Hemostatic Status and Fibrinolytic Response Potential at Different Phases of the Menstrual Cycle

Clinical and Applied Thrombosis/Hemostasis - Tập 11 Số 3 - Trang 295-301 - 2005
Sau Koh1, Rajendra Prasad1, Yoke Fai Fong1
1National University of Singapore, Department of Obstetrics and Gynaecology, National University Hospital, Lower Kent Ridge Road, Singapore

Tóm tắt

Coagulation and fibrinolytic variables including platelet function and endogenous fibrinolytic response were determined in 30 normal healthy women volunteers not on any known medication during the period of study. They were between 18 years and 38 years old and had normal menstrual cycles of between 28 days and 30 days. Blood samples were obtained within one menstrual cycle and after having fasted overnight within days 1 to 3 (menstruation), 5 to 9 (follicular), 10 to 14 (mid-cycle), and 21 to 26 (luteal) of the menstrual cycle. Analysis of variance (ANOVA) showed no significant differences in the hemostatic parameters studied between the phases of the menstrual cycle except for a reduced D-dimer level at mid-cycle. Significant fibrinolytic response was seen after venous occlusion but they were not significantly different between the phases of the menstrual cycle. The women were then divided into either normal weight (n=22) or overweight (n=8) according to World Health Organization (WHO) classification and the data reanalyzed. Elevated tissue plasminogen activator antigen and plasminogen activator inhibitor-1 levels except at menstruation and total protein S except at follicular phase were observed in overweight women together with increased plasminogen level only at luteal phase. Significant endogenous fibrinolytic response seen during the menstrual cycle was not different between normal and overweight women. The study demonstrated that systemic coagulation, fibrinolysis, and platelet function were probably not influenced by natural hormonal changes occurring during the menstrual cycle except for an associated reduced fibrinolytic state at mid-cycle. The hemostatic system in this small group of healthy overweight women studied appeared to be physiologically compromised.

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Tài liệu tham khảo

10.1016/0378-5122(96)00994-2

10.3109/03009738909178559

Cederblad G, 1977, Haemostasis, 6, 294

10.1097/00001721-200207000-00009

10.1055/s-0037-1614855

10.1055/s-0037-1612925

10.1055/s-0037-1613140

10.1055/s-0038-1649686

10.1056/NEJMoa020245

WHO, 1998, Obesity-Preventing and managing the global epidemic: Report of a WHO consultation on obesity

10.1046/j.1467-789X.2002.00056.x

10.1007/BF03344054

10.1038/icb.1989.30

Koh SCL, 1993, J Med Lab Sci, 7, 29

Koh CLS, 1992, Med Sci Res, 20, 601

Koh CLS, 1989, Med Sci Res, 17, 135

10.1530/jrf.0.0960407

10.1161/01.ATV.20.4.1150

10.1055/s-0038-1646463

10.1016/0049-3848(95)91607-M

Thông tin
Thông tin xuất bản

Clinical and Applied Thrombosis/Hemostasis

Tập 11 Số 3

295-301

Thông tin tác giả