Hepatitis C virus infection among patients with non-Hodgkin’s lymphoma in northern India

Hepatology International - Tập 5 - Trang 688-692 - 2011
Subhash Varma1, Madhav C. Menon1, Ashish Garg2, Pankaj Malhotra1, Arpita Sharma2, Yogesh K. Chawla2, Radha K. Dhiman2
1Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India
2Department of Hepatology, Postgraduate Institute of Medical Education and Research, Chandigarh, India

Tóm tắt

Hepatitis C virus (HCV) has been postulated to be an etiological agent for lymphoid malignancies. Whereas a high prevalence of HCV infection in non-Hodgkin’s lymphoma (NHL) patients has been shown to exist in many geographical areas of high HCV prevalence, studies from other parts have not established any form of association. In India, there is a scarcity of data to show either a positive or a negative association between NHL and HCV infection. Therefore, we determined the prevalence of HCV infection in patients with NHL. A total of 228 subjects were included, out of which, the number of newly diagnosed consecutive patients with lymphoproliferative disorders (NHL and CLL) were 57 [mean age, 48.7 years (range: 18–80)] and the control group consisted of 171 subjects [mean age, 48.6 years (range: 18–80)]. We used third generation enzyme immunoassay to detect HCV antibodies. HCV RNA was detected by nested RT-PCR. Among the 57 patients of NHL, 44 (77.2%) had high-grade disease (diffuse large B cell), 6 (10.5%) intermediate-grade (follicular lymphoma), and 7 (12.3%) low-grade (small lymphocytic); 26 patients had B symptoms at diagnosis. None of the patient tested positive for antibody to hepatitis C virus (anti-HCV) while 1 patient (1.75%) tested positive for HCV RNA. Among the age- and sex- matched controls, 2 (1.17%) subjects tested positive for anti-HCV; both were also positive for HCV RNA. HCV infection is unlikely to be associated with lymphoproliferative disorders in northern India and does not play a major role in the pathogenesis of lymphoproliferative disorders.

Tài liệu tham khảo

Epstein MA, Achong BG. Discovery and general biology of the virus. In Epstein MA, Achong BG, editors. The Epstein-Barr Virus. Berlin: Springer; 1979. Vol 11, 1123–1127 Dal Maso L, Franceschi S. Hepatitis C virus and risk of lymphoma and other lymphoid neoplasms: a meta-analysis of epidemiologic studies. Cancer Epidemiol Biomarkers Prev 2006;15:2078–2085 Varma S, Dhiman RK, Srivastava D, et al. Absence of Hepatitis C virus infection among patients with lymphoproliferative disorders in Northern India. Gastroenterology 2004;126:1498–1499 Nanu A, Sharma SP, Chatterjee K, et al. Marker for transfusion transmissible infection in North India. Voluntary and replacement blood donors. Prevalence and trends, 1989–1996. Vox Sanguinous 1997;73:70–73 Duseja A, Arora L, Masih B, Singh H, Gupta A, Behera D, Chawla YK, Dhiman RK. Department of Hepatology, Postgraduate Institute of Medical Education and Research, Chandigarh. Hepatitis B and C virus—prevalence and prevention in health care workers. Trop Gastroenterol 2002;23:125–126 Giannoulis E, Economopoulos T, Mandraveli K, et al. The prevalence of hepatitis C and hepatitis G virus infection in patients with B cell non-Hodgkin lymphomas in Greece: a Hellenic Cooperative Oncology Group Study. Acta Haematol 2004;112:189–193 Zuckerman E, Zuckerman T, Sahar D Streichman S, Attias D, Sabo E, et al. The effect of antiviral therapy on translocation and immunoglobulin gene rearrangement in patients with chronic hepatitis C virus infection. Blood 2001;97:1555–1559 Misiani R, Bellavita P, Fenili D, Vicari O, Marchesi D, Sironi PL, et al. Interferon alfa 2a therapy in cryoglobulinemia associated with hepatitis C virus. N Engl J Med 1994;330:751–756 Sulkowski MS, Emens LA.Regression of splenic lymphoma with villous lymphocytes after treatment of HCV infection. N Engl J Med 2002;347:2168–2170 Negri E, Little D, Boiocchi M, La Vecchia C, Franceschi S. B cell non-Hodgkin’s lymphoma and hepatitis C virus infection: a systematic review. Int J Cancer 2004;111:1–8 Zuckerman E, Zuckerman T, Levine AM, Douer D, Gutekunst K, Mizokami M, et al. Hepatitis C virus infection in patients with B cell non-Hodgkin lymphoma. Ann Intern Med. 1997;127:423–428 Gisbert JP, García-Buey L, Pajares JM, Moreno-Otero R. Prevalence of hepatitis C virus infection in B cell non-Hodgkin’s lymphoma: Systematic review and meta-analysis. Gastroenterology 2003;125:1723–1732 Libra M, Polesel J, Russo AE, De Re V, Cinà D, Serraino D, et al. Extrahepatic disorders of HCV infection: a distinct entity of B cell neoplasia? Int J Oncol 2010;36:1331–1340 Talamini R, Montella M, Crovatto M, Dal Maso L, Crispo A, Negri E, et al. Non-Hodgkin’s lymphoma and hepatitis C virus: A case-control study from northern and southern Italy. Int J Cancer 2004;110:380–385 Shirin H, Davidovitz Y, Avni Y, Petchenko P, Krepel Z, Bruck R, Meytes D. Prevalence of HCV infection in patients with lymphoproliferative disorders. Israel Med J 2002;4:24–27 Salem AK. Prevalence of HCV among Yemeni patients with non-Hodgkin’s lymphoma at AI-Thawra teaching hospital. Gulf J Oncolog 2009;5:22–29 de Sanjose S, Benavente Y, Vajdic CM, Engels EA, Morton LM, Bracci PM, Spinelli JJ, et al. Hepatitis C and non-Hodgkin lymphoma among 4,784 cases and 6,269 controls from the International Lymphoma Epidemiology Consortium. Clin Gastroenterol Hepatol 2008;6:451–458 Spinelli JJ, Lai AS, Krajden M, Andonov A, Gascoyne RD, Connors JM, et al. Hepatitis C virus and risk of non-Hodgkin lymphoma in British Columbia, Canada. Int J Cancer 2008;122:630–633 Cowgill KD, Loffredo CA, Eissa SA, Mokhtar N, Abdel-Hamid M, Fahmy A, Strickland GT. Case-control study of non-Hodgkin’s lymphoma and hepatitis C virus infection in Egypt. Int J Epidemiol 2004;33:1034–1039 Engels EA, Chatterjee N, Cerhan JR, Davis S, Cozen W, Severson RK, et al. Hepatitis C virus infection and non-Hodgkin lymphoma: results of the NCI-SEER multi- center case-control study. Int J Cancer 2004;111:76–80 Brind AM, Watson JP, Burt A, Kestevan P, Wallis J, Proctor SJ, Bassendine MF. Non-Hodgkin’s lymphoma and hepatitis C virus infection. Leukemia and lymphoma 1996;21:127–130 Udomsakdi-Auewarakul C, Auewarakul P, Sukpanichnant S, Muangsup W. Hepatitis C virus infection in patients with non-Hodgkins lymphoma in Thailand. Blood 2000;95:3640–3641 Thalen DJ, Raemaekers J, Galama J, Cooreman MP. Absence of hepatitis C virus infection in non-Hodgkin’s lymphoma. Br J Haematol 1997;96:881–882 Okan V, Yilmaz M, Bayram A, Kis C, Cifci S, Buyukhatipoglu H, Pehlivan M. Prevalence of hepatitis B and C viruses in patients with lymphoproliferative disorders. Int J Hematol 2008;88:403–408 Sonmez M, Bektas O, Yilmaz M, Durmus A, Akdogan E, Topbas M, et al. The relation of lymphoma and hepatitis B virus/hepatitis C virus infections in the region of East Black Sea, Turkey. Tumori 2007;93:536–539 Park SC, Jeong SH, Kim J, Han CJ, Kim YC, Choi KS, et al. High prevalence of hepatitis B virus infection in patients with B cell non-Hodgkin’s lymphoma in Korea. J Med Virol 2008;80:960–966 Schöllkopf C, Smedby KE, Hjalgrim H, Rostgaard K, Panum I, Vinner L, et al. Hepatitis C infection and risk of malignant lymphoma. Int J Cancer 2008;122:1885–1890 Duberg AS, Nordström M, Törner A, Reichard O, Strauss R, Janzon R, et al. Non-Hodgkin’s lymphoma and other nonhepatic malignancies in Swedish patients with hepatitis C virus infection. Hepatology 2005;41:652–659 Kuniyoshi M, Nakamuta M, Sakai H, Enjoji M, Kinukawa N, Kotoh K, et al. Prevalence of hepatitis B or C virus infections in patients with non-Hodgkin’s lymphoma. J Gastroenterol Hepatol 2001;16:215–219 Cucuianu A, Patiu M, Duma M, Basarab C, Soritau O, Bojan A, et al. Hepatitis B and C virus infection in Romanian non-Hodgkin’s lymphoma patients. Br J Haematol 1999;107:353–356 Matsuo K, Kusano A, Sugumar A, Nakamura S, Tajima K, Mueller NE. Effect of hepatitis C virus infection on the risk of non-Hodgkin’s lymphoma: a meta-analysis of epidemiological studies. Cancer Sci 2004;95:745–752