Hemolytic Disease of the Fetus and Newborn: Modern Practice and Future Investigations

Reid, 2004 Moise, 2012, Management and prevention of red cell alloimmunization in pregnancy: a systematic review, Obstet Gynecol, 120, 1132, 10.1097/AOG.0b013e31826d7dc1 Delaney, 2015, Hemolytic disease of the fetus and newborn: managing the mother, fetus, and newborn, Hematology Am Soc Hematol Educ Program, 2015, 146, 10.1182/asheducation-2015.1.146 Eder, 2006, Update on HDFN: new information on long-standing controversies, Immunohematology, 22, 188, 10.21307/immunohematology-2019-379 Markham, 2015, Hemolytic disease of the fetus and newborn due to multiple maternal antibodies, Am J Obstet Gynecol, 213, 68, 10.1016/j.ajog.2015.01.049 Moise, 2000, Non–anti-D antibodies in red-cell alloimmunization, Eur J Obstet Gynecol Reprod Biol, 92, 75, 10.1016/S0301-2115(00)00428-0 Hadley, 1998, The ability of the chemiluminescence test to predict clinical outcome and the necessity for amniocenteses in pregnancies at risk of haemolytic disease of the newborn, Br J Obstet Gynaecol, 105, 231, 10.1111/j.1471-0528.1998.tb10059.x Nance, 1989, Monocyte monolayer assay: an efficient noninvasive technique for predicting the severity of hemolytic disease of the newborn, Am J Clin Pathol, 92, 89, 10.1093/ajcp/92.1.89 Kapur, 2014, Low anti-RhD IgG-fc-fucosylation in pregnancy: a new variable predicting severity in haemolytic disease of the fetus and newborn, Br J Haematol, 166, 936, 10.1111/bjh.12965 Sonneveld, 2015, IgG alloantibodies agianst RBC induced by pregnancy or transfusion have unique glycosylation patterns which correlate with clinical outcomes of hemolytic disease of the fetus or newborn Vaughan, 1998, Inhibition of erythroid progenitor cells by anti-Kell antibodies in fetal alloimmune anemia, N Engl J Med, 338, 798, 10.1056/NEJM199803193381204 Daniels, 2003, Causes of fetal anemia in hemolytic disease due to anti-K, Transfusion, 43, 115, 10.1046/j.1537-2995.2003.00327.x Wagner, 2000, RHD gene deletion occurred in the rhesus box, Blood, 95, 3662, 10.1182/blood.V95.12.3662 Finning, 2007, Fetal genotyping for the K (Kell) and Rh C, c, and E blood groups on cell-free fetal DNA in maternal plasma, Transfusion, 47, 2126, 10.1111/j.1537-2995.2007.01437.x Finning, 2002, Prediction of fetal D status from maternal plasma: introduction of a new noninvasive fetal RHD genotyping service, Transfusion, 42, 1079, 10.1046/j.1537-2995.2002.00165.x Ahaded, 2000, Quantitative determination of anti-K (KEL1) IgG and IgG subclasses in the serum of severely alloimmunized pregnant women by ELISA, Transfusion, 40, 1239, 10.1046/j.1537-2995.2000.40101239.x Lambin, 2002, IgG1 and IgG3 anti-D in maternal serum and on the RBCs of infants suffering from HDN: relationship with the severity of the disease, Transfusion, 42, 1537, 10.1046/j.1537-2995.2002.00239.x Oepkes, 2001, Clinical value of an antibody-dependent cell-mediated cytotoxicity assay in the management of Rh D alloimmunization, Am J Obstet Gynecol, 184, 1015, 10.1067/mob.2001.112970 de Haas, 2015, Haemolytic disease of the fetus and newborn, Vox Sang, 109, 99, 10.1111/vox.12265 Higel, 2016, N-glycosylation heterogeneity and the influence on structure, function and pharmacokinetics of monoclonal antibodies and fc fusion proteins, Eur J Pharm Biopharm, 100, 94, 10.1016/j.ejpb.2016.01.005 Kapur, 2014, A prominent lack of IgG1-fc fucosylation of platelet alloantibodies in pregnancy, Blood, 123, 471, 10.1182/blood-2013-09-527978 practice bulletin no, 2006, 75: management of alloimmunization during pregnancy, Obstet Gynecol, 108, 457 Lindenburg, 2012, Long-term neurodevelopmental outcome after intrauterine transfusion for hemolytic disease of the fetus/newborn: the LOTUS study, Am J Obstet Gynecol, 206, 141, 10.1016/j.ajog.2011.09.024 Ruma, 2007, Combined plasmapheresis and intravenous immune globulin for the treatment of severe maternal red cell alloimmunization, Am J Obstet Gynecol, 196, 138, 10.1016/j.ajog.2006.10.890 Schwartz, 2013, Guidelines on the use of therapeutic apheresis in clinical practice-evidence-based approach from the Writing Committee of the American Society for Apheresis: the sixth special issue, J Clin Apher, 28, 145, 10.1002/jca.21276 2004, Pediatrics, 114, 297, 10.1542/peds.114.1.297 Rath, 2011, Hematological morbidity and management in neonates with hemolytic disease due to red cell alloimmunization, Early Hum Dev, 87, 583, 10.1016/j.earlhumdev.2011.07.010 Smits-Wintjens, 2013, Neonatal morbidity after exchange transfusion for red cell alloimmune hemolytic disease, Neonatology, 103, 141, 10.1159/000343261 Corvaglia, 2012, Intravenous immunoglobulin to treat neonatal alloimmune haemolytic disease, J Matern Fetal Neonatal Med, 25, 2782, 10.3109/14767058.2012.718387 Elalfy, 2011, Early intravenous immunoglobin (two-dose regimen) in the management of severe Rh hemolytic disease of newborn—a prospective randomized controlled trial, Eur J Pediatr, 170, 461, 10.1007/s00431-010-1310-8 Hauschner, 2015, Persistent neonatal thrombocytopenia can be caused by IgA antiplatelet antibodies in breast milk of immune thrombocytopenic mothers, Blood, 126, 661, 10.1182/blood-2014-12-614446 Santhanakrishnan, 2016, Clinically significant anti-KEL RBC alloantibodies are transferred by breast milk in a murine model, Vox Sang, 10.1111/vox.12387 Van de Perre, 2003, Transfer of antibody via mother's milk, Vaccine, 21, 3374, 10.1016/S0264-410X(03)00336-0 Paveglio, 2012, FcRn-mediated intestinal absorption of IgG anti-IgE/IgE immune complexes in mice, Clin Exp Allergy, 42, 1791, 10.1111/j.1365-2222.2012.04043.x Callum, 2014, The AABB recommendations for the choosing wisely campaign of the American Board of Internal Medicine, Transfusion, 54, 2344, 10.1111/trf.12802 van der Schoot, 2003, Prenatal typing of Rh and Kell blood group system antigens: the edge of a watershed, Transfus Med Rev, 17, 31, 10.1053/tmrv.2003.50001 Bowman, 1985, Controversies in Rh prophylaxis. Who needs Rh immune globulin and when should it be given?, Am J Obstet Gynecol, 151, 289, 10.1016/0002-9378(85)90288-1 Sandler, 2015, It's time to phase in RHD genotyping for patients with a serologic weak D phenotype, Transfusion, 55, 680, 10.1111/trf.12941 Kacker, 2015, Financial implications of RHD genotyping of pregnant women with a serologic weak D phenotype, Transfusion, 55, 2095, 10.1111/trf.13074 Anderson, 1999, Successful prevention of post-transfusion Rh alloimmunization by intravenous rho (D) immune globulin (WinRho SD), Am J Hematol, 60, 245, 10.1002/(SICI)1096-8652(199903)60:3<245::AID-AJH16>3.0.CO;2-4 Laspina, 2005, Prevention of post-transfusion RhD immunization using red cell exchange and intravenous anti-D immunoglobulin, Vox Sang, 89, 49, 10.1111/j.1423-0410.2005.00637.x Nester, 2004, Prevention of immunization to D+ red blood cells with red blood cell exchange and intravenous Rh immune globulin, Transfusion, 44, 1720, 10.1111/j.0041-1132.2004.04161.x Schonewille, 2007, High additional maternal red cell alloimmunization after rhesus- and K-matched intrauterine intravascular transfusions for hemolytic disease of the fetus, Am J Obstet Gynecol, 196, 143, 10.1016/j.ajog.2006.10.895 Schonewille, 2015, Extended matched intrauterine transfusions reduce maternal Duffy, Kidd, and S antibody formation, Transfusion, 55, 2912, 10.1111/trf.13231 Brinc, 2009, Mechanisms of anti-D action in the prevention of hemolytic disease of the fetus and newborn, Hematology Am Soc Hematol Educ Program, 185, 10.1182/asheducation-2009.1.185 Kumpel, 2002, On the mechanism of tolerance to the Rh D antigen mediated by passive anti-D (Rh D prophylaxis), Immunol Lett, 82, 67, 10.1016/S0165-2478(02)00020-2 Kapur, 2015, Prophylactic anti-D preparations display variable decreases in fc-fucosylation of anti-D, Transfusion, 55, 553, 10.1111/trf.12880 Goossens, 2013, Mice expressing RHAG and RHD human blood group genes, PLoS One, 8, e80460, 10.1371/journal.pone.0080460 Bernardo, 2014, RhD specific antibodies are not detectable in HLA-DRB1(*)1501 mice challenged with human RhD positive erythrocytes, Adv Hematol, 2014, 470242, 10.1155/2014/470242 Finn, 1961, Experimental studies on the prevention of Rh haemolytic disease, Br Med J, 1, 1486, 10.1136/bmj.1.5238.1486 Kumpel, 2007, Efficacy of RhD monoclonal antibodies in clinical trials as replacement therapy for prophylactic anti-D immunoglobulin: more questions than answers, Vox Sang, 93, 99, 10.1111/j.1423-0410.2007.00945.x Hendrickson, 2010, Storage of murine red blood cells enhances alloantibody responses to an erythroid-specific model antigen, Transfusion, 50, 642, 10.1111/j.1537-2995.2009.02481.x Hendrickson, 2011, Rapid clearance of transfused murine red blood cells is associated with recipient cytokine storm and enhanced alloimmunogenicity, Transfusion, 51, 2445, 10.1111/j.1537-2995.2011.03162.x Smith, 2012, Transfusion in the absence of inflammation induces antigen-specific tolerance to murine RBCs, Blood, 119, 1566, 10.1182/blood-2011-09-382655 Hendrickson, 2006, Recipient inflammation affects the frequency and magnitude of immunization to transfused red blood cells, Transfusion, 46, 1526, 10.1111/j.1537-2995.2006.00946.x Schenten, 2011, The control of adaptive immune responses by the innate immune system, Adv Immunol, 109, 87, 10.1016/B978-0-12-387664-5.00003-0 Stowell, 2015, Anti-KEL sera prevents alloimmunization to transfused KEL RBCs in a murine model, Haematologica, 100, e394, 10.3324/haematol.2015.128603 Brinc, 2007, IgG-mediated immunosuppression is not dependent on erythrocyte clearance or immunological evasion: implications for the mechanism of action of anti-D in the prevention of haemolytic disease of the newborn?, Br J Haematol, 139, 275, 10.1111/j.1365-2141.2007.06764.x Brinc, 2008, Immunology, 124, 141, 10.1111/j.1365-2567.2008.02807.x Bernardo, 2015, IgG-mediated immune suppression to erythrocytes by polyclonal antibodies can occur in the absence of activating or inhibitory Fcgamma receptors in a full mouse model, J Immunol, 195, 2224, 10.4049/jimmunol.1500790 Stowell, 2013, Antigen modulation confers protection to red blood cells from antibody through Fcgamma receptor ligation, J Immunol, 191, 5013, 10.4049/jimmunol.1300885 Zimring, 2009, Antigen loss from antibody-coated red blood cells, Transfus Med Rev, 23, 189, 10.1016/j.tmrv.2009.03.002 Taylor, 2015, Fcgamma-receptor-mediated trogocytosis impacts mAb-based therapies: historical precedence and recent developments, Blood, 125, 762, 10.1182/blood-2014-10-569244 Sullivan, 2015, Anti-RhD mediates loss of RhD antigen following anti-RhD infusion, Blood, 126, 3570, 10.1182/blood.V126.23.3570.3570 Girard-Pierce, 2013, A novel role for C3 in antibody-induced red blood cell clearance and antigen modulation, Blood, 122, 1793, 10.1182/blood-2013-06-508952