Heparin-binding epidermal growth factor-like growth factor (HB-EGF) and proteolytic processing by a disintegrin and metalloproteinases (ADAM): A regulator of several pathways

Seminars in Cell & Developmental Biology - Tập 28 - Trang 22-30 - 2014
Sean R. Taylor1, M.G. Markesbery1, Paul A. Harding1
1Department of Biology, Miami University, Oxford, OH 45056, United States

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Tài liệu tham khảo

Besner, 1990, Isolation and characterization of a macrophage-derived heparin-binding growth factor, Cell Regul, 1, 811, 10.1091/mbc.1.11.811

Higashiyama, 1991, A heparin-binding growth factor secreted by macrophage-like cells that is related to EGF, Science, 251, 936, 10.1126/science.1840698

Chen, 1995, Induction of heparin-binding EGF-like growth factor expression during myogenesis. Activation of the gene by MyoD and localization of the transmembrane form of the protein on the myotube surface, J Biol Chem, 270, 18285, 10.1074/jbc.270.31.18285

Harding, 1996, Characterization of the gene encoding murine heparin-binding epidermal growth factor-like growth factor, Gene, 169, 291, 10.1016/0378-1119(95)00861-6

Nakagawa, 1996, Amino-terminal processing of cell surface heparin-binding epidermal growth factor-like growth factor up-regulates its juxtacrine but not its paracrine growth factor activity, J Biol Chem, 271, 30858, 10.1074/jbc.271.48.30858

Izumi, 1998, A metalloprotease-disintegrin, MDC9/meltrin-gamma/ADAM9 and PKCdelta are involved inTPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor, EMBO J, 17, 7260, 10.1093/emboj/17.24.7260

Asakura, 2002, Cardiac hyper-trophy is inhibited by antagonism of ADAM12 processing of HB-EGF; metalloproteinase inhibitors as a new therapy, Nat Med, 8, 35, 10.1038/nm0102-35

Lemjabbar, 2002, Platelet-activating factor receptor and ADAM10 mediate responses to Staphylococcus aureus in epithelial cells, Nat Med, 8, 41, 10.1038/nm0102-41

Sunnarborg, 2002, Tumor necrosis factor-alpha converting enzyme (TACE) regulates epidermal growth factor receptor ligand availability, J Biol Chem, 277, 838

Yan, 2002, The metalloprotease Kuzbanian (ADAM10) mediates the transactivation of EGF receptor by G protein-coupled receptors, J Cell Biol, 158, 221, 10.1083/jcb.200112026

Nanba, 2003, Proteolytic release of the carboxy-terminal fragment of proHB-EGF causes nuclear export of PLZF, J Cell Biol, 163, 489, 10.1083/jcb.200303017

Zhou, 2007, Amino-terminal deletion of heparin-binding EGF-like growth factor4-127 (HB-EGF) stimulates cell proliferation but lacks insulin-like activity, Cell Prolif, 40, 213, 10.1111/j.1365-2184.2007.00425.x

Thompson, 1994, Characterization of sequences within heparin-binding EGF-like growth factor that mediate interaction with heparin, J Biol Chem, 269, 2541, 10.1016/S0021-9258(17)41979-X

Louie, 1997, Crystal structure of the complex of diphtheria toxin with an extracellular fragment of its receptor, Mol Cell, 1, 67, 10.1016/S1097-2765(00)80008-8

Montelione, 1986, Identification of two anti-parallel beta-sheet conformations in the solution structure of murine epidermal growth factor by proton magnetic resonance, Proc Natl Acad Sci USA, 83, 8594, 10.1073/pnas.83.22.8594

Carver, 1986, A high resolution 1H NMR study of the solution structure of human epidermal growth factor, FEBS Lett, 205, 77, 10.1016/0014-5793(86)80869-9

Collier, 1975, Diphtheria toxin: mode of action and structure, Bacteriol Rev, 39, 54, 10.1128/MMBR.39.1.54-85.1975

Raab, 1994, Biosynthesis and processing by phorbol ester of the cells surface-associated precursor form of heparin-binding EGF-like growth factor, Biochem Biophys Res Commun, 204, 592, 10.1006/bbrc.1994.2500

Atli, 2012, Expression of epidermal growth factor (EGF) and heparin-binding EGF (HB-EGF) mRNA in mare endometrium, Kafkas Universitesi Veteriner Fakultesi Dergisi, 29, 463

Singh, 2005, Autocrine, paracrine and juxtacrine signaling by EGFR ligands, Cell Signal, 17, 1183, 10.1016/j.cellsig.2005.03.026

Steinthorsdottir, 2004, Multiple novel transcription initiation sites for NRG1, Gene, 342, 97, 10.1016/j.gene.2004.07.029

Carpenter, 1991, 69

Plowman, 1990, The amphiregulin gene encodes a novel epidermal growth factor-related protein with tumor-inhibitory activity, Mol Cell Biol, 10, 1969, 10.1128/MCB.10.5.1969

Plowman, 1990, Molecular cloning and expression of an additional epidermal growth factor receptor-related gene, Proc Natl Acad Sci USA, 87, 4905, 10.1073/pnas.87.13.4905

Plowman, 1993, Ligand-specific activation of HER4/p180erbB4, a fourth member of the epidermal growth factor receptor family, Proc Natl Acad Sci USA, 90, 1746, 10.1073/pnas.90.5.1746

Earp, 1995, Heterodimerization and functional interaction between EGF receptor family members: a new signaling paradigm with implications for breast cancer research, Breast Cancer Res Treat, 35, 115, 10.1007/BF00694752

Takeuchi, 2011, EGF receptor in relation to tumor development: molecular basis of responsiveness of cancer cells to EGFR-targeting tyrosine kinase inhibitors, FEBS J, 277, 316, 10.1111/j.1742-4658.2009.07450.x

Shi, 2010, ErbB3/HER3 intracellular domain is competent to bind ATP and catalyze autophosphorylation, Proc Natl Acad Sci USA, 107, 7692, 10.1073/pnas.1002753107

Hynes, 2005, ERBB receptors and cancer: the complexity of targeted inhibitors, Nat Rev Cancer, 5, 341, 10.1038/nrc1609

Riese, 1996, Betacellulin activates the epidermal growth factor receptor and erbB-4, and induces cellular response patterns distinct from those stimulated by epidermal growth factor or neuregulin-beta, Oncogene, 12, 345

Pinkas-Kramarski, 1998, ErbB tyrosine kinases and the two neuregulin families constitute a ligand-receptor network, Mol Cell Biol, 18, 6090, 10.1128/MCB.18.10.6090

Kataoka, 2009, EGFR ligands and their signaling scissors, ADAMs, as new molecular targets for anticancer treatments, J Dermatol Sci, 56, 148, 10.1016/j.jdermsci.2009.10.002

Prenzel, 1999, EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF, Nature, 402, 884, 10.1038/47260

Iwamoto, 2006, ErbB and HB-EGF signaling in heart development and function, Cell Struct Funct, 31, 1, 10.1247/csf.31.1

Fujiyama, 2001, Angiotensin AT(1) and AT(2) receptors differentially regulate angiopoietin-2 and vascular endothelial growth factor expression and angiogenesis by modulating heparin binding-epidermal growth factor (EGF)-mediated EGF receptor transactivation, Circ Res, 88, 22, 10.1161/01.RES.88.1.22

Eguchi, 1998, Calcium-dependent epidermal growth factor receptor transactivation mediates the angiotensin II-induced mitogen-activated protein kinase activation in vascular smooth muscle cells, J Biol Chem, 273, 8890, 10.1074/jbc.273.15.8890

Rigo, 2010, Macrophages may promote cancer growth via a GM-CSF/HB-EGF paracrine loop that is enhanced by CXCL12, Mol Cancer, 9, 273, 10.1186/1476-4598-9-273

Suzuki, 1997, Matrix metalloproteinase-3 releases active heparin-binding EGF-like growth factor by cleavage at a specific juxtamembrane site, J Biol Chem, 272, 31730, 10.1074/jbc.272.50.31730

Yu, 2002, CD44 anchors the assembly of matrilysin/MMP-7 with heparin-binding epidermal growth factor precursor and ErbB4 and regulates female reproductive organ remodeling, Genes Dev, 16, 307, 10.1101/gad.925702

Vinante, 2013, Heparin-binding epidermal growth factor-like growth factor/diphtheria toxin receptor in normal and neoplastic hematopoiesis, Toxins, 5, 1180, 10.3390/toxins5061180

Sahin, 2004, Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands, J Cell Biol, 164, 769, 10.1083/jcb.200307137

Cai, 1998, Neural crest-specific and general expression of distinct metalloprotease-disintegrins in early Xenopus laevis development, Dev Biol, 204, 508, 10.1006/dbio.1998.9017

Olson, 1998, Blastocyst-dependent upregulation of metalloproteinase/disintegrin MDC9 expression in rabbit endometrium, Cell Tissue Res, 293, 489, 10.1007/s004410051141

Cissé, 2005, The disintegrin ADAM9 indirectly contributes to the physiological processing of cellular prion by modulating ADAM10 activity, J Biol Chem, 280, 40624, 10.1074/jbc.M506069200

Peschon, 1998, An essential role for ectodomain shedding in mammalian development, Science, 282, 1281, 10.1126/science.282.5392.1281

Jackson, 2003, Defective valvulogenesis in HB-EGF and TACE-null mice is associated with aberrant BMP signaling, EMBO J, 22, 2704, 10.1093/emboj/cdg264

Sahin, 2007, Ectodomain shedding of the EGF-receptor ligand epigen is mediated by ADAM17, FEBS Lett, 581, 41, 10.1016/j.febslet.2006.11.074

Le Gall, 2009, ADAMs 10 and 17 represent differentially regulated components of a general shedding machinery for membrane proteins such as transforming growth factor alpha, L-selectin, and tumor necrosis factor alpha, Mol Biol Cell, 20, 1785, 10.1091/mbc.E08-11-1135

Horiuchi, 2007, Substrate selectivity of epidermal growth factor-receptor ligand sheddases and their regulation by phorbol esters and calcium influx, Mol Biol Cell, 18, 176, 10.1091/mbc.E06-01-0014

Mann, 1993, Mice with a null mutation of the TGF alpha gene have abnormal skin architecture, wavy hair, and curly whiskers and often develop corneal inflammation, Cell, 73, 249, 10.1016/0092-8674(93)90227-H

Iwamoto, 2003, Heparin-binding EGF-like growth factor and ErbB signaling is essential for heart function, Proc Natl Acad Sci USA, 100, 3221, 10.1073/pnas.0537588100

Chen, 2000, Mice mutant for Egfr and Shp2 have defective cardiac semilunar valvulogenesis, Nat Genet, 24, 296, 10.1038/73528

Miettinen, 1995, Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor, Nature, 376, 337, 10.1038/376337a0

Sibilia, 1995, Strain-dependent epithelial defects in mice lacking the EGF receptor, Science, 269, 234, 10.1126/science.7618085

Threadgill, 1995, Targeted disruption of mouse EGF receptor: effect of genetic background on mutant phenotype, Science, 269, 230, 10.1126/science.7618084

Hartmann, 2002, The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts, Hum Mol Genet, 11, 2615, 10.1093/hmg/11.21.2615

Murayama, 2002, Significance of the association between heparin-binding epidermal growth factor-like growth factor and CD9 in human gastric cancer, Int J Cancer, 98, 505, 10.1002/ijc.10198

Nakamura, 2001, Immunohistochemical distribution of CD9, heparin binding epidermal growth factor-like growth factor, and integrin alpha3beta1 in normal human tissues, J Histochem Cytochem, 49, 439, 10.1177/002215540104900403

Iwamoto, 2000, Heparin-binding EGF-like growth factor: a juxtacrine growth factor, Cytokine Growth Factor Rev, 11, 335, 10.1016/S1359-6101(00)00013-7

Lemmon, 1997, Two EGF molecules contribute additively to stabilization of the EGFR dimer, EMBO J, 16, 281, 10.1093/emboj/16.2.281

Odaka, 1997, Ligand-binding enhances the affinity of dimerization of the extracellular domain of the epidermal growth factor receptor, J Biochem, 122, 116, 10.1093/oxfordjournals.jbchem.a021718

Domagala, 2000, Stoichiometry, kinetic and binding analysis of the interaction between epidermal growth factor (EGF) and the extracellular domain of the EGF receptor, Growth Factors, 18, 11, 10.3109/08977190009003231

Saito, 2004, Differential activation of epidermal growth factor (EGF) receptor downstream signaling pathways by betacellulin and EGF, Endocrinology, 145, 4232, 10.1210/en.2004-0401

Nishi, 2001, N-arginine dibasic convertase is a specific receptor for heparin-binding EGF-like growth factor that mediates cell migration, EMBO J, 20, 3342, 10.1093/emboj/20.13.3342

Lin, 2001, BAG-1 is a novel cytoplasmic binding partner of the membrane form of heparin-binding EGF-like growth factor: a unique role for proHB-EGF in cell survival regulation, J Biol Chem, 276, 30127, 10.1074/jbc.M010237200

Hieda, 2008, Membrane-anchored growth factor, HB-EGF, on the cell surface targeted to the inner nuclear membrane, J Cell Biol, 180, 763, 10.1083/jcb.200710022

Takemura, 2013, Conditional loss of heparin-binding EGF-like growth factor results in enhanced liver fibrosis after bile duct ligation in mice, Biochem Biophys Res Commun, 437, 185, 10.1016/j.bbrc.2013.05.097

Provenzano, 2005, Heparin-binding EGF-like growth factor (HB-EGF) over-expression in transgenic mice downregulates insulin-like growth factor binding protein (IGFBP) -3 and -4 mRNA, Growth Factors, 23, 19, 10.1080/08977140512331344012

Radulescu, 2010, Heparin-binding epidermal growth factor-like growth factor overexpression in transgenic mice increases resistance to necrotizing enterocolitis, J Pediatr Surg, 45, 1933, 10.1016/j.jpedsurg.2010.05.002

Means, 2003, Overexpression of heparin-binding EGF-like growth factor in mouse pancreas results in fibrosis and epithelial metaplasia, Gastroenterology, 124, 1020, 10.1053/gast.2003.50150

Kiso, 2003, Liver regeneration in heparin-binding EGF-like growth factor transgenic mice after partial hepatectomy, Gastroenterology, 124, 701, 10.1053/gast.2003.50097

Mathay, 2008, Heparin-binding EGF-like growth factor is induced by disruption of lipid rafts and oxidative stress in keratinocytes and participates in the epidermal response to cutaneous wounds, J Invest Dermatol, 128, 717, 10.1038/sj.jid.5701069

McCarthy, 1996, Production of heparin-binding epidermal growth factor-like growth factor (HB-EGF) at sites of thermal injury in pediatric patients, J Invest Dermatol, 106, 49, 10.1111/1523-1747.ep12327214

Stoll, 1997, Heparin-binding ligands mediate autocrine epidermal growth factor receptor activation in skin organ culture, J Clin Invest, 100, 1271, 10.1172/JCI119641

Stoll, 2012, Heparin-binding EGF-like growth factor promotes epithelial–mesenchymal transition in human keratinocytes, J Invest Dermatol, 132, 2148, 10.1038/jid.2012.78

Shirakata, 2005, Heparin-binding EGF-like growth factor accelerates keratinocyte migration and skin wound healing, J Cell Sci, 118, 2363, 10.1242/jcs.02346

Hashimoto, 1994, Heparin-binding epidermal growth factor-like growth factor is an autocrine growth factor for human keratinocytes, J Biol Chem, 269, 20060, 10.1016/S0021-9258(17)32127-0

Marikovsky, 1996, Wound fluid-derived heparin-binding EGF-like growth factor (HB-EGF) is synergistic with insulin-like growth factor-I for Balb/MK keratinocyte proliferation, J Invest Dermatol, 106, 616, 10.1111/1523-1747.ep12345413

Wang, 2012, Enhanced keratinocyte proliferation and migration in co-culture with fibroblasts, PLoS One, 7

Cribbs, 2002, Endogenous production of heparin-binding EGF-like growth factor during murine partial-thickness burn wound healing, J Burn Care Rehabil, 23, 116, 10.1097/00004630-200203000-00008

Yu, 2009, Heparin-binding EGF-like growth factor increases intestinal microvascular blood flow in necrotizing enterocolitis, Gastroenterology, 137, 221, 10.1053/j.gastro.2009.03.060

Chen, 2012, Heparin-binding EGF-like growth factor protects intestinal stem cells from injury in a rat model of necrotizing enterocolitis, Lab Invest, 92, 331, 10.1038/labinvest.2011.167

El-Assal, 2005, HB-EGF enhances restitution after intestinal ischemia/reperfusion via PI3K/Akt and MEK/ERK1/2 activation, Gastroenterology, 129, 609, 10.1053/j.gastro.2005.05.054

El-Assal, 2007, Heparin-binding EGF-like growth factor preserves mesenteric microcirculatory blood flow and protects against intestinal injury in rats subjected to hemorrhagic shock and resuscitation, Surgery, 142, 234, 10.1016/j.surg.2007.04.003

Feng, 2007, Heparin-binding epidermal growth factor-like growth factor promotes enterocyte migration and proliferation in neonatal rats with necrotizing enterocolitis, J Pediatr Surg, 42, 214, 10.1016/j.jpedsurg.2006.09.055

Feng, 2005, Heparin-binding EGF-like growth factor (HB-EGF) and necrotizing enterocolitis, Semin Pediatr Surg, 14, 167, 10.1053/j.sempedsurg.2005.05.005

Feng, 2006, Heparin-binding epidermal growth factor-like growth factor decreases the incidence of necrotizing enterocolitis in neonatal rats, J Pediatr Surg, 41, 144, 10.1016/j.jpedsurg.2005.10.018

Radulescu, 2009, Preclinical neonatal rat studies of heparin-binding EGF-like growth factor in protection of the intestines from necrotizing enterocolitis, Pediatr Res., 65, 437, 10.1203/PDR.0b013e3181994fa0

Xia, 2002, Heparin-binding EGF-like growth factor preserves crypt cell proliferation and decreases bacterial translocation after intestinal ischemia/reperfusion injury, J Pediatr Surg, 37, 1081, 10.1053/jpsu.2002.33881

Raab, 1997, Heparin-binding EGF-like growth factor, Biochim Biophys Acta, 1333, F179

Zhang, 1994, Heparin-binding epidermal growth factor-like growth factor is differentially regulated by progesterone and estradiol in rat uterine epithelial and stromal cells, Endocrinology, 134, 1089, 10.1210/endo.134.3.8119147

Zhang, 1994, Progesterone regulation of heparin-binding epidermal growth factor-like growth factor gene expression during sensitization and decidualization in the rat uterus: effects of the antiprogestin, Endocrinology, 135, 1264, 10.1210/endo.135.3.8070371

Wang, 1994, Differential regulation of heparin-binding epidermal growth factor-like growth factor in the adult ovariectomized mouse uterus by progesterone and estrogen, Endocrinology, 135, 1264, 10.1210/endo.135.3.8070372

Kennedy, 1993, Expression of the genes for the epidermal growth factor receptor and its ligands in porcine corpora lutea, Endocrinology, 132, 1857, 10.1210/endo.132.4.8462481

Kennedy, 1994, Expression of the genes for the epidermal growth factor receptor and its ligands in porcine oviduct and endometrium, Biol Reprod, 50, 751, 10.1095/biolreprod50.4.751

Das, 1994, Heparin-binding EGF-like growth factor gene is induced in the mouse uterus temporally by the blastocyst solely at the site of its apposition: a possible ligand for interaction with blastocyst EGF-receptor in implantation, Development, 120, 1071, 10.1242/dev.120.5.1071

Raab, 1996, Mouse preimplantation blastocysts adhere to cells expressing the transmembrane form of heparin-binding EGF-like growth factor, Development, 122, 637, 10.1242/dev.122.2.637

Schwenke, 2013, Control of human endometrial stromal cell motility by PDGF-BB, HB-EGF and trophoblast-secreted factors, PLoS One, 8, e54336, 10.1371/journal.pone.0054336

Wirstlein, 2013, Correlation of the expression of heparanase and heparin-binding EGF-like growth factor in the implantation window of nonconceptual cycle endometrium, Folia Histochem Cytobiol, 51, 127, 10.5603/FHC.2013.0020

D’Ippolito, 2012, Emerging nonanticoagulant role of low molecular weight heparins on extravillous trophoblast functions and on heparin binding-epidermal growth factor and cystein-rich angiogenic inducer 61 expression, Fertil Steril, 98, 1028, 10.1016/j.fertnstert.2012.06.042

Chen, 2012, Effects of low molecular weight heparin and heparin-binding epidermal growth factor on human trophoblast in first trimester, Fertil Steril, 97, 764, 10.1016/j.fertnstert.2011.12.002

Simone, 2012, Low-molecular-weight heparins induce decidual heparin-binding epidermal growth factor-like growth factor expression and promote survival of decidual cells undergoing apoptosis, Fertil Steril, 97, 169, 10.1016/j.fertnstert.2011.10.021

Battegay, 1995, Angiogenesis: mechanistic insights, neovascular diseases, and therapeutic prospects, J Mol Med (Berl), 73, 333, 10.1007/BF00192885

Bergers, 2003, Tumorigenesis and the angiogenic switch, Nat Rev Cancer, 3, 401, 10.1038/nrc1093

Carmeliet, 2011, Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases, Nat Rev Drug Discov, 10, 417, 10.1038/nrd3455

Persano, 2007, Anti-angiogenic gene therapy of cancer: current status and future prospects, Mol Aspects Med, 28, 87, 10.1016/j.mam.2006.12.005

Chan, 2010, PHD2 in tumour angiogenesis, Br J Cancer, 103, 1, 10.1038/sj.bjc.6605682

Yotsumoto, 2013, Molecular hierarchy of heparin-binding EGF-like growth factor-regulated angiogenesis in triple-negative breast cancer, Mol Cancer Res, 11, 506, 10.1158/1541-7786.MCR-12-0428

Bussolino, 1995, Platelet activating factor produced in vitro by Kaposi's sarcoma cells induces and sustains in vivo angiogenesis, J Clin Invest, 96, 940, 10.1172/JCI118142

Ito, 1994, Heparin-binding EGF-like growth factor is a potent mitogen for rat hepatocytes, Biochem Biophys Res Commun, 198, 25, 10.1006/bbrc.1994.1004

Marikovsky, 1993, Appearance of heparin-binding EGF-like growth factor in wound fluid as a response to injury, Proc Natl Acad Sci USA, 90, 3889, 10.1073/pnas.90.9.3889

Ito, 2001, Expression of heparin-binding epidermal growth factor-like growth factor in pancreatic adenocarcinoma, Int J Pancreatol, 29, 47, 10.1385/IJGC:29:1:47

Jayne, 2000, Activated mesothelial cells produce heparin-binding growth factors: implications for tumour metastases, Br J Cancer, 82, 1233, 10.1054/bjoc.1999.1068

Fu, 1999, Heparin-binding epidermal growth factor-like growth factor, a v-Jun target gene, induces oncogenic transformation, Proc Natl Acad Sci USA, 196, 5716, 10.1073/pnas.96.10.5716

Miyoshi, 1997, Membrane-anchored heparin-binding epidermal growth factor-like growth factor acts as a tumor survival factor in a hepatoma cell line, J Biol Chem, 272, 14349, 10.1074/jbc.272.22.14349

Fang, 2001, p53 induction of heparin-binding EGF-like growth factor counteracts p53 growth suppression through activation of MAPK and PI3K/Akt signaling cascades, EMBO J, 20, 1931, 10.1093/emboj/20.8.1931

Harding, 1999, Induction of anchorage independent growth by heparin-binding EGF-like growth factor (HB-EGF), Growth Factors, 17, 49, 10.3109/08977199909001062

Mishima, 1998, Heparin-binding epidermal growth factor-like growth factor stimulates mitogenic signaling and is highly expressed in human malignant gliomas, Acta Neuropathol, 96, 322, 10.1007/s004010050901

De Vos, 2001, Identifying intercellular signaling genes expressed in malignant plasma cells by using complementary DNA arrays, Blood, 98, 771, 10.1182/blood.V98.3.771

Sato, 2012, A potent anti-HB-EGF monoclonal antibody inhibits cancer cell proliferation and multiple angiogenic activities of HB-EGF, PLoS One, 7, e51964, 10.1371/journal.pone.0051964

Dateoka, 2012, Effects of CRM197, a specific inhibitor of HB-EGF, in oral cancer, Med Mol Morphol, 45, 91, 10.1007/s00795-011-0543-6

Yagi, 2009, Synergistic anti-tumor effect of paclitaxel with CRM197, an inhibitor of HB-EGF, in ovarian cancer, Int J Cancer, 124, 1429, 10.1002/ijc.24031

Lau, 1990, Nature and nurture in adipocyte development and growth, Int J Obes, 14, 153

Planat-Benard, 2004, Plasticity of human adipose lineage cells toward endothelial cells: physiological and therapeutic perspectives, Circulation, 109, 656, 10.1161/01.CIR.0000114522.38265.61

Bouloumié, 2002, Angiogenesis in adipose tissue, Ann Endocrinol (Paris), 63, 91

Hutley, 2001, Human adipose tissue endothelial cells promote preadipocyte proliferation, Am J Physiol Endocrinol Metab, 281, E1037, 10.1152/ajpendo.2001.281.5.E1037

Varzaneh, 1994, Extracellular matrix components secreted by microvascular endothelial cells stimulate preadipocyte differentiation in vitro, Metabolism, 43, 906, 10.1016/0026-0495(94)90275-5

Voros, 2003, Differential expression of plasminogen activator inhibitor-1, tumor necrosis factor-alpha, TNF-alpha converting enzyme and ADAMTS family members in murine fat territories, Biochim Biophys Acta, 1625, 36, 10.1016/S0167-4781(02)00589-4

Lijnen, 2008, Angiogenesis and obesity, Cardiovasc Res, 78, 286, 10.1093/cvr/cvm007

Luque, 2003, ADAMTS1/METH1 inhibits endothelial cell proliferation by direct binding and sequestration of VEGF165, J Biol Chem, 278, 23656, 10.1074/jbc.M212964200

Kawaguchi, 2002, ADAM 12 protease induces adipogenesis in transgenic mice, Am J Pathol, 160, 1895, 10.1016/S0002-9440(10)61136-4

Fukumura, 2003, Paracrine regulation of angiogenesis and adipocyte differentiation during in vivo adipogenesis, Circ Res, 93, e88, 10.1161/01.RES.0000099243.20096.FA

Panigrahy, 2002, PPARgamma ligands inhibit primary tumor growth and metastasis by inhibiting angiogenesis, J Clin Invest, 110, 923, 10.1172/JCI0215634

Ren, 2002, PPARgamma knockdown by engineered transcription factors: exogenous PPARgamma2 but not PPARgamma1 reactivates adipogenesis, Genes Dev, 16, 27, 10.1101/gad.953802

Rosen, 1999, PPAR gamma is required for the differentiation of adipose tissue in vivo and in vitro, Mol Cell, 4, 611, 10.1016/S1097-2765(00)80211-7

Abraham, 1993, Heparin-binding EGF-like growth factor: characterization of rat and mouse cDNA clones, protein domain conservation across species, and transcript expression in tissues, Biochem Biophys Res Commun, 190, 125, 10.1006/bbrc.1993.1020

Zhou, 2013, Cellular reprogramming into a brown adipose tissue-like phenotype by co-expression of HB-EGF and ADAM 12S, Growth Factors, 31, 185, 10.3109/08977194.2013.840297

Boguslavsky, 2006, Nuclear lamin A inhibits adipocyte differentiation: implications for Dunnigan-type familial partial lipodystrophy, Hum Mol Genet, 15, 653, 10.1093/hmg/ddi480

Tong, 2011, Lamin A/C deficiency is associated with fat infiltration of muscle and bone, Mech Ageing Dev, 132, 552, 10.1016/j.mad.2011.09.004

Jin, 1999, Src induces morphological changes in A431 cells that resemble epidermal differentiation through an SH3- and Ras-independent pathway, J Cell Sci, 112, 2913, 10.1242/jcs.112.17.2913

Schenone, 2004, Antiproliferative activity of new 1-aryl-4-amino-1H-pyrazolo[3,4-d]pyrimidine derivatives toward the human epidermoid carcinoma A431 cell line, Eur J Med Chem, 39, 939, 10.1016/j.ejmech.2004.07.010

Carpenter, 1990, Epidermal growth factor, J Biol Chem, 265, 7709, 10.1016/S0021-9258(19)38983-5

Naglich, 1992, Expression cloning of a diphtheria toxin receptor: identity with a heparin-binding EGF-like growth factor precursor, Cell, 69, 1051, 10.1016/0092-8674(92)90623-K

Stroobant, 1985, Purification and characterization of vaccinia virus growth factor, Cell, 42, 383, 10.1016/S0092-8674(85)80133-1

Shing, 1993, Betacellulin: a mitogen from pancreatic beta cell tumors, Science, 259, 1604, 10.1126/science.8456283

Carpenter, 1979, Rapid enhancement of protein phosphorylation in A-431 cell membrane preparations by epidermal growth factor, J Biol Chem, 254, 4884, 10.1016/S0021-9258(17)30094-7

Toyoda, 1995, Epiregulin. A novel epidermal growth factor with mitogenic activity for rat primary hepatocytes, J Biol Chem, 270, 7495, 10.1074/jbc.270.13.7495

Higashiyama, 1992, Structure of heparin-binding EGF-like growth factor: multiple forms, primary structure and glycosylation of the mature protein, J Biol Chem, 267, 6205, 10.1016/S0021-9258(18)42682-8

Elenius, 1997, Activation of HER4 by heparin-binding EGF-like growth factor stimulates chemotaxis but not proliferation, EMBO J, 16, 1268, 10.1093/emboj/16.6.1268

Carraway, 1997, Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases, Nature, 387, 512, 10.1038/387512a0

Chang, 1997, Ligands for ErbB-family receptors encoded by a neuregulin-like gene, Nature, 387, 509, 10.1038/387509a0

Derynck, 1984, Human transforming growth factor-alpha: precursor structure and expression in E. coli, Cell, 38, 287, 10.1016/0092-8674(84)90550-6

Massague, 1983, Epidermal growth factor-like transforming growth factor. II. Interaction with epidermal growth factor receptors in human placenta membranes and A431 cells, J Biol Chem, 258, 13614, 10.1016/S0021-9258(17)43959-7