Heart failure and statins—Why do we need a clinical trial?

Zeitschrift für Kardiologie - Tập 94 - Trang 223-230 - 2005
M. Böhm1, A. Hjalmarson2, J. Kjekshus3, U. Laufs1, J. McMurray4, D. J. van Veldhuisen5
1Klinik für Innere Medizin III, Universitätsklinik des Saarlandes, Homburg, Gemany
2Sahlgrenska University Hospital, Divison of Cardiology, Gothenburg, Sweden
3University of Oslo Rikshospitalet, Department of Cardiology, Oslo, Norway
4Gardiner Institute, Division of Cardiovascular Medicine, Western Infirmary, Glasgow, Scotland
5University Hospital Groningen, Department of Cardiology/Thoraxcenter, Groningen, The Netherlands

Tóm tắt

The effect of statins to reduce mortality and morbiditiy in primary and secondary prevention as well as in acute coronary syndroms is well established. Recent data show that pleiotropic effects might also have direct effects on the myocardial cell. However, in chronic heart failure the outcome is inversely related to LDL-plasma concentrations and other pleiotropic effects might impair mitochondrial function. Since there are no safety data on the use of statins in chronic heart failure, a controlled randomized and placebo-controlled trial is urgently needed.

Tài liệu tham khảo

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