Heavy metal ATPase 3 expression controls zinc homeostasis in natural accessions of Arabidopsis thaliana

Alloway BJ (2004) Zinc in soils and crop nutrition. International Zinc Association, Brussels

Andreini C, Banci L, Bertini I, Rosato A (2006) Zinc through the three domains of life. J Proteome Res 5:3173–3178

Becher M, Talke IN, Krall L, Kramer U (2004) Cross-species microarray transcript profiling reveals high constitutive expression of metal homeostasis genes in shoots of the zinc hyperaccumulator Arabidopsis halleri. Plant J 37:251–268

Cai H, Huang S, Che J, Yamaji N, Ma JF (2019) The tonoplast-localized transporter OsHMA3 plays an important role in maintaining Zn homeostasis in rice. J Exp Bot 70:2717–2725

Campos ACAL, Kruijer W, Alexander R, Akkers RC, Danku J, Salt DE, Aarts MGM (2017) Natural variation in Arabidopsis thaliana reveals shoot ionome, biomass, and gene expression changes as biomarkers for zinc defciency tolerance. J Exp Bot 68:3643–3656

Chao DY, Silva A, Baxter I, Huang YS, Nordborg M, Danku J, Lahner B, Yakubova E, Salt DE (2012) Genome-wide association studies identify heavy metal ATPase3 as the primary determinant of natural variation in leaf cadmium in Arabidopsis thaliana. PLoS Genet 8:e1002923

Das U, Haque AFMM, Bari MA, Mandal A, Kabir AH (2021) Computational characterization and expression profile of MTP1 gene associated with zinc homeostasis across dicot plant species. Gene Rep 23:101073

Desbrosses-Fonrouge AG, Voigt K, Schröder A, Arrivault S, Thomine S, Krämer U (2005) Arabidopsis thaliana MTP1 is a Zn transporter in the vacuolar membrane which mediates Zn detoxification and drives leaf Zn accumulation. FEBS Lett 579:4165–4174

Gallego SM, Pena LB, Barcia RA, Azpilicueta CE, Iannone MF, Rosales EP, Zawoznik MS, Groppa MD, Benavides MP (2012) Unravelling cadmium toxicity and tolerance in plants: insight into regulatory mechanisms. Environ Exp Bot 83:33–46

Grotz N, Fox T, Connolly E, Park W, Guerinot ML, Eide D (1998) Identification of a family of zinc transporter genes from Arabidopsis that respond to zinc deficiency. Proc Natl Acad Sci U S A 95(12):7220–7224

Haydon MJ, Kawachi M, Wirtz M, Hillmer S, Rüdger H, Krämer U (2012) Vacuolar nicotianamine has critical and disctinct roles under iron deficiency and for zinc sequestration in Arabidopsis. Plant Cell 24:724–737

Kaur H, Garg N (2021) Zinc toxicity in plants: a review. Planta 253:129

Lee S, Lee J, Ricachenevsky FK, Punshon T, Tappero R, Salt DE, Guerinot ML (2021) Redundant roles of four ZIP family members in zinc homeostasis and seed development in Arabidopsis thaliana. Plant J 108:1162–1173

Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2-∆∆CT method. Methods 25:402–408

MacDiarmid CW, Milanick MA, Eide DJ (2003) Induction of the ZRC1 metal tolerance gene in zinc-limited yeast confers resistance to zinc shock. J Biol Chem 278(17):15065–15072

Morel M, Crouzet J, Gravot A, Auroy P, Leonhardt N, Vavasseur A, Richaud P (2009) AtHMA3, A P1B-ATPase allowing Cd/Zn/Co/Pb vacuolar storage in Arabidopsis. Plant Physiol 149:894–904

Nishida S, Kato A, Tsuzuki C, Yoshida J, Mizuno T (2015) Induction of nickel accumulation in response to zinc deficiency in Arabidopsis thaliana. Int J Mol Sci 16:9420–9430

Pita-Barbosa A, Ricachenevsky FK, Flis PM (2019a) One “OMICS” to integrate them all: ionomics as a result of plant genetics, physiology and evolution. Theor Exp Plant Physiol 31:71–89

Pita-Barbosa A, Ricachenevsky FK, Wilson M, Dottorini T, Salt DE (2019b) Transcriptional plasticity buffers genetic variation in zinc homeostasis. Sci Rep 9:19482

Ricachenevsky FK, Menguer PK, Sperotto RA, Fett JP (2015) Got to hide your Zn away: molecular control of Zn accumulation and biotechnological applications. Plant Sci 236:1–17

Sasaki A, Yamaji N, Ma JF (2014) Overexpression of OsHMA3 enhances Cd tolerance and expression of Zn transporter genes in rice. J Exp Bot 65:6013–6021

Sinclair SA, Krämer U (2012) The zinc homeostasis network of land plants. Biochim Biophys Acta 1823:1553–1567

Sinclair SA, Senger T, Talke IN, Cobbett CS, Haydon MJ, Krämer U (2018) Systemic upregulation of MTP2- and HMA2-mediated Zn partitioning to the shoot supplements local Zn deficiency responses. Plant Cell 30:2463–2479

Zhang J, Zhang M, Shohag MJI, Tian S, Song H, Feng Y, Yang X (2016) Enhanced expression of SaHMA3 plays critical roles in Cd hyperaccumulation and hypertolerance in Cd hyperaccumulator Sedum alfredii Hance. Planta 243:577–589

Zhang L, Wu J, Tang Z, Huang XY, Wang X, Salt DE, Zhao FJ (2019) Variation in the BrHMA3 coding region controls natural variation in cadmium accumulation in Brassica rapa vegetables. J Exp Bot 70:5865–5878

Zhao S, Fernald RD (2005) Comprehensive algorithm for quantitative real-time polymerase chain reaction. J Comput Biol 12:1047–1064