Healthcare Resource Utilization and Costs Associated with Ketosis Events in Pediatric and Adult Patients with Type 1 Diabetes Mellitus in the UK

Nandu Thalange1, Natalie V. J. Aldhouse2, Helen Kitchen2, Daniel E. Howard2, Deniz Tutkunkardas3, Jonas Håkan‐Bloch3
1Norfolk and Norwich University Hospital, Norwich, UK
2DRG Abacus, Manchester, UK
3Novo Nordisk A/S, Søborg, Denmark

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Parekh W, Ashley D, Chubb B, Gillies H, Evans M. Approach to assessing the economic impact of insulin-related hypoglycaemia using the novel Local Impact of Hypoglycaemia Tool. Diabet Med. 2015;32(9):1156–66

Laffel L. Ketone bodies: a review of physiology, pathophysiology and application of monitoring to diabetes. Diabetes Metab Res Rev. 1999;15(6):412–26.

Ng S, Soni A, Agwu J, et al. Clinical guideline: management of type 1 diabetes mellitus during illness in children and young people under 18 years (Sick Day Rules). https://www.bsped.org.uk/clinical/docs/Sick_day_guideline_Main.pdf (2016). Accessed 17 Oct 2016.

Wright J, Ruck K, Rabbitts R, et al. Diabetic ketoacidosis (DKA) in Birmingham, UK, 2000–2009: an evaluation of risk factors for recurrence and mortality. Br J Diabetes Vasc Dis. 2009;9(6):278–82.

Health and Social Information Centre. National diabetes inpatient audit 2015: National report. http://content.digital.nhs.uk/catalogue/PUB20206/nati-diab-inp-audi-15-nat-rep.pdf (2016). Accessed 17 Oct 2016.

Health and Social Information Centre. National diabetes audit 2012–2013: Report 2: Complications and mortality. http://content.digital.nhs.uk/catalogue/PUB16496/nati-diab-audi-12-13-rep2.pdf (2015). Accessed 17 Oct 2016.

Department of Health. NHS reference costs 2014 to 2015. https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/480791/2014-15_National_Schedules.xlsx (2015). Accessed 17 Oct 2016.

Kitabchi AE, Nematollahi LR. BMJ best practice: diabetic ketoacidosis. http://bestpractice.bmj.com/best-practice/monograph/162/highlights/summary.html (2016). Accessed 17 Oct 2016.

NICE. Type 1 diabetes in adults: diagnosis and management (NG17). http://nice.org.uk/guidance/ng17 (2015). Accessed 4 Nov 2016.

NICE. Diabetes (type 1 and type 2) in children and young people: diagnosis and management (NG18). http://nice.org.uk/guidance/ng18 (2015). Accessed 4 Nov 2016.

NICE. Clinical Knowledge Summaries. Diabetes—type 1. Scenario: management—adults. ‘Sick-day rules’. http://cks.nice.org.uk/diabetes-type-1#!scenarioclarification:2 (2016). Accessed 4 Nov 2016.

NICE. Clinical Knowledge Summaries. Diabetes—type 1. Scenario: management—children and young people. ‘Sick day rules.’ http://cks.nice.org.uk/diabetes-type-1#!scenarioclarification:27 (2016). Last Accessed 4 Nov 2016.

NIHR. Good Clinical Practice. http://www.nihr.ac.uk/our-faculty/clinical-research-staff/learning-and-development/national-directory/good-clinical-pratice/ . Accessed 4 Nov 2016.

BHBIA. Legal and ethical guidelines. https://www.bhbia.org.uk/guidelines/legalandethicalguidelines.aspx (2016). Accessed 4 Nov 2016.

Tukey J. Exploratory data analysis. Reading: Addison-Wesley; 1977.

Mathieu C, Zinman B, Hemmingsson JU, al. Efficacy and safety of liraglutide added to insulin treatment in type 1 diabetes: the ADJUNCT ONE treat-to-target randomized trial. Diabetes Care. 2016;39(10):1702–10.

Diabetes UK. Facts and stats. https://www.diabetes.org.uk/About_us/What-we-say/Statistics/ (2015). Accessed 8 Nov 2016.

Office for National Statistics. United Kingdom population 2015 mid-year estimate. https://web.archive.org/web/20161119183858/https://www.ons.gov.uk/peoplepopulationandcommunity/populationandmigration/populationestimates (2016). Accessed 9 Nov 2016.

Brod M, Christensen T, Thomsen TL, Bushnell DM. The impact of non-severe hypoglycemic events on work productivity and diabetes management. Value Health. 2011;14(5):665–71.

Agarwal S, Garvey KC, Raymond JK, Schutta MH. Perspectives on care for young adults with type 1 diabetes transitioning from pediatric to adult health systems: a national survey of pediatric endocrinologists. Pediatr Diabetes. 2016;. doi: 10.1111/pedi.12436 .

Dhaliwal R, Weinstock RS. Management of type 1 diabetes in older adults. Diabetes Spectr. 2014;27(1):9–20.

O’Cathain A, Knowles E, Nicholl J. Testing survey methodology to measure patients’ experiences and views of the emergency and urgent care system: telephone versus postal survey. BMC Med Res Methodol. 2010;10:52.

Thalange N, Deeb L, Iotova V, et al. Insulin degludec in combination with bolus insulin aspart is safe and effective in children and adolescents with type 1 diabetes. Paediatr Diabetes. 2015;16(3):164–76.

Elliott J, Jacques R, Kruger J, et al. Substantial reductions in the number of diabetic ketoacidosis and severe hypoglycaemia episodes requiring emergency treatment lead to reduced costs after structured education in adults with type 1 diabetes. Diabet Med. 2014;31(7):847–53.

Hoffman WH, O’Neill P, Khoury C, Bernstein SS. Service and education for the insulin-dependent child. Diabetes Care. 1978;1(5):285–8.