Helper (CD4+) and Cytotoxic (CD8+) T Cells Promote the Pathology of Dystrophin-Deficient Muscle

Koenig, 1987, Complete cloning of the duchenne muscular dystrophy (DMD) cDNA and preliminary genomic organization of the DMD gene in normal and affected individuals, Cell, 50, 509, 10.1016/0092-8674(87)90504-6

Monaco, 1988, Cloning of the Duchenne/Becker muscular dystrophy locus, Adv. Hum. Genet., 17, 61

Hoffman, 1987, Dystrophin: The protein product of the Duchenne muscular dystrophy locus, Cell, 51, 919, 10.1016/0092-8674(87)90579-4

Petrof, 1993, Dystrophin protects the sarcolemma from stress developed during muscle contraction, Proc. Natl. Acad. Sci. USA, 90, 3710, 10.1073/pnas.90.8.3710

Drachman, 1974, Prednisone in Duchenne muscular dystrophy, Lancet, December 14, 1409, 10.1016/S0140-6736(74)90071-3

Brooke, 1987, Clinical investigation of Duchenne muscular dystrophy. Interesting results in a trial of prednisone, Arch. Neurol., 44, 812, 10.1001/archneur.1987.00520200016010

Granchelli, 1995, Duchenne-like myopathy in double-mutant mdx mice expressing exaggerated mast cell activity, J. Neurol. Sci., 131, 1, 10.1016/0022-510X(95)00089-K

Nahirney, 1997, Quantitative morphology of mast cells in skeletal muscle of normal and genetically dystrophic mice, Anat. Rec., 247, 341, 10.1002/(SICI)1097-0185(199703)247:3<341::AID-AR5>3.0.CO;2-X

Gorospe, J. R. M., Tharp, M., Demitsu, T., and Hoffman, E. P., Dystrophin-deficient myofibers are vulnerable to mast cell granule-induced necrosis. Neuromuscular Disorders4, 325–333, 1994.

Spencer, 1997, Myonuclear apoptosis in dystrophic mdx muscle occurs by perforin-mediated cytotoxicity, J. Clin. Invest., 99, 2745, 10.1172/JCI119464

Engel, 1986, Mononuclear cells in myopathies: Quantitation of functionally distinct subsets, recognition of antigen-specific cell-mediated cytotoxicity in some diseases, and implications for the pathogenesis of the different inflammatory myopathies, Hum. Pathol., 17, 704, 10.1016/S0046-8177(86)80180-0

Cai, 2000, Eosinophilia of dystrophin-deficient muscle is promoted by perforin-mediated cytotoxicity by T cell effectors, Am. J. Pathol., 156, 1789, 10.1016/S0002-9440(10)65050-X

Gussoni, 1994, Specific T cell receptor gene rearrangements at the site of muscle degeneration in Duchenne muscular dystrophy, J. Immunol., 153, 4798, 10.4049/jimmunol.153.10.4798

Pagel, 1999, Covert persistence of mdx mouse myopathy is revealed by acute and chronic effects of irradiation, J. Neurol. Sci., 164, 103, 10.1016/S0022-510X(99)00061-1

Granata, 1998, Gamma irradiation can reduce muscle damage in mdx dystrophic mice, Acta Neuropathol., 96, 564, 10.1007/s004010050936

Harlow, 1988

Estess, 1998, Functional activation of lymphocyte CD44 in peripheral blood is a marker of autoimmune disease activity, J. Clin. Invest., 102, 1173, 10.1172/JCI4235

Haegel, 1993, Activated mouse astrocytes and T cells express similar CD44 variants. Role of CD44 in astrocyte/T cell binding, J. Cell Biol., 122, 1067, 10.1083/jcb.122.5.1067

Arahata, 1984, Monoclonal antibody analysis of mononuclear cells in myopathies I, Ann. Neurol., 16, 193, 10.1002/ana.410160206

Emslie-Smith, 1989, Major histocompatibility complex class I antigen expression, immunolocalization of interferon subtypes, and t cell-mediated cytotoxicity in myopathies, Hum. Pathol., 20, 224, 10.1016/0046-8177(89)90128-7

McDouall, 1990, Nature of the mononuclear infiltrate and the mechanism of muscle damage in juvenile dermatomyositis and Duchenne muscular dystrophy, J. Neurol. Sci., 99, 199, 10.1016/0022-510X(90)90156-H

Kagi, 1994, Fas and perforin pathways as major mechanisms of T cell-mediated cytotoxicity, Science, 265, 528, 10.1126/science.7518614

McDouall, 1989, Expression of class I and class II MHC antigens in neuromuscular diseases, J. Neurol. Sci., 89, 213, 10.1016/0022-510X(89)90023-3

Wardrop, 1999, Oral tolerance in the treatment of inflammatory autoimmune diseases, Inflammation Res., 48, 106, 10.1007/s000110050433