Health-related quality of life issues, including symptoms, in patients with active COVID-19 or post COVID-19; a systematic literature review

Springer Science and Business Media LLC - Tập 30 - Trang 3367-3381 - 2021
Cecilie Delphin Amdal1,2, Madeline Pe3, Ragnhild Sørum Falk1, Claire Piccinin3, Andrew Bottomley3, Juan Ignacio Arraras4, Anne Sophie Darlington5, Kristin Hofsø6,7, Bernard Holzner8, Nina Marie Høyning Jørgensen9, Dagmara Kulis3, Stein Arne Rimehaug10, Susanne Singer11, Katherine Taylor11, Sally Wheelwright12, Kristin Bjordal1,13
1Research Support Services, Oslo University Hospital, Oslo, Norway
2Department of Oncology, Oslo University Hospital, Oslo, Norway
3Quality of Life Department, EORTC, Brussels, Belgium
4Servicio de Navarro de Salud, Pamplona, Spain
5School of Health Sciences, University of Southampton, Southampton, UK
6Department of Research and Development, Oslo University Hospital, Oslo, Norway
7Lovisenberg Diaconal University College, Oslo, Norway
8University Hospital of Psychiatry II, Medical University of Innsbruck, Innsbruck, Austria
9Medical Library at Oslo University Hospital, University of Oslo Library, Oslo, Norway
10Sunnaas Rehabilitation Hospital, Nesoddtangen, Norway
11Institute of Medical Biostatistics, Epidemiology and Informatics, University Medical Centre of Johannes Gutenberg University Mainz, Mainz, Germany
12Health Sciences, University of Southampton, Southampton, UK
13Faculty of Medicine, University of Oslo, Oslo, Norway

Tóm tắt

This systematic review was performed to identify all relevant health-related quality of life (HRQoL) issues associated with COVID-19. A systematic literature search was undertaken in April 2020. In four teams of three reviewers each, all abstracts were independently reviewed for inclusion by two reviewers. Using a pre-defined checklist of 93 criteria for each publication, data extraction was performed independently by two reviewers and subsequently compared and discussed. If necessary, a third reviewer resolved any discrepancies. The search was updated in February 2021 to retrieve new publications on HRQoL issues including issues related to the long-term consequences of COVID-19. The search in April 2020 identified 3342 potentially relevant publications, and 339 publications were selected for full-text review and data extraction. We identified 75 distinct symptoms and other HRQoL issues categorized into 12 thematic areas; from general symptoms such as fever, myalgia, and fatigue, to neurological and psychological issues. The updated search revealed three extra issues experienced during active disease and long-term problems with fatigue, psychological issues and impaired cognitive function. This first comprehensive systematic review provides a detailed overview of the wide range of HRQoL issues experienced by patients with COVID-19 throughout the course of the disease. It demonstrates the devastating impact of the disease and provides critically important information for clinicians, to enable them to better recognize the disease and to provide knowledge important for treatment and follow-up. The results provided the foundation for the international development of a COVID-19 specific patient-reported HRQoL questionnaire.

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