Helicobacter pylori: an up-to-date overview on the virulence and pathogenesis mechanisms
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Waskito LA, Yamaoka Y (2019) The story of Helicobacter pylori: depicting human migrations from the phylogeography. Adv Exp Med Biol 1149:1–16
Hanafiah A, Lopes BS (2020) Genetic diversity and virulence characteristics of Helicobacter pylori isolates in different human ethnic group. Infect Genet Evol 78:104135
Salama NR (2020) Cell morphology as a virulence determinant: lessons from Helicobacter pylori. Curr Opin Microbiol 54:11–17
Kusters JG, Gerrits MM, Van Strijp JA, Vandenbroucke-Grauls CM (1997) Coccoid forms of Helicobacter pylori are the morphologic manifestation of cell death. Infect Immun 65:3672–3679
Reshetnyak VI, Reshetnyak TM (2017) Significance of dormant forms of Helicobacter pylori in ulcerogenesis. World J Gastroenterol 23:4867–4878
Reshetnyak VI, Burnistrov AI, Maev IV (2021) Helicobacter pylori: commensals, symbiont or pathogens? World J Gastroenterol 27(7):545
Krzyżek P, Grande R (2020) Transformation of Helicobacter pylori into Coccoid forms as a challenge for research determining activity of antimicrobial substances. Pathogens 9:184
Lerardi E, Losurdo G, Mileti A, Paolillo R, Giorgio F, Principi M, Di Leo A (2020) The puzzle of coccoid forms of Helicobacter pylori: beyond basic science. Antibiotics (Basel) 9(6):293
Kao C-Y, Sheu B-S, Wu J-J (2016) Helicobacter pylori infection: an overview of bacterial virulence factors and pathogenesis. Biomedical Journal 39(1):14–23
Saxena A, Mukhopadhyar AK, Nandi SP (2020) Helicobacter pylori: perturbation and restoration of gut microbiome. J Biosci 45(1):1–15
Huang Y, Wang Q-L, Cheng D-d, Xu Vot Lu, N-h, (2016) Adhesin and invasion of gastric mucosa epithelial cells by Helicobacter pylori. Front Cell Infect Microbiol 6:159
Alexander SM, Retnakumar RJ, Chouhan D, Devi TNB, Dharmaseelan S, Devadas K, Lamtha SC, Chattopadhyay S (2021) Helicobacter pylori in human stomach: the inconsistencies in clinical outcomes and the probable causes. Front Microbiol 12:713955
Hooi JK, Lai WY, Ng WK, Suen MM, Underwood FE, Tanyingoh D et al (2017) Global prevalence of Helicobacter pylori infection: systematic review and meta-analysis. Gastroenterology 153(2):420–429
Machlowska J, Kapusta P, Baj J, Morsink FHM, Wołkow P, Maciejewski R, Offerhaus GJA, Sitarz R (2020) High-throughput sequencing of gastric cancer patients: unravelling genetic predispositions towards an early-onset subtype. Cancers 12:1981
Gravina AG, Zagari RM, de Musis C, Romano L, Loguercio C, Romano L, Loguercio C, Romano M (2018) Helicobacter pylori and extragastric diseases: a review. World J Gastroenterol 24(29):3204–3221
Narayanan M, Reddy KM, Marsicano E (2018) Peptic ulcer disease and Helicobacter pylori infection. Mo Med 115:219
Watari J, Chen N, Amenta PS, Fukui H, Oshima T, Tomita T et al (2014) Helicobacter pylori associated chronic gastritis, clinical syndromes, precancerous lesions, and pathogenesis of gastric cancer development. World J Gastroenterol: WJG 20:5461
Polyzos SA, Zeglinas C, Artemaki F, Doulberis M, Kazakos E, Katsinelos P et al (2018) Helicobacter pylori infection and esophageal adenocarcinoma: a review and a personal view. Ann Gastroenterol 31:8
Chen TP, Hung HF, Chen MK, Lai HH, Hsu WF, Huang KC et al (2015) Helicobacter pylori infection is positively associated with metabolic syndrome in Taiwanese adults: a cross-sectional study. Helicobacter 20:184–191
Yu XJ, Yang X, Feng L, Wang LL, Dong QJ (2017) Association between Helicobacter pylori infection and angiographically demonstrated coronary artery disease: a meta-analysis. Exp Ther Med 13:787–793
Sato Y, Yoneyama O, Azumaya M, Takeuchi M, Sasaki SY, Yokoyama J et al (2015) The relationship between iron deficiency in patients with Helicobacter pylori-infected nodular gastritis and the serum prohepcidin level. Helicobacter 20:11–18
Pucułek M, Machlowska J, Wierzbicki R, Baj J, Maciejewski R, Sitarz R (2018) Helicobacter pylori associated factors in the development of gastric cancer with special reference to the early-onset subtype. Oncotarget 9(57):31146–31162
Eusebi LH, Zagar RM, Bazzoli F (2014) Epidemiology of Helicobacter pylori infection. Helicobacter 19(S1):1–5
Urita Y, Watanabe T, Kawagoe N, Takemoto I, Tanaka H, Kijima S, Urita C (2013) Role of infected grandmothers in transmission of Helicobacter pylori to children in a Japanese rural town. J Paediat Child Health 49(5):394–398
Mentis A, Lehbours P, Megraud F (2015) Epidemiology and diagnosis of Helicobacter pylori infection. Helicobacter 20:1–7
Stefano K, Marco M, Federica G, Laura B, Barbara B, Gioacchino L (2018) Helicobacter pylori, transmission routes and recurrence of infection: state of the art. Acta Bio Medica: Atenei Parmensis 89(8):72
Thung I, Aramin H, Vavinskaya V, Gupta S, Park JY, Crowe SE, Valasek MA (2016) Review article: the global emergence of Helicobacter pylori antibiotic resistance. Aliment Pharmacol Ther 43:514–533
Costa L, Corre S, Michel V, et al (2019) USF1 defect drives p53 degradation during Helicobacter pylori infection and accelerates gastric carcinogenesis. Gut. 2019;gutjnl-2019–318640
Teng Y-S, Zhao Y-L, Li M-S et al (2020) Upexpression of BHLHE40 in gastric epithelial cells increases CXCL12 production through interaction with p-STAT3 in Helicobacter pylori-associated gastritis. FASEB J 34(1):1169–1181
Wroblewski LE, Choi E, Petersen C et al (2019) Targeted mobilization of Lrig1+ gastric epithelial stem cell populations by a carcinogenic Helicobacter pylori type IV secretion system. Proc Natl Acad Sci U S A 116(39):19652–19658
Blosse A, Levy M, Robe C, Staedel C, Copie-Bergman C, Lehours P (2019) Deregulation of miRNA in Helicobacter pylori-induced gastric MALT lymphoma: from mice to human. J Clin Med 8:6
Baj J, Forma A, Sitarz M, Portincasa P, Garruti G, Krasowska D, Maciejewski R (2021) Helicobacter pylori virulence factors-mechanisms of bacterial pathogenicity in the gastric microenvironment. Cells 10(1):27
Machlowska J, Baj J, Sitarz M, Maciejewski R, Sitarz R (2020) Gastric cancer: epidemiology, risk factors, classification, genomic characteristics and treatment strategies. Int J Mol Sci 21:4012
Baj J, Korona-Głowniak I, Forma A, Maani A, Sitarz E, Rahnama-Hezavah M, Radzikowska E, Portincasa P (2020) Mechanisms of the epithelial–mesenchymal transition and tumor microenvironment in Helicobacter pylori-induced gastric cancer. Cells 9:1055
Palamides P, Jolaiya T, Idowu A, Loell E, Onyekwere C, Ugaogbe R, Agbo I, Lesi D, Ndububa D (2020) Helicobacter pylori patient isolates from South Africa and Nigeria differ in virulence factor, pathogenicity profile and associated gastric diseases outcome. Sci Rep 10:11409
Tomb JF, White O, Kerlavage AR, Clayton RA, Fleischmann RD, Venter JC (1997) The complete genome sequence of the gastric pathogens Helicobacter pylori. Nature 388(6642):539–547
Hunt R, Xiao S, Megraud F, Leon-Barau R, Bazzoli F, Van der Merwe S, Le Mair A (2011) World Gastroenterology Organization Global Guideline. Helicobacter pylori in developing countries. August 2010: WGO global guidelines. South Afr Gastroenterol Rev 9(3):1622
Park YH, Kim N (2015) Review of atrophic gastric and intestinal metaplasia as a pre malignant lesion of gastric cancer. J cancer Prev 20(1):25
Ofori EG, Adinortey CA, Bockarie AS, Kyei F, Tagoe EA, Adinortey MB (2019) Helicibacter pylori infection, virulence genes’ distribution and accompanying clinical outcomes: the West Africa situation. BioMed Res Int 2019
Toh JW, Wilson RB (2020) Pathways of gastric carcinogenesis, Helicobacter pylori virulence and interactions with antioxidant systems, vitamin c and phytochemicals. Int J Mol Sci 21(17):6451
Salama NR, Hartung ML, Mueller A (2013) Life in the human stomach: persistence strategies of the bacterial pathogen Helicobacter pylori. Nature Rev Microbiol 11:385–399
Yamaoka Y, Graham DY (2014) Helicobacter pylori virulence and cancer pathogenesis. Future Oncol 10:1487–1500
Amieva M, Peek RM Jr (2016) Pathobiology of Helicobacter pylori-induced gastric cancer. Gastroenterology 150:64–78
Elhahriri M, Hanza D, Elhew R, Hamza E (2018) Occurrence of cagA+ vacA s1a m1 i1 Helicobacter pylori in farm animals in Egypt and ability to survive in experimentally contaminated UHT milk. Sci Rep 8(1):1–3
Dorer MS, Talarico S, Salama NR (2009) Helicobacter pylori’s unconventional role in health and disease. PLoS Pathog 5:e1000544
Salama NR, Hartung ML, Muller A (2013) Life in the human stomach: persistence strategies of the bacterial pathogen Helicobacter pylori. Natl Rev Microbiol 11:385–399
Kusters JG, van Vliet AHM, Kuipers E (2006) Pathogenesis of Helicobacter pylori infection. Clin Microbiol 19(3):449–490
Yanezawa H, Osaki T, Kamiya S (2015) Biofilm formation by Helicobacter pylori and its involvement for antibiotics resistance. Biomed Res Int 2015(914791):9
Hathroubi S, Hu S, Ottemann KM (2020) Genetic requirements and transcriptomics of Helicobacter pylori biofilm formation on abiotic and biotic surfaces. NPJ Biofilms Microbiomes 6:56
Hathroubi S, Servetas SL, Windham I, Merrell DS, Ottemann KM (2018) Helicobacter pylori biofilm formation and its potential role in pathogenesis. Microbiol Mol Biol Rev 82:e00001-e00018
Fauzia KA, Miftahussurur M, Syam AF, Waskito LA, Doohan D, Rezkitha YAA et al (2020) Biofilm formation and antibiotic resistance phenotype of Helicobacter pylori clinical isolates. Toxins 12:473
Patel SK, Pratap CB, Jain AK, Gulati AK, Nath G (2014) Diagnosis of Helicobacter pylori: what should be the gold standard? World J Gastroenterol 20:12847–12859
Korona-Glowniak I et al (2019) Antibiotic resistance and genotypes of Helicobacter pylori strains in patients with gastroduodenal disease in Southeast Poland. J Clin Med 8
Idowu A, Mzukwa A, Harrison U, Palamides P, Haas R, Mbao M, Njom H (2019) Detection of Helicobacter pylori and its virulence genes (cagA, dupA, and vacA) among patients with gastroduodenal diseases in Chris Hani Baragwanath Academic Hospital. South Africa BMC gastroenterology 19(1):1–10
Sabbagh P, Javanian M, Koppolu V, Vasigala VR, Ebrahimpour S (2019) Helicobacter pylori infection in children: an overview of diagnostic methods. Eur J Clin Microbiol Infect Dis 38(6):1035–1045
Wang Y-K, Kuo F-C, Liu C-J, Wu M-C, Shih H-Y, Wang SSW, Wu J-Y, Kuo C-H, Huang Y-K, Wu D-C (2015) Diagnosis of Helicobacter pylori infection: current options and developments. World J Gastroenterol 21(40):11221–11235
Yañez P, la Garza AM, Pérez-Pérez G, Cabrera L, Muñoz O, Torres J (2000) Comparison of invasive and noninvasive methods for the diagnosis and evaluation of eradication of Helicobacter pylori infection in children. Arch Med Res 31:415–421
Pellicano R, Smedile A, Ponzetto A, Berrutti M, Astegiano M, Saracco G, De Angelis C, Repici A, Morgando A, Abate ML, Fagoonee S, Rizzetto M (2005) How accurate is the culture of Helicobacter pylori in a clinical setting? An appraisal. Panminerva Med 47:191–194
Kovaleva J (2016) Infectious complications in gastrointestinal endoscopy and their prevention. Best Pract Res Clin Gastroenterol 30(5):689–704
Sakai E, Higurashi T, Ohkubo H, Hosono K, Ueda A, Matsuhashi N, Nakajima A (2017) Investigation of small bowel abnormalities in HIV-infected patients using capsule endoscopy. Gastroenterol Res Pract 2017
Megraud F, Lehours P (2007) Helicobacter pylori detection and antimicrobial susceptibility testing. Clin Microbiol Rev 20(2):280
Bilgilier C, Stadlmann A, Makristathis A, Thannesberger J, Kastner MT, Knoflach P, Steiner P, Schöniger C (2018) Prospective multicentre clinical study on inter- and intrapatient genetic resistance of Helicobacter pylori. Clin Microbiol Infect 24(3):267–272
Pantoflickova D, Scott DR, Sachs G, Dorta G, Blum AL (2003) 13C urea breath test (UBT) in the diagnosis of Helicobacter pylori: why does it work better with acid test meals?”. Gut 52(7):933–937
de Francesco V, Zullo A, Perna F, Giorgio F, Hassan C, Vannella L, Lerardi E (2010) Helicobacter pylori antibiotic resistance and [13C] urea breath test values. J Med Microbiol 59(5):588–591
Ogata SK, Kawakami E, Patrício FR, Pedroso MZ, Santos AM (2001) Evaluation of invasive and non-invasive methods for the diagnosis of Helicobacter pylori infection in symptomatic children and adolescents. Sao Paulo Med J119:67–71
Korkmaz H, Kesli R, Karabagli P, Terzi Y (2013) Comparison of the diagnostic accuracy of five different stool antigen tests for the diagnosis of Helicobacter pylori infection. Helicobacter 18:384–391
Yang BL, Yeh C, Kwong WG, Lee SD (2015) A novel one-step Helicobacter pylori saliva antigen test. J Chin Med Assoc 78(2):96–100
Hooton C, Keohane J, Clair J, Azam M, O’Mahony S, Crosbie O, Lucey B (2006) Comparison of three stool antigen assays with the 13C-urea breath test for the primary diagnosis of Helicobacter pylori infection and monitoring treatment outcome. Eur J Gastroenterol Hepatol 18(6):595–599
Fischbach W, Malfertheiner P, Jansen PL, Bolten W, Bornschein J, Buderus S, Veith M (2016) S2k guideline. Helicobacter pylori and gastroduodenal ulcer disease. J Gastroenterol 54 (04):327–363
Abadi TB, Amin. (2018) Diagnosis of Helicobacter pylori using invasive and noninvasive approaches. J Pathog 2018:9064952
Imkamp F, Lauener FN, Pohl D, Lehours P, Vale FF, Jehanne Q, Wagner K (2019) Rapid characterization of virulence determinants in Helicobacter pylori isolated from non-atrophic gastritis patients by next-generation sequencing. J Clin Med 8(7):1030
Jiang X, Xu Z, Zhang T, Li Y, Li W, Tan H (2019) Whole-genome-based Helicobacter pylori Geographic surveillance: visualized and expanded webtool. Front Microbiol 12:687259
Fallone CA, Chiba N, van Zanten SV, Fischbach L, Gisbert JP, Hunt RH, Marshall JK (2016) The Toronto consensus for the treatment of Helicobacter pylori infection in adults. Gastroenterology 151(1):51–69
Chey WD, Leontiadis GI, Howden CW, Moss SF (2017) ACG clinical guideline: treatment of Helicobacter pylori infection. Am J Gastroenterol 112(2):212–239
Malfertheiner P, Megraud F, O’Morain CA, Atherton J, Axon AT, Bazzoli F, Helicobacter E, study group. (2012) Management of Helicobacter pylori infection-the Maastricht IV/Florence consensus report. Gut 61(5):646–664
O’Connor A, Lamarque D, Gisbert JP, O’Morain C (2017) Treatment of Helicobacter pylori infection 2017. Helicobacter 22:e12410
Ayala G, Galvan-Portillo M, Chihu L, Fierros G, Sanchez A, Carrillo B, Silva-Sanchez and study Group J (2011) Resistance to antibiotics and characterization of Helicobacter pylori strains isolated from antrum and body from adults in Mexico. Microb Drug Resist 17(2):149–155
Grande R, Di Marcantonio MC, Robuffo I, Pompillio A, Celia C, Di Mario L, Mincione G (2015) Helicobacter pylori ATCC43629/NCTC 11639 outer membrane vesicles (OMVs) from biofilm and planktonic phase associated with extracellular DNA (eDNA). Front Microbiol 6:1369
Selgrad M, Tammer I, Langner C, Bornschein J, Meiβle J, Kandulski A, Malfertheiner P (2014) Different antibiotic susceptibility between antrum and corpus of the stomach, a possible reason for treatment failure of Helicobacter pylori infection. World J Gastroenterol 20(43):16245–16251
Farzi N, Malekian T, Alebouyeh M, Vaziri F, Zali MR (2015) Genotype diversity and quasi species development of Helicobacter pylori in a single host. Jpn J Infect Dis 68(4):176–180
Yin L, Liu F, Guo C, Wang Q, Pan K, Xu L, Chen Z (2018) Analysis of virulence diversity of 73 Helicobacter pylori strains isolated in Guizhou province. China Mol Med Rep 18(5):4611–4620
Roszczenko-Jasińska P, Wojtyś MI, Jagusztyn-Krynicka EK (2020) Helicobacter pylori treatment in the post-antibiotics era—searching for new drug targets. Appl Microbiol Biotechnol 1–15
Mi M, Wu F, Zhu J, Liu F, Cui G, Wen X, Chen Z (2021) Heterogeneity of Helicobacter pylori strains isolated from patients with gastric disorders in Guiyang. China Infect Drug Resist 14:53
Tag Eldeen LAT, Mohamed MA, Awad MM, Sheir MI, Shams TM, Ragheh MM (2019) A variety of Helicobacter pylori strains colonize the stomach of non-bleeding Egyptian patients with upper gastrointestinal disorders. Bull Natl Res Cent 43:183
Xu C, Soyfoo DM, Wu Y, Xu S (2020) Virulence of Helicobacter pylori outer membrane proteins: an updated review. Eur J Clin Microbiol Infect Dis 39:1821–1830
Kinoshita-Daitoku R, Kiga K, Miyakoshi M, Otsubo R, Ogura Y, Sanada T et al (2021) A bacterial small RNA regulates the adaptation of Helicobacter pylori to the host environment. Nat Commun 12:2085
Gu H (2017) Role of flagella in the pathogenesis of Helicobacter pylori. Curr Microbiol 74(7):863–869
Ansari S, Yamaoka Y (2020) Helicobacter pylori virulence factor cytotoxin-associated gene A (CagA)-mediated gastric pathogenicity. Int J Mol Sci 21(19):7430
Marcus EA, Sachs G, Scott DR (2018) Acid‐regulated gene expression of Helicobacter pylori: insight into acid protection and gastric colonization. Helicobacter 23(3):e12490
Ansari S, Yamaoka Y (2017) Survival of Helicobacter pylori in gastric acidic territory. Helicobacter 22:4
Martínez LE, Hardcastle JM, Wang J, Pincus Z, Tsang J, Hoover TR, Salama NR (2016) Helicobacter pylori strains vary cell shape and flagellum number to maintain robust motility in viscous environments. Mol Microbiol 99(1):88–110
Clyne M, Ocroinin T, Suerbaum S, Josenhans C, Drumm B (2000) Adherence of isogenic flagellum-negative mutants of Helicobacter pylori and Helicobacter mustelae to human and ferret gastric epithelial cells. Infect Immun 68(7):4335
De Brito BB, da Silva FAF, Soares AS, Pereira VA, Santos MLC, Sampaio MM, de Melo FF (2019) Pathogenesis and clinical management of Helicobacter pylori gastric infection. World J Gastroenterol 25(37):5578
García A, Salas-Jara MJ, Herrera C, González C (2014) Biofilm and Helicobacter pylori: from environment to human host. World J Gastroenterol: WJG 20(19):5632
Roier S, Zingl FG, Cakar F, Durakovic S, Kohl P, Eichmann TO, Schild S (2016) A novel mechanism for the biogenesis of outer membrane vesicles in Gram-negative bacteria. Nat Commun 7(1):1–13
Olofsson A, Vaystrom A, Petzold K, Tegtmeyer N, Schleucher J, Carlsson S, Haas R, Backert S, Wai SN et al (2010) Mol Microbiol 77:1539–1555
Yang Y, Hong Y, Cho E, Kim GB, Kim IS (2018) Extracellular vesicles as a platform for membrane-associated therapeutic protein delivery. J Extracell Vesicles 7(1):1440131
Uddin MJ, Dawan J, Jeon G, Yu T, He X, Ahn J (2020) The role of bacterial membrane vesicles in the dissemination of antibiotic resistance and as promising carriers for therapeutic agent delivery. Microorganisms 8(5):670
Keenan J, Day T, Neal S, Cook B, Perez-Perez G, Allardyce R, Bagshaw P (2000) A role for the bacterial outer membrane in the pathogenesis of Helicobacter pylori infection. FEMS Microbiol Lett 182(2):259–264
Chmiela M, Walczak N, Rudnicka K (2018) Helicobacter pylori outer membrane vesicles involvement in the infection development and Helicobacter pylori-related diseases. J Biomed Sci 25(1):1–11
Murray BO, Dawson RA, Alsharaf LM, Winter JA (2020) Protective effects of Helicobacter pylori membrane vesicles against stress and antimicrobial agents. Microbiology 166(8):751
Oleastro M, Ménard A (2013) The role of Helicobacter pylori outer membrane proteins in adherence and pathogenesis. Biology 2(3):1110–1134
Bina JE, Alm RA, Uria-Nickelsen M, Thomas SR, Trust TJ, Hancock REW (2000) Helicobacter pylori uptake and efflux: basis for intrinsic susceptibility to antibiotics in vitro. Antimicrob Agents Chemother 44(2):248
Cover TL, Blaser MJ (1992) Purification and characterization of the vacuolating toxin from Helicobacter pylori. J Biol Chem 267:10570–10575
da Costa DM, dos Santos PE, Rabenhorst SHB (2015) What exists beyond cagA and vacA? Helicobacter pylori genes in gastric diseases. World J Gastroenterol 21(37):10563
Bauwens E, Joosten M, Taganna J, Rossi M, Debraekeleer A, Tay A, Peter F, Backert S et al (2018) In silico proteomic and phylogenetic analysis of the outer membrane protein repertoire of gastric Helicobacter species Sci Rep 8:15453
Ishijima N, Suzuki M, Ashida H, Ichikawa Y, Kanegae Y, Saito I, Mimuro H (2011) BabA-mediated adherence is a potentiator of the Helicobacter pylori type IV secretion system activity. J Biol Chem 286(28):25256–25264
Alzahrani S, Lina TT, Gonzalez J, Pinchuk IV, Beswick EJ, Reyes VE (2014) Effect of Helicobacter pylori on gastric epithelial cells. World J Gastroenterol 20(36):12767
El-sayed MS, Musa N, Eltabbakh M, Abdelhamid DH, Mostafa SMI, Salah MM (2020) Detection of Helicobacter pylori oipA and dupA genes among dyspeptic patients with chronic gastritis. Alexandria Journal of Medicine 56:1
Mahdavi J, Sondén B, Hurtig M, Olfat FO, Forsberg L, Roche N, Borén T (2002) Helicobacter pylori SabA adhesin in persistent infection and chronic inflammation. Science 297(5581):573–578
Doohan D, Rezkitha YAA, Waskito LA, Yamaoka Y, Miftahussurur M (2021) Helicobacter pylori BabA – SabA key roles in the adherence phase: the synergic mechanism for successful colonization and disease development. Toxins 13:485
Horridge DN, Begley AA, Kim J, Aravindan N, Fan K, Forsyth MH (2017) Outer inflammatory protein a (OipA) of Helicobacter pylori is regulated by host cell contact and mediates CagA translocation and interleukin-8 response only in the presence of a functional cag pathogenicity island type IV secretion system. Pathog Dis 75(8):ftx113
Farzi N, Yadegar A, Aghdaei HA, Yamaoka Y, Zali MR (2018) Genetic diversity and functional analysis of oipA gene in association with other virulence factors among Helicobacter pylori isolates from Iranian patients with different gastric diseases. Infect Genet Evol 60:26–34
Al‐Maleki AR, Loke MF, Lui SY, Ramli NSK, Khosravi Y, Ng CG, Vadivelu J (2017) Helicobacter pylori outer inflammatory protein A (O ip A) suppresses apoptosis of AGS gastric cells in vitro. Cellular Microbiol 19(12):e12771
Tegtmeyer N, Harrer A, Schmitt V, Singer BB, Backert S (2019) Expression of CEACAM1 or CEACAM5 in AZ‐521 cells restores the type IV secretion deficiency for translocation of CagA by Helicobacter pylori. Cellular Microbiol 21(1):e12965
Kennemann L, Brenneke B, Andres S, Engstrand L, Meyer TF, Aebischer T, Suerbaum S (2012) In vivo sequence variation in HopZ, a phase-variable outer membrane protein of Helicobacter pylori. Infect Immun 80(12):4364
Belogolova E, Bauer B, Pompaiah M, Asakura H, Brinkman V, Ertl C, Meyer TF (2013) Helicobacter pylori outer membrane protein HopQ identified as a novel T4SS-associated virulence factor. Cellular Microbiol 15(11):1896–1912
Sycuro LK, Wyckoff TJ, Biboy J, Born P, Pincus Z, Vollmer W, Salama NR (2012) Multiple peptidoglycan modification networks modulate Helicobacter pylori’s cell shape, motility, and colonization potential. PLoS Pathog 8(3):e1002603
Cellini L (2014) Helicobacter pylori: a chameleon-like approach to life. World J Gastroenterol 20(19):5575
Percival SL, Suleman L (2014) Biofilms and Helicobacter pylori: dissemination and persistence within the environment and host. World J Gastrointest Pathophysiol 5(3):122
Pinto D, Santos MA, Chambel L (2015) Thirty years of viable but nonculturable state research: unsolved molecular mechanisms. Critical Rev Microbiol 41(1):61–76
Lleo MM, Bonato B, Tafi MC, Signoretto C, Boaretti M, Canepari P (2001) Resuscitation rate in different enterococcal species in the viable but non-culturable state. J Appl Microbiol 91(6):1095–1102
Senoh M, Ghosh-Banerjee J, Ramamurthy T, Colwell RR, Miyoshi SI, Nair GB, Takeda Y (2012) Conversion of viable but nonculturable enteric bacteria to culturable by co-culture with eukaryotic cells. Microbiol Immunol 56(5):342–345
Willén R, Carlén B, Wang X, Papadogiannakis N, Odselius R, Wadström T (2000) Morphologic conversion of Helicobacter pylori from spiral to coccoid form: scanning (SEM) and transmission electron microscopy (TEM) suggest viability. Upsala J Med Sci 105(1):31–40
Andersen AP, Elliott DA, Lawson M, Barland P, Hatcher VB, Puszkin EG (1997) Growth and morphological transformations of Helicobacter pylori in broth media. J Clin Microbiol 35(11):2918
Becker KW, Skaar EP (2014) Metal limitation and toxicity at the interface between host and pathogen. FEMS Microbiol Rev 38(6):1235–1249
Camilo V, Sugiyama T, Touati E (2017) Pathogenesis of Helicobacter pylori infection. Helicobacter 22:e12405
Olson JW, Maier RJ (2002) Molecular hydrogen as an energy source for Helicobacter pylori. Science 298(5599):1788–1790
Ha NC, Oh ST, Sung JY, Cha KA, Lee MH, Oh BH (2001) Supramolecular assembly and acid resistance of Helicobacter pylori urease. Nat Struct Biol 8(6):505–509
Ernst FD, Stoof J, Horrevoets WM, Kuipers EJ, Kusters JG, van Vliet AH (2006) NikR mediates nickel-responsive transcriptional repression of the Helicobacter pylori outer membrane proteins FecA3 (HP1400) and FrpB4 (HP1512). Infect Immun 74(12):6821
Fulkerson JF Jr, Mobley HL (2000) Membrane topology of the NixA nickel transporter of Helicobacter pylori: two nickel transport-specific motifs within transmembrane helices II and III. J Bacteriol 182(6):1722
Wolfram L, Bauerfeind P (2002) Conserved low-affinity nickel-binding amino acids are essential for the function of the nickel permease NixA of Helicobacter pylori. J bacteriol 184(5):1438
Mulrooney SB, Hausinger RP (2003) Nickel uptake and utilization by microorganisms. FEMS Microbiol Rev 27(2–3):239–261
Athmann C, Zeng N, Kang T, Marcus EA, Scott DR, Rektorschek M, Sachs G (2000) Local pH elevation mediated by the intrabacterial urease of Helicobacter pylori cocultured with gastric cells. J Clinical Invest 106(3):339–347
Miller EF, Maier RJ (2014) Ammonium metabolism enzymes aid Helicobacter pylori acid resistance. J Bacteriol 196(17):3074
Nolan KJ, McGee DJ, Mitchell HM, Kolesnikow T, Harro JM, O’Rourke J, Lee A (2002) In vivo behavior of a Helicobacter pylori SS1 nixA mutant with reduced urease activity. Infect Immun 70(2):685
Schmalstig AA, Benoit SL, Misra SK, Sharp JS, Maier RJ (2018) Noncatalytic antioxidant role for Helicobacter pylori urease. J Bacteriol 200(17)
Can F, Karahan C, Dolapci I, Demirbilek M, Tekeli A, Arslan H (2008) Urease activity and urea gene sequencing of coccoid forms of H. pylori induced by different factors. Curr Microbiol 56(2):150–155
Gebert B, Fischer W, Weiss E, Hoffmann R, Haas R (2003) Helicobacter pylori vacuolating cytotoxin inhibits T lymphocyte activation. Science 301(5636):1099–1102
McClain MS, Beckett AC, Cover TL (2017) Helicobacter pylori vacuolating toxin and gastric cancer. Toxins 9(10):316
Kakelar HM, Barzegari A, Dehghani J, Hanifian S, Saeedi N, Barar J, Omidi Y (2019) Pathogenicity of Helicobacter pylori in cancer development and impacts of vaccination. Gastric Cancer 22(1):23–36
Foegeding NJ, Caston RR, McClain MS, Ohi MD, Cover TL (2016) An overview of Helicobacter pylori VacA toxin biology. Toxins 8(6):173
Ricci V (2016) Relationship between VacA toxin and host cell autophagy in Helicobacter pylori infection of the human stomach: a few answers, many questions. Toxins 8(7):203
de Falco M, Lucariello A, Iaquinto S, Esposito V, Guerra G, De Luca A (2015) Molecular mechanisms of Helicobacter pylori pathogenesis. J Cell Physiol 230(8):1702–1707
Yahiro K, Hirayama T, Moss J, Noda M (2016) New insights into VacA intoxication mediated through its cell surface receptors. Toxins 8(5):152
Winter JA, Letley DP, Cook KW, Rhead KR (2014) A role for the vacuolating cytotoxin, vacA, in colonization and Helicobacter pylori-induced metaplasia in the stomach. J Infect Dis 210(6):954–963
Raju D, Hussey S, Ang M, Terebiznik MR, Sibony M, Galindo-Mata E, Jones NL (2012) Vacuolating cytotoxin and variants in Atg16L1 that disrupt autophagy promote Helicobacter pylori infection in humans. Gastroenterology 142(5):1160–1171
Djekic A, Müller A (2016) The immunomodulator VacA promotes immune tolerance and persistent Helicobacter pylori infection through its activities on T-cells and antigen-presenting cells. Toxins 8(6):187
Utsch C, Haas R (2016) VacA’s induction of VacA-containing vacuoles (VCVs) and their immunomodulatory activities on human T cells. Toxins 8(6):190
Muzahhed M (2020) Helicobacter pylori oncogenicity: mechanism, prevention and risk factors. Sci World J
Wroblewski LE, Peek RM Jr, Wilson KT (2010) Helicobacter pylori and gastric cancer: factors that modulate disease risk. Clin Microbiol Rev 23(4):713
Ito Y, Azuma T, Ito S, Suto H, Miyaji H, Yamazaki Y, Kuriyama M (1998) Full-length sequence analysis of the vacA gene from cytotoxic and noncytotoxic Helicobacter pylori. The J Infect Dis 178(5):1391–1398
Atherton JC, Cao P, Peek RM, Tummuru MK, Blaser MJ, Cover TL (1995) Mosaicism in vacuolating cytotoxin alleles of Helicobacter pylori: association of specific vacA types with cytotoxin production and peptic ulceration. J Biol Chem 270(30):17771–17777
Forsyth MH, Atherton JC, Blaser MJ, Cover TL (1998) Heterogeneity in levels of vacuolating cytotoxin gene (vacA) transcription among Helicobacter pylori strains. Infect Immun 66(7):3088
Rhead JL, Letley DP, Mohammadi M, Hussein N, Mohagheghi MA, Hosseini ME, Atherton JC (2007) A new Helicobacter pylori vacuolating cytotoxin determinant, the intermediate region, is associated with gastric cancer. Gastroenterology 133(3):926–936
Shiota S, Suzuki R, Yamaoka Y (2013) The significance of virulence factors in Helicobacter pylori. J Dig Dis 14(7):341–349
Chang WL, Yeh YC, Sheu BS (2018) The impacts of H. pylori virulence factors on the development of gastroduodenal diseases. J Biomed Sci 25:68
Sheikh AF et al (2018) CagA and vacA allelic combination of Helicobacter pylori in gastroduodenal disorders. Microb Pathog 122:144–150
Wang HJ, Wang WC (2000) Expression and binding analysis of GST-VacA fusions reveals that the C-terminal∼ 100-residue segment of exotoxin is crucial for binding in HeLa cells. Biochem Biophys Res Commun 278(2):449–454
Skibinski DA, Genisset C, Barone S, Telford JL (2006) The cell-specific phenotype of the polymorphic vacA midregion is independent of the appearance of the cell surface receptor protein tyrosine phosphatase β. Infect Immun 74(1):49
Letley DP, Rhead JL, Twells RJ, Dove B, Atherton JC (2003) Determinants of non-toxicity in the gastric pathogen Helicobacter pylori. J Biol Chem 27(29):26734–26741
Altobelli A, Bauer M, Valez K, Cover TL, Muller A (2019) Helicobacter pylori VacA targets myeloid cells in the gastric lamina propria to promote peripherally induced regulatory T-cell differentiation and persistent infection. mBio 10:e00261–19
Papini E, De Bernard M, Milia E, Bugnoli M, Zerial M, Rappuoli R, Montecucco C (1994) Cellular vacuoles induced by Helicobacter pylori originate from late endosomal compartments. Proc Natl Acad Sci USA 91(21):9720–9724
Molinari M, Galli C, Norais N, Telford JL, Rappuoli R, Luzio JP, Montecucco C (1997) Vacuoles induced by Helicobacter pylori toxin contain both late endosomal and lysosomal markers. J Biol Chem 272(40):25339–25344
Li Y, Wandinger-Ness A, Goldenring JR, Cover TL (2004) Clustering and redistribution of late endocytic compartments in response to Helicobacter pylori vacuolating toxin. Mol Biol Cell 15(4):1946–1959
Kern B, Jain U, Utsch C, Otto A, Busch B, Jiménez-Soto L, Haas R (2015) Characterization of Helicobacter pylori VacA-containing vacuoles (VCVs), VacA intracellular trafficking and interference with calcium signaling in T lymphocytes. Cellular Microbiol 17(12):1811–1832
Bernard MD, Moschioni M, Habermann A, Griffiths G, Montecucco C (2002) Cell vacuolization induced by Helicobacter pylori VacA cytotoxin does not depend on late endosomal SNAREs. Cellular Microbiol 4(1):11–11
Cover TL, Krishna US, Israel DA, Peek RM (2003) Induction of gastric epithelial cell apoptosis by Helicobacter pylori vacuolating cytotoxin. Can Res 63(5):951–957
Ricci V, Sommi P, Fiocca R, Romano M, Solcia E, Ventura U (1997) Helicobacter pylori vacuolating toxin accumulates within the endosomal-vacuolar compartment of cultured gastric cells and potentiates the vacuolating activity of ammonia. J Pathog 183(4):453–459
Tombol F, Morbiato L, Del Giudice G, Rappuoli R, Zoratti M, Papini E (2001) The Helicobacter pylori VacA toxin is a urea permease that promotes urea diffusion across epithelia. J Clin Invest 108(6):929–937
Genisset C, Puhar A, Calore F, De Bernard M, Dell’Antone P, Montecucco C (2007) The concerted action of the Helicobacter pylori cytotoxin VacA and of the v-ATPase proton pump induces swelling of isolated endosomes. Cell Microbiol 9(6):1481–1490
Chowdhury R (2014) Host cell contact induces fur-dependent expression of virulence factors CagA and VacA in Helicobacter pylori. Helicobacter 19(1):17–25
Noto JM Jr, Peek RM (2012) The Helicobacter pylori:cag pathogenicity island. Methods Mol Biol 921:41–50
Odenbreit S, Püls J, Sedlmaier B et al (2000) Translocation of Helicobacter pylori CagA into gastric epithelial cells by type IV secretion. Science 287:1497–1500
Rohde M, Püls J, Buhrdorf R, Fischer W, Haas R (2003) A novel sheathed surface organelle of the Helicobacter pylori cag type IV secretion system. Mol Microbiol 49(1):219–234
Asahi M, Azuma T, Ito S et al (2000) Helicobacter pylori CagA protein can be tyrosine phosphorylated in gastric epithelial cells. J Exp Med 191:593–602
Behrens I-K, Busch B, Ishikawa-Ankerhold H et al (2020) The HopQ-CEACAM interaction controls CagA translocation, phosphorylation, and phagocytosis of Helicobacter pylori in neutrophils. MBio 11(1):e03256-e3319
Backert S, Selbach M (2005) Tyrosine-phosphorylated bacterial effector proteins: the enemies within. Trends Microbiol 13(10):476–484
Poppe M, Feller SM, Römer G, Wessler S (2007) Phosphorylation of Helicobacter pylori CagA by c-Abl leads to cell motility. Oncogene 26(24):3462–3472
Tammer I, Brandt S, Hartig R, König W, Backert S (2007) Activation of Abl by Helicobacter pylori: a novel kinase for CagA and crucial mediator of host cell scattering. Gastroenterology 132(4):1309–1319
Jones KR, Joo YM, Jang S, Yoo YJ, Lee HS, Chung IS, Cha JH (2009) Polymorphism in the CagA EPIYA motif impacts development of gastric cancer. J Clin Microbiol 47(4):959
Hatakeyama M (2011) Anthropological and clinical implications for the structural diversity of the Helicobacter pylori CagA oncoprotein. Cancer Sci 102(1):36–43
Higashi H, Tsutsumi R, Fujita A, Yamazaki S, Asaka M, Azuma T, Hatakeyama M (2002) Biological activity of the Helicobacter pylori virulence factor CagA is determined by variation in the tyrosine phosphorylation sites. Proc Natl Acad Sci USA 99(22):14428–14433
Tsutsumi R, Higashi H, Higuchi M, Okada M, Hatakeyama M (2003) Attenuation of Helicobacter pylori CagA· SHP-2 signaling by interaction between CagA and C-terminal Src kinase. J Biol Chem 278(6):3664–3670
Bridge DR, Blum FC, Jang S, Kim J, Cha JH, Merrell DS (2017) Creation and initial characterization of isogenic Helicobacter pylori CagA EPIYA variants reveals differential activation of host cell signaling pathways. Sci Rep 7(1):1–14
Roesler BM, Costa SCB, Zeitune JMR (2011) Virulence factors of Helicobacter pylori and their relationship with the development of early and advanced distal intestinal type gastric adenocarcinoma. Gastritis and Gastric Cancer—New Insights in Gastroprotection, Diagnosis and Treatments 259–280
Bridge DR, Merrell DS (2013) Polymorphism in the Helicobacter pylori CagA and VacA toxins and disease. Gut microbes 4(2):101–117
Figura N, Trabalzini L, Mini R, Bernardini G, Scaloni A, Talamo F, Santucci A (2004) Inactivation of Helicobacter pylori cagA gene affects motility. Helicobacter 9(3):185–193
Yeh YC, Kuo HY, Chang WL. et al. (2019) H. pylori isolates with amino acid sequence polymorphisms as presence of both HtrA-L171 & CagL-Y58/E59 increase the risk of gastric cancer. J Biomed Sci 26:4
Palrasu M, Zaika E, El-Rifai W et al (2020) Bacterial CagA protein compromises tumor suppressor mechanisms in gastric epithelial cells. J Clin Invest 130(5):2422–2434
Chung C, Olivares A, Torres E, Yilmaz O, Cohen H, Perez-Perez G (2010) Diversity of VacA intermediate region among Helicobacter pylori strains from several regions of the world. J Clin Microbiol 48(3):690
Lu H, Hsu PI, Graham DY, Yamaoka Y (2005) Duodenal ulcer promoting gene of Helicobacter pylori. Gastroenterology 128:833–848
Alam J, Maiti S, Ghosh P, De R, Chowdhury A, Das S, Macaden R, Devarbhavi H (2012) Significant association of the dupA gene of Helicobacter pylori with duodenal ulcer development in a South-East Indian population. J Med Microbiol 61(9):1295–1302
Hussein NR, Argent RH, Marx CK, Patel SR, Robinson K, Atherton JC (2010) Helicobacter pylori dupA is polymorphic, and its active form induces proinflammatory cytokine secretion by mononuclear cells. J Infect Dis 202(2):261–269
Dadashzadeh K (2017) Relevance of Helicobacter pylori dupA and oipA genotypes and development of gastric disease. Biomed Res 28(19):8179–8183
Pereira WN, Ferraz MA, Zabaglia LM, de Labio RW, Orcini WA, Bianchi Ximenez JP, et al. (2014) Association among H. pylori virulence markers dupA, cagA and vacA in Brazilian patients. J Venom Anim Toxins Incl Trop Dis 20(1):1
Gomes LI et al (2008) Lack of association between Helicobacter pylori infection with dupA-positive strains and gastroduodenal diseases in Brazilian patients. Int J Med Microbiol 298:223–230
Zhang Z et al (2008) The Helicobacter pylori duodenal ulcer promoting gene, dupA in China. BMC Gastroenterol 8:49
Nguyen LT et al (2010) Helicobacter pylori dupA gene is not associated with clinical outcomes in the Japanese population. Clin Microbiol Infect 16:1264–1269
Abadi AT, Taghvaei T, Wolfram L, Kusters JG (2012) Infection with Helicobacter pylori strains lacking dupA is associated with an increased risk of gastric ulcer and gastric cancer development. J Med Microbiol 61:23–30
de Lima Silva LL, Oliveira AKS, Gama AR et al (2021) Helicobacter pylori virulence dupA gene: risk factor or protective factor? Braz J Microbiol 52:1921–1927
Zarzecka U, Modrak-Wójcik A, Figaj D, Apanowicz M, Lesner A, Bzowska A, Skorko-Glonek J (2019) Properties of the HtrA protease from bacterium Helicobacter pylori whose activity is indispensable for growth under stress conditions. Front Microbiology 10:961
Clausen T, Kaiser M, Huber R, Ehrmann M (2011) HTRA proteases: regulated proteolysis in protein quality control. Nature Rev Mol cell Biol 12(3):152–162
Frees D, Brøndsted L, Ingmer H (2013) Bacterial proteases and virulence. Regulated proteolysis in microorganisms 161–192
Hoy B, Löwer M, Weydig C, Carra G, Tegtmeyer N, Geppert T, Wessler S (2010) Helicobacter pylori HtrA is a new secreted virulence factor that cleaves E-cadherin to disrupt intercellular adhesion. EMBO Rep 11(10):798–804
Elmi A, Nasher F, Jagatia H, Gundogdu O, Bajaj-Elliott M, Wren B, Dorrell N (2016) Campylobacter jejuni outer membrane vesicle-associated proteolytic activity promotes bacterial invasion by mediating cleavage of intestinal epithelial cell E-cadherin and occludin. Cell Microbiol 18(4):561–572
Altindis E, Fu Y, Mekalanos JJ (2014) Proteomic analysis of Vibrio cholerae outer membrane vesicles. Proc Natl Acad Sci 111(15):E1548–E1556
Tegtmeyer N, Moodley Y, Yamaoka Y, Pernitzsch SR, Schmidt V, Traverso FR et al (2016) Characterisation of worldwide Helicobacter pylori strains reveals genetic conservation and essentiality of serine protease HtrA. Mol Microbiol 99(5):925–944
Neddermann M, Backert S (2019) How many protein molecules are secreted by single Helicobacter pylori cells: quantification of serine protease HtrA. Cell Microbiol 21(7):e13022
Hansen G, Hilgenfeld R (2013) Architecture and regulation of HtrA-family proteins involved in protein quality control and stress response. Cell Mol Life Sci 70(5):761–775
Lekmeechai S, Su Y-C, Brant M, Alvarado-Kristensson M, Vallstrom A, Obi I, Arnqvist A, Riesbeck K (2018) Helicobacter pylori outer membrane vesicles protect the pathogen from reactive oxygen species of the respiratory burst. Front Microbiol 9:1837
Switala J, Loewen PC (2002) Diversity of properties among catalases. Arch Biochem Biophys 401(2):145–154
Benoit SL, Maier RJ (2016) Helicobacter catalase devoid of catalytic activity protects the bacterium against oxidative stress. J Biol Chem 291(45):23366–23373
Richter C, Mukherjee O, Ermert D, Singh B, Su YC, Agarwal V, Riesbeck K (2016) Moonlighting of Helicobacter pylori catalase protects against complement-mediated killing by utilising the host molecule vitronectin. Sci Rep 6(1):1–13
Sitaraman R, Israel DA, Romero-Gallo J, Peek RM Jr (2012) Cell-associated hemolysis induced by Helicobacter pylori is mediated by phospholipases with mitogen-activated protein kinase-activating properties. J Clin Microbiol 50(3):1014
Lusini P, Figura N, Valassina M, Roviello F, Vindigni C, Trabalzini L, Santucci A (2005) Increased phospholipase activity in Helicobacter pylori strains isolated from patients with gastric carcinoma. Dig Liver Dis 37(4):232–239
Keenan JI, Davis KA, Beaugie CR, McGovern JJ, Moran AP (2008) Alterations in Helicobacter pylori outer membrane and outer membrane vesicle-associated lipopolysaccharides under iron-limiting growth conditions. Innate Immun 14(5):279–290
Zimmermann S, Pfannkuch L, Al-Zeer MA, Bartfeld S, Koch M, Liu J, Meyer TF (2017) ALPK1-and TIFA-dependent innate immune response triggered by the Helicobacter pylori type IV secretion system. Cell Rep 20(10):2384–2395
Yokota SI, Amano KI, Nishitani C, Ariki S, Kuroki Y, Fujii N (2012) Implication of antigenic conversion of Helicobacter pylori lipopolysaccharides that involve interaction with surfactant protein D. Infect Immun 80(8):2956
Dara M, Khashei R, Dehghani B (2017) High frequency of hopQ genotypes among Iranian Helicobacter pylori clinical isolates. Infez Med 25(2):123–126
Feige MH, Sokolova O, Pickenhahn A, Maubach G, Naumann M (2018) HopQ impacts the integrin α5β1-independent NF-κB activation by Helicobacter pylori in CEACAM expressing cells. Int J Med Microbiol 308(5):527–533
Grzeszczuk MJ, Bocian-Ostrzycka KM, Banaś AM, Roszczenko-Jasinska P, Malinowska A, Stralova H, Jagusztyn-Krynicka EK (2018) Thioloxido reductase HP0231 of Helicobacter pylori impacts HopQ-dependent CagA translocation. Int J Med Microbiol 308(8):977–985
Hsu WT, Ho SY, Jian TY, Huang HN, Lin YL, Chen CH, Liao KW (2018) Helicobacter pylori-derived heat shock protein 60 increases the induction of regulatory T-cells associated with persistent infection. Microb Pathog 119:152–161
Zhang J, Zhang X, Wu C, Lu D, Guo G, Mao X, Zou Q (2011) Expression, purification and characterization of arginase from Helicobacter pylori in its apo form. PLoS One 6(10):e26205
Zhang X, Zhang J, Zhang R, Guo Y, Wu C, Mao X, Zou Q (2013) Structural, enzymatic and biochemical studies on Helicobacter pylori arginase. Int J of Biochem cell biol 45(5):995–1002
Morishita K, Takeuchi H, Morimoto N, Shimamura T, Kadota Y, Tsuda M, Sugiura T (2012) Superoxide dismutase activity of Helicobacter pylori per se from 158 clinical isolates and the characteristics. Microbiol Immunol 56(4):262–272
Švagelj D, Terzić V, Dovhanj J, Švagelj M, Cvrković M, Švagelj I (2016) Superoxide dismutases in chronic gastritis. APMIS 124(4):252–256
Negovan A, Iancu M, Tripon F, Crauciuc A, Mocan S, Bănescu C (2018) The CAT-262 C> T, MnSOD Ala16Val, GPX1 Pro198Leu polymorphisms related to oxidative stress and the presence of gastric lesions. J Gastrointestin Liver Dis 27(4):l371-378
Stent A, Every AL, Chionh YT Ng GZ. and Sutton P (2018) Superoxide dismutase from Helicobacter pylori suppresses the production of pro‐inflammatory cytokines during in vivo infection. Helicobacter 23(1):e12459
Shibayama K, Wachino JI, Arakawa Y, Saidijam M, Rutherford NG, Henderson PJ (2007) Metabolism of glutamine and glutathione via γ-glutamyltranspeptidase and glutamate transport in Helicobacter pylori: possible significance in the pathophysiology of the organism. Mol Microbiol 64(2):396–406
Boonyanugomol W, Chomvarin C, Song JY, Kim KM, Kim JM, Cho MJ, Baik SC (2012) Effects of Helicobacter pylori γ-glutamyltranspeptidase on apoptosis and inflammation in human biliary cells. Dig Dis Sci 57(10):2615–2624
Morey P, Meyer TF (2019) The sweeping role of cholesterol depletion in the persistence of Helicobacter pylori infections. In: Backert S (eds) Molecular Mechanisms of Inflammation: Induction, Resolution and Escape by Helicobacter pylori. Curr Top Microbiol Immunol, Vol 421:209–227 Springer, Cham