dis. 136, 1486–1508 1987.

Baumann, M. G. D., Lorenz, L. F., Batterman, S. A. & Zhang, G. Z. Aldehyde emissions from particleboard and medium density fiberboard products. Forest. Prod. J. 50, 75–82 2000.

Nazaroff, W. W. & Weschler, C. J. Cleaning products and air fresheners: Exposure to primary and secondary air pollutants. Atmos. Environ. 38, 2841–2865 2004.

O’Brien, P. J., Siraki, A. G. & Shangari, N. Aldehyde sources, metabolism, molecular toxicity mechanisms, and possible effects on human health. Cr. Rev. Toxicol. 35, 609–662 2005.

Poli, D. et al. Determination of aldehydes in exhaled breath of patients with lung cancer by means of on-fiber- derivatisation SPME-GC/MS. J. Chromatogr. B, Analytical Technologies in the Biomedical and Life Sciences 878, 2643–2651 2010.

Song, M. K. et al. Octanal-induced inflammatory responses in cells relevant for lung toxicity: Expression and release of cytokines in A549 human alveolar cells. Hum. Exp. Toxicol. 33, 710–721 2013.

Ernstgard, L., Iregren, A., Sjogren, B., Svedberg, U. & Johanson, G. Acute effects of exposure to hexanal vapors in humans. JOEM 48, 573–580 2006.

Mraz, M. & Pospisilova, S. MicroRNAs in chronic lymphocytic leukemia: From causality to associations and back. Expert Rev. Hematol. 5, 579–581 2012.

Bartel, D. P. MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell 116, 281–297 2004.

Ambros, V. The functions of animal microRNAs. Nature 431, 350–355 2004.

Cheng, A. M., Byrom, M. W., Shelton, J. & Ford, L. P. Antisense inhibition of human miRNAs and indications for an involvement of miRNA in cell growth and apoptosis. Nucleic Acids Res. 33, 1290–1297 2005.

Lu, J. et al. MicroRNA expression profiles classify human cancers. Nature 435, 834–838 2005.

Taganov, K. D., Boldin, M. P., Chang, K. J. & Baltimore, D. NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses. Proc. Natl. Acad. Sci. U.S.A. 103, 12481–12486 2006.

An, Y. R. & Hwang, S. Y. Toxicology study with microRNA. Mol. Cell. Toxicol. 10, 127–134 2014.

Fukushima, T., Hamada, Y., Yamada, H. & Horii, I. Changes of micro-RNA expression in rat liver treated by acetaminophen or carbon tetrachloride—regulating role of micro-RNA for RNA expression. J. Toxicol. Sci. 32, 401–409 2007.

Hudder, A. & Novak, R. F. miRNAs: Effectors of environmental influences on gene expression and disease. Toxicol. Sci.: An Official Journal of the Society of Toxicology 103, 228–240 2008.

Cho, Y., Song, M. K., Choi, H. S. & Ryu, J. C. Analysis of dose-response to hexanal-induced gene expression in A549 human alveolar cells. BioChip J. 8, 75–82 2014.

Guo, H., Ingolia, N. T., Weissman, J. S. & Bartel, D. P. Mammalian microRNAs predominantly act to decrease target mRNA levels. Nature 466, 835–840 2010.

Huang, J. C. et al. Using expression profiling data to identify human microRNA targets. Nature Methods 4, 1045–1049 2007.

Song, M. K. et al. Analysis of microRNA and mRNA expression profiles highlights alterations in modulation of the MAPK pathway under octanal exposure. Environ. Toxicol. Pharmacol. 37, 84–94 2014.

Feltens, R. et al. Chlorobenzene induces oxidative stress in human lung epithelial cells in vitro. Toxicol. Appl. Pharm. 242, 100–108 2010.

Koehler, C. et al. Aspects of nitrogen dioxide toxicity in environmental urban concentrations in human nasal epithelium. Toxicol. Appl. Pharm. 245, 219–225 2010.

Roggen, E. L., Soni, N. K. & Verheyen, G. R. Respiratory immunotoxicity: An in vitro assessment. Toxicol. in vitro: An International Journal Published in Association with BIBRA 20, 1249–1264 2006.

Farh, K. K. et al. The widespread impact of mammalian MicroRNAs on mRNA repression and evolution. Science 310, 1817–1821 2005.

Favaro, E. et al. MicroRNA-210 regulates mitochondrial free radical response to hypoxia and krebs cycle in cancer cells by targeting iron sulfur cluster protein ISCU. PLoS One 5, e10345 (2010).

Ninomiya, M. et al. Distinct microRNAs expression profile in primary biliary cirrhosis and evaluation of miR 505-3p and miR197-3p as novel biomarkers. PLoS One 8, e66086 (2013).

Zhang, Y., Liao, J. M., Zeng, S. Y. X. & Lu, H. p53 downregulates Down syndrome-associated DYRK1A through miR-1246. Embo Rep. 12, 811–817 2011.

Berridge, M. J., Lipp, P. & Bootman, M. D. The versatility and universality of calcium signalling. Nature Reviews. Molecular Cell Biology 1, 11–21 2000.

Mattson, M. P. & Chan, S. L. Neuronal and glial calcium signaling in Alzheimer’s disease. Cell Calcium 34, 385–397 2003.

Feske, S. Calcium signalling in lymphocyte activation and disease. Nat. Rev. Immunol. 7, 690–702 2007.

Clapham, D. E. Calcium signaling. Cell 131, 1047–1058 (2007).

Mosmann, T. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J. Immunol. Methods 65, 55–63 1983.

Park, Y. S. et al. Identification of three novel mutations in Korean phenylketonuria patients: R53H, N207D, and Y325X. Human Mutation Supplement 1, S121–122 (1998).

Benjamini, Y. & Hochberg, Y. Controlling the false discovery rate - A practical and powerful approach to multiple testing. J. Roy. Stat. Soc. B Met. 57, 289–300 1995.