Hepatic TM6SF2 Is Required for Lipidation of VLDL in a Pre-Golgi Compartment in Mice and Rats
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Younossi, 2016, Global epidemiology of nonalcoholic fatty liver disease-meta-analytic assessment of prevalence, incidence, and outcomes, Hepatology, 64, 73, 10.1002/hep.28431
Cohen, 2011, Human fatty liver disease: old questions and new insights, Science, 332, 1519, 10.1126/science.1204265
Buch, 2015, A genome-wide association study confirms PNPLA3 and identifies TM6SF2 and MBOAT7 as risk loci for alcohol-related cirrhosis, Nat Genet, 47, 1443, 10.1038/ng.3417
Romeo, 2008, Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease, Nat Genet, 40, 1461, 10.1038/ng.257
Kozlitina, 2014, Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease, Nat Genet, 46, 352, 10.1038/ng.2901
Speliotes, 2011, Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits, PLoS Genet, 7, 10.1371/journal.pgen.1001324
Mahdessian, 2014, TM6SF2 is a regulator of liver fat metabolism influencing triglyceride secretion and hepatic lipid droplet content, Proc Natl Acad Sci U S A, 111, 8913, 10.1073/pnas.1323785111
Newberry, 2021, Liver-specific deletion of mouse Tm6sf2 promotes steatosis, fibrosis, and hepatocellular cancer, Hepatology, 74, 1203, 10.1002/hep.31771
Smagris, 2016, Inactivation of Tm6sf2, a gene defective in fatty liver disease, impairs lipidation but not secretion of very low density lipoproteins, J Biol Chem, 291, 10659, 10.1074/jbc.M116.719955
Olofsson, 2000, Intracellular assembly of VLDL: two major steps in separate cell compartments, Trends Cardiovasc Med, 10, 338, 10.1016/S1050-1738(01)00071-8
Wetterau, 1992, Absence of microsomal triglyceride transfer protein in individuals with abetalipoproteinemia, Science, 258, 999, 10.1126/science.1439810
Raabe, 1998, Knockout of the abetalipoproteinemia gene in mice: reduced lipoprotein secretion in heterozygotes and embryonic lethality in homozygotes, Proc Natl Acad Sci U S A, 95, 8686, 10.1073/pnas.95.15.8686
Raabe, 1999, Analysis of the role of microsomal triglyceride transfer protein in the liver of tissue-specific knockout mice, J Clin Invest, 103, 1287, 10.1172/JCI6576
Yamaguchi, 2003, The conversion of apoB100 low density lipoprotein/high density lipoprotein particles to apoB100 very low density lipoproteins in response to oleic acid occurs in the endoplasmic reticulum and not in the Golgi in McA RH7777 cells, J Biol Chem, 278, 42643, 10.1074/jbc.M306920200
Gusarova, 2003, Apolipoprotein B100 exit from the endoplasmic reticulum (ER) is COPII-dependent, and its lipidation to very low density lipoprotein occurs post-ER, J Biol Chem, 278, 48051, 10.1074/jbc.M306898200
Cartwright, 2001, Direct evidence for a two-step assembly of ApoB48-containing lipoproteins in the lumen of the smooth endoplasmic reticulum of rabbit enterocytes, J Biol Chem, 276, 48048, 10.1074/jbc.M104229200
Tang, 2010, Reconstitution of the cell cycle-regulated Golgi disassembly and reassembly in a cell-free system, Nat Protoc, 5, 758, 10.1038/nprot.2010.38
Millar, 2005, Determining hepatic triglyceride production in mice: comparison of poloxamer 407 with Triton WR-1339, J Lipid Res, 46, 2023, 10.1194/jlr.D500019-JLR200
Xia, 2021, Hepatic deletion of Mboat7 (LPIAT1) causes activation of SREBP-1c and fatty liver, J Lipid Res, 62, 100031, 10.1194/jlr.RA120000856
Schweizer, 1991, The isolated ER-Golgi intermediate compartment exhibits properties that are different from ER and cis-Golgi, J Cell Biol, 113, 45, 10.1083/jcb.113.1.45
Newberry, 2021, Liver-specific deletion of Mttp versus Tm6sf2 reveals distinct defects in stepwise VLDL assembly, J Lipid Res, 62, 100080, 10.1016/j.jlr.2021.100080
Hammond, 1994, Quality control in the secretory pathway: retention of a misfolded viral membrane glycoprotein involves cycling between the ER, intermediate compartment, and Golgi apparatus, J Cell Biol, 126, 41, 10.1083/jcb.126.1.41
Siddiqi, 2015, In vitro analysis of the very-low density lipoprotein export from the trans-Golgi network, Curr Protoc Cell Biol, 67, 11211, 10.1002/0471143030.cb1121s67
Li, 2020, Disruption of the ERLIN-TM6SF2-APOB complex destabilizes APOB and contributes to non-alcoholic fatty liver disease, PLoS Genet, 16, 10.1371/journal.pgen.1008955
Alexander, 1976, Subcellular localization of B apoprotein of plasma lipoproteins in rat liver, J Cell Biol, 69, 241, 10.1083/jcb.69.2.241
Boren, 2020, Effects of TM6SF2 E167K on hepatic lipid and very low-density lipoprotein metabolism in humans, JCI Insight, 5, 10.1172/jci.insight.144079
Glaumann, 1968, Lipid composition and turnover of rough and smooth microsomal membranes in rat liver, J Lipid Res, 9, 720, 10.1016/S0022-2275(20)42684-7
Rubin, 1968, Ethanol increases hepatic smooth endoplasmic reticulum and drug-metabolizing enzymes, Science, 159, 1469, 10.1126/science.159.3822.1469
Chin, 1982, Appearance of crystalloid endoplasmic reticulum in compactin-resistant Chinese hamster cells with a 500-fold increase in 3-hydroxy-3-methylglutaryl-coenzyme A reductase, Proc Natl Acad Sci U S A, 79, 1185, 10.1073/pnas.79.4.1185
Claude, 1970, Growth and differentiation of cytoplasmic membranes in the course of lipoprotein granule synthesis in the hepatic cell. I. Elaboration of elements of the Golgi complex, J Cell Biol, 47, 745, 10.1083/jcb.47.3.745
Vincent, 1998, Function of the KKXX motif in endoplasmic reticulum retrieval of a transmembrane protein depends on the length and structure of the cytoplasmic domain, J Biol Chem, 273, 950, 10.1074/jbc.273.2.950
Mashek, 2006, Rat long chain acyl-CoA synthetase 5 increases fatty acid uptake and partitioning to cellular triacylglycerol in McArdle-RH7777 cells, J Biol Chem, 281, 945, 10.1074/jbc.M507646200
Oikawa, 1998, A novel acyl-CoA synthetase, ACS5, expressed in intestinal epithelial cells and proliferating preadipocytes, J Biochem, 124, 679, 10.1093/oxfordjournals.jbchem.a022165
Meller, 2013, Targeting of Acyl-CoA synthetase 5 decreases jejunal fatty acid activation with no effect on dietary long-chain fatty acid absorption, Lipids Health Dis, 12, 88, 10.1186/1476-511X-12-88
Bowman, 2016, Acyl CoA synthetase 5 (ACSL5) ablation in mice increases energy expenditure and insulin sensitivity and delays fat absorption, Mol Metab, 5, 210, 10.1016/j.molmet.2016.01.001
Miura, 2018, Easi-CRISPR for creating knock-in and conditional knockout mouse models using long ssDNA donors, Nat Protoc, 13, 195, 10.1038/nprot.2017.153
Engelking, 2012, Blockade of cholesterol absorption by ezetimibe reveals a complex homeostatic network in enterocytes, J Lipid Res, 53, 1359, 10.1194/jlr.M027599
Folch, 1957, A simple method for the isolation and purification of total lipides from animal tissues, J Biol Chem, 226, 497, 10.1016/S0021-9258(18)64849-5
Cappel, 2019, Pyruvate-carboxylase-mediated anaplerosis promotes antioxidant capacity by sustaining TCA cycle and redox metabolism in liver, Cell Metab, 29, 1291, 10.1016/j.cmet.2019.03.014
Trinh, 2020, Last step in the path of LDL cholesterol from lysosome to plasma membrane to ER is governed by phosphatidylserine, Proc Natl Acad Sci U S A, 117, 18521, 10.1073/pnas.2010682117