Heterogeneity in resistance training-induced muscle strength and mass responses in men and women of different ages

Juha P. Ahtiainen1, Simon Walker1, Heikki Peltonen1, J. Holviala1, Elina Sillanpää2, Laura Karavirta1, Janne Sallinen1, Jussi Mikkola3, Heli Valkeinen4, Antti Mero1, Juha J. Hulmi1, Keijo Häkkinen1
1Department of Biology of Physical Activity, University of Jyväskylä, P.O. Box 35, FI-40014, Jyvaskyla, Finland
2Gerontology Research Center, Department of Health Sciences, University of Jyväskylä, Jyvaskyla, Finland
3Physiology, Research Institute for Olympic Sports, Jyväskylä, Finland
4Department of Welfare, National Institute for Health and Welfare (THL), Helsinki, Finland

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Ahtiainen JP, Hulmi JJ, Kraemer WJ, Lehti M, Pakarinen A, Mero AA, Karavirta L, Sillanpää E, Selänne H, Alen M et al (2009) Strength, [corrected] endurance or combined training elicit diverse skeletal muscle myosin heavy chain isoform proportion but unaltered androgen receptor concentration in older men. Int J Sports Med 30:879–887. doi: 10.1055/s-0029-1238290

Ahtiainen JP, Hulmi JJ, Kraemer WJ, Lehti M, Nyman K, Selänne H, Alen M, Pakarinen A, Komulainen J, Kovanen V et al (2011) Heavy resistance exercise training and skeletal muscle androgen receptor expression in younger and older men. Steroids 76:183–192. doi: 10.1016/j.steroids.2010.10.012

Bamman MM, Petrella JK, Kim JS, Mayhew DL, Cross JM (2007) Cluster analysis tests the importance of myogenic gene expression during myofiber hypertrophy in humans. J Appl Physiol (1985) 102:2232–2239. doi: 10.1152/japplphysiol.00024.2007

Campbell WW, Leidy HJ (2007) Dietary protein and resistance training effects on muscle and body composition in older persons. J Am Coll Nutr 26:696S–703S

Davidsen PK, Gallagher IJ, Hartman JW, Tarnopolsky MA, Dela F, Helge JW, Timmons JA, Phillips SM (2011) High responders to resistance exercise training demonstrate differential regulation of skeletal muscle microRNA expression. J Appl Physiol (1985) 110:309–317. doi: 10.1152/japplphysiol.00901.2010

Devaney JM, Tosi LL, Fritz DT, Gordish-Dressman HA, Jiang S, Orkunoglu-Suer FE, Gordon AH, Harmon BT, Thompson PD, Clarkson PM et al (2009) Differences in fat and muscle mass associated with a functional human polymorphism in a post-transcriptional BMP2 gene regulatory element. J Cell Biochem 107:1073–1082. doi: 10.1002/jcb.22209

Erskine RM, Jones DA, Williams AG, Stewart CE, Degens H (2010) Inter-individual variability in the adaptation of human muscle specific tension to progressive resistance training. Eur J Appl Physiol 110:1117–1125. doi: 10.1007/s00421-010-1601-9

Garber CE, Blissmer B, Deschenes MR, Franklin BA, Lamonte MJ, Lee IM, Nieman DC, Swain DP, American College of Sports Medicine (2011) American College of Sports Medicine position stand. Quantity and quality of exercise for developing and maintaining cardiorespiratory, musculoskeletal, and neuromotor fitness in apparently healthy adults: guidance for prescribing exercise. Med Sci Sports Exerc 43:1334–1359. doi: 10.1249/MSS.0b013e318213fefb

Häkkinen K, Kallinen M, Izquierdo M, Jokelainen K, Lassila H, Mälkiä E, Kraemer WJ, Newton RU, Alen M (1998) Changes in agonist-antagonist EMG, muscle CSA, and force during strength training in middle-aged and older people. J Appl Physiol (1985) 84:1341–1349

Häkkinen K, Pakarinen A, Kraemer WJ, Häkkinen A, Valkeinen H, Alen M (2001a) Selective muscle hypertrophy, changes in EMG and force, and serum hormones during strength training in older women. J Appl Physiol 1985 91:569–580

Häkkinen K, Alen M, Kallinen M, Newton RU, Kraemer WJ (2000a) Neuromuscular adaptation during prolonged strength training, detraining and re-strength-training in middle-aged and elderly people. Eur J Appl Physiol 83:51–62. doi: 10.1007/s004210000248

Häkkinen K, Pakarinen A, Kraemer WJ, Newton RU, Alen M (2000b) Basal concentrations and acute responses of serum hormones and strength development during heavy resistance training in middle-aged and elderly men and women. J Gerontol A Biol Sci Med Sci 55:B95–B105

Häkkinen K, Kraemer WJ, Newton RU, Alen M (2001b) Changes in electromyographic activity, muscle fibre and force production characteristics during heavy resistance/power strength training in middle-aged and older men and women. Acta Physiol Scand 171:51–62. doi: 10.1046/j.1365-201X.2001.00781.x

Holviala JH, Sallinen JM, Kraemer WJ, Alen MJ, Häkkinen KK (2006) Effects of strength training on muscle strength characteristics, functional capabilities, and balance in middle-aged and older women. J Strength Cond Res 20:336–344. doi: 10.1519/R-17885.1

Holviala J, Häkkinen A, Karavirta L, Nyman K, Izquierdo M, Gorostiaga EM, Avela J, Korhonen J, Knuutila VP, Kraemer WJ et al (2010) Effects of combined strength and endurance training on treadmill load carrying walking performance in aging men. J Strength Cond Res 24:1584–1595. doi: 10.1519/JSC.0b013e3181dba178

Holviala J, Kraemer WJ, Sillanpää E, Karppinen H, Avela J, Kauhanen A, Häkkinen A, Häkkinen K (2012) Effects of strength, endurance and combined training on muscle strength, walking speed and dynamic balance in aging men. Eur J Appl Physiol 112:1335–1347. doi: 10.1007/s00421-011-2089-7

Hopkins WG (2000) Measures of reliability in sports medicine and science. Sports Med 30:1–15

Hubal MJ, Gordish-Dressman H, Thompson PD, Price TB, Hoffman EP, Angelopoulos TJ, Gordon PM, Moyna NM, Pescatello LS, Visich PS et al (2005) Variability in muscle size and strength gain after unilateral resistance training. Med Sci Sports Exerc 37:964–972

Hulmi JJ, Kovanen V, Selänne H, Kraemer WJ, Häkkinen K, Mero AA (2009) Acute and long-term effects of resistance exercise with or without protein ingestion on muscle hypertrophy and gene expression. Amino Acids 37:297–308. doi: 10.1007/s00726-008-0150-6

Karavirta L, Häkkinen A, Sillanpää E, Garcia-Lopez D, Kauhanen A, Haapasaari A, Alen M, Pakarinen A, Kraemer WJ, Izquierdo M et al (2011a) Effects of combined endurance and strength training on muscle strength, power and hypertrophy in 40-67-year-old men. Scand J Med Sci Sports 21:402–411. doi: 10.1111/j.1600-0838.2009.01059.x

Karavirta L, Häkkinen K, Kauhanen A, Arija-Blazquez A, Sillanpää E, Rinkinen N, Häkkinen A (2011b) Individual responses to combined endurance and strength training in older adults. Med Sci Sports Exerc 43:484–490. doi: 10.1249/MSS.0b013e3181f1bf0d

Mann S, Beedie C, Balducci S, Zanuso S, Allgrove J, Bertiato F, Jimenez A (2014) Changes in insulin sensitivity in response to different modalities of exercise: a review of the evidence. Diabetes Metab Res Rev 30:257–268. doi: 10.1002/dmrr.2488

Mayhew DL, Hornberger TA, Lincoln HC, Bamman MM (2011) Eukaryotic initiation factor 2B epsilon induces cap-dependent translation and skeletal muscle hypertrophy. J Physiol 589:3023–3037. doi: 10.1113/jphysiol.2010.202432

Mero AA, Hulmi JJ, Salmijärvi H, Katajavuori M, Haverinen M, Holviala J, Ridanpää T, Häkkinen K, Kovanen V, Ahtiainen JP et al (2013) Resistance training induced increase in muscle fiber size in young and older men. Eur J Appl Physiol 113:641–650. doi: 10.1007/s00421-012-2466-x

Mikkola J, Rusko H, Izquierdo M, Gorostiaga EM, Häkkinen K (2012) Neuromuscular and cardiovascular adaptations during concurrent strength and endurance training in untrained men. Int J Sports Med 33:702–710. doi: 10.1055/s-0031-1295475

Mitchell CJ, Churchward-Venne TA, Bellamy L, Parise G, Baker SK, Phillips SM (2013) Muscular and systemic correlates of resistance training-induced muscle hypertrophy. PLoS One 8:e78636. doi: 10.1371/journal.pone.0078636

Oja P, Titze S (2011) Physical activity recommendations for public health: development and policy context. EPMA J 2:253–259. doi: 10.1007/s13167-011-0090-1

Petrella JK, Kim JS, Mayhew DL, Cross JM, Bamman MM (2008) Potent myofiber hypertrophy during resistance training in humans is associated with satellite cell-mediated myonuclear addition: a cluster analysis. J Appl Physiol (1985) 104:1736–1742. doi: 10.1152/japplphysiol.01215.2007

Phillips BE, Williams JP, Gustafsson T, Bouchard C, Rankinen T, Knudsen S, Smith K, Timmons JA, Atherton PJ (2013) Molecular networks of human muscle adaptation to exercise and age. PLoS Genet 9:e1003389. doi: 10.1371/journal.pgen.1003389

Raue U, Trappe TA, Estrem ST, Qian HR, Helvering LM, Smith RC, Trappe S (2012) Transcriptome signature of resistance exercise adaptations: mixed muscle and fiber type specific profiles in young and old adults. J Appl Physiol (1985) 112:1625–1636. doi: 10.1152/japplphysiol.00435.2011

Riechman SE, Balasekaran G, Roth SM, Ferrell RE (2004) Association of interleukin-15 protein and interleukin-15 receptor genetic variation with resistance exercise training responses. J Appl Physiol (1985) 97:2214–2219

Sallinen J, Pakarinen A, Fogelholm M, Alen M, Volek JS, Kraemer WJ, Häkkinen K (2007) Dietary intake, serum hormones, muscle mass and strength during strength training in 49–73-year-old men. Int J Sports Med 28:1070–1076. doi: 10.1055/s-2007-965003

Sillanpää E, Häkkinen A, Nyman K, Mattila M, Cheng S, Karavirta L, Laaksonen DE, Huuhka N, Kraemer WJ, Häkkinen K (2008) Body composition and fitness during strength and/or endurance training in older men. Med Sci Sports Exerc 40:950–958. doi: 10.1249/MSS.0b013e318165c854

Sillanpää E, Häkkinen A, Laaksonen DE, Karavirta L, Kraemer WJ, Häkkinen K (2010) Serum basal hormone concentrations, nutrition and physical fitness during strength and/or endurance training in 39-64-year-old women. Int J Sports Med 31:110–117. doi: 10.1055/s-0029-1242811

Sipilä S, Suominen H (1991) Ultrasound imaging of the quadriceps muscle in elderly athletes and untrained men. Muscle Nerve 14:527–533. doi: 10.1002/mus.880140607

Thalacker-Mercer AE, Petrella JK, Bamman MM (2009) Does habitual dietary intake influence myofiber hypertrophy in response to resistance training? A cluster analysis. Appl Physiol Nutr Metab 34:632–639. doi: 10.1139/H09-038

Timpka S, Petersson IF, Zhou C, Englund M (2014) Muscle strength in adolescent men and risk of cardiovascular disease events and mortality in middle age: a prospective cohort study. BMC Med 12:62

Van Deveire KN, Scranton SK, Kostek MA, Angelopoulos TJ, Clarkson PM, Gordon PM, Moyna NM, Visich PS, Zoeller RF, Thompson PD et al (2012) Variants of the ankyrin repeat domain 6 gene (ANKRD6) and muscle and physical activity phenotypes among European-derived American adults. J Strength Cond Res 26:1740–1748. doi: 10.1519/JSC.0b013e31825c2bef

Walker S, Peltonen H, Sautel J, Scaramella C, Kraemer WJ, Avela J, Häkkinen K (2014) Neuromuscular adaptations to constant vs. variable resistance training in older men. Int J Sports Med 35:69–74. doi: 10.1055/s-0033-1343404

Walker S, Peltonen H, Hakkinen K (2015) Medium-intensity, high-volume “hypertrophic” resistance training did not induce improvements in rapid force production in healthy older men. Age (Dordr) 37:9786. doi: 10.1007/s11357-015-9786-9

Walsh S, Haddad CJ, Kostek MA, Angelopoulos TJ, Clarkson PM, Gordon PM, Moyna NM, Visich PS, Zoeller RF, Seip RL et al (2012) Leptin and leptin receptor genetic variants associate with habitual physical activity and the arm body composition response to resistance training. Gene 510:66–70. doi: 10.1016/j.gene.2012.08.020

Westcott WL (2012) Resistance training is medicine: effects of strength training on health. Curr Sports Med Rep 11:209–216. doi: 10.1249/JSR.0b013e31825dabb8

Xu L, Nicholson P, Wang QJ, Wang Q, Alen M, Cheng S (2010) Fat mass accumulation compromises bone adaptation to load in Finnish women: a cross-sectional study spanning three generations. J Bone Miner Res 25:2341–2349. doi: 10.1002/jbmr.136